Use of Oleogels to Replace Margarine in Steamed and Baked Buns

Bakery products are usually formulated with solid fats, like margarines and shortenings, which contain high levels of saturated and trans-fatty acids and have negative effects on human health. In this study, hydroxypropyl methylcellulose (HPMC) and xanthan gum (XG) were used as oleogelators to prepare oleogels, using sunflower and olive oil, as substitutes for margarine in baked or steamed buns. The effect of oleogels on the physical properties of the buns was evaluated by analyzing the crumb structure, specific volume, height, and texture. In addition, a triangular discriminatory sensory test was conducted, and lipid digestibility was assessed through in vitro digestion studies. Replacement of margarine with oleogels produced steamed buns with no differences in the crumb structure, volume, height, and texture; however, in baked buns, a less porous and harder structure was produced. No differences in texture were observed between the margarine buns and buns made with oleogels when the triangular test was conducted. The extent of lipolysis was not affected when margarine was replaced by oleogels in the baked and steamed buns. The results suggest that using oleogels instead of margarine in buns could represent an interesting strategy to prepare healthier bakery products.

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DESIGN AND EVALUATION OF INTRAGASTRIC BUOYANT TABLETS OF VENLAFAXINE HYDROCHLORIDE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i5.16948 ◽

2017 ◽

Vol 10 (5) ◽

pp. 166

Author(s):

Parasuram Rajam Radhika ◽

Nishala N ◽

Kiruthika M ◽

Sree Iswarya S

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Xanthan Gum ◽

Hydroxypropyl Methylcellulose ◽

Methyl Cellulose ◽

In Vitro Drug Release ◽

Weight Variation ◽

Floating Drug Delivery ◽

Venlafaxine Hydrochloride

Objective: The present study was undertaken to prolong the release of orally administered drug. The aim is to formulate, develop, and evaluate theintragastric buoyant tablets of venlafaxine hydrochloride, which releases the drug in a sustained manner over a period of 12 hrs. Different formulationswere formulated using the polymers Carbopol 934 P, xanthan gum, hydroxypropyl methylcellulose (HPMC K100M) with varying concentration ofdrug: Polymer ratio of 1:1, 1:1.5, 1:2, in which sodium bicarbonate acts as gas generating agent, and microcrystalline cellulose as a diluent.Methods: The tablets were prepared by direct compression and evaluated for tablet thickness, weight variation, tablet hardness, friability, in vitrobuoyancy test, in vitro drug release and Fourier transform infrared spectroscopy. Formulations were evaluated by floating time, floating lag time and in vitro drug release. Dissolution profiles were subjected for various kinetic treatments to analyze the release pattern of drug.Results: It was found that drug release depends on swelling, erosion, and diffusion, thus following the non-Fickian/anomalous type of diffusion.Formulation F8 was considered as an optimized formulation for gastro retentive floating tablet of venlafaxine hydrochloride. The optimizedformulation showed sustained drug release and remained buoyant on the surface of the medium for more than 12 hrs. As the concentration of HPMCK100M increases in the formulation the drug release rate was found to be decreased. The optimized formulation was subjected for the stability studiesand was found to be stable as no significant change was observed in various evaluated parameters of the formulation.Conclusion: It can be concluded that floating drug delivery system of venlafaxine hydrochloride can be successfully formulated as an approach toincrease gastric residence time, thereby improving its bioavailability.Keywords: Venlafaxine hydrochloride, Intragastric buoyant, Floating drug delivery systems, Hydroxypropyl methyl cellulose K100M, Carbopol 934 P,Xanthan gum.

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Fast method for the determination of total fat and trans fatty-acids content in bakery products based on microwave-assisted Soxhlet extraction and medium infrared spectroscopy detection

Analytica Chimica Acta ◽

10.1016/j.aca.2004.04.067 ◽

2004 ◽

Vol 517 (1-2) ◽

pp. 13-20 ◽

Cited By ~ 34

Author(s):

F. Priego-Capote ◽

J. Ruiz-Jiménez ◽

J. Garcı́a-Olmo ◽

M.D. Luque de Castro

Keyword(s):

Fatty Acids ◽

Infrared Spectroscopy ◽

Trans Fatty Acids ◽

Soxhlet Extraction ◽

Fast Method ◽

Bakery Products ◽

Microwave Assisted ◽

Total Fat

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Effects of inhomogeneity on triglyceride digestion of emulsions using an in vitro digestion model (Tiny TIM)

Food & Function ◽

10.1039/c4fo01045k ◽

2016 ◽

Vol 7 (7) ◽

pp. 2979-2995 ◽

Cited By ~ 2

Author(s):

Alexander Oosterveld ◽

Mans Minekus ◽

Esther Bomhof ◽

Franklin D. Zoet ◽

George A. van Aken

Keyword(s):

Fatty Acids ◽

Small Intestine ◽

In Vitro Digestion

The concentration of fatty acids in the small intestine duringin vitrodigestion of emulsions is reported.

