Factors That Determine the Adhesive Strength in a Bioinspired Bone Tissue Adhesive

Phosphoserine-modified cements (PMCs) are a family of wet-field tissue adhesives that bond strongly to bone and biomaterials. The present study evaluated variations in the adhesive strength using a scatter plot, failure mode, and a regression analysis of eleven factors. All single-factor, continuous-variable correlations were poor (R2 < 0.25). The linear regression model explained 31.6% of variation in adhesive strength (R2 = 0.316 p < 0.001), with bond thickness predicting an 8.5% reduction in strength per 100 μm increase. Interestingly, PMC adhesive strength was insensitive to surface roughness (Sa 1.27–2.17 μm) and the unevenness (skew) of the adhesive bond (p > 0.167, 0.171, ANOVA). Bone glued in conditions mimicking the operating theatre (e.g., the rapid fixation and minimal fixation force in fluids) produced comparable adhesive strength in laboratory conditions (2.44 vs. 1.96 MPa, p > 0.986). The failure mode correlated strongly with the adhesive strength; low strength PMCs (<1 MPa) failed cohesively, while high strength (>2 MPa) PMCs failed adhesively. Failure occurred at the interface between the amorphous surface layer and the PMC bulk. PMC bonding is sufficient for clinical application, allowing for a wide tolerance in performance conditions while maintaining a minimal bond strength of 1.5–2 MPa to cortical bone and metal surfaces.

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New Flexible Cyanoacrylate Tissue Adhesive Adhflex®: Adhesion and Performance in Inguinal Hernia Repair

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.638.73 ◽

2015 ◽

Vol 638 ◽

pp. 73-78

Author(s):

Ana M. Villarreal-Gómez ◽

Manuel Martínez-Paíno ◽

José Miguel Martín-Martínez

Keyword(s):

Inguinal Hernia ◽

Hernia Repair ◽

Inguinal Hernia Repair ◽

Chain Length ◽

Alkyl Chain ◽

High Strength ◽

Alkyl Chain Length ◽

Tissue Adhesive ◽

Tissue Adhesives ◽

Adhesion Properties

Sutures and cyanoacrylate high strength tissue adhesives are commonly used for wound closure in several surgical applications. Although effective for closing simple and small incisions, cyanoacrylate adhesives were limited by compromising adhesion and stiffness, i.e. cyanoacrylates with short alkyl chain length showed higher adhesion but lower flexibility than the ones with long alkyl chain length. In this paper, a new concept of flexible and high strength tissue cyanoacrylate based adhesive - Adhflex®- is presented. The balance between adhesion and flexibility in Adhflex® was achieved by adding an inert (i.e. non-reactive) chemical to a short alkyl chain length cyanoacrylate able to partially inhibit its polymerization in presence of moisture. Adhesion properties of Adhflex®were superior as compared to other commercial cyanoacrylate tissue adhesives (i.e. higher traction and shear strength). Furthermore, Adhflex®has been successfully used in a clinical trial for inguinal hernia repair (case study) as the surgery time with respect to suturing was reduced substantially, the comfort of the patient was improved (i.e. reduced tension after surgery, reduced allergic reaction) and the scare was minimal.

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Processing and Characterization of Tissue Adhesive from Rice Starch Nanocomposites

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.123-125.363 ◽

2010 ◽

Vol 123-125 ◽

pp. 363-366 ◽

Cited By ~ 4

Author(s):

Watee Puntuwat ◽

Sathiya Wongsa ◽

Jiraporn Poonyawatpornkul ◽

Sittiporn Punyanitya ◽

Anirut Raksujarit

Keyword(s):

