scholarly journals Solid Lipid Nanoparticles as Carriers of Natural Phenolic Compounds

Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 998
Author(s):  
Alexandra Borges ◽  
Victor de Freitas ◽  
Nuno Mateus ◽  
Iva Fernandes ◽  
Joana Oliveira
Keyword(s):  
Phenolic Compounds ◽  
Solid Lipid Nanoparticles ◽  
Biological Effects ◽  
Lipid Nanoparticles ◽  
Promising Technique ◽  
Major Drawback ◽  
Preparation Methods ◽  
Solid Lipid ◽  
Anti Oxidant ◽  
Natural Phenolic Compounds

Phenolic compounds are one of the most widespread classes of compounds in nature, with several beneficial biological effects being associated with their anti-oxidant and anti-carcinogenic activities. Their application in the prevention or treatment of numerous chronic diseases have been studied, but a major drawback is still the low bioavailability of these compounds, as well as their instability towards pH, temperature, and light in some cases. Nanotechnology has emerged as an alternative to overcome these limitations, and the use of lipidic encapsulation systems is a promising technique to achieve an efficient drug delivery, protecting molecules from external factors and improving their bioavailability. In this review, solid lipid nanoparticles and nanostructured lipid carriers are highlighted as an important tool for the improvement of the bioavailability and stability of natural phenolic compounds, including their preparation methods and functionalization approaches and the discussion of several applications for putative use in cosmetic and pharmacologic products.

Fermentation of bioactive solid lipid nanoparticles by human gut microflora

2016 ◽  
Vol 7 (1) ◽  
pp. 516-529 ◽  
Author(s):  
Ana Raquel Madureira ◽  
Débora Campos ◽  
Beatriz Gullon ◽  
Cláudia Marques ◽  
Luís M. Rodríguez-Alcalá ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Intestinal Epithelium ◽  
Solid Lipid Nanoparticles ◽  
Oral Delivery ◽  
Lipid Nanoparticles ◽  
Gut Microflora ◽  
Human Gut ◽  
Solid Lipid ◽  
Harsh Conditions

Solid lipid nanoparticles (SLNs) can be used for oral delivery of phenolic compounds in order to protect them from the harsh conditions of digestion and improve their bioavailability in the intestinal epithelium.

scholarly journals Transmucosal Solid Lipid Nanoparticles to Improve Genistein Absorption via Intestinal Lymphatic Transport

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 267
Author(s):  
Antonella Obinu ◽  
Giovanni Pietro Burrai ◽  
Roberta Cavalli ◽  
Grazia Galleri ◽  
Rossana Migheli ◽  
...  
Keyword(s):  
Intestinal Mucosa ◽  
Solid Lipid Nanoparticles ◽  
Biological Effects ◽  
Lipid Nanoparticles ◽  
Neuroprotective Activity ◽  
Testing Time ◽  
Solid Lipid ◽  
First Pass Metabolism ◽  
First Pass ◽  
Pass Metabolism

Genistein (GEN) is a soy-derived isoflavone that exhibits several biological effects, such as neuroprotective activity and the prevention of several types of cancer and cardiovascular disease. However, due to its poor water solubility and the extensive first-pass metabolism, the oral bioavailability of GEN is limited. In this work, solid lipid nanoparticles (SLN) were developed to preferentially reach the intestinal lymphatic vessels, avoiding the first-pass metabolism of GEN. GEN-loaded SLN were obtained by a hot homogenization process, and the formulation parameters were chosen based on already formulated studies. The nanoparticles were characterized, and the preliminary in vitro chylomicron formation was evaluated. The cell uptake of selected nanocarriers was studied on the Caco-2 cell line and intestinal mucosa. The SLN, characterized by a spherical shape, showed an average diameter (about 280 nm) suitable for an intestinal lymphatic uptake, good stability during the testing time, and high drug loading capacity. Furthermore, the intestinal mucosa and Caco-2 cells were found to uptake SLN. The approximately two-fold increase in particle size suggested a possible interaction between SLN and the lipid components of chylomicrons like phospholipid; therefore, the results may support the potential for these SLN to improve oral GEN bioavailability via intestinal lymphatic absorption.

scholarly journals A concise review on preparation methods used for the development of solid lipid nanoparticles

2021 ◽  
Vol 11 (1-s) ◽  
pp. 162-169
Author(s):  
Vasu Deva Reddy Matta
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Oral Drug Delivery ◽  
Lipid Nanoparticles ◽  
Water Soluble ◽  
Oral Drug ◽  
Preparation Methods ◽  
Hydrophilic Drugs ◽  
Solid Lipid

