scholarly journals Early Diagnosis of Lung Cancer in the United Arab Emirates: Challenges and Strategic Recommendations

2021 ◽  
Vol 11 (3) ◽  
pp. 671-678
Author(s):  
Humaid O. Al-Shamsi ◽  
Hassan Jaffar ◽  
Bassam Mahboub ◽  
Faraz Khan ◽  
Usama Albastaki ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Early Diagnosis ◽  
United Arab Emirates ◽  
National Level ◽  
Delayed Diagnosis ◽  
Suspected Case ◽  
Contributing Factors ◽  
Published Evidence ◽  
Cause Of Deaths ◽  
Delayed Referral

In the United Arab Emirates (UAE), lung cancer (LC) was the third leading cause of deaths due to cancer in 2017. Around 80% of the patients in the UAE are diagnosed at a late stage, rendering the treatment less effective in improving survival outcomes. Lack of awareness of disease symptomatology, deficient screening initiatives, misdiagnosis, and delayed referral to the specialist are contributing factors for delayed diagnosis. Effective screening at a primary care setting can be crucial for early diagnosis, referral to specialists, and enhancing patient outcomes. It is important to establish screening and referral guidelines through which each suspected case can be identified and provided timely intervention. Although the international screening and referral pathway framework are comprehensive, several regional barriers need to be addressed before they can be adapted at the national level. A group of LC experts from the UAE deliberated on issues like delayed diagnosis of LC and strategic recommendations for overcoming the challenges. The discussion was based on the review of the published evidence, international and regional guidelines for screening and early diagnosis of LC. Herein, we present a guideline, endorsed by the esteemed panel of experts, for aiding early diagnosis and optimizing the management of LC in the UAE.

Coumarin Hybrids: Promising Scaffolds in the Treatment of Breast Cancer

2019 ◽  
Vol 19 (17) ◽  
pp. 1443-1458 ◽  
Author(s):  
Rohit Bhatia ◽  
Ravindra K. Rawal
Keyword(s):  
Breast Cancer ◽  
Lung Cancer ◽  
Therapeutic Agents ◽  
Toxicity Profile ◽  
Biological Targets ◽  
Organ Systems ◽  
Hybrid Molecules ◽  
Cause Of Deaths ◽  
Low Toxicity ◽  
Diverse Mode

: Breast cancer is the most common invasive cancer in women, and the second main cause of deaths in women, after lung cancer. There is continuous advancement in the development of therapeutic agents against breast cancer in recent years and it is still in progress. Development of hybrid molecules by combining different pharmacophores to obtain significant biological activity is an excellent approach. Coupling of coumarin scaffold with other distinct motifs has led to the design of newer compounds against breast cancer. These distinct pharmacophores possess a diverse mode of action as well as selectivity. It has been reported in the literature that coumarin hybrids possess significant potency against breast cancer by binding to various biological targets which are associated with breast cancer. Due to low toxicity profile on various organ systems, coumarin hybrids have nowadays attracted the keen attention of researchers to explore their therapeutic ability against breast cancer. Reported coumarin hybrids include coupling with isoxazole, thiazole, monastrol, chalcone, triazole, sulphonamide, triphenylethylene, benzimidazole, pyran, imidazole, stilbene, oestrogen, phenylsulphonylfuroxan, etc. In the present review, a description of various coumarin hybrid molecules has been presented along with their structural-activity relationships.

Emerging Biomarkers and Contributing Factors of Prostate Cancer.