Adhesive Bond ◽

Raw Material ◽

Tissue Adhesive ◽

Rice Starch ◽

X Ray Diffraction ◽

Tissue Adhesives ◽

Health Ministry ◽

X Ray ◽

Standard Product

The objective of this work is make tissue adhesives agent from Thai rice starch, then test the final products for scientific and medical properties following the laws of Thai health ministry, to demonstrate that this product can be used safely, as same as the standard product. The principal raw material is pharmaceutical grade, Thai rice starch powder. The additives are hydroxyapatite (HA) nanopowder, carboxymethylcellulose, lactic acid, gelatin, polyvinylalcohol and glycerol. All materials will be mixed in distilled water under high temperature, and dried into starch tissue adhesives plate hydrogel. The final product will be kept in medical package and sent for sterilization by gamma radiation. These products will be characterized by scanning electron microscopy (SEM), x-ray diffraction (XRD), stability in water, and adhesive bond strength test in wet environment.

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Cyclic Tests and Numerical Analyses on Bolt-Connected Precast Reinforced Concrete Deep Beams

Applied Sciences ◽

10.3390/app11125356 ◽

2021 ◽

Vol 11 (12) ◽

pp. 5356

Author(s):

Jing Li ◽

Lizhong Jiang ◽

Hong Zheng ◽

Liqiang Jiang ◽

Lingyu Zhou

Keyword(s):

Reinforced Concrete ◽

Failure Mode ◽

Seismic Performance ◽

High Strength ◽

Length Ratio ◽

Frame Structures ◽

Initial Stiffness ◽

Frame Buildings ◽

Parametric Analyses ◽

Bending Failure

A bolt-connected precast reinforced concrete deep beam (RDB) is proposed as a lateral resisting component that can be used in frame structures to resist seismic loads. RDB can be installed in the steel frame by connecting to the frame beam with only high-strength bolts, which is different from the commonly used cast-in-place RC walls. Two 1/3 scaled specimens with different height-to-length ratios were tested to obtain their seismic performance. The finite element method is used to model the seismic behavior of the test specimens, and parametric analyses are conducted to study the effect on the height-to-length ratio, the strength of the concrete and the height-to-thickness ratio of RDBs. The experimental and numerical results show that the RDB with a low height-to-length ratio exhibited a shear–bending failure mode, while the RDB with a high height-to-length ratio failed with a shear-dominated failure mode. By comparing the RDB with a height-to-length ratio of 2.0, the ultimate capacity, initial stiffness and ductility of the RDB with a height-to-length ratio of 0.75 increased by 277%, 429% and 141%, respectively. It was found that the seismic performance of frame structures could be effectively adjusted by changing the height-to-length ratio and length-to-thickness of the RDB. The RDB is a desirable lateral-resisting component for existing and new frame buildings.

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Steel Plate Cold-Rolled Section Steel Embedded High-Strength Concrete Low-Rise Shear Wall Seismic Performance

Advances in Civil Engineering ◽

10.1155/2018/8362319 ◽

2018 ◽

Vol 2018 ◽

pp. 1-18

Author(s):

Min Gan ◽

Yu Yu ◽

Liren Li ◽

Xisheng Lu

Keyword(s):

Bearing Capacity ◽

Failure Mode ◽

Seismic Performance ◽

High Strength Concrete ◽

Steel Plate ◽

Shear Walls ◽

High Strength ◽

Shear Wall ◽

Steel Plates ◽

Strength Concrete

Four test pieces with different steel plate center-to-center distances and reinforcement ratios are subjected to low-cycle repeat quasistatic loading to optimize properties as failure mode, hysteretic curve, skeleton curve, energy dissipation parameters, strength parameters, and seismic performance of high-strength concrete low-rise shear walls. The embedded steel plates are shown to effectively restrict wall crack propagation, enhance the overall steel ratio, and improve the failure mode of the wall while reducing the degree of brittle failure. Under the same conditions, increasing the spacing between the steel plates in the steel plate concrete shear wall can effectively preserve the horizontal bearing capacity of the shear wall under an ultimate load. The embedded steel plates perform better than concealed bracing in delaying stiffness degeneration in the low-rise shear walls, thus safeguarding their long-term bearing capacity. The results presented here may provide a workable basis for shear wall design optimization.