Solid lipid nanoparticles (SLNs) are in submicron size range nanoparticles and are made of biocompatible and biodegradable materials (mainly composed of lipids and surfactants) capable of incorporating both lipophilic and hydrophilic drugs. SLNs are also considered as substitute to other colloidal drug systems, also used as controlled systems and targeted delivery. SLNs can be considered as an alternative for oral drug delivery vehicle to improve the oral bioavailability of drugs, associated reduction of drug toxicity and stability of drug in both GIT and plasma. There are different techniques used for the preparation of SLNs. Generally, the preparation of SLNs and any other nanoparticle system necessitates a dispersed system as precursor; otherwise particles are produced through the use of a particular instrumentation. This review provides the summary on the techniques or methods used for the development of SLNs of poorly water soluble drugs for improved drug delivery. Keywords: Solid lipid nanoparticles, controlled delivery, precursor, techniques.

Technological stability of solid lipid nanoparticles loaded with phenolic compounds: Drying process and stability along storage

2017 ◽  
Vol 196 ◽  
pp. 1-10 ◽  
Author(s):  
Débora A. Campos ◽  
Ana Raquel Madureira ◽  
Bruno Sarmento ◽  
Maria Manuela Pintado ◽  
Ana Maria Gomes
Keyword(s):  
Phenolic Compounds ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Drying Process ◽  
Solid Lipid

scholarly journals Cytotoxicity and Biological Efficacy of Exendin-4-Encapsulated Solid Lipid Nanoparticles in INS-1 Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Hee-Sook Jun ◽  
Gongdeuk Bae ◽  
Young Tag Ko ◽  
Yoon Sin Oh
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Biological Effects ◽  
Lipid Nanoparticles ◽  
Pharmacokinetic Studies ◽  
Mrna Levels ◽  
Solid Lipid ◽  
Vehicle Treatment ◽  
Glucagon Like Peptide 1

Exendin-4 (Ex-4), a peptide of glucagon-like peptide-1 receptor agonist, is a potent insulinotropic agent and alternative drug delivery systems to increase therapeutic utility have been explored. We developed exendin-4-encapsulated solid lipid nanoparticles (Eudragit Ex-4 SLNs) and compared the effects of Eudragit Ex-4 SLNs with those of native Ex-4 on INS-1 cells. We observed no significant toxic effects of nanoparticles at concentrations from 1 nM to 100 nM. Similar to Ex-4, Eudragit Ex-4 SLNs stimulated the production of cyclic AMP at 10 nM. Moreover, unlike treatment with the vehicle, treatment with 10 nM Eudragit Ex-4 SLNs increased insulin mRNA levels and insulin secretion. These insulinotropic effects of Eudragit Ex-4 SLNs were comparable to those of Ex-4. Thus, ourin vitroresults suggest that the biological effects of Eudragit Ex-4 SLNs are similar to those of Ex-4, and furtherin vivopharmacokinetic studies are required to propose an alternative sustained release drug system.

scholarly journals Effects of Lipid-Based Encapsulation on the Bioaccessibility and Bioavailability of Phenolic Compounds

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5545
Author(s):  
Gulay Ozkan ◽  
Tina Kostka ◽  
Tuba Esatbeyoglu ◽  
Esra Capanoglu
Keyword(s):  
Phenolic Compounds ◽  
Solid Lipid Nanoparticles ◽  
Water Solubility ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Health Promoting

Phenolic compounds (quercetin, rutin, cyanidin, tangeretin, hesperetin, curcumin, resveratrol, etc.) are known to have health-promoting effects and they are accepted as one of the main proposed nutraceutical group. However, their application is limited owing to the problems related with their stability and water solubility as well as their low bioaccessibility and bioavailability. These limitations can be overcome by encapsulating phenolic compounds by physical, physicochemical and chemical encapsulation techniques. This review focuses on the effects of encapsulation, especially lipid-based techniques (emulsion/nanoemulsion, solid lipid nanoparticles, liposomes/nanoliposomes, etc.), on the digestibility characteristics of phenolic compounds in terms of bioaccessibility and bioavailability.

Enhancement of oral bioavailability of pentoxifylline by solid lipid nanoparticles

2009 ◽  
Vol 00 (00) ◽  
pp. 090820062440031-9 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Mohsen Minayian ◽  
Elaheh Moazen
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Lipid Nanoparticles ◽  
Solid Lipid
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