scholarly journals Lipoprotein Lipase and Its Delivery of Fatty Acids to the Heart

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1016
Author(s):  
Rui Shang ◽  
Brian Rodrigues
Keyword(s):  
Fatty Acids ◽  
Endothelial Cell ◽  
Lipoprotein Lipase ◽  
Apical Surface ◽  
Luminal Surface ◽  
Plasma Fatty Acids ◽  
Atp Generation ◽  
Cell Lining

Ninety percent of plasma fatty acids (FAs) are contained within lipoprotein-triglyceride, and lipoprotein lipase (LPL) is robustly expressed in the heart. Hence, LPL-mediated lipolysis of lipoproteins is suggested to be a key source of FAs for cardiac use. Lipoprotein clearance by LPL occurs at the apical surface of the endothelial cell lining of the coronary lumen. In the heart, the majority of LPL is produced in cardiomyocytes and subsequently is translocated to the apical luminal surface. Here, vascular LPL hydrolyzes lipoprotein-triglyceride to provide the heart with FAs for ATP generation. This article presents an overview of cardiac LPL, explains how the enzyme works, describes key molecules that regulate its activity and outlines how changes in LPL are brought about by physiological and pathological states such as fasting and diabetes, respectively.

scholarly journals The microbiome affects liver sphingolipids and plasma fatty acids in a murine model of the Western diet based on soybean oil

2021 ◽  
pp. 108808
Author(s):  
Sara C. Di Rienzi ◽  
Elizabeth L. Johnson ◽  
Jillian L. Waters ◽  
Elizabeth A. Kennedy ◽  
Juliet Jacobson ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Soybean Oil ◽  
Murine Model ◽  
Western Diet ◽  
Plasma Fatty Acids

Fatty acids in tea shoots (Camellia sinensis (L.) O. Kuntze) and their effects on the growth of retinal RF/6A endothelial cell lines

2007 ◽  
Vol 51 (2) ◽  
pp. 221-228 ◽  
Author(s):  
Sheng-rong Shen ◽  
Hai-ning Yu ◽  
Ping Chen ◽  
Jun-jie Yin ◽  
Yao-kang Xiong
Keyword(s):  
Fatty Acids ◽  
Endothelial Cell ◽  
Cell Lines ◽  
Camellia Sinensis

scholarly journals Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat

1999 ◽  
Vol 276 (5) ◽  
pp. R1425-R1433 ◽  
Author(s):  
Gertjan van Dijk ◽  
Randy J. Seeley ◽  
Todd E. Thiele ◽  
Mark I. Friedman ◽  
Hong Ji ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Body Weight ◽  
Energy Expenditure ◽  
Neuropeptide Y ◽  
Caloric Restriction ◽  
Resting Energy Expenditure ◽  
Corticotropin Releasing Hormone ◽  
Plasma Fatty Acids ◽  
The Third ◽  
Ad Libitum

To investigate whether brain leptin involves neuropeptidergic pathways influencing ingestion, metabolism, and gastrointestinal functioning, leptin (3.5 μg) was infused daily into the third cerebral ventricular of rats for 3 days. To distinguish between direct leptin effects and those secondary to leptin-induced anorexia, we studied vehicle-infused rats with food available ad libitum and those that were pair-fed to leptin-treated animals. Although body weight was comparably reduced (−8%) and plasma glycerol was comparably increased (142 and 17%, respectively) in leptin-treated and pair-fed animals relative to controls, increases in plasma fatty acids and ketones were only detected (132 and 234%, respectively) in pair-fed rats. Resting energy expenditure (−15%) and gastrointestinal fill (−50%) were reduced by pair-feeding relative to the ad libitum group, but they were not reduced by leptin treatment. Relative to controls, leptin increased hypothalamic mRNA for corticotropin-releasing hormone (CRH; 61%) and for proopiomelanocortin (POMC; 31%) but did not reduce mRNA for neuropeptide Y. These results suggest that CNS leptin prevents metabolic/gastrointestinal responses to caloric restriction by activating hypothalamic CRH- and POMC-containing pathways and raise the possibility that these peripheral responses to CNS leptin administration contribute to leptin’s anorexigenic action.

Effects of extra virgin olive oil and pecan nuts on plasma fatty acids in patients with stable coronary artery disease

Nutrition ◽  
2021 ◽  
pp. 111411
Author(s):  
Aline Ramos de Araújo ◽  
Geni Rodrigues Sampaio ◽  
Lucas Ribeiro da Silva ◽  
Vera Lúcia Portal ◽  
Melissa Medeiros Markoski ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Coronary Artery ◽  
Olive Oil ◽  
Stable Coronary Artery Disease ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Plasma Fatty Acids ◽  
Artery Disease

Serum Lipid Profile and Plasma Fatty Acids Levels in Hemodialysis Pediatric Patients-Possible Deficiency of Essential Fatty Acids

Kidney ◽  
2010 ◽  
Vol 19 (6) ◽  
pp. 316-323 ◽  
Author(s):  
Manal Fuad Elshamaa ◽  
Samar Mohamed Sabry ◽  
Eman Ahmed Elghoroury ◽  
Gamila Soliman El-Saaid ◽  
Dina Kandil
Keyword(s):  
Fatty Acids ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Pediatric Patients ◽  
Essential Fatty Acids ◽  
Serum Lipid Profile ◽  
Plasma Fatty Acids
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