scholarly journals Evaluation of Helicobacter pylori Infection, Neutrophil–Lymphocyte Ratio and Platelet–Lymphocyte Ratio in Dyspeptic Patients

2020 ◽  
Vol 11 (1) ◽  
pp. 2-9
Author(s):  
Banu Boyuk ◽  
Dogukan Saydan ◽  
Osman Mavis ◽  
Hande Erman
Keyword(s):  
Helicobacter Pylori ◽  
Negative Correlation ◽  
Mean Corpuscular Volume ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Significant Difference ◽  
H Pylori ◽  
The Relationship ◽  
Positive Groups

Recent studies have shown a correlation between Helicobacter pylori (H. Pylori) infection and the neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). The aim of this study was to investigate the relationship between H. Pylori infection and hematimetric indices in patients with dyspepsia symptoms. Overall, 448 patients who underwent gastroscopy were analyzed retrospectively. Histopathological evaluation of biopsies according to H. pylori presence was classified as H. Pylori positive and negative groups, which are analyzed in relation with hematimetric indices. NLR and PLR measurements did not show a statistically significant difference between H. pylori negative and positive groups (p > 0.05). NLR revealed a negative correlation between hemoglobin (HGB), iron, and ferritin measurements in the correlation analysis of the H. Pylori positive group (r = −0.133, p = 0.031; r = −0.270, p = 0.002; r = −0.162, p = 0.032). Again, with PLR, there was a negative correlation between HGB, mean corpuscular volume (MCV), iron, and ferritin measurements (r = −0.310, p = 0.001, r = −0.187, p = 0.002, r = −0.335, p = 0.001; r = −0.290; p = 0.001). The results of our study do not reveal an association between H. pylori presence and inflammatory response, which is evaluated by NLR and PLR measurements in patients with dyspepsia. However, low serum iron and ferritin values of H. pylori-positive patients suggest the effect of H. pylori on iron metabolism.

scholarly journals ROLE OF HEMATOLOGICAL PARAMETERS IN EARLY DIAGNOSIS OF COVID-19 IN A TERTIARY CARE CENTRE

2021 ◽  
Vol 5 (6) ◽  
Author(s):  
Angira Saha ◽  
Sakar Saxena ◽  
Romi Srivastava ◽  
Sanjeev Narang
Keyword(s):  
Early Diagnosis ◽  
Hematological Parameters ◽  
Tertiary Care ◽  
Tertiary Care Centre ◽  
College Hospital ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Significant Difference

Aim: To evaluate the role of biomarkers from blood samples of COVID-19 patients admitted in Index Medical College Hospital & R.C. Material & Methods: Hematological parameters such as Neutrophil lymphocyte ratio (NLR), Platelet lymphocyte ratio (PLR) & Systemic Inflammatory Index (SII) were studied in RT-PCR positive patients to evaluate the utility of these parameters for early diagnosis of COVID-19. Results: The study showed that there was statistically significant difference in test groups in reference to Neutrophil lymphocyte ratio (NLR) & SII values (p<0.05). But no statistically significant difference was observed between test groups in reference to Platelet lymphocyte ratio (PLR) values (p>0.05). Conclusion: Leukocyte, Neutrophil, NLR & SII values can be used in the early diagnosis of COVID-19. Keywords: NLR, SII, Leukocyte, Neutrophil

scholarly journals Effect of Helicobacter pylori Infection on Serum Lipid Profile

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Mohamadreza Haeri ◽  
Mahmoud Parham ◽  
Neda Habibi ◽  
Jamshid Vafaeimanesh
Keyword(s):  
Helicobacter Pylori ◽  
Lipid Profile ◽  
Blood Sugar ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Population Data ◽  
Serum Lipid Profile ◽  
Significant Difference ◽  
H Pylori ◽  
The Relationship

