scholarly journals Application of Machine Learning to Electroencephalography for the Diagnosis of Primary Progressive Aphasia: A Pilot Study

2021 ◽  
Vol 11 (10) ◽  
pp. 1262
Author(s):  
Carlos Moral-Rubio ◽  
Paloma Balugo ◽  
Adela Fraile-Pereda ◽  
Vanesa Pytel ◽  
Lucía Fernández-Romero ◽  
...  

Background. Primary progressive aphasia (PPA) is a neurodegenerative syndrome in which diagnosis is usually challenging. Biomarkers are needed for diagnosis and monitoring. In this study, we aimed to evaluate Electroencephalography (EEG) as a biomarker for the diagnosis of PPA. Methods. We conducted a cross-sectional study with 40 PPA patients categorized as non-fluent, semantic, and logopenic variants, and 20 controls. Resting-state EEG with 32 channels was acquired and preprocessed using several procedures (quantitative EEG, wavelet transformation, autoencoders, and graph theory analysis). Seven machine learning algorithms were evaluated (Decision Tree, Elastic Net, Support Vector Machines, Random Forest, K-Nearest Neighbors, Gaussian Naive Bayes, and Multinomial Naive Bayes). Results. Diagnostic capacity to distinguish between PPA and controls was high (accuracy 75%, F1-score 83% for kNN algorithm). The most important features in the classification were derived from network analysis based on graph theory. Conversely, discrimination between PPA variants was lower (Accuracy 58% and F1-score 60% for kNN). Conclusions. The application of ML to resting-state EEG may have a role in the diagnosis of PPA, especially in the differentiation from controls. Future studies with high-density EEG should explore the capacity to distinguish between PPA variants.

2020 ◽  
Author(s):  
Charalambos Themistocleous ◽  
Bronte Ficek ◽  
Kimberly Webster ◽  
Dirk-Bart den Ouden ◽  
Argye E. Hillis ◽  
...  

AbstractBackgroundThe classification of patients with Primary Progressive Aphasia (PPA) into variants is time-consuming, costly, and requires combined expertise by clinical neurologists, neuropsychologists, speech pathologists, and radiologists.ObjectiveThe aim of the present study is to determine whether acoustic and linguistic variables provide accurate classification of PPA patients into one of three variants: nonfluent PPA, semantic PPA, and logopenic PPA.MethodsIn this paper, we present a machine learning model based on Deep Neural Networks (DNN) for the subtyping of patients with PPA into three main variants, using combined acoustic and linguistic information elicited automatically via acoustic and linguistic analysis. The performance of the DNN was compared to the classification accuracy of Random Forests, Support Vector Machines, and Decision Trees, as well as expert clinicians’ classifications.ResultsThe DNN model outperformed the other machine learning models with 80% classification accuracy, providing reliable subtyping of patients with PPA into variants and it even outperformed auditory classification of patients into variants by clinicians.ConclusionsWe show that the combined speech and language markers from connected speech productions provide information about symptoms and variant subtyping in PPA. The end-to-end automated machine learning approach we present can enable clinicians and researchers to provide an easy, quick and inexpensive classification of patients with PPA.


2021 ◽  
pp. 1-10
Author(s):  
Charalambos Themistocleous ◽  
Bronte Ficek ◽  
Kimberly Webster ◽  
Dirk-Bart den Ouden ◽  
Argye E. Hillis ◽  
...  

Background: The classification of patients with primary progressive aphasia (PPA) into variants is time-consuming, costly, and requires combined expertise by clinical neurologists, neuropsychologists, speech pathologists, and radiologists. Objective: The aim of the present study is to determine whether acoustic and linguistic variables provide accurate classification of PPA patients into one of three variants: nonfluent PPA, semantic PPA, and logopenic PPA. Methods: In this paper, we present a machine learning model based on deep neural networks (DNN) for the subtyping of patients with PPA into three main variants, using combined acoustic and linguistic information elicited automatically via acoustic and linguistic analysis. The performance of the DNN was compared to the classification accuracy of Random Forests, Support Vector Machines, and Decision Trees, as well as to expert clinicians’ classifications. Results: The DNN model outperformed the other machine learning models as well as expert clinicians’ classifications with 80% classification accuracy. Importantly, 90% of patients with nfvPPA and 95% of patients with lvPPA was identified correctly, providing reliable subtyping of these patients into their corresponding PPA variants. Conclusion: We show that the combined speech and language markers from connected speech productions can inform variant subtyping in patients with PPA. The end-to-end automated machine learning approach we present can enable clinicians and researchers to provide an easy, quick, and inexpensive classification of patients with PPA.


