scholarly journals The Link between Periodontal Disease and Oral Cancer—A Certainty or a Never-Ending Dilemma?

2021 ◽  
Vol 11 (24) ◽  
pp. 12100
Author(s):  
Zinovia Surlari ◽  
Dragoș Ioan Virvescu ◽  
Elena-Raluca Baciu ◽  
Roxana-Ionela Vasluianu ◽  
Dana Gabriela Budală
Keyword(s):  
Oral Cancer ◽  
Periodontal Disease ◽  
Tooth Loss ◽  
The Body ◽  
Confounding Factors ◽  
Local Inflammation ◽  
Periodontal Bacteria ◽  
Bone Damage ◽  
Research Findings ◽  
The Relationship

Periodontal disease can have a substantial systemic influence on the body that extends beyond the oral cavity and can lead to local inflammation, bone damage, and tooth loss. A great number of studies suggest that periodontitis and oral cancer are linked, however it is unclear if specific periodontal bacteria promote the development of systemic illness. The mediators of the relationship between those two pathologies are still being discovered, but the research findings indicate the existence of a correlation. Additional research, including confounding factors, is needed to strengthen this link.

Mortal Body, Immortal Mind

2012 ◽  
Vol 17 (1) ◽  
pp. 5-26
Author(s):  
Hans Goller
Keyword(s):  
Brain Activity ◽  
The Body ◽  
Activity Data ◽  
Brain Functions ◽  
Body Experiences ◽  
Research Findings ◽  
The Relationship ◽  
Near Death Experiences ◽  
The Brain ◽  
Alternative Theories

Neuroscientists keep telling us that the brain produces consciousness and consciousness does not survive brain death because it ceases when brain activity ceases. Research findings on near-death-experiences during cardiac arrest contradict this widely held conviction. They raise perplexing questions with regard to our current understanding of the relationship between consciousness and brain functions. Reports on veridical perceptions during out-of-body experiences suggest that consciousness may be experienced independently of a functioning brain and that self-consciousness may continue even after the termination of brain activity. Data on studies of near-death-experiences could be an incentive to develop alternative theories of the body-mind relation as seen in contemporary neuroscience.

The relationship between periodontal disease, tooth loss and decreased skeletal bone mineral density in ageing women

Gerodontology ◽  
2017 ◽  
Vol 34 (4) ◽  
pp. 441-445 ◽  
Author(s):  
Ivana Savić Pavičin ◽  
Jelena Dumančić ◽  
Tomislav Jukić ◽  
Tomislav Badel
Keyword(s):  
Bone Mineral Density ◽  
Periodontal Disease ◽  
Bone Mineral ◽  
Tooth Loss ◽  
Mineral Density ◽  
Skeletal Bone ◽  
The Relationship

scholarly journals Association between apoptosis inhibitor of macrophage and microsatellite instability status in colorectal cancer

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wen-juan Huang ◽  
Xin Wang ◽  
Meng-lin Zhang ◽  
Li Li ◽  
Rui-tao Wang
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
High Frequency ◽  
The Body ◽  
Confounding Factors ◽  
Cellular Debris ◽  
Favorable Clinical Outcome ◽  
Apoptosis Inhibitor ◽  
The Relationship ◽  
Apoptosis Inhibitor Of Macrophage

Abstract Background The microsatellite instability (MSI) in colorectal cancer (CRC) has a more favorable clinical outcome and is characterized by highly upregulated expression of various immunological checkpoints than microsatellite stable (MSS) tumors. Apoptosis inhibitor of macrophage (AIM) is a circulating protein and circulates throughout the body to remove cellular debris. The aim of this study was to evaluate the association between MSI status and AIM levels in CRC patients. Methods In this study, we evaluated the levels of AIM by Enzyme Linked Immuno-Sorbent Assay (ELISA) in serum of 430 CRC patients. All patients’ clinical and laboratory characteristics at initial diagnosis were collected. The relationship between AIM levels and MSI status was examined. Results 64 patients (14.9%) were identified as having MSI-H (high-frequency MSI) and 366 casess (85.1%) having MSS. Patients with an MSI-H phenotype had lower AIM levels compared with MSS patients. Moreover, AIM levels were correlated with histological type and MSI status. Logistic regression analysis revealed that decreased AIM levels were independently associated with MSI-H phenotype after adjusting confounding factors. Conclusion Reduced AIM levels are associated with MSI-H subtyping of CRC. Further research on the involvement of AIM in MSI-H CRC is needed.

