scholarly journals Identification of Modulated MicroRNAs Associated with Breast Cancer, Diet, and Physical Activity

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2555 ◽  
Author(s):  
Luca Falzone ◽  
Maria Grimaldi ◽  
Egidio Celentano ◽  
Livia S. A. Augustin ◽  
Massimo Libra
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Physical Exercise ◽  
Mirna Expression ◽  
Healthy Lifestyles ◽  
Dietary Interventions ◽  
Diet And Physical Activity ◽  
Bioinformatic Approaches ◽  
Cancer Diet ◽  
Selection Of

Background: Several studies have shown that healthy lifestyles prevent the risk of breast cancer (BC) and are associated with better prognosis. It was hypothesized that lifestyle strategies induce microRNA (miRNA) modulation that, in turn, may lead to important epigenetic modifications. The identification of miRNAs associated with BC, diet, and physical activity may give further insights into the role played by lifestyle interventions and their efficacy for BC patients. To predict which miRNAs may be modulated by diet and physical activity in BC patients, the analyses of different miRNA expression datasets were performed. Methods: The GEO DataSets database was used to select miRNA expression datasets related to BC patients, dietary interventions, and physical exercise. Further bioinformatic approaches were used to establish the value of selected miRNAs in BC development and prognosis. Results: The analysis of datasets allowed the selection of modulated miRNAs associated with BC development, diet, and physical exercise. Seven miRNAs were also associated with the overall survival of BC patients. Conclusions: The identified miRNAs may play a role in the development of BC and may have a prognostic value in patients treated with integrative interventions including diet and physical activity. Validation of such modulated miRNAs on BC patients undergoing lifestyle strategies will be mandatory.

scholarly journals Physical activity as a therapeutic strategy in mental health: an integrative review with implication for nursing care

2017 ◽  
Vol 21 (3) ◽  
Author(s):  
Bruno da Silva Lourenço ◽  
Maria Angélica de Almeida Peres ◽  
Isaura Setenta Porto ◽  
Rosane Mara Pontes de Oliveira ◽  
Virginia Faria Damásio Dutra
Keyword(s):  
Physical Activity ◽  
Mental Disorders ◽  
Nursing Care ◽  
Therapeutic Strategy ◽  
Scientific Evidence ◽  
Well Being ◽  
Integrative Review ◽  
Healthy Lifestyles ◽  
Practical Effect ◽  
Selection Of

Abstract This study is an integrative review with the aim to identify and describe the scientific evidence of the practical effect of physical activity in people with mental disorders. For the selection of articles, the databases CINAHL, MEDLINE, LILACS, SciELO, Cochrane and Scopus were used. The sample of this review consisted of eight articles. Their analysis resulted in the categories: obesity and metabolic syndrome, specialized nursing, sedentary and healthy lifestyles, support and social network, incentive to the practice of physical activity, and anxiety and physical activity. The benefits to physical health were partially elucidated by the sample. The implications for nursing care arise from the therapeutic efficacy of physical activity by people with mental disorders, adding individual and collective benefits that provide socialization and promotion of well-being.

scholarly journals Effects of Activity Tracker-Based Counselling and Live-Web Exercise on Breast Cancer Survivors during Italy COVID-19 Lockdown

2021 ◽  
Vol 6 (2) ◽  
pp. 50
Author(s):  
Andrea Di Blasio ◽  
Teresa Morano ◽  
Federica Lancia ◽  
Gianluca Viscioni ◽  
Angelo Di Iorio ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Light Intensity ◽  
Physical Exercise ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Sedentary Time ◽  
Physical Activities ◽  
Activity Tracker ◽  
Personal Feedback

Background: To prevent and fight the increase of daily sedentary time and to promote and stimulate the positive effects of physical activity and exercise on health, both traditional interventions and new strategies are important for breast cancer survivors (BCS). The research goal was to compare the effects of weekly personal feedback, based on objectively measured physical activity, on the trends of both daily sedentary time and on the physical activity of BCS (E− group) with those of an intervention also including online supervised physical exercise sessions (E+ group), during the Italy COVID-19 lockdown. Methods: The Italian COVID-19 emergency allowed the possibility to also observe the effects of social and personal limitations. A total of 51 BCS were studied over an 18-week period and had an objective registration of day-to-day sedentary time, physical activity, and sleep. Both subsamples received weekly or fortnight personal feedback. Data were analysed considering four key periods, according to the COVID-19 emergency steps. Results: Statistical analysis showed an additive effect for sedentary time and a multiplicative effect both for light-to vigorous and light-intensity physical activities. The E− group had a high overall sedentary time and a different trend of light-to vigorous and light-intensity physical activities, with a reduction from the 1st to the 2nd periods (national and personal restrictions), showing a significant rise just at the end of the national restrictions. Conclusions: The use of an activity tracker and its accompanying app, with the reception of weekly tailored advice and supervised online physical exercise sessions, can elicit proper physical activity recomposition in BCS in the COVID-19 era.

scholarly journals Effectiveness of diet and physical activity interventions amongst adults attending colorectal and breast cancer screening: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Samuel T. Orange ◽  
Kirsty M. Hicks ◽  
John M. Saxton
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Vegetable Intake ◽  
Dietary Interventions ◽  
Physical Activity Interventions ◽  
Mean Differences ◽  
Quality Evidence

