Blastocystis sp. Carriage and Irritable Bowel Syndrome: Is the Association Already Established?

Background: The aim of the present study is to describe the occurrence of Blastocystis sp. detection among asymptomatic subjects and patients with irritable bowel syndrome in order to evaluate the potential association between irritable bowel syndrome and the parasitic infection. Methods: Cross-sectional study where adult patients with irritable bowel syndrome diagnosed according to Rome IV criteria were included. A control group was formed by asymptomatic subjects older than 18 years. Exclusion criteria were: immunosuppressive condition or having received any drug with demonstrated activity against Blastocystis sp. within the last 6 months before study inclusion. Epidemiological and clinical information was collected from all included participants. Two stool samples were obtained from all participants: one sample for microscopic examination and one sample for Blastocystis sp. PCR detection. Blastocystis sp. infection was defined by the positivity of any of the diagnostic techniques. Results: Seventy-two participants were included (36 asymptomatic subjects and 36 patients with irritable bowel syndrome). Thirty-five (48.6%) were men, and median age of participants was 34 (IQR 29–49) years. The overall rate of Blastocystis sp. carriage was 27.8% (20/72). The prevalence assessed through microscopic examination was 22.2% (16/72), while the prevalence measured by PCR was 15.3% (11/72). When comparing the presence of Blastocystis sp. between asymptomatic subjects and IBS patients, we did not find any statistically significant difference (36.1% vs. 19.4% respectively, p = 0.114). Conclusions: regarding the occurrence of Blastocystis sp., no differences were found between asymptomatic participants and patients with irritable bowel disease irrespective of the diagnostic technique performed.

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Quantitation of Colonic Cells as Severity Markers in Patients with Irritable Bowel Syndrome

Galen Medical Journal ◽

10.31661/gmj.v7i0.1063 ◽

2018 ◽

Vol 7 ◽

pp. e1063

Author(s):

Mohammad Bagher Miri ◽

Amir Sadeghi ◽

Afshin Moradi ◽

Mohammad Rostami-Nejad ◽

Mohammad-Javad Ehsani-Ardekani ◽

...

Keyword(s):

T Cells ◽

Irritable Bowel Syndrome ◽

Mast Cells ◽

Inflammatory Cells ◽

Normal Subjects ◽

Intraepithelial Lymphocytes ◽

Control Group ◽

Case Group ◽

Cross Sectional ◽

Irritable Bowel

Background: Irritable bowel syndrome (IBS) is the most common gastrointestinal syndrome. Routine histopathology and immunohistochemistry (IHC) evaluations have shown an increase in the number of different inflammatory cells in the colon of IBS patients. In this study, we have compared the number of intraepithelial lymphocytes (IELs), eosinophils, mast cells and CD3+ T cells, in IBS patients and normal subjects. Materials and Methods: In 2016, seventy-nine patients with IBS and seventy-nine healthy subjects who underwent colonoscopy for other non-specific causes and with no pathologic findings, were enrolled in this cross-sectional study. Biopsy specimens obtained from the colon were stained, using IHC methods to determine the number of IELs, eosinophils, mast cells and CD3+ T cells. Quantitative and qualitative variables were compared between the two groups, using a Chi-square test and Student’s t-test. Results: Seventy-nine patients with IBS, 79.7% females with a mean age of 42.5±14.6 years, were recruited, as the case group, and seventy-nine individuals, 51.9% females with a mean age of 39.7±18.9 years, were enrolled as controls. The average number of IELs per high power fields (hpf) was found to be higher in the IBS group, and this difference was statistically significant (32.8±11.8 vs. 28.6±12.9; P=0.034). Also, the mean count/hpf of CD3+ T lymphocytes (23.1±7.9 vs. 20.2±8.1; P=0.024) and mast cells (7.6±3.1 vs. 6.6±3.0; P=0.041) were significantly higher in the IBS group, compared to the control group. The number of eosinophils was higher in the IBS group, but the differences were not statistically significant (P=0.066). Conclusion: According to the results, we suggest that analysis of immune cells and IELs in intestinal biopsies might be an appropriate method for diagnosis of IBS. [GMJ.2018;7:e1063]

