scholarly journals Simultaneous Measurement of Gastric Emptying of a Soup Test Meal Using MRI and Gamma Scintigraphy

Diagnostics ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 170 ◽  
Author(s):  
Asseel Khalaf ◽  
Caroline L. Hoad ◽  
Elaine Blackshaw ◽  
Jaber Alyami ◽  
Robin C. Spiller ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Test Meal ◽  
Retention Rate ◽  
Stomach Contents ◽  
Individual Variability ◽  
Gamma Scintigraphy ◽  
Clinical Value ◽  
Significant Difference ◽  
Magnetic Resonance Imaging Mri ◽  
The Individual

Measurement of gastric emptying is of clinical value for a range of conditions. Gamma scintigraphy (GS) has an established role, but the use of magnetic resonance imaging (MRI) has recently increased. Previous comparison studies between MRI and GS showed good correlation, but were performed on separate study days. In this study, the modalities were alternated rapidly allowing direct comparison with no intra-individual variability confounds. Twelve healthy participants consumed 400 g of Technetium-99m (99mTc)-labelled soup test meal (204 kcal) and were imaged at intervals for 150 min, alternating between MRI and GS. The time to empty half of the stomach contents (T1/2) and retention rate (RR) were calculated and data correlated. The average T1/2 was similar for MRI (44 ± 6 min) and GS (35 ± 4 min) with a moderate but significant difference between the two modalities (p < 0.004). The individual T1/2 values were measured, and MRI and GS showed a good positive correlation (r = 0.95, p < 0.0001), as well as all the RRs at each time point up to 120 min. Gastric emptying was measured for the first time by MRI and GS on the same day. This may help with translating the use of this simple meal, known to elicit reliable, physiological, and pathological gastrointestinal motor, peptide, and appetite responses.

Gastric emptying as assessed by barium-impregnated polyethylene spheres in healthy dogs consuming a commercial kibble ration

2001 ◽  
Vol 37 (5) ◽  
pp. 444-452 ◽  
Author(s):  
OL Nelson ◽  
AE Jergens ◽  
KG Miles ◽  
WF Christensen
Keyword(s):  
Gastric Emptying ◽  
Test Meal ◽  
Lag Phase ◽  
Significant Difference ◽  
Before And After ◽  
Healthy Dogs ◽  
Lag Phases

Barium-impregnated polyethylene spheres (BIPS) were used to assess gastric emptying in medium-sized dogs consuming a commercial kibble ration. Two sizes of spheres were used: 1.5 mm and 5.0 mm in diameter. Ventrodorsal and right lateral recumbent radiographs were taken immediately before and after consumption of the test meal, and then hourly. The lag phase and the time to 25% (GET25), 50% (GET50), and 75% (GET75) gastric emptying of each sized marker were calculated. There was no significant difference between the lag phases of the small and large BIPS. There was a significant difference between the 1.5 and 5.0 markers at GET25, GET50, and GET75 in these medium-sized dogs. In a majority (70%) of the dogs in this study, GET25 of the 1.5-mm marker occurred at 4.73+/-1.44 hours; GET50 (1.5 mm) occurred at 8.29+/-1.62 hours, and GET75 (1.5 mm) occurred at 10.82+/-1.35 hours. The 5.0-mm markers tended to empty erratically and slowly. Four of the eight dogs retained some of the large markers in their stomachs at the end of the study period (24 hours).

scholarly journals Effect of guar gum on gastric emptying of test meals of varying energy content in growing pigs

1986 ◽  
Vol 55 (1) ◽  
pp. 99-109 ◽  
Author(s):  
Anna L. Rainbird
Keyword(s):  
Gastric Emptying ◽  
Test Meal ◽  
Guar Gum ◽  
Energy Content ◽  
Stomach Contents ◽  
Complete Removal ◽  
High Energy ◽  
Gastric Ph ◽  
Growing Pigs ◽  
Postprandial Blood Glucose