Background. Some studies suggest a significant relationship between Helicobacter pylori infection and atherogenesis; but the mechanism of the relationship is almost unknown. The current study aimed at evaluating the relationship between H. pylori infection and serum lipid profile. Patients and Methods. The current study was conducted on 2573 patients, from 2008 to 2015. The serum anti-Helicobacter pylori antibody titer and serum lipid profile were assessed in the study population; data were statistically analyzed by SPSS version 16. P values < 0.05 were considered significant. Results. In the current study, 66.5% of the cases were serologically positive for H. pylori. Among male cases, the level of low density lipoprotein (LDL) was higher in patients with H. pylori infection, compared with that of the ones without the infection (P=0.03); although level of triglyceride (TG) was higher and the level of high density lipoprotein (HDL) was lower in the cases with H. pylori infection; there was no statistically significant difference between the cases with and without H. pylori infection regarding the level of HDL and TG. Among female cases, the level of TG was significantly lower in patients with H. pylori infection, compared with that of the ones without the infection (P=0.001); but there was no significant difference between the cases with and without H. pylori infection regarding the level of LDL and HDL. The mean fasting blood sugar (FBS) in the cases with H. pylori infection was significantly higher than that of the ones without the infection (P=0.04). Conclusion. According to the results of the current study, the levels of LDL and FBS were high among the male cases with H. pylori infection. However, in females with H. pylori infection the level of TG was low; hence, it seems that the atherogenicity of H. pylori affected the level of blood sugar more.

Relationship between Helicobacter pylori and development of hepatocellular carcinoma: A systematic review and meta-analysis.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 4091-4091
Author(s):  
Samragnyi Madala ◽  
Kira MacDougall ◽  
Balarama Krishna Surapaneni ◽  
Robin Park ◽  
Anup Kasi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Helicobacter Pylori ◽  
Causal Relationship ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Control Group ◽  
Significant Difference ◽  
H Pylori ◽  
The Relationship

4091 Background: The relationship between Helicobacter pylori (H.pylori) and hepatocellular carcinoma (HCC) was first proposed in 1994. Since then, several studies have been performed to explore the association. The role of Hepatitis C (HCV) viruses coexisting with H.pylori in causing HCC was also studied. With the emergence of data in this regard, a causal relationship has been postulated, but not confirmed, and hence the relationship remains controversial. Our meta-analysis aims to summarize the research on this topic and investigate if there exists a relationship between H. pylori infection and the development of HCC and if the presence of HCV along with H.pylori plays a role in liver carcinogenesis. Methods: Following PRISMA guidelines, we performed a systematic review of all relevant studies published in the literature using keywords “Helicobacter pylori” and “Hepatocellular carcinoma” on major literature databases, including PubMed, EMBASE, Web of Science, and Cochrane controlled trials register. A total of 656 studies were identified between 1994 to March 2020, out of which 26 studies qualified under our selection criteria. Patients positive for HCC are included as cases and patients that did not have HCC under control group. In both groups, H.pylori positive patients and their HCV status, was identified. Results: Out of the 26 studies included in the final analysis, the prevalence of H. pylori infection was 64.78% (561 of 866) amongst HCC cases and 47.92% (1718 of 3585) in the non-HCC control group. The summary odds ratio for the association of H. pylori infection with the risk for HCC using the random-effects model was determined to be 4.75 (95% CI, 3.06-7.37), I²=63%. Subgroup analysis to determine the odds of developing HCC in the presence of H.pylori and HCV coinfection, was 13.97 (95% CI, 3.94-49.61), I²=81%. Whereas, the odds of developing HCC in the presence of only HCV without H.pylori was found to be 2.21 (0.70-6.94), I²=79. Subgroup analysis by study design showed no significant difference between the study groups (P= 0.5705). Conclusions: Our meta-analysis showed a positive association between H. pylori infection and the development of HCC. It showed a significantly higher risk of developing HCC in the presence of HCV infection along with H.pylori. Further prospective cohort studies are needed to prove the causal relationship, especially in cases of Hepatitis B, C coinfection, and cirrhotic patients.[Table: see text]

scholarly journals The Relationship Between Duration of Hemodialysis, Helicobacter pylori and CagA Seropositivity in Patients with Chronic Kidney Disease

2020 ◽  
Vol 25 (3) ◽  
pp. 383-390
Author(s):  
Oğuzhan Özcan ◽  
Hüseyin Erdal ◽  
Burçin Özer ◽  
Filiz Kaçmaz ◽  
Faruk Turgut
Keyword(s):  
Helicobacter Pylori ◽  
Short Term ◽  
Igg Antibody ◽  
Dialysis Treatment ◽  
Reactive Protein ◽  
Significant Difference ◽  
Automated Hematology Analyzer ◽  
H Pylori ◽  
The Relationship