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Coping styles and defense mechanisms utilised by patients suffering from irritable bowel syndrome

Health SA Gesondheid ◽

10.4102/hsag.v4i1.8 ◽

1999 ◽

Vol 4 (1) ◽

pp. 28-34 ◽

Cited By ~ 1

Author(s):

Raylene Pokroy ◽

Aliza Mayer ◽

Anita D Stuart ◽

H Gertie Pretorius

Keyword(s):

Irritable Bowel Syndrome ◽

Defense Mechanisms ◽

White Women ◽

Coping Styles ◽

Control Group ◽

Ways Of Coping ◽

Ways Of Coping Questionnaire ◽

Irritable Bowel Syndrome Group ◽

Significant Difference ◽

Irritable Bowel

The goal of the research was to determine whether people suffering from lrritable Bowel Syndrome (IBS), differ from non-Irritable Bowel Syndrome sufferers in terms of their coping styles and defense mechanisms. The research project was divided into two studies, namely: the first studied coping styles used by lrritable Bowel Syndrome sufferers and the second study focused on the defense mechanisms of the same group. The sample consisted of 30 white women between the ages of 25 and 55 years, diagnosed with lrritable Bowel Syndrome. A control group, consisting of 30 same-aged white women was also studied studied. The results show a significant difference between the lrritable Bowel Syndrome group and the non-Irritable Bowel Syndrome group as measured by the Ways of Coping Questionnaire (WCQ), the Defense Mechanisms lnventory (DMI) and the Coping perations Preference Enquiry (COPE). The implicati&s of these studies may be of great value in the non-pharmacological management or control of lrritable Bowel Syndrome. Possible directions for future research are proposed.OpsommingDie doel van die navorsing was om vas te stel of mense wat aan Prikkelbare Dermsindroom (PDS) ly, verskil van nie-Prikkelbare Dermsindroom lyers in terme van hulle hanteringsmeganismes en verdedigingsmeganismes. Die navorsing is in twee studies verdeel, naamlik: die eerste het hanteringstyle bestudeer wat gebruik word deur persone wat aan Prikkelbare Dermsindroom ly en die tweede studie het die verdedigingsmeganismes bestudeer in dieselfde groep. Die steekproef het bestaan uit 30 wit vrouens tussen die ouderdomme van 25 en 55 jaar wat gediagnoseer is met Prikkelbare Dermsindroom. 'n Kontrolegroep, bestaande uit 30 wit vrouens in dieselfde ouderdomsgroep, is ook bestudeer. Die resultate dui op 'n statisties beduidende verskil tussen die Prikkelbare Dermsindroom groep en die nie-Prikkelbare Dermsindroom groep soos gemeet deur die "Ways of Coping Questionnaire", die "Defense Mechanisms lnventory (DMI)" en die "Coping Operations Preference Enquiry (COPE)". Die implikasie van die studies mag van groot waarde wees in die nie-farmakologiese bestuur of beheer van Prikkelbare Dermsindroom. Moontlike rigtings vir toekomstige navorsing word voorgestel.

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Managing irritable bowel syndrome: The impact of micro-physiotherapy

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2015-0044 ◽

2017 ◽

Vol 14 (2) ◽

Cited By ~ 1

Author(s):

Daniel Grosjean ◽

Patrice Benini ◽

Pierre Carayon

Keyword(s):

