scholarly journals Chemical Diversity and Biological Activities of Essential Oils from Licaria, Nectrandra and Ocotea Species (Lauraceae) with Occurrence in Brazilian Biomes

Biomolecules ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 869
Author(s):  
Júlia Karla A. M. Xavier ◽  
Nayara Sabrina F. Alves ◽  
William N. Setzer ◽  
Joyce Kelly R. da Silva
Keyword(s):  
Systematic Review ◽  
Biological Activities ◽  
Geographic Area ◽  
Chemical Diversity ◽  
Caryophyllene Oxide ◽  
Collection Site ◽  
Sesquiterpene Hydrocarbons ◽  
Antifungal Potential ◽  
Germacrene D ◽  
Chemical Profiles

Lauraceae species are known as excellent essential oil (EO) producers, and their taxa are distributed throughout the territory of Brazil. This study presents a systematic review of chemical composition, seasonal studies, occurrence of chemical profiles, and biological activities to EOs of species of Licaria, Nectandra, and Ocotea genera collected in different Brazilian biomes. Based on our survey, 39 species were studied, with a total of 86 oils extracted from seeds, leaves, stem barks, and twigs. The most representative geographic area in specimens was the Atlantic Forest (14 spp., 30 samples) followed by the Amazon (13 spp., 30 samples), Cerrado (6 spp., 14 samples), Pampa (4 spp., 10 samples), and Caatinga (2 spp., 2 samples) forests. The majority of compound classes identified in the oils were sesquiterpene hydrocarbons and oxygenated sesquiterpenoids. Among them, β-caryophyllene, germacrene D, bicyclogermacrene, caryophyllene oxide, α-bisabolol, and bicyclogermacrenal were the main constituents. Additionally, large amounts of phenylpropanoids and monoterpenes such as safrole, 6-methoxyelemicin, apiole, limonene, α-pinene, β-pinene, 1,8-cineole, and camphor were reported. Nectandra megatopomica showed considerable variation with the occurrence of fourteen chemical profiles according to seasonality and collection site. Several biological activities have been attributed to these oils, especially cytotoxic, antibacterial, antioxidant and antifungal potential, among other pharmacological applications.

scholarly journals Chemical Diversity and Therapeutic Effects of Essential Oils of Aniba Species from the Amazon: A Review

Plants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1854
Author(s):  
Rafaela C. S. da Trindade ◽  
Júlia Karla A. M. Xavier ◽  
William N. Setzer ◽  
José Guilherme S. Maia ◽  
Joyce Kelly R. da Silva
Keyword(s):  
Essential Oils ◽  
Biological Activities ◽  
Hierarchical Cluster ◽  
Geographic Area ◽  
Chemical Diversity ◽  
Therapeutic Effects ◽  
Tropical Regions ◽  
Main Compound ◽  
Chemical Profiles ◽  
Amazonas State

Lauraceae families have great diversity in the world’s tropical regions and are represented mainly by aromatic shrubs and trees with significant production of essential oils (EOs). This work presents a review of the EO chemical profiles from specimens of Aniba, including their seasonal variations, geographical distributions, and biological activities in the Amazon biome. Based on the survey, 15 species were reviewed, representing 167 oil samples extracted from leaves, twig barks, and woods. Brazilian Amazon was the most representative geographic area in the number of specimens, highlighting the locations Belém, (Pará state, PA) (3 spp., 37 samples), Santarém (PA) (3 spp., 10 samples), Carajás (PA) (3 spp., 7 samples), and Manaus (Amazonas state, AM) (3 spp., 16 samples). The main compound classes identified in oils were benzenoids and phenylpropanoids, represented by 1-nitro-2-phenylethane, benzyl salicylate, benzyl benzoate and methyleugenol, along with terpenoids, especially monoterpenes and sesquiterpenes, such as linalool, α-phellandrene, β-phellandrene, β-selinene, and spathulenol. The EOs from Aniba showed considerable variation in the chemical profiles according to season and collection site. The hierarchical cluster analysis classified the samples into two main groups according to chemical composition. This review highlights its comprehensive and up-to-date information on history, conservation, traditional uses, chemosystematics, pharmacological potential of Aniba species.

scholarly journals Chemical Composition of the Essential Oil of Croton bonplandianus from India

2014 ◽  
Vol 9 (2) ◽  
pp. 1934578X1400900
Author(s):  
Rajesh K. Joshi
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Chemical Composition ◽  
Essential Oil ◽  
Gas Chromatography Mass Spectrometry ◽  
Caryophyllene Oxide ◽  
Aerial Parts ◽  
Sesquiterpene Hydrocarbons ◽  
Germacrene D ◽  
Total Oil