Introduction: The aim of this study was to investigate the relationship between Helicobacter pylori occurrence and, Cytotoxinassociated gene A (CagA) seropositivity with hemodialysis (HD) duration, Serum C-reactive protein (CRP) and hemogram parameters in hemodialysis patients. Materials and Methods: This study included 165 prevalent HD patients. Blood samples were collected before dialysis treatment of the patients. The samples were then centrifuged at 1500 x g for 10 min. immediately after collection. The presence of serum IgG antibody for H. pylori was determined using commercial ELISA kits. Serum anti-CagA IgG antibody of H. pylori positive patients was determined by ELISA method using commercial ELISA kits. CRP levels were measured by nephelometric method, and hemogram parameters were analyzed using fully automated hematology analyzer. Results: We found that the CRP levels of the patients having H. pylori were significantly high. However, there was no significant difference between CRP levels of long-term hemodialysis (LTHD) and short -term hemodialysis (STHD) patients. The possibility of being seropositive of CagA for STHD patients having H. pylori was found to be 2.3 times higher than that of LTHD patients. In addition to that, the periodicity of gastrointestinal (GI) bleeding was significantly high in STHD patients. Conclusion: In conclusion, we found no relationship between dialysis duration and H. pylori prevalence. However, we observed significantly higher odds ratio for CagA seropositivity in patients receiving STHD. These findings suggest that longer dialysis treatment can cause improving effects on H. pylori virulence. Further studies are needed to verify these findings.

A Study of the Relationship between Helicobacter pylori and Recurrent Aphthous Stomatitis Using a Urea Breath Test

2009 ◽  
Vol 10 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Maryam Baharvand ◽  
Ziba Maleki ◽  
Kaveh Alavi ◽  
Ali Akbar Sayyari ◽  
Leila Sayyari
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Urea Breath Test ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Control Group ◽  
Peptic Ulcers ◽  
Significant Difference ◽  
H Pylori ◽  
The Relationship

Abstract Aim Helicobacter pylori (H. pylori) is one of the most common, well-known pathogenic agents in the development of peptic ulcers. Some investigators have shown a relationship between H. pylori and recurrent aphthous stomatitis (RAS). However, this relationship is controversial. The aim of this study was to determine the association between H. pylori and RAS using the urea breath test (UBT). Methods and Materials Forty-three patients with RAS and 44 non-RAS controls were evaluated. There were no differences in gender or age in the two groups. The UBT was used to detect H. pylori infection. Data were analyzed using the Chi Square Test. Results Sixteen individuals in the RAS patients (37.2%) and 14 individuals in the control group (31.8%) had a positive breath test. The difference was not considered statistically significant (p=0.597). Conclusion In the present study no statistically significant difference was found between frequency of a positive UBT in the RAS patients and the control group. Clinical Significance Since the probability of a positive test was higher in the more severe cases this factor needs to be considered in the diagnosis and treatment of RAS. Citation Maleki Z, Sayyari AA, Alvavi K, Sayyari L, Baharvand M. A Study on the Relationship between Helicobacter pylori and Recurrent Aphthous Stomatitis Using a Urea Breath Test. J Contemp Dent Pract 2009 January; (10)1:009-016.

scholarly journals Relationship between Helicobacter pylori-positivity in the gallbladder and stomach and effect on gallbladder pathologies

2019 ◽  
Vol 47 (10) ◽  
pp. 4904-4910
Author(s):  
Aziz Ari ◽  
Cihad Tatar ◽  
Enver Yarikkaya
Keyword(s):  
Helicobacter Pylori ◽  
Case Control Study ◽  
Pancreatic Head ◽  
Case Control ◽  
Head Cancer ◽  
Pancreatic Head Cancer ◽  
Significant Difference ◽  
H Pylori ◽  
The Relationship ◽  
Control Study

