scholarly journals Physical Activity Prevents Cartilage Degradation: A Metabolomics Study Pinpoints the Involvement of Vitamin B6

Cells ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 1374 ◽  
Author(s):  
Deiana ◽  
Malerba ◽  
Dalle Carbonare ◽  
Cheri ◽  
Patuzzo ◽  
...  
Keyword(s):  
Physical Activity ◽  
Vitamin B6 ◽  
Cartilage Degradation ◽  
Protective Role ◽  
Before And After ◽  
Metabolomics Study ◽  
Cartilage Cells ◽  
First Time ◽  
Chondrosarcoma Cell Line

Osteoarthritis (OA) is predominantly characterized by the progressive degradation of articular cartilage, the connective tissue produced by chondrocytes, due to an imbalance between anabolic and catabolic processes. In addition, physical activity (PA) is recognized as an important tool for counteracting OA. To evaluate PA effects on the chondrocyte lineage, we analyzed the expression of SOX9, COL2A1, and COMP in circulating progenitor cells following a half marathon (HM) performance. Therefore, we studied in-depth the involvement of metabolites affecting chondrocyte lineage, and we compared the metabolomic profile associated with PA by analyzing runners’ sera before and after HM performance. Interestingly, this study highlighted that metabolites involved in vitamin B6 salvage, such as pyridoxal 5’-phosphate and pyridoxamine 5’-phosphate, were highly modulated. To evaluate the effects of vitamin B6 in cartilage cells, we treated differentiated mesenchymal stem cells and the SW1353 chondrosarcoma cell line with vitamin B6 in the presence of IL1β, the inflammatory cytokine involved in OA. Our study describes, for the first time, the modulation of the vitamin B6 salvage pathway following PA and suggests a protective role of PA in OA through modulation of this pathway.

The effects of dehydration and local soil on parasite recovery: A preliminary paleoparasitological evaluation on experimental coprolites

The Holocene ◽  
2021 ◽  
pp. 095968362110499
Author(s):  
Darío Alejandro Ramirez ◽  
Mariana Fabra ◽  
Samanta Xavier ◽  
Alena Mayo Iñiguez
Keyword(s):  
Equal Mass ◽  
Central Argentina ◽  
Soil Sediment ◽  
Local Soil ◽  
Before And After ◽  
Fresh Feces ◽  
Flotation Technique ◽  
First Time ◽  
Taphonomic Processes

Experimental paleoparasitological approaches have been used in order to optimize the methodology previously to the application in archeological samples. In this study we evaluated the action of dehydration and local soil (Central Argentina) on the loss of parasite eggs in experimental coprolites, using two parasitological techniques: spontaneous sedimentation and sucrose-flotation. Experimental coprolites comprised fresh human feces, positive for Hymenolepis nana, Ascaris sp., and Enterobius vermicularis, submitted to controlled artificial dehydration. Experimental coprolites with soil addition were prepared by mixing archeological sediment with equal mass of fresh feces. Helminth eggs were counted and eggs per gram were estimated in each subsample. Statistical analyses were applied to compare subsamples before and after desiccation and with and without addition of soil sediment. The performance of parasitological methods statistically differed, the sucrose flotation technique being the less effective when fresh feces and experimental coprolites were analyzed. Partial deformation of eggs was observed via both techniques only in subsamples containing H. nana eggs. However, this was not seen in Ascaris sp. subsamples, possibly due to eggshell composition. We found that sample desiccation significantly decreased the number of eggs in the experimental coprolites. Mixing archeological sediment with the fecal material also resulted in significantly fewer eggs surviving, independent of desiccation. This shows that climate and soil in which archeological fecal samples are found can strongly influence the survival of parasite eggs from past populations. The small amount of parasite evidence often found in paleoparasitological analyses, including Central Argentina, could be attributed to the action of taphonomic processes rather than to the real absence of infection in these ancient populations. Importantly, the study highlights the role of local soil, confirmed for the first time by empirical data. The research provides valuable insights into the understanding of the paleoparasitological results of the region and of general paleoparasitology.

scholarly journals Differential Activation of Fetal Hofbauer Cells in Primigravidas Is Associated with Decreased Birth Weight in Symptomatic Placental Malaria