Irritable Bowel Syndrome ◽

Holistic Approach ◽

Study Groups ◽

Control Group ◽

Double Blind Study ◽

Self Healing ◽

Double Blind ◽

Significant Difference ◽

Irritable Bowel ◽

The Impact

AbstractBackgroundIrritable bowel syndrome (IBS) has a complex pathology, high prevalence and large impact on patients’ quality of life. As conventional therapy may yield unsatisfactory results, a more holistic approach may be desirable. The current study assessed the effect of micro-physiotherapy on the severity of IBS symptoms.MethodsIn a double-blind study, 61 recurrent IBS patients were randomised to two sessions of micro-physiotherapy or sham micro-physiotherapy. Inclusion criteria were the presence of ≥1 IBS symptom from abdominal pain, constipation, diarrhoea or bloating. Exclusion criteria were previous major intestinal surgery and the presence of chronic diseases. The mean patient age was 53.5±15.3 years. Micro-physiotherapy consisted of micro-palpatory examination to identify osteopathic lesions, followed by micro-massage to stimulate self-healing. The control group underwent a sham procedure. The presence and severity of symptoms was assessed at baseline and at 1-month follow-up by the same gastroenterologist.ResultsTwo patients did not complete the study. There was a significant difference in percentage of patients that improved after the first session, at 74 % for the micro-physiotherapy group and 38 % for the sham group, respectively (p=0.005). After the second session, the initial improvement was maintained in both groups, although with no further gains, and the differences between the study groups remained significant (p=0.007).ConclusionsMicro-physiotherapy significantly improves IBS symptoms and should be explored further for use in mainstream healthcare.

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Lack of Association Found betweenHelicobacter pyloriInfection and Diarrhea-Predominant Irritable Bowel Syndrome: A Multicenter Retrospective Study

Gastroenterology Research and Practice ◽

10.1155/2016/3059201 ◽

2016 ◽

Vol 2016 ◽

pp. 1-7 ◽

Cited By ~ 8

Author(s):

Feng Xiong ◽

Man Xiong ◽

Zonghui Ma ◽

Senxiong Huang ◽

Aimin Li ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Retrospective Study ◽

Control Group ◽

Significant Difference ◽

Long Term Follow Up ◽

Rome Iii ◽

H Pylori ◽

Irritable Bowel

Aims. The association betweenHelicobacter pylori(H. pylori) infection and diarrhea-predominant irritable bowel syndrome (IBS-D) is still controversial. Here we performed a retrospective study to explore this issue.Methods. A total of 502 inpatients with Rome III confirmed IBS-D and knownH. pyloristatus from 8 hospitals were enrolled.H. pylori-positive patients, hospitalized in the recent year, were followed up to evaluate the effects ofH. pylorieradication on IBS-D clinical course.Results. Of the 502 IBS-D patients, 206 wereH. pylori-positive, with an infection rate that has no significant difference with that of the general population in Guangdong province (p=0.348). For patients followed up, no significant differences were noted as to overall symptoms (p=0.562), abdominal pain/discomfort (p=0.777), bloating (p=0.736), stool frequency (p=0.835), or stool characteristics (p=0.928) between theH. pylori-eradicated group and the control group. The results were the same in long-term follow-up patients except the improvement of bloating, which showed that the bloating score in theH. pylori-eradicated group was significantly lower (p=0.047).Conclusions. No significant correlation betweenH. pyloriinfection and IBS-D was noted. Overall, IBS-D patients may not benefit fromH. pylorieradication.

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Cognitive performance in irritable bowel syndrome: evidence of a stress-related impairment in visuospatial memory

Psychological Medicine ◽

10.1017/s0033291713002171 ◽

2013 ◽

Vol 44 (7) ◽

pp. 1553-1566 ◽

Cited By ~ 55

Author(s):

