scholarly journals Tetraspanins: Physiology, Colorectal Cancer Development, and Nanomediated Applications

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5662
Author(s):  
Stefan Titu ◽  
Cristiana Maria Grapa ◽  
Teodora Mocan ◽  
Ovidiu Balacescu ◽  
Alexandru Irimie
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Crucial Role ◽  
Drug Delivery Systems ◽  
Transmembrane Proteins ◽  
Cancer Development ◽  
Human Organism ◽  
Cell Physiology ◽  
Targeting Vector ◽  
Potential Use

Tetraspanins are transmembrane proteins expressed in a multitude of cells throughout the organism. They contribute to many processes that surround cell–cell interactions and are associated with the progress of some diseases, including cancer. Their crucial role in cell physiology is often understated. Furthermore, recent studies have shown their great potential in being used as targeting molecules. Data have suggested the potential of tetraspanins as a targeting vector for nanomediated distribution and delivery for colorectal cancer applications. Our aim is to provide a review on the important part that tetraspanins play in the human organism and highlight their potential use for drug delivery systems using nanotechnology.

Preparation and characterization of magnetic nanoparticles and their impact on anticancer drug binding and release processes moderated through a 1sttier dendrimer

RSC Advances ◽  
2016 ◽  
Vol 6 (44) ◽  
pp. 37391-37402 ◽  
Author(s):  
Shivani R. Pandya ◽  
Man Singh
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Drug Binding ◽  
Potential Use ◽  
Release Processes

MNPs show superparamagnetic character which moderates the structural ability of TTDMM to bind silibinin (SB) and methotrexate (MTX) anticancer drugs for their potential use in drug delivery systems.

Pretargeted Theranostics

2021 ◽  
Author(s):  
Markus Staudt ◽  
Matthias M. Herth ◽  
Christian B.M. Poulie
Keyword(s):  
Drug Delivery ◽  
Radionuclide Therapy ◽  
Drug Delivery Systems ◽  
Targeted Radionuclide Therapy ◽  
Site Specific ◽  
Radiation Burden ◽  
Drug Delivery Vehicles ◽  
Diagnostic Measures ◽  
Delivery Vehicles ◽  
Targeting Vector

Personalized medicine is becoming an integral part of our healthcare system, in which theranostics play a fundamental role. Nanomedicines such as monoclonal antibodies are a commonly used targeting vector in such approaches due to their outstanding targeting abilities as well as their capabilities to function as drug delivery vehicles. However, the application of nanomedicines in a clinical setting is connected with several challenges. For example, nanomedicines typically possess slow pharmacokinetics in respect to target accumulation and excretion. For targeted radionuclide therapy, this results in high radiation burden to healthy tissue. For drug delivery systems, long circulation and excretion times of the nanomedicine complicate site-specific release approaches and limit as such the usability of these strategies. One way to circumvent these challenges is the use of pretargeting strategies, which allow to separate the accumulation and excretion of nanomedicines from the actual diagnostic or therapeutic application. As such, pretargeting allows to use theranostic concepts utilizing the same nanomedicine and determine the success chances with diagnostic measures before initiating therapy. This chapter will explain the concept of pretargeted theranostics, which pretargeting systems have thus far been developed and compare how these systems performed.

scholarly journals GRP78 Protein Expression in Ovarian Cancer Patients and Perspectives for a Drug-Targeting Approach

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Florence Delie ◽  
Patrick Petignat ◽  
Marie Cohen
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Drug Targeting ◽  
Drug Delivery Systems ◽  
Ovarian Cancer Cell ◽  
Glucose Deprivation ◽  
Chaperone Protein ◽  
Low Levels ◽  
Potential Use ◽  
Glucose Regulated Protein

Glucose-regulated protein of 78 kD (GRP78) is a chaperone protein mainly located in the endoplasmic reticulum (ER). This protein is normally present at low levels in adult cells but its expression is triggered by ER stress including glucose deprivation and hypoxia. In tumor cells, it is overexpressed with fraction of protein found at the cell surface. This paper presents the physiology of GRP78 in the context of ovarian cancer and its potential use as drug delivery systems targeting ovarian cancer cell.

scholarly journals Biodegradable Polymers as Drug Delivery Systems for Bone Regeneration

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 95 ◽  
Author(s):  
Kaoru Aoki ◽  
Naoto Saito
Keyword(s):  
Drug Delivery ◽  
Regenerative Medicine ◽  
Bone Regeneration ◽  
Drug Delivery Systems ◽  
Calcium Phosphates ◽  
Delivery Systems ◽  
Polymer Scaffolds ◽  
Synthetic Scaffold ◽  
And Performance ◽  
Potential Use

Regenerative medicine has been widely researched for the treatment of bone defects. In the field of bone regenerative medicine, signaling molecules and the use of scaffolds are of particular importance as drug delivery systems (DDS) or carriers for cell differentiation, and various materials have been explored for their potential use. Although calcium phosphates such as hydroxyapatite and tricalcium phosphate are clinically used as synthetic scaffold material for bone regeneration, biodegradable materials have attracted much attention in recent years for their clinical application as scaffolds due their ability to facilitate rapid localized absorption and replacement with autologous bone. In this review, we introduce the types, features, and performance characteristics of biodegradable polymer scaffolds in their role as DDS for bone regeneration therapy.

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