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Stephanie L. Gaw ◽  
Bethann S. Hromatka ◽  
Sadiki Ngeleza ◽  
Sirirak Buarpung ◽  
Nida Ozarslan ◽  
...  
Keyword(s):  
Birth Weight ◽  
Placental Malaria ◽  
Perinatal Outcomes ◽  
Protective Role ◽  
Cross Sectional ◽  
Macrophage Response ◽  
Hofbauer Cells ◽  
Infant Birth ◽  
First Time

Background. Placental malaria is a leading global cause of low birth weight neonates, especially in first-time mothers. To better understand the role of innate immunity in placental malaria, we investigated the relationships between histopathological markers of placental malaria, fetal and maternal macrophage responses, and perinatal outcomes in a cross-sectional case control study of pregnant women presenting with symptomatic malaria at the time of delivery. Results. Primigravidas showed increased hemozoin deposition in placental villi (p=0.02), syncytiotrophoblasts (p=0.01), and fetal Hofbauer cells (p=0.01). The percentage of hemozoin-positive villi negatively correlated with infant birth weight (regression coefficient [b] = -0.03 kg decrease in birth weight per % increase in hemozoin-positive villi, p=0.035). Malaria-infected placentas showed a twofold increase in Hofbauer cells (p<0.001) and maternal macrophages (p<0.001). Placental malaria was associated with a threefold increase in the percentage of M2 maternal macrophages (19.2% vs 6.4%, p=0.01). Primigravidas showed a significant decrease in the Hofbauer cell M2-percentage in placental malaria (92.7% vs. 97.0%, p=0.04), which was predictive of infant birth weight (b=0.08 kg increase in birth weight per % increase in M2 Hofbauer cells, p=0.001). There was no association between maternal macrophage response and infant birth weights. Conclusions. Placentas with malarial infection had increased numbers of fetal Hofbauer cells in the villous stroma and maternal macrophages in the intervillous space. In primigravidas, decreased anti-inflammatory M2-type Hofbauer cells were predictive of lower birth weight. M2-type maternal macrophages were increased in placental malaria, but there was no association with gravidity or birth weight. These results suggested a protective role of M2 Hofbauer cells in fetal growth restriction.

Physical activity as a protective factor for successful aging

2019 ◽  
Vol 29 (87) ◽  
pp. 47-52
Author(s):  
Andrzej Jopkiewicz ◽  
Monika Królicka–Czerniak ◽  
Anita Zaręba
Keyword(s):  
Physical Activity ◽  
Prefrontal Cortex ◽  
Cognitive Processes ◽  
Cognitive Aging ◽  
Successful Aging ◽  
Protective Factor ◽  
Protective Role ◽  
Factors Affecting ◽  
The Brain

To divide the types of aging (successful, usual and impaired), as well as factors affecting this process, the protective role of physical activity was discussed in the literature. It was emphasized that physical activity is also a very important protective factor for cognitive aging - mainly executive function and memory. The prefrontal cortex and hippocampus, i.e. the regions of the brain responsible for the control and course of cognitive processes, show susceptibility to stimulation, which is movement exercises, which are prevention of degenerative changes within the brain.

scholarly journals Protective role of physical activity on type 2 diabetes: Analysis of effect modification by race-ethnicity

2017 ◽  
Vol 10 (2) ◽  
pp. 166-178 ◽  
Author(s):  
William R. Boyer ◽  
James R. Churilla ◽  
Samantha F. Ehrlich ◽  
Scott E. Crouter ◽  
Lyndsey M. Hornbuckle ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 2 Diabetes ◽  
Protective Role ◽  
Effect Modification ◽  
Race Ethnicity

scholarly journals Heart Rate Reactivity to Mental Stress in Athlete and Non-Athlete Children

2020 ◽  
Vol 3 (118) ◽  
pp. 4-12
Author(s):  
Krisztina Ábel ◽  
Attila Rausz Szabó ◽  
Attila Szabo
Keyword(s):  
Physical Activity ◽  
Heart Rate ◽  
Psychosocial Stress ◽  
Mental Stress ◽  
Classical Music ◽  
Mental Arithmetic ◽  
Protective Role ◽  
Heart Rate Reactivity ◽  
Arithmetic Task ◽  
Before And After