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Surgical Tissue Adhesives: Host Tissue Response, Adhesive Strength and Clinical Performance

SURGICAL ADHESIVES and SEALANTS ◽

10.1201/9780429332500-9 ◽

2020 ◽

pp. 61-69

Author(s):

D. Toriumi

Keyword(s):

Adhesive Strength ◽

Clinical Performance ◽

Host Tissue ◽

Tissue Response ◽

Tissue Adhesives

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Effect of Autoclave Cure Time and Surface Preparation on Film Adhesive Bond in Lightweight Material Joints

Volume 2: Computer Technology and Bolted Joints ◽

10.1115/pvp2018-84009 ◽

2018 ◽

Author(s):

Isotta Morfini ◽

Luca Goglio ◽

Giovanni Belingardi ◽

Sayed A. Nassar

Keyword(s):

Failure Mode ◽

Load Transfer ◽

Mechanical Performance ◽

Surface Preparation ◽

Adhesive Bond ◽

Lap Joints ◽

Mode Analysis ◽

Bonding Parameters ◽

Film Adhesive ◽

Cure Time

This study investigates the effect of cure time and surface roughness on mechanical performance of single lap joints (SLJ). Test joints are made of aluminum/aluminum or aluminum/magnesium adherends that are autoclave-bonded using a commercially available film adhesive. Joint mechanical performance is assessed in terms of the static load transfer capacity (LTC), fatigue life and failure mode. Except for the cure time, all the rates of the other autoclave-bonding parameters are kept constant; namely, the level of cure temperature and pressure, as well as the rates of autoclave heating, cooling, pressurization and depressurization. Test data, failure mode analysis, discussion, observations and conclusions are provided.

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Using silica mineral waste as aggregate in a green high strength concrete: workability, strength, failure mode, and morphology assessment

Australian Journal of Civil Engineering ◽

10.1080/14488353.2018.1472539 ◽

2018 ◽

Vol 16 (2) ◽

pp. 122-128 ◽

Cited By ~ 24

Author(s):

Palanisamy Murthi ◽

Paul Awoyera ◽

Palanisamy Selvaraj ◽

Devi Dharsana ◽

Ravindran Gobinath

Keyword(s):

Failure Mode ◽

High Strength Concrete ◽

High Strength ◽

Strength Concrete ◽

Strength Failure ◽

Silica Mineral ◽

Mineral Waste

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Analysis of seismic performance and research of load capacity of steel reinforced high strength concrete columns with rectangular helical hoops

Advances in Structural Engineering ◽

10.1177/1369433220981659 ◽

2020 ◽

pp. 136943322098165

Author(s):

Jianyang Xue ◽

Xin Zhang ◽

Xiaojun Ke

Keyword(s):

Failure Mode ◽

Seismic Performance ◽

Calculation Method ◽

High Strength Concrete ◽

Failure Modes ◽

Shear Failure ◽

High Strength ◽

Shear Capacity ◽

Strength Concrete ◽

Shear Span

This paper mainly focused on the seismic performance and shear calculation method of steel reinforced high-strength concrete (SRHC) columns with rectangular helical hoops. An experimental investigation was performed in this paper. Eleven SRHC columns with rectangular helical hoops and one with ordinary hoops were constructed at the laboratory of Guangxi university. The failure modes, hysteresis loops, envelope curves, characteristic loads and displacements and cumulative damage analysis are presented and investigated. It can be seen from the test results that the failure modes of SRHC columns can be divided into three types with the shear span ratio increased, namely, shear baroclinic failure mode, flexure-shear failure mode and flexure failure mode. In addition, the specimens with rectangular helical hoops have plumper hysteretic loops. Shear span ratio is the main influencing factor of characteristic load; the axial compression ratio and concrete strength have less influence on characteristic load, while stirrup ratio has little effect on the characteristic load. Finally, a calculation method for shear capacity of SRHC columns under shear baroclinic failure and flexure-shear failure mode is proposed.

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