scholarly journals P0398PREVALENCE OF RED COMPLEX OF PERIODONTAL DISEASE BACTERIA IN TONSILS OF IGA NEPHROPATHY PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Yasuyuki Nagasawa ◽  
Ryota Nomura ◽  
Taro Misaki ◽  
Seigo Ito ◽  
Shuhei Naka ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Iga Nephropathy ◽  
Chronic Tonsillitis ◽  
Rt Pcr ◽  
Specific Primers ◽  
Tannerella Forsythia ◽  
Primary Glomerulonephritis ◽  
Periodontal Bacteria ◽  
The Relationship ◽  
Written Informed Consent

Abstract Background and Aims IgA nephropathy (IgAN) is one of most common primary glomerulonephritis, whose pathogenesis had remained unclear. We had reported that C.rectus and T.denticola, kinds of major periodontal disease bacteria, in tonsils with IgA nephropathy patients were specific to IgAN patients compared with chronic tonsillitis (Nagasawa-Y et al, Plos One, 2014). We also reported C.rectus and S.mutans increased proteinuria synergistically (Misaki-T et al, Nephron, 2018). Red complex of bacteria related with periodontal disease consists of P.gingivalis, T.denticola, and Tannerella forsythia, which has strongest pathogenicity of periodontal disease (Figure 1). But, in this point there were no report of prevalence of red complex of periodontal bacteria in IgA nephropathy. In this study, we evaluated the periodontal disease bacteria including P.gingivalis, T.denticola, and Tannerella forsythia in tonsils of IgAN patients, and the relationship between these periodontal bacteria clinical features in IgAN patients. Method Tonsils were obtained from 23 IgAN patients and 63 chronic tonsillitis patients when the tonsillectomy was operated. mRNAs were extracted from tonsils and the prevalences of P.gingivalis, T.denticola, and Tannerella forsythia were evaluated by RT-PCR using bacteria specific primers. All patients gave the written informed consent which was approved by Hyogo College of medicine. Results Average age was 33+-14 in IgAN patients, and the age in control patients was 27+-7. The average proteinuria in IgAN patietns was 0.9+-1.1g/gcre, and average hematuria was (2+). The prevalence of T.denticola was very low in both groups (0%, 1.6% respectively). The prevalence of P.gingivalis in IgA patients was significantly higher than that in control patients (33% vs 3.2%, respectively, P<0.0001), and the prevalence of Tannerella forsythia in IgAN patients was also significantly higher than that in control (28% vs 6.4%, respectively, P<0.05) which had not been reported (Figure 2). The types of cilia of P.gingivalis (fim A types) were also evaluated. Obviously untypeable of fim A, which is usually minor type, was dominant in IgAN patients. Conclusion Prevalence of red complex of periodontal disease bacteria, especially P.gingivalis, Tannerella forsythia in IgAN patient was higher than that in control. Red complex of periodontal disease bacteria might have some relationship with pathogenesis of IgAN

scholarly journals Gender Differences in the Relationship Between Periodontal Disease, Tooth Loss, and Atherosclerosis

Stroke ◽  
2004 ◽  
Vol 35 (9) ◽  
pp. 2029-2035 ◽  
Author(s):  
Moïse Desvarieux ◽  
Christian Schwahn ◽  
Henry Völzke ◽  
Ryan T. Demmer ◽  
Jan Lüdemann ◽  
...  
Keyword(s):  
Gender Differences ◽  
Periodontal Disease ◽  
Tooth Loss ◽  
The Relationship

scholarly journals A review of the relationship between tooth loss, periodontal disease, and cancer

