scholarly journals Granular Cell Dermatofibroma: When Morphology Still Matters

2021 ◽  
Vol 8 (3) ◽  
pp. 371-375
Author(s):  
Gerardo Cazzato ◽  
Anna Colagrande ◽  
Antonietta Cimmino ◽  
Maricla Marrone ◽  
Alessandra Stellacci ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Fibrous Histiocytoma ◽  
Granular Cell ◽  
Soft Tissue Tumors ◽  
Histopathological Diagnosis ◽  
Histological Features ◽  
Cellular Changes ◽  
Aggressive Tumor ◽  
Cell Variant

Dermatofibroma, also known as “fibrous histiocytoma”, is one of the most common cutaneous soft-tissue tumors. Many variants of dermatofibromas have been described, and knowledge of these variations is important to avoid misdiagnosis of a possibly more aggressive tumor. Histological features of different variants can coexist in the same lesion, but typical common fibrous histiocytoma features are generally found, at least focally, in all cases. However, when cellular changes make up the majority of the lesion, the histopathological diagnosis can become more complex and requires immunohistochemical investigations for correct nosographic classification. We present the case of a cutaneous fibrous histiocytoma, “granular cell” variant, found on the left leg of a 74-year-old woman.

scholarly journals Malignant Fibrous Histiocytoma in Dogs and Cats

1979 ◽  
Vol 16 (2) ◽  
pp. 199-208 ◽  
Author(s):  
C. A. Gleiser ◽  
G. L. Raulston ◽  
J. H. Jardine ◽  
K. N. Gray
Keyword(s):  
Soft Tissue ◽  
Giant Cell ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Tumors ◽  
Fibrous Histiocytomas ◽  
Malignant Fibrous Histiocytomas ◽  
Multinucleated Cells ◽  
Cell Variant ◽  
And Function

Five soft tissue tumors of varied morphology in dogs and cats were classified as malignant fibrous histiocytomas on the basis of their histologic composition. All were composed of varying mixtures of histiocytes and fibroblasts and three contained large multinucleated cells. This giant cell variant of malignant fibrous histiocytoma was seen only in cats. These tumors are comparable to those described in man as malignant fibrous histiocytoma on the basis of the malignant histiocyte and its varied morphology and function.

scholarly journals A rare case of cutaneous granular cell tumour

2021 ◽  
Vol 9 (8) ◽  
pp. 2482
Author(s):  
Rohini Arumugam ◽  
Leena Dennis Joseph ◽  
Vidhya Venkatesan ◽  
C. D. Narayanan
Keyword(s):  
Soft Tissue ◽  
Female Patient ◽  
Rare Case ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Soft Tissue Tumors ◽  
Cell Tumor ◽  
Cell Tumour ◽  
Granular Cell Tumour ◽  
Uncertain Etiology

Granular cell tumors are uncommon tumors of uncertain etiology. It accounts for approximately 0.5% of all soft tissue tumors. However, the involvement of skin is rare. Only few cases of cutaneous granular cell tumor is reported till date. Here, we present a case of cutaneous granular cell tumor in a 48 years female patient.

scholarly journals Role of Intraoperative Pathology Consultation by Imprint and Scrape Cytology in Soft Tissue Tumors and Tumor-Like Lesions

Sarcoma ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Rupali Gautam ◽  
Harsh Mohan ◽  
Uma Handa ◽  
Bhumika Bisht
Keyword(s):  
Soft Tissue ◽  
Diagnostic Yield ◽  
Soft Tissue Tumors ◽  
Histopathological Diagnosis ◽  
Cytological Diagnosis ◽  
Therapeutic Decision Making ◽  
Tumor Like Lesions ◽  
Scrape Cytology ◽  
Gross Examination