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LINAGLIPTIN AND GLICLAZIDE DI-LOADED EXTENDED-RELEASE NANOPARTICLES: FORMULATION AND EVALUATION

Wiadomości Lekarskie ◽

10.36740/wlek202109212 ◽

2021 ◽

Vol 74 (9) ◽

pp. 2315-2322

Author(s):

Firas Aziz Rahi ◽

Muath Sheet Mohammed Ameen ◽

Mohammed Shamil Fayyadh

Keyword(s):

Particle Size ◽

Xanthan Gum ◽

Extended Release ◽

Hydroxypropyl Methylcellulose ◽

In Vitro Release ◽

Entrapment Efficiency ◽

Hplc Method ◽

Electronic Microscopy ◽

Vitro Release

The aim: This work aimed to formulate gliclazide and linagliptin extended-release nanoparticles. Materials and methods: A HPLC method was developed and validated to determine gliclazide and linagliptin at the same time without interference. The nanoparticles were prepared by emulsion solvent evaporation using two polymers, namely hydroxypropyl methylcellulose (HPMC) 4000 cps and xanthan gum. Results: Nanoparticles prepared were characterized for drug contents, production yield and entrapment efficiency, zeta potential, particle size, morphology by transmission electronic microscopy (TEM) and in-vitro release rate. The formulae GLH1, GLX1 and GHX1 showed release of linagliptin more than 75% after 8 hrs. While the only formula among the three (GHX1) showed release of gliclazide more than 80% after 8 h. So, the formula GHX1 showed acceptable release of more than 80% of both gliclazide and linagliptin after 8 h. Conclusions: The formula GHX1 which containing (0.5:1 xanthan gum: drugs) was the best nanoparticles formula which released more than 80% of both drugs after 8 h and could achieve good extended release over 24 h.

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SUSTAINED RELEASE HYDROPHILIC MATRICES BASED ON XANTHAN GUM AND HYDROXYPROPYL METHYLCELLULOSE: DEVELOPMENT, OPTIMIZATION, IN VITRO AND IN VIVO EVALUATION

Journal of Applied Pharmacy ◽

10.21065/19204159.2.89 ◽

2010 ◽

Vol 2 ◽

pp. 89-103

Author(s):

Muhammad Sajid Hamid Akash . ◽

Ikram Ullah Khan . ◽

Syed Nisar Hussain Shah . ◽

Sajid Asghar . ◽

Asif massud . ◽

...

Keyword(s):

Sustained Release ◽

Xanthan Gum ◽

Hydroxypropyl Methylcellulose ◽

In Vivo Evaluation ◽

Hydrophilic Matrices

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In Vitro Digestion of Grape Seed Oil Inhibits Phospholipid-Regulating Effects of Oxidized Lipids

Biomolecules ◽

10.3390/biom10050708 ◽

2020 ◽

Vol 10 (5) ◽

pp. 708 ◽

Cited By ~ 2

Author(s):

Sarah Fruehwirth ◽

Sofie Zehentner ◽

Mohammed Salim ◽

Sonja Sterneder ◽

Johanna Tiroch ◽

...

Keyword(s):

Fatty Acids ◽

Seed Oil ◽

In Vitro Digestion ◽

Grape Seed ◽

Dietary Lipids ◽

Lipid Absorption ◽

Oxidized Lipids ◽

Grape Seed Oil ◽

Oxidized Triacylglycerols

The intake of dietary lipids is known to affect the composition of phospholipids in gastrointestinal cells, thereby influencing passive lipid absorption. However, dietary lipids rich in polyunsaturated fatty acids, such as vegetable oils, are prone to oxidation. Studies investigating the phospholipid-regulating effect of oxidized lipids are lacking. We aimed at identifying the effects of oxidized lipids from moderately (18.8 ± 0.39 meq O2/kg oil) and highly (28.2 ± 0.39 meq O2/kg oil) oxidized and in vitro digested cold-pressed grape seed oils on phospholipids in human gastric tumor cells (HGT-1). The oils were analyzed for their antioxidant constituents as well as their oxidized triacylglycerol profile by LC-MS/MS before and after a simulated digestion. The HGT-1 cells were treated with polar oil fractions containing epoxidized and hydroperoxidized triacylglycerols for up to six hours. Oxidized triacylglycerols from grape seed oil were shown to decrease during the in vitro digestion up to 40% in moderately and highly oxidized oil. The incubation of HGT-1 cells with oxidized lipids from non-digested oils induced the formation of cellular phospholipids consisting of unsaturated fatty acids, such as phosphocholines PC (18:1/22:6), PC (18:2/0:0), phosphoserine PS (42:8) and phosphoinositol PI (20:4/0:0), by about 40%–60%, whereas the incubation with the in vitro digested oils did not affect the phospholipid metabolism. Hence, the gastric conditions inhibited the phospholipid-regulating effect of oxidized triacylglycerols (oxTAGs), with potential implications in lipid absorption.