2008 ◽  
Vol 19 (9) ◽  
pp. 895-907 ◽  
Author(s):  
Mara S. Meyer ◽  
Kaumudi Joshipura ◽  
Edward Giovannucci ◽  
Dominique S. Michaud
Keyword(s):  
Periodontal Disease ◽  
Tooth Loss ◽  
The Relationship

scholarly journals Screening and prophylaxis of periodontitis in the prevention of oral cavity cancer and its complications

2017 ◽  
Vol 63 (2) ◽  
pp. 73-79
Author(s):  
Iulia Cristina Micu ◽  
◽  
Alexandra Roman ◽  
Andrada Şoancă ◽  
Daniela Condor ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Oral Cavity ◽  
Periodontal Disease ◽  
Negative Impact ◽  
Local Level ◽  
Systemic Disease ◽  
Blood Stream ◽  
The Body ◽  
Oral Microbiome ◽  
Rapid Progression

Periodontitis is a complex, multifactorial infectious disease, which affects a high proportion of the global population. Recent studies show that periodontal disease has strong negative impact on the homeostasis of the oral cavity but has also been associated with several systemic diseases. Although some correlation mechanisms between periodontitis and certain systemic disease have been described further extensive investigations are needed to establish causality. Periodontitis could be involved in the onset and progression of some types of cancers, especially oral cancer due to chronic inflammation. The release of citokines and inflammatory markers at a local level and in the blood stream can disregulate the variables of the body and can be directly involved in the mechanim of tumorigenesis. Another hypothesis relies on the role of disbiosis of the oral microbiome and the structural and functional alterations of the subgingival flora which define periodontitis in the oral cancer development. The prevalence of oral cancer is very high and continous increase at an alarming rate globally. The rapid progression and aggressive behavior of oral cancer, the high mortality rate, the comorbidities and negative effect on the quality of life after cancer treatment but most importantly the low survival rate on the long term highlight the need to supress all the potential risk factors in order to prevent this disease. Periodontal status evaluation and periodontal therapy should be initiated in patients undergoing cancer therapy in order to lower the risk of complications associated with radiation- and chemotherapy. Also on the long run treatment of periodontal disease could prevent the development of a new oropharyngial carcinoma.

Causes of coercive management behaviour, dimensions and occupations

2020 ◽  
Vol 28 (6) ◽  
pp. 1175-1199
Author(s):  
Frederick Doe ◽  
Bill Buenar Puplampu ◽  
Alexander Preko
Keyword(s):  
Well Being ◽  
The Body ◽  
Policy Implications ◽  
Research Interest ◽  
Least Squares Regression ◽  
Content Type ◽  
Management Behaviour ◽  
Research Findings ◽  
Context Specific ◽  
The Relationship