Author(s):  
V Umarani ◽  
A Julian ◽  
J Deepa

Sentiment analysis has gained a lot of attention from researchers in the last year because it has been widely applied to a variety of application domains such as business, government, education, sports, tourism, biomedicine, and telecommunication services. Sentiment analysis is an automated computational method for studying or evaluating sentiments, feelings, and emotions expressed as comments, feedbacks, or critiques. The sentiment analysis process can be automated using machine learning techniques, which analyses text patterns faster. The supervised machine learning technique is the most used mechanism for sentiment analysis. The proposed work discusses the flow of sentiment analysis process and investigates the common supervised machine learning techniques such as multinomial naive bayes, Bernoulli naive bayes, logistic regression, support vector machine, random forest, K-nearest neighbor, decision tree, and deep learning techniques such as Long Short-Term Memory and Convolution Neural Network. The work examines such learning methods using standard data set and the experimental results of sentiment analysis demonstrate the performance of various classifiers taken in terms of the precision, recall, F1-score, RoC-Curve, accuracy, running time and k fold cross validation and helps in appreciating the novelty of the several deep learning techniques and also giving the user an overview of choosing the right technique for their application.


Author(s):  
Sheela Rani P ◽  
Dhivya S ◽  
Dharshini Priya M ◽  
Dharmila Chowdary A

Machine learning is a new analysis discipline that uses knowledge to boost learning, optimizing the training method and developing the atmosphere within which learning happens. There square measure 2 sorts of machine learning approaches like supervised and unsupervised approach that square measure accustomed extract the knowledge that helps the decision-makers in future to require correct intervention. This paper introduces an issue that influences students' tutorial performance prediction model that uses a supervised variety of machine learning algorithms like support vector machine , KNN(k-nearest neighbors), Naïve Bayes and supplying regression and logistic regression. The results supported by various algorithms are compared and it is shown that the support vector machine and Naïve Bayes performs well by achieving improved accuracy as compared to other algorithms. The final prediction model during this paper may have fairly high prediction accuracy .The objective is not just to predict future performance of students but also provide the best technique for finding the most impactful features that influence student’s while studying.


2019 ◽  
Vol 8 (4) ◽  
pp. 2187-2191

Music in an essential part of life and the emotion carried by it is key to its perception and usage. Music Emotion Recognition (MER) is the task of identifying the emotion in musical tracks and classifying them accordingly. The objective of this research paper is to check the effectiveness of popular machine learning classifiers like XGboost, Random Forest, Decision Trees, Support Vector Machine (SVM), K-Nearest-Neighbour (KNN) and Gaussian Naive Bayes on the task of MER. Using the MIREX-like dataset [17] to test these classifiers, the effects of oversampling algorithms like Synthetic Minority Oversampling Technique (SMOTE) [22] and Random Oversampling (ROS) were also verified. In all, the Gaussian Naive Bayes classifier gave the maximum accuracy of 40.33%. The other classifiers gave accuracies in between 20.44% and 38.67%. Thus, a limit on the classification accuracy has been reached using these classifiers and also using traditional musical or statistical metrics derived from the music as input features. In view of this, deep learning-based approaches using Convolutional Neural Networks (CNNs) [13] and spectrograms of the music clips for MER is a promising alternative.


Author(s):  
Muskan Patidar

Abstract: Social networking platforms have given us incalculable opportunities than ever before, and its benefits are undeniable. Despite benefits, people may be humiliated, insulted, bullied, and harassed by anonymous users, strangers, or peers. Cyberbullying refers to the use of technology to humiliate and slander other people. It takes form of hate messages sent through social media and emails. With the exponential increase of social media users, cyberbullying has been emerged as a form of bullying through electronic messages. We have tried to propose a possible solution for the above problem, our project aims to detect cyberbullying in tweets using ML Classification algorithms like Naïve Bayes, KNN, Decision Tree, Random Forest, Support Vector etc. and also we will apply the NLTK (Natural language toolkit) which consist of bigram, trigram, n-gram and unigram on Naïve Bayes to check its accuracy. Finally, we will compare the results of proposed and baseline features with other machine learning algorithms. Findings of the comparison indicate the significance of the proposed features in cyberbullying detection. Keywords: Cyber bullying, Machine Learning Algorithms, Twitter, Natural Language Toolkit


Author(s):  
Anirudh Reddy Cingireddy ◽  
Robin Ghosh ◽  
Supratik Kar ◽  
Venkata Melapu ◽  
Sravanthi Joginipeli ◽  
...  