Abstract Purpose To estimate the effectiveness of tailored physical activity and dietary interventions amongst adults attending colorectal and breast cancer screening. Methods Five literature databases were systematically searched to identify randomised controlled trials (RCTs) of tailored physical activity and/or dietary interventions with follow-up support initiated through colorectal and breast cancer screening programmes. Outcomes included markers of body fatness, physical activity, and dietary intake. Mean differences (MDs) or standardised mean differences (SMDs) with 95% confidence intervals (CIs) were pooled using random effects models. Results Five RCTs met the inclusion criteria encompassing a total of 722 participants. Diet and physical activity interventions led to statistically significant reductions in body mass (MD − 1.6 kg, 95% CI − 2.7 to − 0.39 kg; I2 = 81%; low quality evidence), body mass index (MD − 0.78 kg/m2, 95% CI − 1.1 to − 0.50 kg/m2; I2 = 21%; moderate quality evidence), and waist circumference (MD − 2.9 cm, 95% CI − 3.8 to − 1.91; I2 = 0%; moderate quality evidence), accompanied by an increase in physical activity (SMD 0.31, 95% CI 0.13 to 0.50; I2 = 0%; low quality evidence) and fruit and vegetable intake (SMD 0.33, 95% CI 0.01 to 0.64; I2 = 51%; low quality evidence). Conclusion There is low quality evidence that lifestyle interventions involving follow-up support lead to modest weight loss and increased physical activity and fruit and vegetable intake. Due to the modest intervention effects, low quality of evidence and small number of studies, further rigorously designed RCTs with long-term follow-up of modifiable risk factors and embedded cost–benefit analyses are warranted (PROSPERO ref: CRD42020179960).

scholarly journals Body Expression-Based Intervention Programs for Persons with Intellectual Disabilities: A Systematic Review

2020 ◽  
Vol 17 (20) ◽  
pp. 7569
Author(s):  
María-Jesús Lirola ◽  
Gerardo Ruiz-Rico ◽  
Antonia-Irene Hernández-Rodríguez ◽  
María-Esther Prados-Megías
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Physical Exercise ◽  
Intellectual Disabilities ◽  
Social Inclusion ◽  
Quality Criteria ◽  
Population Group ◽  
Summary Table ◽  
Prisma Statement ◽  
Selection Of

The benefits of physical exercise on human health are widely known. However, the level of physical activity in the majority of the population is considered insufficient. People with intellectual disabilities (ID), in particular, show this lack of physical activity to a greater extent. It has been noted that the promotion of activities focused on corporal expression (CE) stimulates the motivation to carry out physical exercise in this population group. The aim of this study was to carry out a systematic review of the last ten years of CE programs carried out in people with ID. The criteria established in the PRISMA statement were followed in the literature search. The databases consulted were Scopus, Web of Science, Pubmed, PsycInfo and Elton B. Stephens Company (EBSCO). Eight exclusion criteria were established for the selection of articles. For the analysis of the selected research, three quality criteria for interventions were established. Subsequently, a summary table with the characteristics of each study was made. In conclusion, it can be stated that CE programs in people with ID report benefits at both physical and psychosocial levels. It is necessary to extend this approach for the promotion of healthy physical activity that advocates social inclusion.

scholarly journals The Effects of Diet and Dietary Interventions on the Quality of Life among Breast Cancer Survivors: A Cross-Sectional Analysis and a Systematic Review of Experimental Studies

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 322 ◽  
Author(s):  
Martina Barchitta ◽  
Andrea Maugeri ◽  
Roberta Magnano San Lio ◽  
Annalisa Quattrocchi ◽  
Flori Degrassi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Physical Activity ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Experimental Studies ◽  
Dietary Interventions ◽  
Cross Sectional ◽  
High Consumption

There is an ongoing need for solid evidence about the effects of healthy behaviors, and particularly diet, on the quality of life (QoL) among breast cancer survivors. We first conducted a cross-sectional study on 68 Italian stage I-III breast cancer survivors, to investigate the association of adherence to the Mediterranean diet (MD), physical activity and weight status with QoL. Adherence to MD and physical activity was assessed using structured questionnaires. QoL was assessed using the European Organization for the Research and Treatment of Cancer Quality-of-Life tools. We showed that low consumption of red meat and carbonated beverages, daily consumption of wine and high consumption of dishes seasoned with sofrito had beneficial effects on several QoL subscales. By contrast, using olive oil as the main culinary fat, low consumption of commercial sweets and high consumption of nuts were associated with negative effects. Overall, these findings resulted in a null effect of adherence to MD on QoL. Furthermore, we observed better QoL sub-scores among women who performed moderate physical activity (i.e., diarrhea) and those who were underweight/normal weight (i.e., physical functioning and dyspnea) if compared with their counterparts (p-values ≤ 0.003 after correction for multiple comparison). Next, we performed a systematic review of nine experimental studies to summarize whether dietary interventions might improve QoL among breast cancer patients. All the studies demonstrated significant improvements in overall QoL and/or its subscales after the interventions. However, differences in study design, interventions and tools used for QoL assessment did not allow us to provide an overall estimate. Moreover, only a single-arm trial evaluated the effect of an exclusive dietary-based intervention, while others combined dietary recommendations with physical activity and weight loss programs. For these reasons, our study encourages more efforts to improve the robustness of current evidence, through more homogenous tools, larger population-based studies and further randomized controlled trials.

scholarly journals Population Attributable Risk for Breast Cancer: Diet, Nutrition, and Physical Exercise

1998 ◽  
Vol 90 (5) ◽  
pp. 389-394 ◽  
Author(s):  
Mezzetti Maura ◽  
Peter Boyle ◽  
Carlo La Vecchia ◽  
Adriano Decarli ◽  
Renato Talamini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Exercise ◽  
Population Attributable Risk ◽  
Attributable Risk ◽  
Cancer Diet
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