scholarly journals Separation of Fructosyl Oligosaccharides in Maple Syrup by Using Charged Aerosol Detection

Foods ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3160
Author(s):  
Kanta Sato ◽  
Tetsushi Yamamoto ◽  
Kuniko Mitamura ◽  
Atsushi Taga
Keyword(s):  
Natural Products ◽  
Physical Properties ◽  
Analytical Method ◽  
High Sensitivity ◽  
Maple Syrup ◽  
Charged Aerosol Detection ◽  
Charged Aerosol ◽  
Natural Foods ◽  
Shed Light

Fructosyl oligosaccharides, including fructo-oligosaccharide (FOS), are gaining popularity as functional oligosaccharides and have been found in various natural products. Our previous study suggested that maple syrup contains an unidentified fructosyl oligosaccharide. Because these saccharides cannot be detected with high sensitivity using derivatization methods, they must be detected directly. As a result, an analytical method based on charged aerosol detection (CAD) that can detect saccharides directly was optimized in order to avoid relying on these structures and physical properties to clarify the profile of fructosyl oligosaccharides in maple syrup. This analytical method is simple and can analyze up to hepta-saccharides in 30 min. This analytical method was also reliable and reproducible with high validation values. It was used to determine the content of saccharides in maple syrup, which revealed that it contained not only fructose, glucose, and sucrose but also FOS such as 1-kestose and nystose. Furthermore, we discovered a fructosyl oligosaccharide called neokestose in maple syrup, which has only been found in a few natural foods. These findings help to shed light on the saccharides profile of maple syrup.

scholarly journals Radiochemistry, Production Processes, Labeling Methods, and ImmunoPET Imaging Pharmaceuticals of Iodine-124

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 414
Author(s):  
Krishan Kumar ◽  
Arijit Ghosh
Keyword(s):  
Physical Properties ◽  
Imaging Modality ◽  
Target Selection ◽  
Positron Emission Tomography Imaging ◽  
High Sensitivity ◽  
High Specificity ◽  
Production Processes ◽  
Positron Emission ◽  
Significant Research ◽  
Clinical Environments

Target-specific biomolecules, monoclonal antibodies (mAb), proteins, and protein fragments are known to have high specificity and affinity for receptors associated with tumors and other pathological conditions. However, the large biomolecules have relatively intermediate to long circulation half-lives (>day) and tumor localization times. Combining superior target specificity of mAbs and high sensitivity and resolution of the PET (Positron Emission Tomography) imaging technique has created a paradigm-shifting imaging modality, ImmunoPET. In addition to metallic PET radionuclides, 124I is an attractive radionuclide for radiolabeling of mAbs as potential immunoPET imaging pharmaceuticals due to its physical properties (decay characteristics and half-life), easy and routine production by cyclotrons, and well-established methodologies for radioiodination. The objective of this report is to provide a comprehensive review of the physical properties of iodine and iodine radionuclides, production processes of 124I, various 124I-labeling methodologies for large biomolecules, mAbs, and the development of 124I-labeled immunoPET imaging pharmaceuticals for various cancer targets in preclinical and clinical environments. A summary of several production processes, including 123Te(d,n)124I, 124Te(d,2n)124I, 121Sb(α,n)124I, 123Sb(α,3n)124I, 123Sb(3He,2n)124I, natSb(α, xn)124I, natSb(3He,n)124I reactions, a detailed overview of the 124Te(p,n)124I reaction (including target selection, preparation, processing, and recovery of 124I), and a fully automated process that can be scaled up for GMP (Good Manufacturing Practices) production of large quantities of 124I is provided. Direct, using inorganic and organic oxidizing agents and enzyme catalysis, and indirect, using prosthetic groups, 124I-labeling techniques have been discussed. Significant research has been conducted, in more than the last two decades, in the development of 124I-labeled immunoPET imaging pharmaceuticals for target-specific cancer detection. Details of preclinical and clinical evaluations of the potential 124I-labeled immunoPET imaging pharmaceuticals are described here.

Internal Organizational Measurement for Control of Magnetorheological Fluid Properties

2006 ◽  
Vol 129 (4) ◽  
pp. 423-428 ◽  
Author(s):  
John R. Lloyd ◽  
Miquel O. Hayesmichel ◽  
Clark J. Radcliffe
Keyword(s):  
Magnetic Field ◽  
Physical Properties ◽  
High Sensitivity ◽  
Time Varying ◽  
Measurable Effect ◽  
Mr Fluid ◽  
Fluid State ◽  
Mr Fluids ◽  
Fluid Properties ◽  
Field Excitation

Magnetorheological (MR) fluids change their physical properties when subjected to a magnetic field. As this change occurs, the specific values of the physical properties are a function of the fluid’s time-varying organization state. This results in a nonlinear, hysteretic, time-varying fluid property response to direct magnetic field excitation. Permeability, resistivity and permittivity changes of MR fluid were investigated and their suitability to indicate the organizational state of the fluid, and thus other transport properties, was determined. High sensitivity of permittivity and resistivity to particle organization and applied field was studied experimentally. The measurable effect of these material properties can be used to implement an MR fluid state sensor.

scholarly journals SEMANTIC ASPECT OF ARABIC MORPHOLOGY: IDEAS AND THEORIES/ وقفات دلالية في الصرف العربي أفكار و رؤى

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Abdulwahab Ajao Salaudeen
Keyword(s):  
Analytical Method ◽  
General View ◽  
Arabic Morphology ◽  
Semantic Element ◽  
Semantic Aspect ◽  
Shed Light

<p>This research aims to shed light on a semantic aspect of Arabic morphology; the study shows that Arabic morphologists emphasized formative aspect more than the grammatical element which made Arabic morphology difficult to comprehend, it has gone to the level of generalizing some rules without giving semantic element adequate attention. There is no doubt on the fact that the formative element of Arabic morphology has to go side by side with semantic aspect to simplify and clarify its study. However, this research points out the advantages of applying the theory of Semantic /Analytical Field for identifying the characteristics of each morphological forms. The researcher applies the descriptive and analytical method to give a general view of this morpho- semantic study.</p><p><strong></strong><strong>Keywords</strong>: Semantic; Arabic Morphology; Ideas; Visions</p>

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