Intraoperative pathologic consultation plays an essential role in therapeutic decision making, possibly avoiding under or overtreatment of the patient. Common indications for intraoperative consultation include obtaining a diagnosis in an unknown pathology, ruling out malignancy, confirming a provisional diagnosis, and assessing margin status. Fifty patients undergoing surgery for soft tissue tumors or tumor-like lesions were included in the present prospective study to evaluate the role of intraoperative pathologic consultation by imprint and scrape cytology. Careful and quick gross examination of the specimen was performed, followed by processing for imprint and scrape smears. The prepared smears were evaluated by three pathologists and the cytological diagnosis compared subsequently with final histopathological diagnosis. Intraoperative consultation was primarily requested to make or confirm preoperative diagnosis. In 44.0% cases, no previous tissue/cytological diagnosis was available. In 56.0% cases, previous pathological diagnosis was available, but the reports were inconclusive or were reported from outside our institute. The diagnostic yield of imprint smears was 24% (5 malignant, 6 benign, and 1 inconclusive), and scrape smears was 100% (10 malignant, 38 benign, and 2 inconclusive). Paraffin-embedded sections yielded diagnosis in 100% cases (11 malignant, 38 benign, and 1 nonneoplastic). Imprint smears alone were not of much help in intraoperative diagnosis. Scrape smears were found to be superior to imprint smears in terms of diagnostic yield and accuracy. Combined imprint and scrape smear cytology did not provide any advantage in intraoperative provisional tissue diagnosis in soft tissue tumors.

Elastofibroma: Diagnosis and Treatment of Six Cases

2009 ◽  
Vol 75 (4) ◽  
pp. 338-342
Author(s):  
Alison L. Burton ◽  
Andrea C. Federico ◽  
Kelly M. Mcmasters
Keyword(s):  
Soft Tissue ◽  
Imaging Techniques ◽  
Soft Tissue Tumors ◽  
Elastic Fibers ◽  
Anatomical Location ◽  
Malignant Soft Tissue Tumors ◽  
Cellular Changes ◽  
Pleural Surface ◽  
The Right ◽  
Malignant Soft Tissue

Elastofibroma is a rare, benign pseudotumor that arises from connective tissue, most commonly found at the right scapular tip. These tumors usually can be distinguished from malignant soft-tissue tumors by their anatomical location and also through imaging techniques. Although elastofibroma is rare, it is important for surgeons to be aware of this diagnosis to prevent unnecessary biopsies and unnecessary operations. We report a series of six patients, four of whom were female, with a median age of 62.5 years, diagnosed with and treated for elastofibroma. Five of the six patients had unilateral lesions, while one patient had bilateral elastofibromas. All unilateral lesions were found on the right side. The elastofibroma in five of six patients was located on the subscapular tip, the remaining patient's elastofibroma was found on the chest wall external to the pleural surface. The pathogenesis of this lesion is discussed, as recent evidence suggests a neoplastic origin to elastofibroma. Additionally, cellular changes occurring in elastofibroma may reflect the pathogenesis of other disorders of elastic fibers.

scholarly journals Undifferentiated pleomorphic sarcoma: Diagnosis of exclusion

2017 ◽  
Vol 03 (02) ◽  
pp. 133-135
Author(s):  
Pragati S. Upasham ◽  
Sharayu P. Dighavkar ◽  
Prakash M. Roplekar
Keyword(s):  
Soft Tissue ◽  
Lower Extremity ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas ◽  
Soft Tissue Tumors ◽  
High Grade ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Malignant Soft Tissue Tumors ◽  
Pleomorphic Sarcoma ◽  
Malignant Soft Tissue

AbstractMalignant soft-tissue tumors which were designated as malignant fibrous histiocytoma are regrouped by the WHO (in 2002) under the new entity termed as “undifferentiated pleomorphic sarcoma.”1 It accounts for less than 5% of all adult soft-tissue sarcomas. Here, we report the lesion in a 70-year-old man who presented with high-grade undifferentiated pleomorphic sarcoma in the lower extremity.

