Vascular Calcification in Rodent Models—Keeping Track with an Extented Method Assortment

Vascular calcification is a multifaceted disease and a significant contributor to cardiovascular morbidity and mortality. The calcification deposits in the vessel wall can vary in size and localization. Various pathophysiological pathways may be involved in disease progression. With respect to the calcification diversity, a great number of research models and detection methods have been established in basic research, relying mostly on rodent models. The aim of this review is to provide an overview of the currently available rodent models and quantification methods for vascular calcification, emphasizing animal burden and assessing prospects to use available methods in a way to address the 3R principles of Russel and Burch: “Replace, Reduce and Refine”.

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Faculty Opinions recommendation of Effect of clonidine on cardiovascular morbidity and mortality after noncardiac surgery.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1098085.554064 ◽

2007 ◽

Author(s):

Cesare Gregoretti

Keyword(s):

Noncardiac Surgery ◽

Cardiovascular Morbidity ◽

Morbidity And Mortality ◽

Cardiovascular Morbidity And Mortality

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Added Burden of Major Depressive Disorder on Cardiovascular Morbidity and Mortality Among Patients with Cardiovascular Disease and the Modifying Effects of Antidepressants: A National Retrospective Cohort Study

Journal of Affective Disorders ◽

10.1016/j.jad.2021.07.082 ◽

2021 ◽

Author(s):

Mehala Subramaniapillai ◽

Vincent Chin-Hung Chen ◽

Roger S. McIntyre ◽

Yao-Hsu Yang ◽

Yi-Lung Chen

Keyword(s):

Cardiovascular Disease ◽

Major Depressive Disorder ◽

Cohort Study ◽

Depressive Disorder ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Cardiovascular Morbidity ◽

Morbidity And Mortality ◽

Major Depressive ◽

Cardiovascular Morbidity And Mortality

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Soluble CD40 Ligand Is Predictive of Cardiovascular Morbidity and Mortality at Two-Year Follow-Up in Patients on Haemodialysis From North-Western Tuscany

High Blood Pressure & Cardiovascular Prevention ◽

10.2165/00151642-200714030-00119 ◽

2007 ◽

Vol 14 (3) ◽

pp. 145-196

Author(s):

G B Desideri ◽

L Ghiadoni ◽

F Cipollone ◽

A Mezzetti ◽

G Passacquale ◽

...

Keyword(s):

Cd40 Ligand ◽

Cardiovascular Morbidity ◽

Morbidity And Mortality ◽

Soluble Cd40 Ligand ◽

Cardiovascular Morbidity And Mortality ◽

North Western

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Cardiovascular Morbidity and Mortality in High-Risk Populations: Epidemiology and Opportunities for Risk Reduction

Journal of Clinical Hypertension ◽

10.1111/j.1524-6175.2007.07722.x ◽

2007 ◽

Vol 9 ◽

pp. 11-15 ◽

Cited By ~ 15

Author(s):

Wanpen Vongpatanasin

Keyword(s):

High Risk ◽

Risk Reduction ◽

Cardiovascular Morbidity ◽

Morbidity And Mortality ◽

Cardiovascular Morbidity And Mortality ◽

High Risk Populations

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Letter to the Editor on “Traditional Cardiovascular Risk Factors Strongly Underestimate the 5-Year Occurrence of Cardiovascular Morbidity and Mortality in Spinal Cord Injured Individuals”

Archives of Physical Medicine and Rehabilitation ◽

10.1016/j.apmr.2021.05.019 ◽

2021 ◽

Author(s):

Thomas J. Barton ◽

David A. Low ◽

Esmee A. Bakker ◽

Thomas Janssen ◽

Sonja de Groot ◽

...

Keyword(s):

Risk Factors ◽

Spinal Cord ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Cardiovascular Morbidity ◽

Morbidity And Mortality ◽

Letter To The Editor ◽

Cardiovascular Morbidity And Mortality ◽

Spinal Cord Injured

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THE IMPACT OF RENAL DYSFUNCTION ON IN HOSPITAL CARDIOVASCULAR MORBIDITY AND MORTALITY IN ACUTE CORONARY SYNDROME

Heart ◽

10.1136/heartjnl-2012-302920a.241 ◽

2012 ◽

Vol 98 (Suppl 2) ◽

pp. E92.1-E92

Author(s):

Delifalah Delifalah

Keyword(s):

Acute Coronary Syndrome ◽

Renal Dysfunction ◽

Cardiovascular Morbidity ◽

Morbidity And Mortality ◽

Coronary Syndrome ◽

Cardiovascular Morbidity And Mortality ◽

The Impact

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Predictive, mechanistic, and therapeutic studies on hypertension and cardiovascular morbidity and mortality

Journal of Hypertension ◽

10.1097/hjh.0000000000000268 ◽

2014 ◽

Vol 32 (8) ◽

pp. 1549-1550 ◽

Cited By ~ 1

Author(s):

Alberto Zanchetti

Keyword(s):

Cardiovascular Morbidity ◽

Morbidity And Mortality ◽

Cardiovascular Morbidity And Mortality

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STUDY OF MICROALBUMINURIA IN PATIENTS WITH NORMOGLYCEMIC HYPERTENSION

10.36106/ijsr/4505067 ◽

2021 ◽

pp. 68-70

Author(s):

Ketan Prajapati ◽

Sanket Makwana ◽

M. J. Sonagara

Keyword(s):

Body Mass Index ◽

Essential Hypertension ◽

Body Mass ◽

Independent Predictor ◽

Blood Pressure Measurement ◽

Cardiovascular Morbidity ◽

Morbidity And Mortality ◽

Hypertensive Patients ◽

Arterial Blood ◽

Cardiovascular Morbidity And Mortality

INTRODUCTION:Hypertension is one of the most important risk factors for cardiovascular disease. The incidence of microalbuminuria is more common among hypertensive patients, even in nondiabetic patients. Microalbuminuria is an independent predictor of cardiovascular morbidity and mortality in patients with essential hypertension. Therefore, current guidelines recommend routine screening of microalbuminuria in hypertensive patients to ensure appropriate interventions are initiated early in the disease process before progression to chronic kidney disease and/or renal failure. AIMS & OBJECTIVES:This study is done to estimate the prevalence of microalbuminuria in patients with normoglycemic hypertension and to identify other variables associated with it. MATERIAL & METHODS:In this study, we randomly selected 100 patients with essential hypertension based on inclusion and exclusion criteria. CBC, renal function test, 24-hour urine albumin excretion (UAE), Body mass index (BMI), and arterial blood pressure measurement were done among all selected patients. Data entry was done in Microsoft Ofce Excel and analysis was done using the software package Epi Info (Version 7.1.5) from CDC, Atlanta, U.S.A. OBSERVATIONS & RESULTS: The study was conducted among 100 hypertensive patients out of which 74 were male and 24 were female. Out of 100 patients, microalbuminuria was present in 44 patients. Mean arterial pressure was found high among patients with microalbuminuria than patients without microalbuminuria. The presence of microalbumin in urine was found to increase with the increasing severity of hypertension. Mean body mass index and serum creatinine were found higher in the microalbuminuric group than the normoalbuminuric group. CONCLUSION:The incidence of microalbuminuria is more common among hypertensive patients, even in nondiabetic patients. The presence of microalbuminuria is an independent predictor of cardiovascular morbidity and mortality in patients with essential hypertension. Screening for microalbuminuria is a relatively simple process, should facilitate early vascular disease detection.

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