Effects of Moxonidine Administration on Serum Neuropeptide Y Levels in Hypertensive Individuals: A Prospective Observational Study

Moxonidine is a centrally acting, anti-hypertensive medication that exerts additional metabolic properties. It is unknown whether its effects are mediated by neurotransmitters or sympathetic tone regulators, including Neuropeptide Y (NPY). In this study, we evaluated the effects of moxonidine administration on serum NPY in humans. Methods: Ninety individuals with mild or moderate arterial hypertension that required monotherapy were categorized in three age and gender-matched groups according to their Body Mass Index (BMI) as normal weight (n = 30), overweight (n = 30), and obese (n = 30). Moxonidine was administered in therapeutic doses of up to 0.6 mg daily for 12 weeks, and clinical, biochemical and hormonal parameters were recorded. Results: In all three groups, a decrease in systolic and diastolic blood pressure and heart rate was shown. After treatment, BMI, 24 h urine catecholamines and catecholamines’ metabolites, and serum total cholesterol were also reduced. Most importantly, we found a decrease in serum NPY levels in all study groups, with the largest mean decrease in the group of obese and overweight participants compared to normal weight. Conclusions: Moxonidine administration results in improvement in cardio-metabolic parameters, as well as a decrease in serum NPY levels, which therefore represents it being a potent agent against obesity-associated hypertension. Its involvement in energy balance regulation warrants further investigation.

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The Association of Body Mass Index and Waist Circumference with Blood Pressure Depends on Age and Gender: A Study of 10,928 Non-Smoking Adults in the Greek EPIC Cohort

European Journal of Epidemiology ◽

10.1023/b:ejep.0000036582.38987.ca ◽

2003 ◽

Vol 19 (8) ◽

pp. 803-809 ◽

Cited By ~ 23

Author(s):

Vassiliki Benetou ◽

Christina Bamia ◽

Dimitrios Trichopoulos ◽

Theodoros Mountokalakis ◽

Theodora Psaltopoulou ◽

...

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Waist Circumference ◽

Body Mass ◽

Age And Gender ◽

Greek Epic ◽

And Gender

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Maternal body mass index and oxytocin in augmentation of labour in nulliparous women: a prospective observational study

BMJ Open ◽

10.1136/bmjopen-2020-044754 ◽

2021 ◽

Vol 11 (3) ◽

pp. e044754

Author(s):

Anna Ramö Isgren ◽

Preben Kjölhede ◽

Sara Carlhäll ◽

Marie Blomberg

Keyword(s):

Body Mass Index ◽

Observational Study ◽

Body Mass ◽

Infusion Rate ◽

Maximum Rate ◽

Prospective Observational Study ◽

Normal Weight ◽

Nulliparous Women ◽

Oxytocin Infusion ◽

Labour Ward

ObjectiveTo evaluate oxytocin use for augmentation of labour in relation to body mass index (BMI) on admission to the labour ward, focusing on cumulative oxytocin dose and maximum rate of oxytocin infusion during the first stage of labour.DesignProspective observational study.SettingSeven hospitals in Sweden.Participants1097 nulliparous women with singleton cephalic presentation pregnancy, ≥37 weeks of gestation, spontaneous onset of labour and treatment with oxytocin infusion for labour augmentation. The study population was classified into three BMI subgroups on admission to the labour ward: normal weight (18.5–24.9), overweight (25.0–29.9) and obese (≥30.0). The cumulative oxytocin dose was measured from the start of oxytocin infusion until the neonate was born.Primary outcomeCumulative oxytocin dose.Secondary outcomeMaximum rate of oxytocin infusion during the active phase of first stage of labour.ResultsThe mean cumulative oxytocin dose increased in the BMI groups (normal weight 2278 mU, overweight 3108 mU and obese 4082 mU (p<0.0001)). However, when adjusted for the confounders (cervical dilatation when oxytocin infusion was started, fetal birth weight, epidural analgesia), the significant difference was no longer seen. The maximum oxytocin infusion rate during the first stage of labour differed significantly in the BMI groups when adjusted for the confounding factors individually but not when adjusted for all three factors simultaneously. In addition, the maximum oxytocin infusion rate was significantly higher in women with emergency caesarean section compared with women with vaginal delivery.ConclusionsWomen with increasing BMI with augmentation of labour received a higher cumulative oxytocin dose and had a higher maximum oxytocin infusion rate during first stage of labour, however, when adjusted for relevant confounders, the difference was no longer seen. In the future, the guidelines for augmentation of labour with oxytocin infusion might be reconsidered and include modifications related to BMI.