The essential oil obtained from the aerial parts of Croton bonplandianus Baill. was analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). A total of 37 compounds have been identified, representing 96.2% of the total oil. The main constituents were identified as β-caryophyllene (16.7%), germacrene D (14.7%), borneol (8.3%), Z-β-damascenone (6.(%), isobornyl acetate (6.2%), α-humulene (6.1%), germacrene A (5.2%) and caryophyllene oxide (4.5%). The oil was rich in sesquiterpene hydrocarbons (60.1%).

scholarly journals Essentials Oils from Brazilian Eugenia and Syzygium Species and Their Biological Activities

Biomolecules ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1155
Author(s):  
Jamile S. da Costa ◽  
Ellen de Nazaré S. da Cruz ◽  
William N. Setzer ◽  
Joyce Kelly do R. da Silva ◽  
José Guilherme S. Maia ◽  
...  
Keyword(s):  
Biological Activity ◽  
South America ◽  
Biological Activities ◽  
Herbal Medicines ◽  
Chemical Diversity ◽  
Pharmacological Properties ◽  
Sesquiterpene Hydrocarbons ◽  
Leishmania Spp ◽  
Alternative Sources ◽  
Interspecific Diversity

The Eugenia and Syzygium genera include approximately 1000 and 1800 species, respectively, and both belong to the Myrtaceae. Their species present economic and medicinal importance and pharmacological properties. Due to their chemical diversity and biological activity, we are reporting the essential oils of 48 species of these two genera, which grow in South America and found mainly in Brazil. Chemically, a total of 127 oil samples have been described and displayed a higher intraspecific and interspecific diversity for both Eugenia spp. and Syzygium spp., according to the site of collection or seasonality. The main volatile compounds were sesquiterpene hydrocarbons and oxygenated sesquiterpenes, mainly with caryophyllane and germacrane skeletons and monoterpenes of mostly the pinane type. The oils presented many biological activities, especially antimicrobial (antifungal and antibacterial), anticholinesterase, anticancer (breast, gastric, melanoma, prostate), antiprotozoal (Leishmania spp.), antioxidant, acaricidal, antinociceptive and anti-inflammatory. These studies can contribute to the rational and economic exploration of Eugenia and Syzygium species once they have been identified as potent natural and alternative sources to the production of new herbal medicines.

scholarly journals A Systematic Review on Secondary Metabolites of Paecilomyces Species: Chemical Diversity and Biological Activity

Planta Medica ◽  
2020 ◽  
Vol 86 (12) ◽  
pp. 805-821 ◽  
Author(s):  
Xiu-Qi Li ◽  
Kuo Xu ◽  
Xin-Min Liu ◽  
Peng Zhang
Keyword(s):  
Systematic Review ◽  
Secondary Metabolites ◽  
Biocontrol Agent ◽  
Biological Activities ◽  
Chemical Diversity ◽  
Bioactive Metabolites ◽  
Comprehensive Overview ◽  
Lead Compounds ◽  
Metabolic Products ◽  
Near Future

AbstractFungi are well known for their ability to synthesize secondary metabolites, which have proven to be a rich resource for exploring lead compounds with medicinal and/or agricultural importance. The genera Aspergillus, Penicillium, and Talaromyces are the most widely studied fungal groups, from which a plethora of bioactive metabolites have been characterized. However, relatively little attention has been paid to the genus Paecilomyces, which has been reported to possess great potential for its application as a biocontrol agent. Meanwhile, a wide structural array of metabolites with attractive bioactivities has been reported from this genus. This review attempts to provide a comprehensive overview of Paecilomyces species, with emphasis on the chemical diversity and relevant biological activities of these metabolic products. Herein, a total of 148 compounds and 80 references are cited in this review, which is expected to be beneficial for the development of medicines and agrochemicals in the near future.

scholarly journals Essential Oils of the Leaf and Stem of Polyalthia viridis Craib and Their Biological Activities

2021 ◽  
Vol 16 (9) ◽  
pp. 1934578X2110320
Author(s):  
Ninh T. Son ◽  
Tuan A. Le ◽  
Dinh T. T. Thuy ◽  
Dinh L. Nguyen ◽  
Tran T. Tuyen ◽  
...  
Keyword(s):  
Essential Oils ◽  
Inhibitory Concentration ◽  
Biological Activities ◽  
Gas Chromatography Mass Spectrometry ◽  
No Production ◽  
Flame Ionization Detection ◽  
Flame Ionization ◽  
Sesquiterpene Hydrocarbons ◽  
Germacrene D ◽  
Bv2 Microglial Cells

