scholarly journals Feedforward Artificial Neural Network-Based Colorectal Cancer Detection Using Hyperspectral Imaging: A Step towards Automatic Optical Biopsy

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 967
Author(s):  
Boris Jansen-Winkeln ◽  
Manuel Barberio ◽  
Claire Chalopin ◽  
Katrin Schierle ◽  
Michele Diana ◽  
...  

Currently, colorectal cancer (CRC) is mainly identified via a visual assessment during colonoscopy, increasingly used artificial intelligence algorithms, or surgery. Subsequently, CRC is confirmed through a histopathological examination by a pathologist. Hyperspectral imaging (HSI), a non-invasive optical imaging technology, has shown promising results in the medical field. In the current study, we combined HSI with several artificial intelligence algorithms to discriminate CRC. Between July 2019 and May 2020, 54 consecutive patients undergoing colorectal resections for CRC were included. The tumor was imaged from the mucosal side with a hyperspectral camera. The image annotations were classified into three groups (cancer, CA; adenomatous margin around the central tumor, AD; and healthy mucosa, HM). Classification and visualization were performed based on a four-layer perceptron neural network. Based on a neural network, the classification of CA or AD resulted in a sensitivity of 86% and a specificity of 95%, by means of leave-one-patient-out cross-validation. Additionally, significant differences in terms of perfusion parameters (e.g., oxygen saturation) related to tumor staging and neoadjuvant therapy were observed. Hyperspectral imaging combined with automatic classification can be used to differentiate between CRC and healthy mucosa. Additionally, the biological changes induced by chemotherapy to the tissue are detectable with HSI.

2021 ◽  
Vol 14 ◽  
pp. 263177452110146
Author(s):  
Nasim Parsa ◽  
Michael F. Byrne

Colonoscopy remains the gold standard exam for colorectal cancer screening due to its ability to detect and resect pre-cancerous lesions in the colon. However, its performance is greatly operator dependent. Studies have shown that up to one-quarter of colorectal polyps can be missed on a single colonoscopy, leading to high rates of interval colorectal cancer. In addition, the American Society for Gastrointestinal Endoscopy has proposed the “resect-and-discard” and “diagnose-and-leave” strategies for diminutive colorectal polyps to reduce the costs of unnecessary polyp resection and pathology evaluation. However, the performance of optical biopsy has been suboptimal in community practice. With recent improvements in machine-learning techniques, artificial intelligence–assisted computer-aided detection and diagnosis have been increasingly utilized by endoscopists. The application of computer-aided design on real-time colonoscopy has been shown to increase the adenoma detection rate while decreasing the withdrawal time and improve endoscopists’ optical biopsy accuracy, while reducing the time to make the diagnosis. These are promising steps toward standardization and improvement of colonoscopy quality, and implementation of “resect-and-discard” and “diagnose-and-leave” strategies. Yet, issues such as real-world applications and regulatory approval need to be addressed before artificial intelligence models can be successfully implemented in clinical practice. In this review, we summarize the recent literature on the application of artificial intelligence for detection and characterization of colorectal polyps and review the limitation of existing artificial intelligence technologies and future directions for this field.


Horticulturae ◽  
2021 ◽  
Vol 7 (5) ◽  
pp. 103
Author(s):  
Inés Hernández ◽  
Salvador Gutiérrez ◽  
Sara Ceballos ◽  
Rubén Iñíguez ◽  
Ignacio Barrio ◽  
...  

Plant diseases and pests cause a large loss of world agricultural production. Downy mildew is a major disease in grapevine. Conventional techniques for plant diseases evaluations are time-consuming and require expert personnel. This work investigates novel sensing technologies and artificial intelligence applications for assessing downy mildew in grapevine under laboratory conditions. In our methodology, machine vision is applied to assess downy mildew sporulation, while hyperspectral imaging is used to explore its potential capability towards early detection of this disease. Image analysis applied to RGB leaf disc images is used to estimate downy mildew (Plamopara viticola) severity in grapevine (Vitis vinifera L. cv Tempranillo). A determination coefficient (R2) of 0.76 ** and a root mean square error (RMSE) of 20.53% are observed in the correlation between downy mildew severity by computer vision and expert’s visual assessment. Furthermore, an accuracy of 81% is achieved to detect downy mildew early using hyperspectral images. These results indicate that non-invasive sensing technologies and computer vision can be applied for assessing and quantify sporulation of downy mildew in grapevine leaves. The severity of this key disease is evaluated in grapevine under laboratory conditions. In conclusion, computer vision, hyperspectral imaging and machine learning could be applied for important disease detection in grapevine.


