Effect of Adult Weight Gain on Non-Alcoholic Fatty Liver Disease and Its Association with Anthropometric Parameters in the Lean Japanese Population

Limited data are available on the prevalence of non-alcoholic fatty liver disease (NAFLD) and its association with adult weight gain (AWG) in the lean population. This study aimed to determine the prevalence of NAFLD and to investigate whether AWG is associated with NAFLD in the lean Japanese population. We retrospectively analyzed patients who underwent abdominal ultrasonography as part of the annual health checkup between January 2019 and December 2019. Participants were classified into two groups: those with AWG ≥ 10 kg (AWG group, n = 497), and those without gain (non-AWG group, n = 3006). To adjust for the confounding effects, we generated 482 pairs using 1:1 propensity score matching. The associations between AWG and NAFLD, anthropometric parameters and NAFLD were investigated using univariate logistic regression analysis. We identified NAFLD in 197 (5.6%) participants. AWG was significantly associated with NAFLD (odds ratio (OR), 1.81; p = 0.003). Waist circumference was significantly associated with NAFLD in both the AWG (OR, 1.24; p < 0.001) and non-AWG groups (OR, 1.17; p < 0.001). The association between body mass index and NAFLD existed in the former group (OR, 1.76; p < 0.001), but was not significant in the latter group. AWG is a risk factor for NAFLD even in the lean Japanese population, and associations between anthropometric parameters and NAFLD become stronger if AWG coexists.

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Probiotics and Prebiotics as a Strategy for Non-Alcoholic Fatty Liver Disease, a Narrative Review

Foods ◽

10.3390/foods10081719 ◽

2021 ◽

Vol 10 (8) ◽

pp. 1719

Author(s):

Valentina Castillo ◽

Fernanda Figueroa ◽

Karoll González-Pizarro ◽

Paz Jopia ◽

Claudia Ibacache-Quiroga

Keyword(s):

Liver Disease ◽

Gut Microbiota ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Communicable Disease ◽

Anthropometric Parameters ◽

Alcoholic Fatty Liver ◽

Risks Factors ◽

Alcoholic Fatty Liver Disease ◽

Non Communicable Disease

Non-alcoholic fatty liver disease (NAFLD) is a chronic non-communicable disease, with a prevalence of 25% worldwide. This pathology is a multifactorial illness, and is associated with different risks factors, including hypertension, hyperglycemia, dyslipidemia, and obesity. Beside these predisposing features, NAFLD has been related to changes in the microbiota, which favor the disease progression. In this context, the modulation of the gut microbiota has emerged as a new therapeutic target for the prophylaxis and treatment of NAFLD. This review describes the changes in the gut microbiota associated with NAFLD and the effect of probiotics, prebiotics, and synbiotics on the gut microbiota, liver damage, anthropometric parameters, blood lipids, inflammation markers and insulin resistance in these patients.

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Clinical characteristics and longitudinal changes of patients with non-alcoholic fatty liver disease in 2 decades: the NAGALA study

BMC Gastroenterology ◽

10.1186/s12876-021-01809-2 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Takuro Okamura ◽

Yoshitaka Hashimoto ◽

Masahide Hamaguchi ◽

Akihiro Obora ◽

Takao Kojima ◽

...

Keyword(s):

Body Mass Index ◽

Liver Disease ◽

Fatty Liver ◽

Body Mass ◽

Fatty Liver Disease ◽

Abdominal Ultrasonography ◽

Alcoholic Fatty Liver ◽

The Past ◽

Significant Difference ◽

Alcoholic Fatty Liver Disease

Abstract Background In this study, to clarify the evolving background of people with non-alcoholic fatty liver disease (NAFLD), we compared the current prevalence of NAFLD with that of 2 decades ago. Methods We included two cohorts. The past cohort was from 1994 to 1997 and included 4279 men and 2502 women. The current cohort was from 2014 to 2017 and included 8918 men and 7361 women. NAFLD was diagnosed by abdominal ultrasonography. Results The prevalence of NAFLD increased in both genders throughout these 2 decades (18.5% in the past cohort and 27.1% in the current cohort for men; and 8.0% in the past cohort and 9.4% in the current cohort for women). The prevalence of hyperglycemia increased, whereas the prevalence of low high-density lipoprotein cholesterol levels and hypertriglyceridemia significantly decreased. There was no significant difference in the mean body mass index. Multivariate analysis revealed that the prevalence of obesity and body mass index were significantly associated with the prevalence of NAFLD in both the past and current cohorts. Conclusions The incidence of NAFLD significantly increased throughout these 2 decades, and obesity is the most prevalent factor. Thus, body weight management is an essential treatment option for NAFLD.