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Heritability of the metabolic syndrome and its components in the Tehran Lipid and Glucose Study (TLGS)

Genetics Research ◽

10.1017/s001667231200050x ◽

2012 ◽

Vol 94 (6) ◽

pp. 331-337 ◽

Cited By ~ 30

Author(s):

MARYAM ZARKESH ◽

MARYAM SADAT DANESHPOUR ◽

BITA FAAM ◽

MOHAMMAD SADEGH FALLAH ◽

NIMA HOSSEINZADEH ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Hdl Cholesterol ◽

Age And Gender ◽

The Metabolic Syndrome ◽

Biological Parents ◽

Heritability Estimation ◽

Low Hdl ◽

And Gender ◽

Continuous Traits

SummaryGrowing evidence suggests that metabolic syndrome (MetS) has both genetic and environmental bases. We estimated the heritability of the MetS and its components in the families from the Tehran Lipid and Glucose Study (TLGS). We investigated 904 nuclear families in TLGS with two biological parents and at least one offspring (1565 parents and 2448 children), aged 3–90 years, for whom MetS information was available and had at least two members of family with MetS. Variance component methods were used to estimate age and sex adjusted heritability of metabolic syndrome score (MSS) and MetS components using SOLAR software. The heritability of waist circumference (WC), HDL-cholesterol (HDL-C), triglycerides (TGs), fasting blood sugar (FBS), systolic blood pressure (SBP) and diastolic blood pressure (DBP) as continuous traits after adjusting for age and gender were 27, 46, 36, 29, 25, 26 and 15%, respectively, and MSS had a heritability of 15%. When MetS components were analysed as discrete traits, the estimates of age and gender adjusted heritability for MetS, abdominal obesity, low HDL-C, high TG, high FBS and high blood pressure (BP) were 22, 40, 34, 38 and 23%, respectively (P < 0·05). Three factors were extracted from the six continuous traits of the MetS including factor I (BP), factor II (lipids) and factor III (obesity and FBS). Heritability estimation for these three factors were 7, 13 (P < 0·05) and 2%, respectively. The highest heritability was for HDL-C and TG. The results strongly encourage efforts to identify the underlying susceptibility genes.

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Serum Cathepsin S Is Associated with Serum C-Reactive Protein and Interleukin-6 Independently of Obesity in Elderly Men

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2010-0328 ◽

2010 ◽

Vol 95 (9) ◽

pp. 4460-4464 ◽

Cited By ~ 18

Author(s):

E. Jobs ◽

U. Risérus ◽

E. Ingelsson ◽

J. Helmersson ◽

E. Nerpin ◽

...

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Confidence Interval ◽

Regression Coefficient ◽

Normal Weight ◽

Cathepsin S ◽

C Reactive Protein ◽

Elderly Men ◽

Community Based ◽

Reactive Protein

Objective: Cathepsin S has been suggested provide a mechanistic link between obesity and atherosclerosis, possibly mediated via adipose tissue-derived inflammation. Previous data have shown an association between circulating cathepsin S and inflammatory markers in the obese, but to date, community-based reports are lacking. Accordingly, we aimed to investigate the association between serum levels of cathepsin S and markers of cytokine-mediated inflammation in a community-based sample, with prespecified subgroup analyses in nonobese participants. Methods: Serum cathepsin S, C-reactive protein (CRP), and IL-6 were measured in a community-based cohort of elderly men (Uppsala Longitudinal Study of Adult Men; mean age 71 years, n = 991). CRP and IL-6 were also measured at a reexamination after 7 yr. Results: After adjustment for age, body mass index, fasting plasma glucose, diabetes treatment, systolic blood pressure, diastolic blood pressure, hypertension treatment, serum cholesterol, serum high-density lipoprotein cholesterol, prior cardiovascular disease, smoking, and leisure time physical activity, higher cathepsin S was associated with higher CRP (regression coefficient for 1 sd increase, 0.13; 95% confidence interval 0.07–0.19; P < 0.001) and higher serum IL-6 (regression coefficient for 1 sd increase, 0.08; 95% confidence interval 0.01–0.14; P = 0.02). These associations remained similar in normal-weight participants (body mass index <25 kg/m2, n = 375). In longitudinal analyses, higher cathepsin S at baseline was associated with higher serum CRP and IL-6 after 7 yr. Conclusions: These results provide additional evidence for the interplay between cathepsin S and inflammatory activity and suggest that this association is present also in normal-weight individuals in the community.

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Body Mass Index and Helicobacter pylori among Obese and Non-Obese Patients in Najran, Saudi Arabia: A Case-Control Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph15112586 ◽

2018 ◽

Vol 15 (11) ◽

pp. 2586 ◽

Cited By ~ 1

Author(s):

Ali Al-Zubaidi ◽

Abdo Alzobydi ◽

Saeed Alsareii ◽

AbdulazizTurky Al-Shahrani ◽

Naweed Alzaman ◽

...