2020 ◽  
pp. 1-11
Author(s):  
Wenjuan Ma ◽  
Xuesi Zhao ◽  
Yuxiu Guo

The application of artificial intelligence and machine learning algorithms in education reform is an inevitable trend of teaching development. In order to improve the teaching intelligence, this paper builds an auxiliary teaching system based on computer artificial intelligence and neural network based on the traditional teaching model. Moreover, in this paper, the optimization strategy is adopted in the TLBO algorithm to reduce the running time of the algorithm, and the extracurricular learning mechanism is introduced to increase the adjustable parameters, which is conducive to the algorithm jumping out of the local optimum. In addition, in this paper, the crowding factor in the fish school algorithm is used to define the degree or restraint of teachers’ control over students. At the same time, students in the crowded range gather near the teacher, and some students who are difficult to restrain perform the following behavior to follow the top students. Finally, this study builds a model based on actual needs, and designs a control experiment to verify the system performance. The results show that the system constructed in this paper has good performance and can provide a theoretical reference for related research.


2020 ◽  
Vol 2 ◽  
pp. 58-61 ◽  
Author(s):  
Syed Junaid ◽  
Asad Saeed ◽  
Zeili Yang ◽  
Thomas Micic ◽  
Rajesh Botchu

The advances in deep learning algorithms, exponential computing power, and availability of digital patient data like never before have led to the wave of interest and investment in artificial intelligence in health care. No radiology conference is complete without a substantial dedication to AI. Many radiology departments are keen to get involved but are unsure of where and how to begin. This short article provides a simple road map to aid departments to get involved with the technology, demystify key concepts, and pique an interest in the field. We have broken down the journey into seven steps; problem, team, data, kit, neural network, validation, and governance.


2019 ◽  
Vol 17 (1) ◽  
pp. 69-76
Author(s):  
Mohammad Shiddiq Ghozali

Perkembangan Teknologi Informasi dan Komunikasi begitu pesat di zaman sekarang ini. Diikuti pula dengan perkembangan di bidang Artificial Intelligence (AI) atau Kecerdasan Buatan. Di Indonesia sendiri masih belum begitu populer dikalangan masyarakat akan tetapi perusahaan-perusahaan IT berlomba-lomba menciptakan inovasi dibidang Kecerdasan Buatan dan penerapan Kecerdasan Buatan disegala aspek kehidupan. Contoh kasus di Automated Teller Machine (ATM), seringkali terjadi kejahatan di ATM seperti pengintaian nomor pin, skimming, lebanese loop dan kejahatan lainnya. Walaupun di ATM sudah terdapat CCTV akan tetapi penjahat menggunakan alat bantu untuk menutupi wajahnya seperti helm, topi, masker dan kacamata hitam. Biasanya didepan pintu masuk ATM terpampang larangan untuk tidak menggunakan helm, topi, masker dan kacamata hitam serta tidak membawa rokok. Akan tetapi larangan itu masih tetap ada yang melanggar, dikarenakan tidak ada tindak lanjut ketika seseorang menggunakan benda-benda yang dilarang dibawa kedalam ATM. Oleh karena itu penulis membuat sistem pendeteksi obyek di bidang Kecerdasan Buatan untuk mendeteksi benda-benda yang dilarang digunakan ketika berada di ATM. Salah satu metode yang digunakan untuk menciptakan Object Detection yaitu You Only Look Once (YOLO). Implementasi ide ini tersedia pada DARKNET (open source neural network). Cara kerja YOLO yaitu dengan melihat seluruh gambar sekali, kemudian melewati jaringan saraf sekali langsung mendeteksi object yang ada. Oleh karena itu disebut You Only Look Once (YOLO). Pada penelitian ini, penulis membuat sistem yang masih dalam bentuk pengembangan, sehingga menjalankannya masih menggunakan command prompt. Keywords : Automated Teller Machine (ATM), Kecerdasan Buatan, Pendeteksi Obyek, You Only Look Once (YOLO)  


2020 ◽  
Vol 96 (3s) ◽  
pp. 585-588
Author(s):  
С.Е. Фролова ◽  
Е.С. Янакова

Предлагаются методы построения платформ прототипирования высокопроизводительных систем на кристалле для задач искусственного интеллекта. Изложены требования к платформам подобного класса и принципы изменения проекта СнК для имплементации в прототип. Рассматриваются методы отладки проектов на платформе прототипирования. Приведены результаты работ алгоритмов компьютерного зрения с использованием нейросетевых технологий на FPGA-прототипе семантических ядер ELcore. Methods have been proposed for building prototyping platforms for high-performance systems-on-chip for artificial intelligence tasks. The requirements for platforms of this class and the principles for changing the design of the SoC for implementation in the prototype have been described as well as methods of debugging projects on the prototyping platform. The results of the work of computer vision algorithms using neural network technologies on the FPGA prototype of the ELcore semantic cores have been presented.


Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1129
Author(s):  
Audrius Dulskas ◽  
Tomas Poskus ◽  
Inga Kildusiene ◽  
Ausvydas Patasius ◽  
Rokas Stulpinas ◽  
...  

We aimed to report the results of the implementation of the National Colorectal Cancer (CRC) Screening Program covering all the country. The National Health Insurance Fund (NHIF) reimburses the institutions for performing each service; each procedure within the program has its own administrative code. Information about services provided within the program was retrieved from the database of NHIF starting from the 1 January 2014 to the 31 December 2018. Exact date and type of all provided services, test results, date and results of biopsy and histopathological examination were extracted together with the vital status at the end of follow-up, date of death and date of emigration when applicable for all men and women born between 1935 and 1968. Results were compared with the guidelines of the European Union for quality assurance in CRC screening and diagnosis. The screening uptake was 49.5% (754,061 patients) during study period. Participation rate varied from 16% to 18.1% per year and was higher among women than among men. Proportion of test-positive and test-negative results was similar during all the study period—8.7% and 91.3% annually. Between 9.2% and 13.5% of test-positive patients received a biopsy of which 52.3–61.8% were positive for colorectal adenoma and 4.6–7.3% for colorectal carcinoma. CRC detection rate among test-positive individuals varied between 0.93% and 1.28%. The colorectal cancer screening program in Lithuania coverage must be improved. A screening database is needed to systematically evaluate the impact and performance of the national CRC screening program and quality assurance within the program.


Author(s):  
Daniel Overhoff ◽  
Peter Kohlmann ◽  
Alex Frydrychowicz ◽  
Sergios Gatidis ◽  
Christian Loewe ◽  
...  

Purpose The DRG-ÖRG IRP (Deutsche Röntgengesellschaft-Österreichische Röntgengesellschaft international radiomics platform) represents a web-/cloud-based radiomics platform based on a public-private partnership. It offers the possibility of data sharing, annotation, validation and certification in the field of artificial intelligence, radiomics analysis, and integrated diagnostics. In a first proof-of-concept study, automated myocardial segmentation and automated myocardial late gadolinum enhancement (LGE) detection using radiomic image features will be evaluated for myocarditis data sets. Materials and Methods The DRG-ÖRP IRP can be used to create quality-assured, structured image data in combination with clinical data and subsequent integrated data analysis and is characterized by the following performance criteria: Possibility of using multicentric networked data, automatically calculated quality parameters, processing of annotation tasks, contour recognition using conventional and artificial intelligence methods and the possibility of targeted integration of algorithms. In a first study, a neural network pre-trained using cardiac CINE data sets was evaluated for segmentation of PSIR data sets. In a second step, radiomic features were applied for segmental detection of LGE of the same data sets, which were provided multicenter via the IRP. Results First results show the advantages (data transparency, reliability, broad involvement of all members, continuous evolution as well as validation and certification) of this platform-based approach. In the proof-of-concept study, the neural network demonstrated a Dice coefficient of 0.813 compared to the expert's segmentation of the myocardium. In the segment-based myocardial LGE detection, the AUC was 0.73 and 0.79 after exclusion of segments with uncertain annotation.The evaluation and provision of the data takes place at the IRP, taking into account the FAT (fairness, accountability, transparency) and FAIR (findable, accessible, interoperable, reusable) criteria. Conclusion It could be shown that the DRG-ÖRP IRP can be used as a crystallization point for the generation of further individual and joint projects. The execution of quantitative analyses with artificial intelligence methods is greatly facilitated by the platform approach of the DRG-ÖRP IRP, since pre-trained neural networks can be integrated and scientific groups can be networked.In a first proof-of-concept study on automated segmentation of the myocardium and automated myocardial LGE detection, these advantages were successfully applied.Our study shows that with the DRG-ÖRP IRP, strategic goals can be implemented in an interdisciplinary way, that concrete proof-of-concept examples can be demonstrated, and that a large number of individual and joint projects can be realized in a participatory way involving all groups. Key Points:  Citation Format


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