Plants of the genus Polyalthia can be seen as a rich resource of essential oils type terpenoids. In this study, the essential oils obtained by hydro-distillation from the leaf and stem of Polyalthia viridis were analysed by gas chromatography/mass spectrometry–flame ionization detection. Thirty-nine constituents (95.3%) were identified in the leaf oils and 42 constituents (90.9%) in the stem oils. Sesquiterpene hydrocarbons and oxygenated sesquiterpenes were the main constituents of both oils, in which 2 sesquiterpene hydrocarbons, germacrene D (45.1%-47.4%) and bicyclogermacrene (8.2%-17.1%), were the 2 major compounds. The stem oils inhibited the growth of 3 cancer cell lines, HepG2, MCF7, and A549, with half inhibitory concentration (IC50) values of 56.7 to 68.4 μg/mL. The stem oils also successfully suppressed the growth of the filamentous fungus Aspergillus niger and the yeast Candida albicans with minimum inhibitory concentration values of 50 μg/mL. P viridis oils suppressed NO production in lipopolysaccharide-stimulated BV2 microglial cells, with IC50 values of 57.6 to 76.7 μg/mL.

scholarly journals Essential Oils Composition of Croton Species from the Amazon

2013 ◽  
Vol 8 (10) ◽  
pp. 1934578X1300801 ◽  
Author(s):  
Nathalie A. Turiel ◽  
Alcy F. Ribeiro ◽  
Elisangela Elena N. Carvalho ◽  
Vanessa D. Domingos ◽  
Flávia Cristina A. Lucas ◽  
...  
Keyword(s):  
Essential Oils ◽  
Caryophyllene Oxide ◽  
Volatile Constituents ◽  
Monoterpene Hydrocarbons ◽  
Sesquiterpene Hydrocarbons ◽  
Germacrene D

The essential oils of leaves and twigs from the Euphorbiaceous Croton draconoides, C. urucurana and Julocroton triqueter were obtained and analyzed by GC and GC-MS. In total, 101 volatile constituents were identified, comprising an average of 90% of the oil, mostly made up of mono- and sesquiterpenes. The monoterpene hydrocarbons varied from 1.2 to 40.2%, the sesquiterpene hydrocarbons from 34.0 to 49.6% and the oxygenated sesquiterpenes from 11.5 to 51.3%. The main compounds found in the oil of C. draconoides were β-pinene (16.9%), α-pinene (16.5%), curzerene (12.8%), germacrene D (9.0%), γ-elemene (4.7%), and elemol (4.4%). The oil of C. urucurana showed sesquicineole (23.0%), dehydro-sesquicineole (13.8%), β-caryophyllene (7.9%), β-bisabolol (5.0%), germacrene D (4.2%) and β-elemene (4.1%) as the chief compounds. The oil of J. triqueter was dominated by β-caryophyllene (16.3%), β-phellandrene (10.2%), spathulenol (5.1%), caryophyllene oxide (5.0%), δ-cadinene (4.3%), ( E)-nerolidol (4.3%), and α-copaene (4.1%).

scholarly journals Chemical Profile and Biological Activities of Essential Oil from Artemisia vulgaris L. Cultivated in Brazil

2019 ◽  
Vol 12 (2) ◽  
pp. 49 ◽  
Author(s):  
Sonia Malik ◽  
Ludmilla de Mesquita ◽  
Carolina Silva ◽  
José de Mesquita ◽  
Emmeline de Sá Rocha ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Essential Oil ◽  
Essential Oils ◽  
Haemonchus Contortus ◽  
Biological Activities ◽  
Anthelmintic Activity ◽  
Artemisia Vulgaris ◽  
Chemical Profile ◽  
Sesquiterpene Hydrocarbons ◽  
Germacrene D

Essential oil from the leaves of Artemisia vulgaris L. (Compositae) cultivated in Brazil was investigated for its chemical composition and biological activities including antibacterial, antifungal, and anthelmintic. The constituents of essential oils isolated by hydro-distillation were examined by GC-MS and a total of 18 components were identified. The essential oil was dominated by oxygenated sesquiterpenes (44.4%), sesquiterpene hydrocarbons (33.3%), and oxygenated monoterpenes (16.6%). Caryophyllene (37.45%), germacrene D (16.17%), and humulene (13.66%) were the major components. The essential oils from A. vulgaris showed bactericidal and fungicidal properties against Staphylococcus aureus and Candida albicans, respectively. Anthelmintic activity against Haemonchus contortus was absent in this essential oil. Altogether above results indicate that essential oils from A. vulgaris can be used for various medicinal purposes.