Keyword(s):

Body Mass Index ◽

Helicobacter Pylori ◽

Saudi Arabia ◽

Body Mass ◽

Upper Endoscopy ◽

Obese Patients ◽

Age And Gender ◽

Total Prevalence ◽

And Gender ◽

Saudi Patients

Objective: We examine obese and non-obese patients with respect to Helicobacter pylori (H. pylori) positive-infection (HPPI) and associated factors, specifically body mass index (BMI). Methods: This study took place in the Department of Endoscopy of a central hospital in the Najran region of Saudi Arabia (SA). A total of 340 obese Saudi patients (BMI ≥ 30 kg/m2) who had undergone diagnostic upper endoscopy before sleeve gastrectomy, were compared with 340 age and gender-matched control patients (BMI < 30 kg/m2) who had undergone diagnostic upper endoscopy for other reasons. Data collected included diagnosis of HPPI. Descriptive and multivariable binary logistic regression was conducted. Results: Mean patient age was 31.22 ± 8.10 years, and 65% were males. The total prevalence of HPPI was 58% (95% CI = 54–61%) with obese patients presenting significantly more HPPI than non-obese patients (66% vs. 50%, OR = 1.98, 95% CI = 1.45–2.70, p < 0.0005). Age and gender did not associate significantly with HPPI (p = 0.659, 0.200, respectively) and increases in BMI associated significantly with increases in HPPI (p < 0.0005). BMI remained a significant factor in HPPI when modelled with both age and gender (OR = 1.022, 95% CI = 1.01–1.03, p < 0.0005). Conclusions: Within the limitations of this study, the significance of HPPI in obese Saudi patients residing in the Najran region in SA was demonstrated alongside the significance role of BMI in HPPI.

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Making the Objectives of Individuals Sports Body Mass Index, by Age and Gender Analysis

International journal of Science Culture and Sport ◽

10.14486/ijscs197 ◽

2014 ◽

Vol 2 (6) ◽

pp. 255-255

Author(s):

İbrahim Kubilay TÜRKAY

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Gender Analysis ◽

Age And Gender ◽

And Gender

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Percentile Charts for Body Mass Index of Indian Down Syndrome Children

Journal of Pediatric Genetics ◽

10.1055/s-0041-1724115 ◽

2021 ◽

Author(s):

Harvinder Kaur ◽

Anil Kumar Bhalla ◽

Inusha Panigrahi

Keyword(s):

Body Mass Index ◽

Down Syndrome ◽

Body Mass ◽

Overweight And Obesity ◽

World Health ◽

Growth Charts ◽

Indian Children ◽

Age And Gender ◽

And Gender ◽

Gender Specific

AbstractGrowth charts are used to detect growth impairment, overweight, and obesity among Down syndrome (DS) children belonging to different population groups. Due to nonavailability of similar information, age, and gender specific body mass index (BMI) charts for DS children of Indian origin, based on serial data, have been developed. A total of 752 boys and 373 girls diagnosed as cases of DS at <1 month to 10 years of age enrolled from the “genetic clinic” were followed up in the “growth clinic/growth laboratory” of the institute, following a mixed-longitudinal growth research design. BMI was calculated from body weight and length/height measured at 6-month-age intervals by using standardized techniques and instruments. Age and sex-specific percentile growth charts for BMI were generated for age range <1 month to 10 years by using the LMS method. DS children remained wasted (BMI <3rd percentile) up to 6 months of age; thereafter, BMI increased to exhibit close similarity with their normal Multicentre Growth Reference Study (World Health Organization 2006) and Indian Academy of Pediatrics (2015) counterparts up to 5 to 10 years, respectively. The percentage of obese DS girls (8.76%) outnumbered boys with DS (4.1%). The use of age and gender specific BMI growth charts may be made for comparative purpose, to assess nutritional status of Indian children with DS, to initiate suitable need-based intervention to improve their overall health and for timely institution of target interventions to prevent growth faltering in this vulnerable population.

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Changes regarding Age and Correlations between Serum Lipids and Body Mass Index in Humankind

Methods of Information in Medicine ◽

10.1055/s-0038-1634435 ◽

2002 ◽

Vol 41 (03) ◽

pp. 202-208 ◽

Cited By ~ 2

Author(s):

I. Yamasawa ◽

S. Kamohara ◽

M. Shiota ◽

T. Komori ◽

Y. Watanabe ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Serum Lipids ◽

Density Lipoprotein ◽

Atherogenic Index ◽

Health Examination ◽

Age And Gender ◽

Gender And Age ◽

Specialized Care ◽

And Gender

Summary Objectives: To improve insight into age and gender related distributions of serum lipids and their correlation with body mass index (BMI). Methods: Serum lipids embracing atherogenic index (AI) and BMI were analyzed from the results obtained in 19,823 men and 14,788 women undergoing a health examination between 1986 and 1996. Results: The changes in total cholesterol (TC), triglyceride (TG), AI and BMI differed regarding gender. Although high-density lipoprotein-cholesterol (HDL-C) showed a flat pattern for all ages in both genders, its level in women was higher than in men. The ratio of the number in the unsuitable range to those in the suitable range increased with age as to TC in both sexes, then more than half of the population have an unsuitable level in the sixth decade. As for the correlation between serum lipids and BMI: TC, TG and AI correlated positively, but HDL-C correlated negatively. There were significant gaps between both age and gender. Conclusions: We suggest that the normal range of values of serum lipids needs to be revised according to gender and age to evaluate the risk status for a cardio-cerebrovascular disease more precisely in the field of preventive medicine. Simpler guidelines are preferable in specialized care as well as in general practice, particularly since computer technology is not yet universally adapted. In the near future, when computed information technology will be as common as the electricity and the telephone are current on the whole earth, all guidelines will have to be computed on the spot and personally.

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