P. J. Kennedy ◽

G. Clarke ◽

A. O‘Neill ◽

J. A. Groeger ◽

E. M. M. Quigley ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Cognitive Performance ◽

Hpa Axis ◽

Spatial Working Memory ◽

Control Group ◽

Visuospatial Memory ◽

Cross Sectional ◽

Co Morbidity ◽

Cortisol Levels ◽

Irritable Bowel

BackgroundCentral nervous system (CNS) dysfunction is a prominent feature of the functional gastrointestinal (GI) disorder, irritable bowel syndrome (IBS). However, the neurobiological and cognitive consequences of key pathophysiological features of IBS, such as stress-induced changes in hypothalamic–pituitary–adrenal (HPA)-axis functioning, is unknown. Our aim was to determine whether IBS is associated with cognitive impairment, independently of psychiatric co-morbidity, and whether cognitive performance is related to HPA-axis function.MethodA cross-sectional sample of 39 patients with IBS, a disease control group of 18 patients with Crohn's disease (CD) in clinical remission and 40 healthy age- and IQ-matched control participants were assessed using the Paired Associates Learning (PAL), Intra-Extra Dimensional Set Shift (IED) and Spatial Working Memory (SWM) tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB) and a computerized Stroop test. HPA-axis function was determined by measuring the cortisol awakening response (CAR).ResultsIBS patients exhibited a subtle visuospatial memory deficit at the PAL six- pattern stage (p = 0.03), which remained after psychiatric co-morbidity was controlled for (p = 0.04). Morning cortisol levels were lower in IBS (p = 0.04) and significantly associated with visuospatial memory performance within IBS only (p = 0.02).ConclusionsFor the first time, altered cognitive function on a hippocampal-mediated test of visuospatial memory, which was related to cortisol levels and independent of psychiatric co-morbidity, has been identified in IBS. Visuospatial memory impairment may be a common, but currently neglected, component of IBS. Further elucidation of the nature of this impairment may lead to a greater understanding of the underlying pathophysiology of IBS, and may provide novel therapeutic approaches.

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Association of anxiety-depressive disorders with irritable bowel syndrome among patients attending a rural family practice center: a comparative cross-sectional study

General Psychiatry ◽

10.1136/gpsych-2021-100553 ◽

2021 ◽

Vol 34 (6) ◽

pp. e100553

Author(s):

Alaa Adel Mohammed ◽

Heba Ahmed Moustafa ◽

Hebatallah Nour-Eldein ◽

Rabab Atta Saudi

Keyword(s):

Irritable Bowel Syndrome ◽

Family Practice ◽

Depressive Disorders ◽

Dietary Habits ◽

Cross Sectional Study ◽

Sectional Study ◽

Lifestyle Habits ◽

Cross Sectional ◽

Significant Difference ◽

Irritable Bowel

BackgroundComorbidity of irritable bowel syndrome (IBS) and psychiatric disorders is common, and the prevalence of at least one psychiatric disorder has been reported as high as 80% among patients with IBS.AimsTo explore the association of anxiety-depressive disorders with IBS and its different subtypes, and to evaluate the associations of lifestyle habits, dietary habits and sleeping quality with IBS.MethodsA comparative cross-sectional study was conducted at the AL-Mahsama Family Practice Center, Ismailia, Egypt. It was carried out between October 2019 and October 2020. Participants were categorised into 175 patients with IBS, diagnosed using the Rome IV criteria, and 175 patients without IBS. A semistructured questionnaire was used to collect data on sociodemographic characteristics, lifestyle habits, dietary habits and sleep quality from both groups. The Hamilton Anxiety Rating Scale was used to assess anxiety symptoms, whereas the Beck Depression Inventory Second Edition was used to assess depression symptoms.ResultsThere was a high statistically significant difference between both groups with regard to age, education, occupation and socioeconomic status (SES), being a smoker, being physically inactive, having sleep disturbance and having irregular meals; being either obese or overweight was more reported in the IBS group. There was a high statistically significant difference in the rate of anxiety and depression between patients with and without IBS. Mild, moderate and severe anxiety were reported in 37.1%, 42.9% and 20.0% of patients with IBS while most (80.0%) of the patients without IBS reported mild anxiety. Regarding depression, mild, moderate and severe depression were reported in 60.0%, 14.3% and 25.7% of the patients with IBS while most (82.9%) of the non-IBS participants reported mild depression.ConclusionsThe study shows a significant association between anxiety-depressive disorders and IBS, but no significant associations between anxiety-depressive disorders and IBS subtypes.