scholarly journals Exploring the Chemical Space of Macro- and Micro-Algae Using Comparative Metabolomics

2021 ◽  
Vol 9 (2) ◽  
pp. 311
Author(s):  
Alison H. Hughes ◽  
Florent Magot ◽  
Ahmed F. Tawfike ◽  
Cecilia Rad-Menéndez ◽  
Naomi Thomas ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Biological Diversity ◽  
Chemical Space ◽  
Biological Activities ◽  
Chemical Diversity ◽  
Liquid Chromatography Mass Spectrometry ◽  
Depth Analysis ◽  
Comparative Metabolomics ◽  
Chemical Profiles

With more than 156,000 described species, eukaryotic algae (both macro- and micro-algae) are a rich source of biological diversity, however their chemical diversity remains largely unexplored. Specialised metabolites with promising biological activities have been widely reported for seaweeds, and more recently extracts from microalgae have exhibited activity in anticancer, antimicrobial, and antioxidant screens. However, we are still missing critical information on the distinction of chemical profiles between macro- and microalgae, as well as the chemical space these metabolites cover. This study has used an untargeted comparative metabolomics approach to explore the chemical diversity of seven seaweeds and 36 microalgal strains. A total of 1390 liquid chromatography-mass spectrometry (LC-MS) features were detected, representing small organic algal metabolites, with no overlap between the seaweeds and microalgae. An in-depth analysis of four Dunaliella tertiolecta strains shows that environmental factors may play a larger role than phylogeny when classifying their metabolomic profiles.

scholarly journals Analysis of Essential Oils from Scutellaria orientalis ssp. alpina and S. utriculata by GC and GC-MS

2011 ◽  
Vol 6 (9) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Carmen Formisano ◽  
Daniela Rigano ◽  
Felice Senatore ◽  
Franco Piozzi ◽  
Nelly Apostolides Arnold
Keyword(s):  
Chemical Composition ◽  
Essential Oils ◽  
Caryophyllene Oxide ◽  
Main Constituent ◽  
Hexadecanoic Acid ◽  
Aerial Parts ◽  
Sesquiterpene Hydrocarbons ◽  
Germacrene D

The chemical composition of the essential oils obtained from aerial parts of Scutellaria orientalis L. ssp. alpina (Boiss.) O. Schwarz and S. utriculata Labill. growing wild in Lebanon, were analyzed by GC and GC-MS. In S. orientalis ssp. alpina, strongly characterized by sesquiterpenes (41.2%) and particularly sesquiterpene hydrocarbons (31.7%), hexahydrofarnesylacetone (11.7%) was recognized as the main constituent, together with hexadecanoic acid (7.6%), caryophyllene (7.4%), caryophyllene oxide (6.8%), 4-vinylguaiacol (5.4%) and germacrene D (5.4%). S. utriculata oil was instead constituted above all by monoterpenes (42.2%), particularly oxygen containing monoterpenes (39.9%), and in this oil the main compounds were linalool (20.1%), 4-vinyl guaiacol (15.5%), α-terpineol (8.9%), ( E)-nerolidol (8.9%) and geraniol (8.2%).

scholarly journals Chemical Diversity and Biological Activities of Phaeosphaeria Fungi Genus: A Systematic Review

2018 ◽  
Vol 4 (4) ◽  
pp. 130 ◽  
Author(s):  
Am El-Demerdash
Keyword(s):  
Systematic Review ◽  
Natural Products ◽  
Cyclic Peptides ◽  
Biological Activities ◽  
Chemical Diversity ◽  
Wide Scope ◽  
Lead Discovery ◽  
Chemical Structures ◽  
Drug Lead ◽  
Microbial Natural Products

Microbial natural products (MNPs) have been identified as important hotspots and effective sources for drug lead discovery. The genus Phaeosphaeria (family: Phaeosphaeriaceae, order: Pleosporales), in particular, has produced divergent chemical structures, including pyrazine alkaloids, isocoumarins, perylenequinones, anthraquinones, diterpenes, and cyclic peptides, which display a wide scope of biological potentialities. This contribution comprehensively highlights, over the period 1974–2018, the chemistry and biology of the isolated natural products from the micro-filamentous Phaeosphaeria fungi genus. A list of 71 compounds, with structural and biological diversities, were gathered into 5 main groups.

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