Solid State Sensors for Hydrogen Peroxide Detection

Hydrogen peroxide (H2O2) is a key molecule in numerous physiological, industrial, and environmental processes. H2O2 is monitored using various methods like colorimetry, luminescence, fluorescence, and electrochemical methods. Here, we aim to provide a comprehensive review of solid state sensors to monitor H2O2. The review covers three categories of sensors: chemiresistive, conductometric, and field effect transistors. A brief description of the sensing mechanisms of these sensors has been provided. All three sensor types are evaluated based on the sensing parameters like sensitivity, limit of detection, measuring range and response time. We highlight those sensors which have advanced the field by using innovative materials or sensor fabrication techniques. Finally, we discuss the limitations of current solid state sensors and the future directions for research and development in this exciting area.

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Solid-State Fluorescence-based Sensing of TATP via Hydrogen Peroxide Detection

ACS Sensors ◽

10.1021/acssensors.8b01029 ◽

2019 ◽

Vol 4 (1) ◽

pp. 134-142 ◽

Cited By ~ 10

Author(s):

Shengqiang Fan ◽

Jonathan Lai ◽

Paul L. Burn ◽

Paul E. Shaw

Keyword(s):

Hydrogen Peroxide ◽

Solid State ◽

Hydrogen Peroxide Detection ◽

Solid State Fluorescence

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Hydrogen Peroxide Detection by Super-Porous Hybrid CuO/Pt NP Platform: Improved Sensitivity and Selectivity

Nanomaterials ◽

10.3390/nano10102034 ◽

2020 ◽

Vol 10 (10) ◽

pp. 2034

Author(s):

Rakesh Kulkarni ◽

Sundar Kunwar ◽

Rutuja Mandavkar ◽

Jae-Hun Jeong ◽

Jihoon Lee

Keyword(s):

Hydrogen Peroxide ◽

Physical Vapor Deposition ◽

Active Sites ◽

Limit Of Detection ◽

Synergetic Effect ◽

High Sensitivity ◽

Detection Range ◽

Hydrogen Peroxide Detection ◽

Sensitivity And Selectivity ◽

Hybrid Platform

A super-porous hybrid platform can offer significantly increased number of reaction sites for the analytes and thus can offer advantages in the biosensor applications. In this work, a significantly improved sensitivity and selectivity of hydrogen peroxide (H2O2) detection is demonstrated by a super-porous hybrid CuO/Pt nanoparticle (NP) platform on Si substrate as the first demonstration. The super-porous hybrid platform is fabricated by a physiochemical approach combining the physical vapor deposition of Pt NPs and electrochemical deposition of super-porous CuO structures by adopting a dynamic hydrogen bubble technique. Under an optimized condition, the hybrid CuO/Pt biosensor demonstrates a very high sensitivity of 2205 µA/mM·cm2 and a low limit of detection (LOD) of 140 nM with a wide detection range of H2O2. This is meaningfully improved performance as compared to the previously reported CuO-based H2O2 sensors as well as to the other metal oxide-based H2O2 sensors. The hybrid CuO/Pt platform exhibits an excellent selectivity against other interfering molecules such as glucose, fructose, dopamine, sodium chloride and ascorbic acid. Due to the synergetic effect of highly porous CuO structures and underlying Pt NPs, the CuO/Pt architecture offers extremely abundant active sites for the H2O2 reduction and electron transfer pathways.

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Hydrogen Peroxide Detection by Super-Porous Hybrid CuO/Pt NP Platform: Improved Sensitivity and Selectivity

10.20944/preprints202008.0456.v1 ◽

2020 ◽

Author(s):

Rakesh Kulkarni ◽

Sundar Kunwar ◽

Rutuja Mandavkar ◽

Jae−Hun Jeong ◽

Jihoon Lee

Keyword(s):

Hydrogen Peroxide ◽

Physical Vapor Deposition ◽

Active Sites ◽

Limit Of Detection ◽

Synergetic Effect ◽

High Sensitivity ◽

Hydrogen Peroxide Detection ◽

Wide Range ◽

Sensitivity And Selectivity ◽

Hybrid Platform

A super-porous hybrid platform can offer significantly increased number of reaction sites for the analytes and thus can offer advantages in the biosensor applications. In this work, a significantly improved sensitivity and selectivity of hydrogen peroxide (H2O2) cancer sensor is demonstrated by a super-porous hybrid CuO/Pt NP platform. The super-porous hybrid platform is fabricated by a physiochemical approach combining the physical vapor deposition of Pt NPs and electrochemical deposition of super-porous CuO structures by adopting a dynamic hydrogen bubble technique. Under an optimized condition, the hybrid CuO/Pt biosensor demonstrates a very high sensitivity of 2,205 µA/mM∙cm2 and a low limit of detection (LOD) of 140 nM with a wide range of H2O2 detection. This is meaningfully improved performance as compared to the CuO-based H2O2 sensors as well as to the previously reported metal oxide based H2O2 sensors. The hybrid CuO/Pt platform exhibits excellent selectivity against other interfering molecules such as glucose, fructose, dopamine, and ascorbic acid. Due to the synergetic effect of highly porous CuO structures and underlying Pt NPs, the CuO/Pt architecture offers extremely abundant active sites for the H2O2 reduction and electron transfer pathways.