Objective Helicobacter pylori commonly occurs in the stomach, but localizations outside the stomach and related diseases have also been investigated. However, the relationship between H. pylori and gallstones remains controversial. We aimed to investigate the relationships between H. pylori in the stomach and the gallbladder and gallstones. Methods This prospective case-control study included patients who underwent cholecystectomy because of gallstones, pancreatic head cancer, or hepatic resection. The patients were separated into two groups according to the detection of H. pylori in gallbladder samples using Giemsa staining. Stomach H. pylori status was based on previous gastroscopy. Results The study enrolled 60 patients, comprising 27 patients with gallstones and 33 without. There was no significant difference in the incidence of gallstones between patients with or without H. pylori in the stomach or gallbladder. Furthermore, the presence of H. pylori in the stomach was measured in 14 patients and was significantly correlated with H. pylori in the gallbladder. Conclusion The current study showed no relationship between the occurrence of gallstones and the presence of H. pylori in either the gallbladder or the stomach. In contrast to previous reports, this suggests that H. pylori does not play a role in the development of gallstones.

CouldHelicobacter pyloriplay a role in the aetiopathogenesis of tympanosclerosis?

2011 ◽  
Vol 125 (11) ◽  
pp. 1121-1124 ◽  
Author(s):  
A Iriz ◽  
A Eryilmaz ◽  
C Gocer ◽  
A Acar ◽  
S Boynuegri ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Clinical Study ◽  
Otitis Media ◽  
Preliminary Investigation ◽  
Chronic Otitis Media ◽  
Radical Mastoidectomy ◽  
Significant Difference ◽  
H Pylori ◽  
The Relationship ◽  
Controlled Clinical Study

AbstractAim:The aetiology of tympanosclerosis is not yet clear. This prospective, controlled, clinical study investigated the relationship betweenHelicobacter pyloriand tympanosclerosis aetiology.Materials and methods:The study included 14 patients with tympanosclerosis and 26 with other forms of chronic otitis media. All patients underwent surgery for chronic otitis media. Mucosal biopsies were taken, and examined forH pyloriusing the Campylobacter-Like Organism (CLO) test.Results:Tympanoplasty was performed in 29 patients (72.5 per cent), radical mastoidectomy in eight (20 per cent) and myringoplasty in three (7.5 per cent). The presence ofH pyloriwas tested in all tympanosclerosis biopsies, but in only 26.9 per cent of biopsies from other forms of chronic otitis media. A statistically significant difference inH pyloripresence was found (p ≤ 0.01).Conclusion:This study represents a preliminary investigation of the association betweenH pyloriand tympanosclerosis development.

scholarly journals Can Neutrophil/Lymphocyte Ratio Be Used as an Indicator of Inflammation in Patients with Hyperthyroidism?

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Murat Dağdeviren ◽  
Tolga Akkan ◽  
Dilek Yapar ◽  
Serdar Karakaya ◽  
Tanyel Dağdeviren ◽  
...  
Keyword(s):  
Negative Correlation ◽  
Significant Negative Correlation ◽  
The Other ◽  
Control Group ◽  
Graves Disease ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Significant Difference ◽  
Group Members ◽  
Hyperthyroid Patients

Abstract In our study, we aimed to evaluate changes in the neutrophil and lymphocyte series and investigate whether the neutrophil/lymphocyte ratio (NLR) is indicative of inflammations in patients with hyperthyroidism. A total of 161 patients were enrolled, 121 of which had hyperthyroidism (71 Graves’ Disease (GD) and 50 non-Graves hyperthyroidism (NGH) patients) and 40 of which were control group members. Retrospectively, patients’ neutrophil and lymphocyte counts were taken, and the NLR was calculated. While the number of neutrophils was significantly lower in the GD group (p = 0.003), there was no significant difference between the NGH and the control group. In the GD group, NLR values were significantly lower than the other two groups (median 1.39 for GD, median 1.84 for NGH and median 1.83 for the control group, p < 0.001). Only three patients in the GD group had neutropenia. There was also a significant negative correlation between free T3 and neutrophil count and NLR in hyperthyroid patients (r = -0.28, p = 0.001 and r = -0.34, p < 0.001, respectively). In our study, we found that NLR did not in crease in hyperthyroid patients and that this ratio decreased due to the decrease in neutrophil levels in GD. We thus concluded that NLR is not a suitable indicator of hyperthyroidism.

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