Purpose The purpose of this paper is to identify the specific causes of individual dimensions of coercive management behaviour (CMB) and identify the relationship between individual causes of CMB and the deployment of individual dimension of CMB as well as propose the matching of anti-CMB solutions to occupational types. Design/methodology/approach This study used a sample of 371 respondents randomly selected from 10 of 100 accredited universities in Ghana. The data were gathered using an instrument that was measured on five-point Likert scale, ranging from “strongly disagree = 1” to “strongly agree = 5”. Then the least squares regression analysis was also used in testing the hypothesis. Findings This study identified the potent effect of causality in determining the CMB in organisations. Again, a regression of the individual causes on individual dimensions of CMB clearly shows that there is a strong relationship between specific causes and individual dimensions of CMB. The results show clearly that each CMB cause has a different effect and unequal level of significance in relation to specific dimensions. Research limitations/implications Though this research attempted to find the relationship between causes of CMB and the CMB dimensions deployed in universities, the identified causes are only the causes elucidated through a new scale developed Doe (2018). Other possible causes of CMB were not factored into this research’s objectives. It is possible therefore that further research can link some other causes not mentioned in this work to dimensions of CMB which are intimidation, threat to personal standing, threat to professional standing, social isolation and work-related harassment. It is therefore suggested that more research will be necessary to ascertain which dimensions produce which effects and in what proportion in victims of CMB. Second, as a result of the fact that this is a novel area, formulating a hypothesis for the mediation of occupational types in the relationship between causes and dimensions is difficult. Hence, although the findings present a theory of a moderation of occupational characteristics on the relationship between causes of CMB and specific dimensions of CMB in the university, this theory was not tested. However, in spite of this, the researchers propose this perspective as the paper’s contribution to the body of the literature as a novel research interest worth looking into. It is thus relevant and significant to ignite research interest in this direction. Finally, data used in the study was conjoint thereby leaving no room for a comparative analysis of public versus private universities. This limitation should therefore provide a base for further research. Practical implications The research findings have practical policy implications. This includes providing the basis for designing policies that suit the needs of employees in any organisation. This therefore prevents a one-size-fits-all approach which may not be effective in all cases. Second, corporate governance is enhanced through the identification and resolving of context-specific factors that provide the seedbed for institutionalised bullying. Theoretically, the research findings also have implications. The findings enhance the cause and effect discussion of the phenomenon in the sense that being able to identify what causes more harm to the well-being of employees in a given organisation provides the vital link to crafting the right context-specific antidote to the phenomenon. Again, the relationship between causes of CMB and dimensions of CMB has been established. Having established this relationship, it is recommended that research focus should be directed at investigating differences in organisational cultures of various occupations and how they contribute towards providing the ideal environment for the causative factors in the CMB phenomenon to thrive. The establishment of the relationship between occupation types and causes and/or dimensions of CMB will unearth the critical nexus that needs to be found between type of occupations and the reverse relationship they have with causes through the lens of the dimensions deployed in the organisation. This will further enhance the understanding of the CMB phenomenon. Originality/value This study contributes significantly to research by bringing to attention of researchers and practitioners the linkage between causes and dimensions of CMB and thus enables organisations to tailor solutions to this phenomenon to the most pertinent causes of the dimensions experienced by victims.

scholarly journals Relevansi dan Urgensi Kecerdasan Spritual, Intelektual dan Emosional dalam Perspektif Islam

2018 ◽  
Vol 14 (2) ◽  
pp. 151-160
Author(s):  
Amaliyah Amaliyah
Keyword(s):  
Emotional Intelligence ◽  
The Body ◽  
Spiritual Intelligence ◽  
Educational Institutions ◽  
Input Process ◽  
Islamic Perspective ◽  
Human Formation ◽  
Research Findings ◽  
Body And Soul ◽  
The Relationship

The formation of a man who is faithful and devoted to God becomes the first and main goal of the implementation of education. The process of forming a faithful and pious human requires several components including input, process and product components. The input components are students' including intelligence, motivation, interests and the others. This present Islamic educational institutions and public education institutions, more dominant in intellectual intelligence than on emotional intelligence and spiritual intelligence. The process of human formation that believes and cautiously requires spiritual, intellectual and emotional intelligence simultaneously because these three bits of intelligence have interconnected functions and goals. The purpose of this research is to know the differences and similarities between spiritual, intellectual and emotional intelligence, and the relationship between spiritual, intellectual and emotional intelligence in the Islamic perspective. The research findings are the source of intellectual intelligence and emotional intelligence is the spiritual intelligence source of spiritual intelligence is Tauhid, The source of intellectual intelligence and emotional intelligence are logical and phenomenal data. The human structure at the level of the body and soul is called intellectual and emotional intelligence. The human structure at the level of the Spirit/Ruh is called spiritual intelligence Keywords:Relevance, Spiritual intelligence, Intellectual intelligenc,  Emotional intelligence, Islamic perspective Abstrak Pembentukan manusia yang beriman dan bertakwa kepada Allah, menjadi tujuan utama dan pertama dalam penyelenggaraan pendidikan  Islam. Proses untuk membentuk manusia yang beriman dan bertakwa memerlukan beberapa komponen antara lain komponen input, proses dan produk. Komponen input yakni keadaan diri siswa, meliputi kecerdasan, motivasi, minat dan laian-lain. Pada saat ini lembaga pendidikan  Islam dan lembaga pendidikan  umum, lebih dominan pada kecerdasan  intelektual dibanding pada kecerdasan emosional dan kecerdasan spiritual. Proses pembentukan  manusia yang beriman dan bertakwa membutuhkan kecerdasan spiritual, intelektual dan emosional secara simultan, karena ketiga kecerdasan itu memiliki fungsi dan tujuan yang saling berhubungan. Tujuan penelitian ini adalah mengetahui perbedaan dan persamaan antara  kecerdasan spiritual, intelektual dan  emosional serta hubungan antara kecerdasan spiritual, intelektual dan emosional dalam perspektif Islam. Hasil temuan penelitian adalah sumber dari kecerdasan  intelektual dan kecerdasan emosional, adalah kecerdasan spiritual. Sumber kecerdasan spiritual adalah tauhid. Sumber kecerdasan intelektual dan kecerdasan emosional adalah  data logis dan fenomenal. Struktur manusia  pada level jasad disebut kecerdasan intelektual dan emosional. Struktur manusia  pada level Ruh disebut kecerdasan spiritual Kata Kunci: Relevansi, Kecerdasan spiritual, Kecerdasan intelektual, Kecerdasan emosional, Perspektif islam