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Expedite Fluorescent Sensor Prototype for Hydrogen Peroxide Detection with Long-Life Test Substrates

ACS Omega ◽

10.1021/acsomega.1c00471 ◽

2021 ◽

Author(s):

Qianqian Chen ◽

Li Yang ◽

Keke Guo ◽

Jialin Yang ◽

Ji-Min Han

Keyword(s):

Hydrogen Peroxide ◽

Fluorescent Sensor ◽

Life Test ◽

Hydrogen Peroxide Detection ◽

Long Life

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Direct and rapid measurement of hydrogen peroxide in human blood using a microfluidic device

Scientific Reports ◽

10.1038/s41598-021-82623-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

R. Gaikwad ◽

P. R. Thangaraj ◽

A. K. Sen

Keyword(s):

Hydrogen Peroxide ◽

Microfluidic Device ◽

Human Blood ◽

Blood Cells ◽

Limit Of Detection ◽

Point Of Care ◽

Time Interval ◽

Fluorescence Measurement ◽

Rapid Measurement ◽

Automated Method

AbstractThe levels of hydrogen peroxide ($${\mathrm{H}}_{2}{\mathrm{O}}_{2}$$ H 2 O 2 ) in human blood is of great relevance as it has emerged as an important signalling molecule in a variety of disease states. Fast and reliable measurement of $${\mathrm{H}}_{2}{\mathrm{O}}_{2}$$ H 2 O 2 levels in the blood, however, continues to remain a challenge. Herein we report an automated method employing a microfluidic device for direct and rapid measurement of $${\mathrm{H}}_{2}{\mathrm{O}}_{2}$$ H 2 O 2 in human blood based on laser-induced fluorescence measurement. Our study delineates the critical factors that affect measurement accuracy—we found blood cells and soluble proteins significantly alter the native $${\mathrm{H}}_{2}{\mathrm{O}}_{2}$$ H 2 O 2 levels in the time interval between sample withdrawal and detection. We show that separation of blood cells and subsequent dilution of the plasma with a buffer at a ratio of 1:6 inhibits the above effect, leading to reliable measurements. We demonstrate rapid measurement of $${\mathrm{H}}_{2}{\mathrm{O}}_{2}$$ H 2 O 2 in plasma in the concentration range of 0–49 µM, offering a limit of detection of 0.05 µM, a sensitivity of 0.60 µM−1, and detection time of 15 min; the device is amenable to the real-time measurement of $${\mathrm{H}}_{2}{\mathrm{O}}_{2}$$ H 2 O 2 in the patient’s blood. Using the linear correlation obtained with known quantities of $${\mathrm{H}}_{2}{\mathrm{O}}_{2}$$ H 2 O 2 , the endogenous $${\mathrm{H}}_{2}{\mathrm{O}}_{2}$$ H 2 O 2 concentration in the blood of healthy individuals is found to be in the range of 0.8–6 µM. The availability of this device at the point of care will have relevance in understanding the role of $${\mathrm{H}}_{2}{\mathrm{O}}_{2}$$ H 2 O 2 in health and disease.

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Influence of the Electrolyte Salt Concentration on DNA Detection with Graphene Transistors

Biosensors ◽

10.3390/bios11010024 ◽

2021 ◽

Vol 11 (1) ◽

pp. 24

Author(s):

Agnes Purwidyantri ◽

Telma Domingues ◽

Jérôme Borme ◽

Joana Rafaela Guerreiro ◽

Andrey Ipatov ◽

...

Keyword(s):

Phosphate Buffer ◽

Species Interactions ◽

Field Effect ◽

Field Effect Transistors ◽

Limit Of Detection ◽

Debye Length ◽

Intermolecular Forces ◽

Single Layer Graphene ◽

Dna Adsorption

Liquid-gated Graphene Field-Effect Transistors (GFET) are ultrasensitive bio-detection platforms carrying out the graphene’s exceptional intrinsic functionalities. Buffer and dilution factor are prevalent strategies towards the optimum performance of the GFETs. However, beyond the Debye length (λD), the role of the graphene-electrolytes’ ionic species interactions on the DNA behavior at the nanoscale interface is complicated. We studied the characteristics of the GFETs under different ionic strength, pH, and electrolyte type, e.g., phosphate buffer (PB), and phosphate buffer saline (PBS), in an automatic portable built-in system. The electrostatic gating and charge transfer phenomena were inferred from the field-effect measurements of the Dirac point position in single-layer graphene (SLG) transistors transfer curves. Results denote that λD is not the main factor governing the effective nanoscale screening environment. We observed that the longer λD was not the determining characteristic for sensitivity increment and limit of detection (LoD) as demonstrated by different types and ionic strengths of measuring buffers. In the DNA hybridization study, our findings show the role of the additional salts present in PBS, as compared to PB, in increasing graphene electron mobility, electrostatic shielding, intermolecular forces and DNA adsorption kinetics leading to an improved sensitivity.

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