scholarly journals Metachronous Occurrence of Granular Cell Tumor in Breast Skin and Scalp: Diagnostic Challenging Differentiating Benign from Malignant and a Literature Review

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Hampar Akkaya ◽  
Havva Serap Toru ◽  
Ebru Sebnem Ayva ◽  
Zulfikar Karabulut ◽  
Cicek Durusoy
Keyword(s):  
Soft Tissue ◽  
Clinical Features ◽  
Granular Cell Tumor ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Histopathological Diagnosis ◽  
Diagnostic Challenge ◽  
True Nature ◽  
Incomplete Removal

Granular cell tumor (GCT) is a Schwann cell related benign neoplasm of soft tissue. GCT is an uncommon entity that occurs in a wide variety of body sites, but it is generally presented in the skin, oral cavity, superficial soft tissue, and respiratory and digestive tracts. Most of the GCTs are benign but clinically and radiologically these may mimic malignancy. Histopathological diagnosis is gold standard for establishing the true nature of the lesion. GCT is most commonly solitary but in about 10% of cases can be multifocal, usually involving various skin and soft tissue sites versus involving various internal sites. Therefore, these can involve skin and soft tissue or submucosa and viscera. GCT is usually benign; however, local recurrence is common due to incomplete removal. Malignant cases are rarely reported in 1-2% of cases. In this study, we report clinical and histopathological findings of a 36-year-old woman with metachronous GCT in breast and scalp. The clinical features raise the question of whether these are metachronous benign GCTs or whether this is establishment of malignant behavior. The aim of this report is to present the histopathological and clinical features of GCT and the diagnostic challenge of differentiating benign from malignant GCT.

scholarly journals Scapular Angiomatoid Fibrous Histiocytoma with EWSR1-CREB1 Fusion in an Adult Patient

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Hiroshi Kobayashi ◽  
Naohiro Makise ◽  
Aya Shinozaki-Ushiku ◽  
Yuki Ishibashi ◽  
Masachika Ikegami ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Lymph Node ◽  
Magnetic Resonance ◽  
Soft Tissue ◽  
Fibrous Histiocytoma ◽  
Histopathological Diagnosis ◽  
Axillary Lymph ◽  
Rare Tumor ◽  
Resonance Imaging ◽  
Angiomatoid Fibrous Histiocytoma

Background. Angiomatoid fibrous histiocytoma (AFH) is a rare intermediate malignant tumor that arises mainly in soft tissues, especially in the superficial extremities of patients younger than 30 years. There have been a few reports of AFH arising from sites other than soft tissue, including bone, and unusual site and age make it difficult to diagnose this rare tumor. Case Presentation. Here, we present a case of a 54-year-old man who was examined for chest pain, and computed tomography (CT) incidentally detected a bone tumor at the scapula with destruction of cortical bone and invasion into soft tissue. Magnetic resonance imaging revealed multiple cystic components with fluid-fluid levels. FDG-PET showed uptake at the axillary lymph node. The CT-guided needle biopsy revealed spindle cell sarcoma on histopathology. After neoadjuvant chemotherapy, a scapulectomy was performed. The final postresection histopathological diagnosis was the same as the preoperative diagnosis, and no obvious chemotherapeutic effect was observed. Next-generation sequencing of RNA isolated from paraffin-embedded tumor tissue revealed that these lesions harbored the EWSR1-CREB1 fusion gene, and the tumor was diagnosed as AFH. C-reactive protein level, which was elevated preoperatively, decreased after the operation, and there was no recurrence or metastasis 5 years after the treatment. Conclusion. The diagnosis of AFH is difficult when the tumor has an atypical presentation. Comprehensive genomic analysis, especially RNA sequencing, is efficient in diagnosing this rare tumor. Moreover, magnetic resonance imaging findings identical to AFH in soft tissue, the presence of paraneoplastic symptoms such as elevated inflammatory markers, and lymph node swelling were clues towards suspecting this tumor.

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