scholarly journals Thermal Triggered Release of Menthol from Different Carriers: A Comparative Study

2020 ◽  
Vol 10 (5) ◽  
pp. 1677
Author(s):  
Min Wei ◽  
Xuyan Song ◽  
Xi Pan ◽  
Ran Li ◽  
Chan Chen ◽  
...  
Keyword(s):  
Controlled Release ◽  
Guar Gum ◽  
Sorbitan Monostearate ◽  
Ambient Conditions ◽  
Carrier System ◽  
Triggered Release ◽  
Thermally Induced ◽  
Thermally Responsive ◽  
Tailored Design ◽  
Carrier Systems

The design of appropriate thermally responsive fragrance carrier systems is of significant importance for the application of fragrance in the food and tobacco industries. In this study, we investigate the potential of sorbitan monostearate and guar gum for the stabilization of menthol under ambient conditions and the thermally-induced release of menthol. Our results show that the sorbitan monostearate carrier could well stabilize the menthol for at least up to 15 days with neglectable menthol loss due to the favorable binding of menthol on the sorbitan monostearate carrier. In addition, rapid and controlled release of menthol could take place at a temperature of 80 °C in the sorbitan monostearate carrier system. As a comparison, guar gum could not stabilize menthol as a result of its poor compatibility. Our results suggest that sorbitan monostearate can be an ideal carrier material for the support of fragrance. In addition, our results also provide a useful guide for the tailored design of thermally responsive fragrance carriers.

Versatile Use of Nanosponge in the Pharmaceutical Arena: A Mini-Review

2020 ◽  
Vol 14 (4) ◽  
pp. 351-359
Author(s):  
Shubham Shrestha ◽  
Sankha Bhattacharya
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Porous Structure ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Carrier System ◽  
Current Review ◽  
Long Time ◽  
Preparation Techniques

Drug delivery for a long time has been a major problem in the pharmaceutical field. The development of a new Nano-carrier system called nanosponge has shown the potential to solve the problem. Nanosponge has a porous structure and can entrap the drug in it. It can carry both hydrophilic and hydrophobic drugs. They also provide controlled release of the drugs and can also protect various substances from degradation. Nanosponge can increase the solubility of drugs and can also be formulated into an oral, topical and parenteral dosage form. The current review explores different preparation techniques, characterization parameters, as well as various applications of nanosponge. Various patents related to nanosponge drug delivery system have been discussed in this study.

New star-shape memory polyurethanes capable of thermally induced recovery and hydrogen bond-self-healing

2021 ◽  
Author(s):  
Zonghui Huang ◽  
Jianfeng Ban ◽  
Lulu Pan ◽  
Shuqing Cai ◽  
Junqiu Liao
Keyword(s):  
Hydrogen Bond ◽  
Shape Memory ◽  
Self Healing ◽  
Thermally Induced ◽  
Thermally Responsive

Star-shape memory polyurethanes that combine thermally responsive and self-healing properties.

scholarly journals Preparation and Sustained-Release Performance of PLGA Microcapsule Carrier System

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1758
Author(s):  
Shuaikai Ren ◽  
Chunxin Wang ◽  
Liang Guo ◽  
Congcong Xu ◽  
Yan Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Biomedical Applications ◽  
Encapsulation Efficiency ◽  
Drug Carriers ◽  
Optimum Conditions ◽  
Carrier System ◽  
Preparation Conditions ◽  
Encapsulation Rate ◽  
Release Drug ◽  
Release Curve

Microcapsules have been widely studied owing to their biocompatibility and potential for application in various areas, particularly drug delivery. However, the size of microcapsules is difficult to control, and the size distribution is very broad via various encapsulation techniques. Therefore, it is necessary to obtain microcapsules with uniform and tailored size for the construction of controlled-release drug carriers. In this study, emulsification and solvent evaporation methods were used to prepare a variety of ovalbumin-loaded poly (lactic-co-glycolic acid) (PLGA) microcapsules to determine the optimal preparation conditions. The particle size of the PLGA microcapsules prepared using the optimum conditions was approximately 200 nm, which showed good dispersibility with an ovalbumin encapsulation rate of more than 60%. In addition, porous microcapsules with different pore sizes were prepared by adding a varying amount of porogen bovine serum albumin (BSA) to the internal water phase. The release curve showed that the rate of protein release from the microcapsules could be controlled by adjusting the pore size. These findings demonstrated that we could tailor the morphology and structure of microcapsules by regulating the preparation conditions, thus controlling the encapsulation efficiency and the release performance of the microcapsule carrier system. We envision that this controlled-release novel microcapsule carrier system shows great potential for biomedical applications.

Recent advances in CO2 bubble-generating carrier systems for localized controlled release

Biomaterials ◽  
2017 ◽  
Vol 133 ◽  
pp. 154-164 ◽  
Author(s):  
Yu-Jung Lin ◽  
Chieh-Cheng Huang ◽  
Wei-Lin Wan ◽  
Ching-Hua Chiang ◽  
Yen Chang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Recent Advances ◽  
Carrier Systems

Synthesis, characterization and drug release studies of poly(2-hydroxyethyl methacrylate)/KIT-5 nanocomposite as an innovative organic–inorganic hybrid carrier system

RSC Advances ◽  
2015 ◽  
Vol 5 (16) ◽  
pp. 12463-12471 ◽  
Author(s):  
Roozbeh Javad Kalbasi ◽  
Ali Zirakbash
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Hybrid Material ◽  
Great Promise ◽  
Hydroxyethyl Methacrylate ◽  
Carrier System ◽  
Inorganic Hybrid ◽  
Drug Molecules ◽  
System P ◽  
Release Studies

PHEMA/KIT-5 with various pore sizes was prepared. Efficient encapsulation of drug molecules inside the pores of the hybrid material and controlled release of them in an aqueous medium, suggest the great promise of the composite as a carrier system.