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A School-Based Study of Irritable Bowel Syndrome in Medical Students in Beijing, China: Prevalence and Some Related Factors

Gastroenterology Research and Practice ◽

10.1155/2014/124261 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 7

Author(s):

Yang Liu ◽

Liang Liu ◽

Yi Yang ◽

Yuxi He ◽

Yanli Zhang ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Medical Students ◽

Sleep Disorder ◽

Life Stress ◽

Cross Sectional Study ◽

Control Group ◽

Related Factors ◽

Cross Sectional ◽

Irritable Bowel ◽

Beijing China

Purpose. To investigate the prevalence and some related factors about irritable bowel syndrome (IBS) in medical students.Methods. A cross-sectional study was carried out from February 2014 to Jun 2014 in Beijing University of Chinese Medicine, Beijing, China. All participants were asked to completed self-administered questionnaires.Results.Seven hundred and sixty-seven medical students (23.26±2.88years, 25.6% males) completed the survey. The prevalence of IBS was 33.3%, with a high prevalence in women (36.1%). Among the IBS patients, 112 cases were IBS-M (43.9%) and 77.6% had moderately severe IBS. There were no statistical differences between control group and IBS patients in anxiety and depression scores (P>0.05). The total score of Pittsburgh sleep quality index (PSQI) was significantly higher for medical students with IBS and 35.5% of IBS patients had severe sleep disorder; the scores of child trauma questionnaire (CTQ) and student-life stress inventory (SLSI) were also higher in IBS patients. Sex and sleep disorder were independently associated with IBS (OR, 1.914, 95%CI, 1.281–2.860; OR, 1.143, 95%CI, 1.074–1.216).Conclusion. Our study has many valuable findings and they may provide valuable suggestions for the necessary intervention and treatment measures towards medical students.

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A Cross-Sectional Study of the Association between Overnight Call and Irritable Bowel Syndrome in Medical Students

Canadian Journal of Gastroenterology ◽

10.1155/2012/865915 ◽

2012 ◽

Vol 26 (5) ◽

pp. 281-284 ◽

Cited By ~ 8

Author(s):

Malcolm Wells ◽

Lee Roth ◽

Morgan McWilliam ◽

Kim Thompson ◽

Nilesh Chande

Keyword(s):

Quality Of Life ◽

Irritable Bowel Syndrome ◽

Medical Students ◽

Demographic Data ◽

Paper Copy ◽

Gastrointestinal Symptoms ◽

Cross Sectional ◽

Significant Difference ◽

Irritable Bowel

BACKGROUND: Shift work has been associated with irritable bowel syndrome (IBS), which includes gastrointestinal symptoms such as abdominal pain, constipation and diarrhea. Overnight call shifts also lead to a disruption of the endogenous circadian rhythm.HYPOTHESIS: Medical students who perform intermittent overnight call shifts will demonstrate a higher prevalence of IBS symptoms when compared with medical students who perform no overnight call shifts.METHODS: First- and second-year (preclinical) medical students have no overnight call requirements, whereas third- and fourth-year medical (clerkship) students do have overnight call requirements. All medical students at the Schulich School of Medicine and Dentistry (London, Ontario) were invited to complete an anonymous, web-based survey or an identical paper copy that included demographic data, the Rome III questionnaire and the IBS-Quality of Life measure (IBS-QOL). The prevalence of IBS symptoms and quality of life secondary to those symptoms were determined.RESULTS: Data were available for 247 medical students (110 pre-clinical students, 118 clerkship students and 19 excluded surveys). There was no significant difference in the presence of IBS between preclinical and clerkship students (21 of 110 [19.1%] versus 26 of 118 [22.0%]; P=0.58). The were no significant differences in mean (± SD) IBS-QOL score of those with IBS between preclinical (43.5±8.3) and clerkship students (45.7±13.8) (P=0.53).CONCLUSIONS: Participation in overnight call was not associated with the development of IBS or a lower quality of life secondary to IBS in medical students.