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Correlations between serum FGF21 and IRISIN levels and nutritional, biochemical, and anthropometric parameters in non-alcoholic fatty liver disease

Clinical Nutrition ◽

10.1016/j.clnu.2018.06.1757 ◽

2018 ◽

Vol 37 ◽

pp. S211

Author(s):

M. İlhan ◽

E. Kahramanoğlu Aksoy ◽

Z. Goktas

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Anthropometric Parameters ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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Coenzyme Q10 Attenuates High-fat Diet-induced Non-alcoholic Fatty Liver Disease Through Activation of AMPK Pathway (P06-060-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz031.p06-060-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Chen Ke ◽

Ling Wenhua

Keyword(s):

Liver Disease ◽

Weight Gain ◽

Fatty Liver ◽

High Fat Diet ◽

Fatty Liver Disease ◽

Control Group ◽

High Fat ◽

Alcoholic Fatty Liver ◽

Ampk Pathway ◽

Alcoholic Fatty Liver Disease

Abstract Objectives To explore whether CoQ10 has an effect on NAFLD and the potential mechanism. Methods 2.1 Animal studies Thirty male C57BL/6 J mice (four weeks) were randomly distributed into three groups (n = 10): control group (10% Kcal from fat), the high-fat group (60% Kcal from fat), the CoQ10 group (CoQ10 1800 mg/kg, 60% Kcal from fat). The intervention time is 24 weeks. 2.2 Biochemical indicator Serum and liver biochemical markers were detected with appropriate test kits. 2.3 Histopathological evaluation H&E staining, immunohistochemistry and immunofluorescence were used to valuate the degree of NAFLD. Results 3.1 CoQ10 ameliorates high-fat diet-induced weight gain and dyslipidaemia. CoQ10 decreased the weight gain (Fig. 1A). In addition, CoQ10 reduced the high-fat diet-induced subcutaneous and visceral fat. Serum levels of TC and TG decreased in mice fed HFD with supplementation of CoQ10 (Fig. 1C). The level of HDL-c showed an unremarkable increase in mice supplemented with CoQ10, while LDL-c in this group decreased (Fig. 1D). 3.2 CoQ10 inhibited NAFLD induced by high-fat diet. The lipid droplet was reduced in the mice fed CoQ10(Fig. 2A). Analysis of Sirius Red staining showed that hepatic fibrosis was ameliorated in the mice fed CoQ10(Fig. 2B). Staining of macrophage marker, F4/80, and the leukocyte marker, CD45 showed that CoQ10 can alleviate inflammation(Fig.2C, D). CoQ10 also induce the injury of liver(Fig. 2E). 3.3 CoQ10 regulates liver lipid metabolism. CoQ10 reversed the increase of ACC and FAS and reversed the decrease of PPAR-α and CPT-1 both in mRNA and protein expression. CoQ10 could activate AMPK. Conclusions Co Q10 may attenuates high-fat diet-induced non-alcoholic fatty liver disease through activation of AMPK pathway. Funding Sources The key Project of National Natural Science Fund (grant number: 81730090). Supporting Tables, Images and/or Graphs

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Prevalence of and risk factors for non-alcoholic fatty liver disease in a non-obese Japanese population, 2011–2012

Journal of Gastroenterology ◽

10.1007/s00535-014-0948-9 ◽

2014 ◽

Vol 50 (1) ◽

pp. 95-108 ◽

Cited By ~ 69

Author(s):

Kenichi Nishioji ◽

Yoshio Sumida ◽

Mai Kamaguchi ◽

Naomi Mochizuki ◽

Masao Kobayashi ◽

...

Keyword(s):

Risk Factors ◽

Liver Disease ◽

Fatty Liver ◽

Japanese Population ◽

Fatty Liver Disease ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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Higher flavonoid intake is associated with a lower progression risk of non-alcoholic fatty liver disease in adults: a prospective study

British Journal Of Nutrition ◽

10.1017/s0007114520002846 ◽

2020 ◽

pp. 1-11

Author(s):

Qing-wei Zhong ◽

Yan-yan Wu ◽

Feng Xiong ◽

Meng Liu ◽

Yu-ping Liu ◽

...