2020 ◽  
Vol 16 ◽  
Author(s):  
Mini Dahiya ◽  
Monu Yadav ◽  
Kalpana Nagpal ◽  
Nidhi Sharma ◽  
Kajal Joshi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Tumor Suppressor Genes ◽  
Therapeutic Strategy ◽  
Cannabinoid Receptors ◽  
Contributing Factors ◽  
Cause Of Deaths ◽  
Pharmaceutical Industries ◽  
Brca1 Brca2 ◽  
Molecular Pathophysiology

: Prostate Cancer (PC) is one the most prominent cause of deaths in males worldwide especially in western countries. The exhaustive research into prostate cancer to date has demonstrated ELAC2, RNASEL, MSR1, NBS1, CHEK2, MYC, BCL-2, c-Kit, tumor suppressor genes, BRCA1, BRCA2, PACE4, GSTP1, PTEN,CDKN1B, NKX3.1, KLF6, FOXA1, Retinoblastoma, p53, androgen receptor, kallikreins, ETS, CYP17, SRD5A2, E-cadherin, KAI1/CD82, hepsin, AMACR, PIM1, MTA-1, EZH2, EPHB2, growth factors & its receptors, cannabinoid receptors, annexins, oxidative stress and inflammation are entailed changes underlying the initiation, development, and progression of PC. Furthermore, oncology would shift from a reactive to proactive discipline so exploring these targets open new area of research. Therefore, the present review is focused on molecular pathophysiology biomarkers for the progression of PC that would encourage the researchers and pharmaceutical industries to investigate potential therapeutic strategy to overcome demerits of currently available clinically therapies.

scholarly journals Lung cancer molecular mutations and abnormal glycosylation as biomarkers for early diagnosis

2021 ◽  
Vol 27 ◽  
pp. 100311
Author(s):  
Shuang Yang ◽  
Jun Xia ◽  
Zeren Yang ◽  
Mingming Xu ◽  
Shuwei Li
Keyword(s):  
Lung Cancer ◽  
Early Diagnosis ◽  
Abnormal Glycosylation

The Early Diagnosis of Primary Lung Cancer by Cytologic Methods

1951 ◽  
Vol 20 (3) ◽  
pp. 237-256 ◽  
Author(s):  
SEYMOUR M. FARBER ◽  
ALLEN K. McGRATH ◽  
MORTIMER A. BENIOFF ◽  
LLOYD W. ESPEN
Keyword(s):  
Lung Cancer ◽  
Early Diagnosis ◽  
Primary Lung Cancer

Meta-analysis of associations between cooking oil fumes exposure and lung cancer risk

2021 ◽  
pp. 1420326X2110306
Author(s):  
Xiaofang Zhang ◽  
Lei Rao ◽  
Qinghong Liu ◽  
Qin Yang
Keyword(s):  
Lung Cancer ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Cooking Methods ◽  
Contributing Factors ◽  
Cancer Prevalence ◽  
Cooking Oil ◽  
Cooking Oil Fumes ◽  
The Times ◽  
Pan Frying

Lung cancer is one of the most common cancers and cooking oil fumes (COF) are considered as the potential dangerous contributing factors. This study, a meta-analysis was conducted to analyse the correlation between exposure to COF and risk of lung cancer. Literature from 1980 to 2020 were searched and 29 studies were selected for analysis. Results showed that population exposed to COF had significant differences in lung cancer prevalence (P < 0.05). The odds ratio (OR) values of different periods (before 2000, 2000–2010 and 2010–2020) were significantly different. Using ventilation equipment had the OR of 0.54. Liao cuisine, Fujian cuisine, Shanghai cuisine, Jingdong cuisine and Shaanxi cuisine had the ORs (95% confidence interval) of 1.91 (1.62, 2.25), 2.38 (1.80, 3.16), 1.56 (1.29, 1.89), 2.58 (1.63, 4.09) and 1.57 (1.16, 2.11), respectively. These results revealed that exposure to COF could increase the risk of lung cancer, but the risk was gradually reduced with the changes of the times and the use of ventilation equipment. Different cooking methods in different regions caused different risks of lung cancer. The risk of lung cancer caused by COF mainly produced by deep-frying, quick-frying, stir-frying and pan-frying is higher than in other methods.

scholarly journals Establishment of a serological molecular model for the early diagnosis and progression monitoring of bone metastasis in lung cancer

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Xiaoyan Teng ◽  
Lirong Wei ◽  
Liming Han ◽  
Daliu Min ◽  
Yuzhen Du
Keyword(s):  
Lung Cancer ◽  
Bone Metastasis ◽  
Early Diagnosis ◽  
Molecular Model
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