Frequent testing of the entire population would help to identify individuals with active COVID-19 and allow us to identify concealed carriers. Molecular tests, antigen tests, and antibody tests are being widely used to confirm COVID-19 in the population. Molecular tests such as the real-time reverse transcription-polymerase chain reaction (rRT-PCR) test will take a minimum of 3 hours to a maximum of 4 days for the results. The authors suggest using machine learning and data mining tools to filter large populations at a preliminary level to overcome this issue. The ML tools could reduce the testing population size by 20 to 30%. In this study, they have used a subset of features from full blood profile which are drawn from patients at Israelita Albert Einstein hospital located in Brazil. They used classification models, namely KNN, logistic regression, XGBooting, naive Bayes, decision tree, random forest, support vector machine, and multilayer perceptron with k-fold cross-validation, to validate the models. Naïve bayes, KNN, and random forest stand out as the most predictive ones with 88% accuracy each.


2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Patricio Wolff ◽  
Manuel Graña ◽  
Sebastián A. Ríos ◽  
Maria Begoña Yarza

Background. Hospital readmission prediction in pediatric hospitals has received little attention. Studies have focused on the readmission frequency analysis stratified by disease and demographic/geographic characteristics but there are no predictive modeling approaches, which may be useful to identify preventable readmissions that constitute a major portion of the cost attributed to readmissions.Objective. To assess the all-cause readmission predictive performance achieved by machine learning techniques in the emergency department of a pediatric hospital in Santiago, Chile.Materials. An all-cause admissions dataset has been collected along six consecutive years in a pediatric hospital in Santiago, Chile. The variables collected are the same used for the determination of the child’s treatment administrative cost.Methods. Retrospective predictive analysis of 30-day readmission was formulated as a binary classification problem. We report classification results achieved with various model building approaches after data curation and preprocessing for correction of class imbalance. We compute repeated cross-validation (RCV) with decreasing number of folders to assess performance and sensitivity to effect of imbalance in the test set and training set size.Results. Increase in recall due to SMOTE class imbalance correction is large and statistically significant. The Naive Bayes (NB) approach achieves the best AUC (0.65); however the shallow multilayer perceptron has the best PPV and f-score (5.6 and 10.2, resp.). The NB and support vector machines (SVM) give comparable results if we consider AUC, PPV, and f-score ranking for all RCV experiments. High recall of deep multilayer perceptron is due to high false positive ratio. There is no detectable effect of the number of folds in the RCV on the predictive performance of the algorithms.Conclusions. We recommend the use of Naive Bayes (NB) with Gaussian distribution model as the most robust modeling approach for pediatric readmission prediction, achieving the best results across all training dataset sizes. The results show that the approach could be applied to detect preventable readmissions.


Hippocampus ◽  
2019 ◽  
Vol 29 (11) ◽  
pp. 1127-1132
Author(s):  
Marianne Chapleau ◽  
Maxime Montembeault ◽  
Mariem Boukadi ◽  
Christophe Bedetti ◽  
Robert Laforce ◽  
...  

2020 ◽  
Vol 19 ◽  
pp. 153303382090982
Author(s):  
Melek Akcay ◽  
Durmus Etiz ◽  
Ozer Celik ◽  
Alaattin Ozen

Background and Aim: Although the prognosis of nasopharyngeal cancer largely depends on a classification based on the tumor-lymph node metastasis staging system, patients at the same stage may have different clinical outcomes. This study aimed to evaluate the survival prognosis of nasopharyngeal cancer using machine learning. Settings and Design: Original, retrospective. Materials and Methods: A total of 72 patients with a diagnosis of nasopharyngeal cancer who received radiotherapy ± chemotherapy were included in the study. The contribution of patient, tumor, and treatment characteristics to the survival prognosis was evaluated by machine learning using the following techniques: logistic regression, artificial neural network, XGBoost, support-vector clustering, random forest, and Gaussian Naive Bayes. Results: In the analysis of the data set, correlation analysis, and binary logistic regression analyses were applied. Of the 18 independent variables, 10 were found to be effective in predicting nasopharyngeal cancer-related mortality: age, weight loss, initial neutrophil/lymphocyte ratio, initial lactate dehydrogenase, initial hemoglobin, radiotherapy duration, tumor diameter, number of concurrent chemotherapy cycles, and T and N stages. Gaussian Naive Bayes was determined as the best algorithm to evaluate the prognosis of machine learning techniques (accuracy rate: 88%, area under the curve score: 0.91, confidence interval: 0.68-1, sensitivity: 75%, specificity: 100%). Conclusion: Many factors affect prognosis in cancer, and machine learning algorithms can be used to determine which factors have a greater effect on survival prognosis, which then allows further research into these factors. In the current study, Gaussian Naive Bayes was identified as the best algorithm for the evaluation of prognosis of nasopharyngeal cancer.


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