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Differential effects of various trans fatty acids isomers on apoptosis rate of human umbilical vein endothelial cell in vitro

Heart ◽

10.1136/heartjnl-2011-300867.135 ◽

2011 ◽

Vol 97 (Suppl 3) ◽

pp. A47-A47 ◽

Cited By ~ 1

Author(s):

P. Qiang ◽

S. Hai ◽

H. Dezhi ◽

H. Weitong

Keyword(s):

Fatty Acids ◽

Endothelial Cell ◽

Trans Fatty Acids ◽

Umbilical Vein ◽

Human Umbilical Vein ◽

Differential Effects ◽

Apoptosis Rate

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In Vitro and In Vivo Digestibility of Soybean, Fish, and Microalgal Oils, and Their Influences on Fatty Acid Distribution in Tissue Lipid of Mice

Molecules ◽

10.3390/molecules25225357 ◽

2020 ◽

Vol 25 (22) ◽

pp. 5357

Author(s):

Bo-Ram Na ◽

Jeung-Hee Lee

Keyword(s):

Fatty Acids ◽

Fatty Acid ◽

Fatty Acid Distribution ◽

Docosapentaenoic Acid ◽

In Vitro Digestion ◽

Fish Oils ◽

Microalgal Oil ◽

Mouse Tissues

The digestion rates of microalgal (docosahexaenoic acid, DHA, 56.8%; palmitic acid, 22.4%), fish (DHA, 10.8%; eicosapentaenoic acid, EPA, 16.2%), and soybean oils (oleic, 21.7%; linoleic acid, 54.6%) were compared by coupling the in vitro multi-step and in vivo apparent digestion models using mice. The in vitro digestion rate estimated based on the released free fatty acids content was remarkably higher in soybean and fish oils than in microalgal oil in 30 min; however, microalgal and fish oils had similar digestion rates at longer digestion. The in vivo digestibility of microalgal oil (91.49%) was lower than those of soybean (96.50%) and fish oils (96.99%). Among the constituent fatty acids of the diet oils, docosapentaenoic acid (DPA) exhibited the highest digestibility, followed by EPA, DHA, palmitoleic, oleic, palmitic, and stearic acid, demonstrating increased digestibility with reduced chain length and increased unsaturation degree of fatty acid. The diet oils affected the deposition of fatty acids in mouse tissues, and DHA concentrations were high in epididymal fat, liver, and brain of mice fed microalgal oil. In the present study, microalgal oil showed lower in vitro and in vivo digestibility, despite adequate DHA incorporation into major mouse organs, such as the brain and liver.

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DESIGN AND IN VITRO CHARACTERIZATION OF FLOATING TABLETS OF METRONIDAZOLE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2019.v12i3.31018 ◽

2019 ◽

pp. 539-544

Author(s):

CHINNA ESWARAIAH M ◽

JAYA S

Keyword(s):

Drug Release ◽

Xanthan Gum ◽

Hydroxypropyl Methylcellulose ◽

Matrix Tablets ◽

In Vitro Dissolution ◽

Release Mechanism ◽

Content Uniformity ◽

Matrix Tablet ◽

N Value

Objective: The objective of the present study was to formulate the effervescent floating matrix tablet of metronidazole and to evaluate the effect of varying concentrations of hydrophilic polymers on drug release. Methods: Drug excipients interaction was studied by Fourier transform infrared spectrophotometer. The effervescent floating matrix tablets were prepared by direct compression technique using hydroxypropyl methylcellulose (HPMCK4) and xanthan gum alone and in combination as release retardants. Microcrystalline cellulose was used as diluent. Sodium bicarbonate was used as effervescent agent. The prepared matrix tablets were evaluated for their physicochemical parameters such as weight variation, hardness, friability, content uniformity, buoyancy time, and in vitro dissolution. Results: Micromeritic properties and post-compression parameters were evaluated and all the parameters were found within the acceptable limit. The drug release data were subjected to different models to evaluate release kinetics and mechanism of drug release. The matrix tablets prepared with xanthan gum and a mixture of xanthan gum and HPMCK4 were retarded the drug release up to 12 h. The release mechanism of metronidazole was evaluated on the basis of release exponent n value in Peppas model. The n value of the formulations ranged from 0.46 to 0.89 which indicated Case II transport and zero-order release. Conclusion: Floating matrix tablet is the simple, efficient, and economic method to sustain the release of metronidazole to eradicate Helicobacter pylori in peptic ulcer disease.

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