Background. Research suggests that exercise training and/or physical fitness may be associated with lower heart rate reactivity and faster recovery from psychosocial stress. This relationship was rarely studied in children despite the potential protective role of physical activity in stress that may start in early life stages. Methods. In this laboratory investigation we examined 18 athlete and non-athlete children before, during and following exposure to mental stress which consisted of the Stroop Color Word Task and a mental arithmetic task, both distracted by classical music, in a counterbalanced research design. Results. The results based on absolute heart rate measures suggested that athletes exhibited lower heart rates in the stress-anticipation period as well as during the stress period than non-athletes. However, based on relative measures these differences vanished. The two groups of children did not differ in perceived arousal, perceived stressfulness of the mental tasks, and the self-reported feeling states before and after stress. Further, they did not differ in their performance on the two stress-eliciting active-coping tasks as indicated by the number of correct answers. Conclusion. These results appear to suggest that athletic status in children is unrelated to heart rate reactivity and other subjective psychological experiences before, during and after acute psychosocial stress.  Keywords: adolescent, exercise, fitness, physical activity, relative measures.

scholarly journals Trajectories of Functional Health Following Stroke: The Role of Social Resources

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 847-847
Author(s):  
Takeshi Nakagawa ◽  
Taiji Noguchi ◽  
Ayane Komatsu ◽  
Masumi Ishihara ◽  
Tami Saito
Keyword(s):  
Social Participation ◽  
Functional Decline ◽  
Protective Role ◽  
Social Resources ◽  
Stroke Onset ◽  
Functional Health ◽  
Japanese Adults ◽  
Before And After ◽  
Crucial Information

Abstract Stroke is one of the major causes of disability in old age. Predictors for the functional prognosis have been studied, but the role of social resources in recovery has not studied as much. We examined whether social resources available before and after stroke onset improved functional prognoses. Data was derived from longitudinal data collected between 1987 and 2006 from Japanese adults aged 60 years and older. We identified 396 people who had experienced their self- or proxy-reported first stroke during follow-up (age at stroke onset: M = 76.0, SD = 6.9; 74.2% women). Functional health was measured by self- or proxy-reported activities of daily living. Social resources were indexed as residential status, contact with non-coresident children, social participation, and perceived support. Analyses were adjusted for age at stroke onset, gender, and education. A multiphase growth model showed that functional health typically deteriorated surrounding stroke and gradually declined thereafter. There were also individual differences in the trajectories of functional health. Individuals who more frequently participated in social groups prior to stroke and those who came to participate more frequently thereafter exhibited less functional decline immediately following stroke. Our findings indicate that social participation plays a protective role against adverse prognoses following stroke regardless of when individuals start participating. Inclusive communities would enable older adults to remain independent. Our study was limited in that crucial information about stroke, such as objective measures of initial severity, was not available and that individuals with more severe stroke may have dropped out after the onset.

scholarly journals DEPRESSION AMONG OLDER CANADIAN REFUGEES: THE PROTECTIVE ROLE OF SOCIAL SUPPORT

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S539-S539
Author(s):  
Esme Fuller-Thomson ◽  
Shen (Lamson) Lin ◽  
Karen Kobayashi ◽  
Simran R Arora ◽  
Hongmei Tong ◽  
...  
Keyword(s):  
Physical Activity ◽  
Social Support ◽  
Chronic Pain ◽  
Secondary Analysis ◽  
Protective Role ◽  
Health Conditions ◽  
Sociodemographic Characteristics ◽  
Targeted Interventions ◽  
Prevalence Of Depression

Abstract This study’s objective was to identify which factors attenuate refugees’ higher odds of depression. A secondary analysis of 272 refugees and 29,398 non-refugees in the Canadian Longitudinal Study on Aging, a 2012 study of Canadians aged 45 to 85, was conducted. The prevalence of depression was higher among refugees than non-refugees (22.1% vs 15.2%, p&lt;.001). The age-sex adjusted odds of depression for refugees (OR=1.70, p&lt;.001) was only modestly attenuated when sociodemographic characteristics, physical health conditions, chronic pain, binge drinking and level of physical activity were taken into account (ORs ranged from 1.61 to 1.70, all p&lt;.05). However, in the model adjusting for social support, the odds of depression for refugees was reduced to non-significance (OR=1.30, p=0.92). Refugees have higher odds of depression than non-refugees, and this excess vulnerability is associated with lower levels of social support. Targeted interventions to decrease isolation and improve refugees’ social support warrant greater attention

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