1. Existing information on whether the action of guar gum in decreasing postprandial blood glucose concentrations is due, at least in part, to a reduced rate of gastric emptying is conflicting, possibly because three types of test meals have been used. In order to test whether the type of test meal used influences the action of guar gum, these three types of meal were compared, either without or with guar gum, in growing pigs. The meals were: a high-energy meal (HEM), a low-energy milky drink (LEMD) and a glucose drink (GD).2. Six pigs were prepared with a simple gastric cannula which allowed complete removal of the stomach contents just before or 0.5, 1, 2 or 4 h after feeding.3. The three types of test meal without guar gum gave rise to very different postprandial profiles of gastric pH and of digesta and dry matter (DM) emptying from the stomach.4. Addition of guar gum to the GD significantly raised gastric pH at 0.5 and 1 h after feeding but, when it was added to HEM, gastric pH was only significantly raised 4 h after feeding. No significant effect on gastric pH was seen when guar gum was added to LEMD.5. Although addition of guar gum to GD had no significant effect on the emptying of digesta from the stomach, when added to HEM the rate of emptying of digesta was significantly reduced 1, 2 and 4 h after feeding. Addition of guar gum to LEMD only significantly increased the amount of digesta remaining in the stomach 2 h after feeding.6. There was no significant effect on the emptying of DM from the stomach when guar gum was added to either HEM or LEMD. However, addition of guar gum to GD significantly reduced the mean rate of emptying of DM 0.5 h after feeding.7. Addition of guar gum to either LEMD or GD had no significant effect on the DM concentration of the evacuated gastric digesta. However, addition of guar gum to HEM significantly lowered the DM concentration of the evacuated gastric digesta 1, 2 and 4 h after feeding.8. It was concluded that differences in test meal composition and also in the methods used to measure gastric emptying could account for the discrepancies previously reported. The results suggest that although guar gum may reduce the rate of gastric emptying under some conditions, this is unlikely to be the only mechanism by which it acts.

scholarly journals The Role of Ultrasonography in the Diagnosis of Functional Dyspepsia

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mirjana Cvetković ◽  
Igor Jovanović ◽  
Slobodanka Crevar-Marinović ◽  
Marija Branković ◽  
Olga Mandić ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Functional Dyspepsia ◽  
Test Meal ◽  
Healthy Subjects ◽  
Metabolic Diseases ◽  
Epigastric Pain ◽  
Postprandial Fullness ◽  
Epigastric Pain Syndrome ◽  
Significant Difference ◽  
Antral Area

Abstract Background: Functional dyspepsia (FD) is a syndrome mostly diagnosed by subjective patients’ symptoms after excluding organic, systemic and metabolic diseases. Aim: The goal of this study is to evaluate gastric emptying in patients with functional dyspepsia, by measuring the antral area (cm2) after the intake of a test meal using ultrasonography as an objective and widely applicable method. Material and Methods: This study included 30 patients (mean age of 46.53 ±9.73 years) with symptoms of FD according to the ROMA IV criteria and 30 healthy individuals (mean age of 42.87 ±4.42 years). A 5 MHz ultrasound probe was used to measure the stomach antral area at 6 different time points: in the fasting state, following the meal intake at 5, 30, 60, 90 and 120 min postprandially. Results: The antral area was statistically significantly larger after a 30-minute postprandial period in patients with FD comparing to healthy controls (p<0.05). There was a statistically significant difference in the rate of gastric emptying at 120 minutes in patients with functional dyspepsia, compared to healthy subjects (p <0.01). Patients with postprandial distress syndrome had the average value of gastric emptying 48.25 compared to 56.09 in patients with epigastric pain syndrome (p <0.05). The slowest emptying was observed in patients with nausea and postprandial fullness (p <0.05). Conclusion: Functional dyspepsia is associated with delayed gastric emptying. Using ultrasonography to measure the antral area helps us to assess gastric emptying and therefore to assess patients with functional dyspepsia. The antral area was significantly larger in patients with functional dyspepsia compared to healthy subjects after the test meal, suggesting slower gastric emptying in the dyspeptic patients. Since the diagnosis of functional dyspepsia is based mostly on diverse patients’ symptoms, using ultrasonography to measure the antral area helps us to objectively assess this problem.

scholarly journals Re-analysing the data from Moffatt et al. (2020): A textbook illustration of the absence of evidence fallacy

2020 ◽  
Author(s):  
Ladislas Nalborczyk
Keyword(s):  
Muscular Activity ◽  
Individual Variability ◽  
P Value ◽  
Physiological Measures ◽  
Limited Evidence ◽  
Individual Level ◽  
Final Sample ◽  
Significant Difference ◽  
Self Reports ◽  
The Individual

Moffatt et al. (2020) reported the results of an experiment (N = 26 in the final sample) comparing the facial electromyographic correlates of mental rumination and distraction, following an experimentally induced stressor. Based on the absence of significant difference in the perioral muscular activity between the rumination and distraction conditions, Moffatt et al. (2020) concluded that self-reported inner experience was unrelated to peripheral muscular activity as assessed using surface electromyography. We suggest this conclusion is at best hasty. Indeed, concluding on the absence of an effect based on an under-powered non-significant p-value is strongly uninformative. Moreover, the relation between self-reports and physiological measures was not directly assessed, but only indirectly inferred from differences (or absence thereof) in group averages. Given the ample inter-individual variability in these measures (as suggested by our reanalysis), we think inferring the individual-level relation between self-reports and physiological measures from group averages is inappropriate. Given these limitations, we conclude that there is limited evidence for the main conclusion put forward by Moffatt et al. (2020) and we suggest ways forward, both from a theoretical and from a methodological perspective. Complete source code, reproducible analyses, and figures are available at https://osf.io/ba3gk/.