Testing Long-Term Predictions from Hydro-Geochemical Models

1993 ◽  
Vol 333 ◽  
Author(s):  
William E. Glassley ◽  
Carol J. Bruton ◽  
William L. Bourcier
Keyword(s):  
Yucca Mountain ◽  
Taupo Volcanic Zone ◽  
Ambient Conditions ◽  
Volcanic Zone ◽  
Site Specific ◽  
Thermally Induced ◽  
Induced Flow ◽  
Geochemical Models ◽  
Kinetics And Thermodynamic

ABSTRACTThermally induced flow of liquid water and water vapor at the potential repository site at Yucca Mountain, Nevada, will extend hundreds of meters away from the repository edge. The resultant transfer of heat and mass will sufficiently perturb the ambient conditions such that a variety of mineralogical and chemical reactions will occur that may modify hydrological properties. The consequences of this “coupling” of geochemical and hydrological processes will vary through time, and will occur to different degrees in four regimes (T < Tboiling; T = Tboiling; T > T boiling; cooling) that will develop within the repository block. The dominant processes in the regimes differ, and reflect the local balance between: 1) kinetics and equilibrium; 2) dissolution and precipitation; 3) evaporation and boiling; and 4) fluid flow in matrix and fractures. Simulations were conducted of the evolution of these regimes, using laboratory derived kinetics and thermodynamic data, and site specific mineralogical and hydrological properties. These simulations identify regions where chemical and mineralogical equilibrium is likely to be achieved, and where net changes in hydrological properties will be concentrated. Tests of the results of these simulations have been initiated using field data from the Taupo Volcanic Zone, New Zealand. A preliminary series of calculations suggest that relative changes in porosity of as much as ± 20% to 30% may be possible for rocks with an initial porosity of 10%.

Magnetically controlled release of recombinant tissue plasminogen activator from chitosan nanocomposites for targeted thrombolysis

2016 ◽  
Vol 4 (15) ◽  
pp. 2578-2590 ◽  
Author(s):  
Jyh-Ping Chen ◽  
Chih-Hsin Liu ◽  
Hao-Lung Hsu ◽  
Tony Wu ◽  
Yu-Jen Lu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Targeted Delivery ◽  
Chitosan Nanoparticles ◽  
Recombinant Tissue Plasminogen Activator ◽  
Triggered Release ◽  
Magnetic Chitosan ◽  
Tissue Plasminogen ◽  
Thrombolysis Therapy

Targeted delivery and triggered release of rtPA-encapsulated magnetic chitosan nanoparticles with the guidance of a magnet could be used for remote-controlled thrombolysis therapy.

Preparation, characterization and application in controlled release of Ibuprofen-loaded Guar Gum/Montmorillonite Bionanocomposites

2017 ◽  
Vol 135 ◽  
pp. 52-63 ◽  
Author(s):  
Joanna Dziadkowiec ◽  
Rola Mansa ◽  
Ana Quintela ◽  
Fernando Rocha ◽  
Christian Detellier
Keyword(s):  
Controlled Release ◽  
Guar Gum

Photo-triggered release of 5-fluorouracil from a MOF drug delivery vehicle

2018 ◽  
Vol 54 (55) ◽  
pp. 7617-7620 ◽  
Author(s):  
Kristina Roth Stefaniak ◽  
Charity C. Epley ◽  
Joshua J. Novak ◽  
Margaret L. McAndrew ◽  
Hannah D. Cornell ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Small Molecules ◽  
Metal Organic Framework ◽  
Delivery Vehicle ◽  
Triggered Release ◽  
Drug Delivery Vehicle ◽  
Metal Organic ◽  
Organic Framework

A nano metal–organic-framework (nanoMOF) was employed as a first-of-its kind drug delivery vehicle (DDV) for the photo-controlled release of therapeutics with simultaneous breakdown of the carrier into small molecules.

Surfactant-Based Anhydrous Nano Carrier System for Poorly Aqueous Soluble Anti-Cancer Drugs

2021 ◽  
pp. 413-432
Author(s):  
Shekhar Verma ◽  
Nagendra Chandrawanshi ◽  
Vishal Jain
Keyword(s):  
Controlled Release ◽  
Primary Objective ◽  
Water Soluble ◽  
Cancer Drug ◽  
Cancer Drugs ◽  
Carrier System ◽  
Anti Cancer ◽  
New Chemical Entities ◽  
Poorly Water Soluble ◽  
Nano Emulsion

Around 40% of new chemical entities and drugs are lipophilic or poor aqueous soluble in nature. Among them many anti-cancer drugs are also consist lipophilic properties. Available poorly water soluble anti-cancer drugs are paclitaxel, etoposide, and docetaxel. To get better stability of those anti-cancer drug via encapsulation and searching suitable carrier system for the controlled release, design and development requires of anhydrous nano carrier system. However, to deliver and entrapment of these kind of anti-cancer drugs are very essential with avoidance of water free preparation to get suitable controlled release application and achieve targeting site. The primary objective of proposed chapter is to develop and design novel stable anhydrous or non-aqueous nano emulsion carrier system and provide suitable carrier system for poorly aqueous soluble anti-cancer drugs. Another important aim is to design and develop better stabilizing agent by combining different type of surfactant, co-surfactant, and co-solvent.

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