scholarly journals Is Periodontal Disease a Red Flag for Breast Cancer Among Postmenopausal Female Smokers? An Update of the Last Decade

Perio J ◽  
2020 ◽  
Vol 4 (1) ◽  
pp. 24-37
Author(s):  
Neelam Das
Keyword(s):  
Breast Cancer ◽  
Protein Kinase ◽  
Cigarette Smoking ◽  
Periodontal Disease ◽  
Tooth Loss ◽  
Oral Microbiome ◽  
Janus Kinase ◽  
Chronic Periodontal Disease ◽  
The Relationship ◽  
Postmenopausal Female

Periodontal disease is characterized by a chronic inflammation produced in response to a disease-associated, multispecies bacterial community in the subgingival region. In recent years, interest has focused on the potential role of periodontal disease in cancer pathogenesis. In this review, we presented a summary showing a strong association between breast cancer and poor oral health, presence of periodontitis-associated bacteria, tooth loss, and clinical signs of periodontitis. Proinflammatory pathways are activated either by mono- or polymicrobial infections, resulting in an increase in the expression of proinflammatory molecules such as interleukin (IL)-6, IL-8, IL-1β, and tumor necrosis factor (TNF)-α. In addition, it has been shown that several periodontitis-associated species induce the expression of genes related to cell proliferation, cell cycle, apoptosis, transport, and immune and inflammatory responses. Intriguingly, many of these pathways are linked to carcinogenesis. Among them, the activation of Toll-like receptors (TLRs) and antiapoptotic pathways (such as the phosphoinositide-3-kinase-protein kinase B/Akt [PI3K-PKB/Akt], Janus kinase/signal transducers and activators of transcription [JAK/STAT], and mitogen-activated protein kinase [MAPK] pathways), the reduction of proapoptotic protein expression, the increase in cell migration and invasion, and the enhancement in metastasis are addressed. Cigarette smoking is one of the major causes of carcinogenesis. The incidence of breast cancer is increasing worldwide, making it the most common type of cancer among women. The etiology of breast cancer is multifactorial and cigarette smoking is one of the risk factors that has recently been shown to be associated with breast cancer. The relationship between cigarette smoking and breast cancer is due to one of the important components of cigarette smoke, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which is a representative carcinogen of N-nitrosamines that has gained focus in breast cancer carcinogenesis. The purpose of this review is to investigate the relationship between breast cancer and chronic periodontal disease changes that can occur at the oral level, including alterations of the oral microbiome, and pathological conditions among postmenopausal female smokers. Chronic periodontal disease and tooth loss were highly prevalent in postmenopausal breast cancer survivors. Based on this traditional review, the importance of dentists is clear in proposing to patients with breast cancer appropriate therapies and dedicated prevention sessions.

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