scholarly journals Relative and absolute test-retest reliabilities of pressure pain threshold in patients with knee osteoarthritis

2018 ◽  
Vol 18 (2) ◽  
pp. 229-236 ◽  
Author(s):  
Neeraja Srimurugan Pratheep ◽  
Pascal Madeleine ◽  
Lars Arendt-Nielsen
Keyword(s):  
Knee Osteoarthritis ◽  
Pain Sensitivity ◽  
Pain Threshold ◽  
Pressure Pain Threshold ◽  
Individual Variability ◽  
Minimal Detectable Change ◽  
Systematic Bias ◽  
Pressure Pain ◽  
Significant Difference ◽  
The Individual

Abstract Background and aims: Pressure pain threshold (PPT) and PPT maps are commonly used to quantify and visualize mechanical pain sensitivity. Although PPT’s have frequently been reported from patients with knee osteoarthritis (KOA), the absolute and relative reliability of PPT assessments remain to be determined. Thus, the purpose of this study was to evaluate the test-retest relative and absolute reliability of PPT in KOA. For that purpose, intra- and interclass correlation coefficient (ICC) as well as the standard error of measurement (SEM) and the minimal detectable change (MDC) values within eight anatomical locations covering the most painful knee of KOA patients was measured. Methods: Twenty KOA patients participated in two sessions with a period of 2 weeks±3 days apart. PPT’s were assessed over eight anatomical locations covering the knee and two remote locations over tibialis anterior and brachioradialis. The patients rated their maximum pain intensity during the past 24 h and prior to the recordings on a visual analog scale (VAS), and completed The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and PainDetect surveys. The ICC, SEM and MDC between the sessions were assessed. The ICC for the individual variability was expressed with coefficient of variance (CV). Bland-Altman plots were used to assess potential bias in the dataset. Results: The ICC ranged from 0.85 to 0.96 for all the anatomical locations which is considered “almost perfect”. CV was lowest in session 1 and ranged from 44.2 to 57.6%. SEM for comparison ranged between 34 and 71 kPa and MDC ranged between 93 and 197 kPa with a mean PPT ranged from 273.5 to 367.7 kPa in session 1 and 268.1–331.3 kPa in session 2. The analysis of Bland-Altman plot showed no systematic bias. PPT maps showed that the patients had lower thresholds in session 2, but no significant difference was observed for the comparison between the sessions for PPT or VAS. No correlations were seen between PainDetect and PPT and PainDetect and WOMAC. Conclusions: Almost perfect relative and absolute reliabilities were found for the assessment of PPT’s for KOA patients. Implications: The present investigation implicates that PPT’s is reliable for assessing pain sensitivity and sensitization in KOA patients.

Writing in Aphasia Rehabilitation: Cursive vs Manuscript

1976 ◽  
Vol 41 (4) ◽  
pp. 523-529 ◽  
Author(s):  
Daniel R. Boone ◽  
Harold M. Friedman
Keyword(s):  
Correct Response ◽  
The Other ◽  
Read Aloud ◽  
Writing Style ◽  
Reading And Writing ◽  
Manual Responses ◽  
Significant Difference ◽  
Written Form ◽  
The Individual ◽  
Read Number

Reading and writing performance was observed in 30 adult aphasic patients to determine whether there was a significant difference when stimuli and manual responses were varied in the written form: cursive versus manuscript. Patients were asked to read aloud 10 words written cursively and 10 words written in manuscript form. They were then asked to write on dictation 10 word responses using cursive writing and 10 words using manuscript writing. Number of words correctly read, number of words correctly written, and number of letters correctly written in the proper sequence were tallied for both cursive and manuscript writing tasks for each patient. Results indicated no significant difference in correct response between cursive and manuscript writing style for these aphasic patients as a group; however, it was noted that individual patients varied widely in their success using one writing form over the other. It appeared that since neither writing form showed better facilitation of performance, the writing style used should be determined according to the individual patient’s own preference and best performance.