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Clinical-Reported Outcomes Of Deferoxamine Versus Deferasirox In The Treatment Of Homozygous BetaThalassemia

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v9ispl1.1382 ◽

2018 ◽

Vol 9 (SPL1) ◽

Author(s):

Zeina A Munim Al-Thanoon ◽

Mustafa Basil ◽

Nasih A Al-Kazzaz

Keyword(s):

Serum Ferritin ◽

Iron Chelation ◽

Iron Chelator ◽

Beta Thalassemia ◽

Control Group ◽

Current Standard ◽

Cross Sectional ◽

Significant Difference ◽

Multiple Blood ◽

Group 2

Iron chelation therapy with deferoxamine (DFO),the current standard for the treatment of iron overload in patients with betathalassemia,requires regular subcutaneous or intravenous infusions. This can lead to reduced quality of life and poor adherence,resulting in increased morbidity and mortality in iron-overloaded patients with beta-thalassemia. Deferasirox (DFX) is an orally administered iron chelator that has been approved for use in many countries. The requirement of an effective,well tolerated iron chelator with a less demanding mode of administration has led to the development of deferasirox. The present study was aimed to compare the satisfaction and compliance with deferoxamine versus deferasirox (Exjade®),a novel oral iron chelator in patients with transfusion - dependent beta- thalassemia. A cross-sectional,single-center investigation study was carried out in the Thalassemia Center of Ibn-Atheer Teaching Hospital in Nineveh province,Iraq. One hundred and eight thalassemic patients aged between 2- 20 years old having received multiple blood transfusions and a serum ferritin greater than 1500 ng/ml. Patients were randomised into two groups. Group 1 received deferoxamine at a dose of 20-50mg/kg/day and group 2 received deferasirox at the dose of 10-30 mg/kg/day. Another 56 apparently healthy volunteers were used as a control group. The assessment of chelation was done during the period between November 2013 and February 2014 by measurement of serum ferritin. Satisfaction and compliance was assessed by using a special questionnaire prepared by the researcher. Out of the 108 thalassemic patients enrolled there was no discontinuation in treatment with the two drugs under study. The serum ferritin did not change significantly in any of the chelation groups. In comparison with the patients who were treated with DFO,those receiving DFX reported a significantly higher rate of compliance and satisfaction (P < 0.05). However,no significant difference was observed between the two groups regarding their satisfaction (P > 0.05).Compliance with deferasirox (50 %) was more than that with deferoxamine (20 %). Satisfaction with deferoxamine was significantly lower than deferasirox (p= 0.00).

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Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms

Scientific Reports ◽

10.1038/s41598-021-87158-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

L. Quénéhervé ◽

D. Drui ◽

J. Blin ◽

M. Péré ◽

E. Coron ◽

...

Keyword(s):

Quality Of Life ◽

Irritable Bowel Syndrome ◽

Adrenal Insufficiency ◽

Gastrointestinal Symptoms ◽

Control Group ◽

Non Profit ◽

Acute Adrenal Insufficiency ◽

Irritable Bowel ◽

Rome Iv

AbstractGastrointestinal symptoms are frequent in acute adrenal insufficiency. Although digestive symptoms can significantly reduce quality of life, they are rarely described in patients with treated chronic adrenal insufficiency (CAI). We aimed to characterize digestive symptoms in CAI patients. We used the section pertaining functional bowel disorders of the Rome IV questionnaire. A questionnaire was published on the website of the non-profit patient association “Adrenals” (NPPA of CAI patients) for five months. Information on demographics, characteristics of adrenal insufficiency, digestive symptoms and quality of life was collected. The relatives of CAI patients served as a control group. We analyzed responses of 33 control subjects and 119 patients (68 primary adrenal insufficiency (PAI), 30 secondary adrenal insufficiency (SAI) and 21 congenital adrenal hyperplasia (CAH)). Abdominal pain at least once a week over the past 3 months was reported by 40%, 47% and 33% of patients with PAI, SAI and CAH respectively versus 15% for the controls (p = 0.01). Symptoms were consistent with the Rome IV criteria for irritable bowel syndrome in 27%, 33% and 33% of patients respectively versus 6% for the controls (p < 0.0001). Quality of life was described as poor or very poor in 35%, 57% and 24% of patients respectively versus 5% for the controls (p < 0.0001). In conclusion, digestive symptoms are frequent and incapacitating in CAI patients and similar to symptoms of irritable bowel syndrome in 30% of CAI patients. Assessment and management of digestive symptoms should be considered a priority for physicians treating patients with CAI.

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