Keyword(s):

Liver Disease ◽

Prospective Study ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Health Study ◽

Model Assessment ◽

Abdominal Ultrasonography ◽

Alcoholic Fatty Liver ◽

Flavonoid Intake ◽

Alcoholic Fatty Liver Disease

Abstract Flavonoid-rich foods have shown a beneficial effect against non-alcoholic fatty liver disease (NAFLD) in short-term randomised trials. It is uncertain whether the usual dietary intake of flavonoids may benefit patients with NAFLD. The present study evaluated the association between the usual intake of flavonoids and the risk of progression in NAFLD. The prospective study included 2694 adults from the Guangzhou Nutrition and Health Study. Face-to-face interviews using a seventy-nine-item FFQ were administered to assess habitual dietary flavonoid intake, while abdominal ultrasonography was conducted to evaluate the presence and degree of NAFLD, with measurements conducted 3 years apart. After adjustment for potential confounders, higher flavonoid intakes were gradely associated with reduced risks of worsen NAFLD status. The relative risks of worsening (v. non-worsening) NAFLD in the highest (v. lowest) quintile were 0·71 (95 % CI 0·54, 0·93) for total flavonoids, 0·74 (95 % CI 0·57, 0·95) for flavanones, 0·74 (95 % CI 0·56, 0·96) for flavan-3-ols, 0·90 (95 % CI 0·68, 1·18) for flavonols, 0·73 (95 % CI 0·56, 0·93) for flavones, 0·79 (95 % CI 0·61, 1·02) for isoflavones and 0·74 (95 % CI 0·57, 0·96) for anthocyanins. An L-shaped relationship was observed between total flavonoid intake and the risk of NAFLD progression. Path analyses showed that the association between flavonoids and NAFLD progression was mediated by decreases in serum cholesterol and homeostasis model assessment of insulin resistance. This prospective study showed that higher flavonoid intake was associated with a lower risk of NAFLD progression in the elderly overweight/obese Chinese population.

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The Impact of PNPLA3 rs738409 Genetic Polymorphism and Weight Gain ≥10 kg after Age 20 on Non-Alcoholic Fatty Liver Disease in Non-Obese Japanese Individuals

PLoS ONE ◽

10.1371/journal.pone.0140427 ◽

2015 ◽

Vol 10 (10) ◽

pp. e0140427 ◽

Cited By ~ 26

Author(s):

Kenichi Nishioji ◽

Naomi Mochizuki ◽

Masao Kobayashi ◽

Mai Kamaguchi ◽

Yoshio Sumida ◽

...

Keyword(s):

Liver Disease ◽

Weight Gain ◽

Genetic Polymorphism ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Alcoholic Fatty Liver ◽

The Impact ◽

Alcoholic Fatty Liver Disease

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SARCOPENIA AND SEVERITY OF NON-ALCOHOLIC FATTY LIVER DISEASE

Arquivos de Gastroenterologia ◽

10.1590/s0004-2803.201900000-66 ◽

2019 ◽

Vol 56 (4) ◽

pp. 357-360 ◽

Cited By ~ 1

Author(s):

Josilda Ferreira CRUZ ◽

Yasmim Anayr Costa FERRARI ◽

Carla Perez MACHADO ◽

Nathalia Nascimento SANTANA ◽

Allan Victor Hora MOTA ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Hepatic Steatosis ◽

Lower Limb ◽

Fatty Liver Disease ◽

Lower Limbs ◽

Abdominal Ultrasonography ◽

Alcoholic Fatty Liver ◽

Post Test ◽

Alcoholic Fatty Liver Disease

ABSTRACT BACKGROUND: Non-alcoholic fatty liver disease is characterized by deposition of lipids in the hepatic parenchyma exceeding 5% of liver weight in the absence of other conditions, such as viral or alcoholic hepatitis and metabolic disease. Non-alcoholic fatty liver disease is the most common form of chronic liver disease in several countries. In addition to liver complications, recent studies have shown a relation between liver fat and sarcopenia. OBJECTIVE: Determine the association between sarcopenia and the severity of non-alcoholic hepatic steatosis diagnosed by abdominal ultrasonography. METHODS: A clinical, cross-sectional study was conducted with a sample of male and female adults (18 to 70 years of age) submitted to ultrasonography for the investigation of non-alcoholic hepatic steatosis. Evaluations were also performed for the determination of upper and lower limb muscle strength. Data analysis was performed with the aid of the SPSS 22.0 program and involved ANCOVA and the Bonferroni post hoc test, with P-value <0.05 considered indicative of statistical significance. RESULTS: One hundred two patients were submitted to abdominal ultrasonography, 57.8% of whom presented some degree of non-alcoholic hepatic steatosis. The presence and degree of fatty liver infiltration were significantly associated with the sarcopenic index, determined by the ratio between upper and lower limb strength and BMI (P=0.009 and post-test P=0.028 for upper limbs; P=0.006 and post-test P=0.013 for lower limbs). CONCLUSION: In the present study, an association was found between the sarcopenic index and non-alcoholic hepatic steatosis, with an inversely proportional relation between this index and the severity of fatty infiltration. This finding offers further evidence of the metabolic interaction of the liver, adipose tissue and muscle.

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