Aftermath Effect Of GST On Consumer Purchasing Power

2019 ◽  
Vol 118 (5) ◽  
pp. 122-131
Author(s):  
S. Thowseaf ◽  
M. Ayisha Millath ◽  
K. Malik Ali
Keyword(s):  
Living Standard ◽  
Purchasing Power ◽  
Percentage Increase ◽  
Defense System ◽  
Key Factors ◽  
Predominant Role ◽  
Tax System ◽  
Significant Difference ◽  
The Individual ◽  
Taxation System

Tax is an important source of income for the country. It is through tax; country strengthens its defense system, infrastructure, and government. Hence, tax system plays a predominant role in developing country’s economy. The complication in taxation system and liberty for taxpayers are key factors generating loopholes for corruption. GST is superior taxation system over VAT but, if neither properly implemented nor scrutinized according to the economy, it is people residing get affected.  GST taxation system is capable of increasing legal transaction, reducing corruption and complexity that exists in current taxation. India is 166th country to adopt GST and GST taxation slab in India is 0%, 5%, 12%, 18% and 28%.  Although average Tax levied is 14.8750% in India, it is 28% tax that is levied for most of the commodities, which are directly or indirectly used in everyday life of common individuals. Despite, GST being favorable to distributor in-terms of profit and government to attain tax by increasing legal transaction through invoice. It is noted that for the same percentage of taxation, the amount does not vary for VAT and GST. The tax slab decreased for 71 commodities and no change in 21 commodities; there has been an increase in tax slab for 60 commodities. 26% taxation was levied for most commodities considered was currently levied by 28% taxation which is greater than before. It was found that average tax percentage reduced was calculated to be 6.07143. The average tax percentage increase was calculated to be 4.7833 percentage for the considered commodities. The overall tax average tax percentage is estimated to be 14.8750% which does not have a significant difference concerning tax levied before GST, which was calculated to be 15.7829% for considered commodities. Therefore, the consumer purchasing power and overall living standard of the individual in India will remain almost same.

THE STUDY OF THE INDIVIDUAL VARIABILITY OF THE LINEAR DIMENSIONS OF THE SPHENOID SINUS

2019 ◽  
Vol 21 (1) ◽  
pp. 64-70
Author(s):  
O.V. Mareev ◽  
◽  
G.O. Mareev ◽  
M.E. Gutynina ◽  
D.A. Maksimova ◽  
...  
Keyword(s):  
Sphenoid Sinus ◽  
Individual Variability ◽  
Linear Dimensions ◽  
The Individual

scholarly journals A comparison between Asians and Caucasians in the dimensions of the femoral isthmus based on a 3D-CT analysis of 1189 adult femurs

2021 ◽  
Author(s):  
Darius M. Thiesen ◽  
Dimitris Ntalos ◽  
Alexander Korthaus ◽  
Andreas Petersik ◽  
Karl-Heinz Frosch ◽  
...  
Keyword(s):  
Proximal Femur ◽  
Strong Predictor ◽  
Matched Pair ◽  
3D Ct ◽  
Femur Fractures ◽  
Matched Pair Analysis ◽  
Significant Difference ◽  
Ct Analysis ◽  
Ct Data ◽  
The Individual

Abstract Introduction For successful intramedullary implant placement at the femur, such as nailing in unstable proximal femur fractures, the use of an implant that at least reaches or exceeds the femoral isthmus and yields sufficient thickness is recommended. A number of complications after intramedullary femoral nailing have been reported, particularly in Asians. To understand the anatomical features of the proximal femur and their ethnic differences, we aimed to accurately calculate the femoral isthmus dimensions and proximal distance of Asians and Caucasians. Methods In total, 1189 Asian and Caucasian segmented 3D CT data sets of femurs were analyzed. The individual femoral isthmus diameter was precisely computed to investigate whether gender, femur length, age, ethnicity or body mass index have an influence on isthmus diameters. Results The mean isthmus diameter of all femurs was 10.71 ± 2.2 mm. A significantly larger diameter was found in Asians when compared to Caucasians (p < 0.001). Age was a strong predictor of the isthmus diameter variability in females (p < 0.001, adjusted r2 = 0.299). With every year of life, the isthmus showed a widening of 0.08 mm in women. A Matched Pair Analysis of 150 female femurs showed a significant difference between isthmus diameter in Asian and Caucasian femurs (p = 0.05). In 50% of the cases the isthmus was found in a range of 2.4 cm between 16.9 and 19.3 cm distal to the tip of the greater trochanter. The female Asian femur differs from Caucasians as it is wider at the isthmus. Conclusions In absolute values, the proximal isthmus distance did not show much variation but is more proximal in Asians. The detailed data presented may be helpful in the development of future implant designs. The length and thickness of future standard implants may be considered based on the findings.

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