scholarly journals Recent Advances of Taxol-Loaded Biocompatible Nanocarriers Embedded in Natural Polymer-Based Hydrogels

Gels ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 33
Author(s):  
Silvia Voci ◽  
Agnese Gagliardi ◽  
Roberto Molinaro ◽  
Massimo Fresta ◽  
Donato Cosco
Keyword(s):  
Potential Role ◽  
Tumor Therapy ◽  
Chemical Properties ◽  
Natural Polymer ◽  
Natural Polymers ◽  
Recent Advances ◽  
Physico Chemical ◽  
Polar Media ◽  
Anti Cancer ◽  
Cancer Activity

The discovery of paclitaxel (PTX) has been a milestone in anti-cancer therapy and has promoted the development and marketing of various formulations that have revolutionized the therapeutic approach towards several malignancies. Despite its peculiar anti-cancer activity, the physico-chemical properties of PTX compromise the administration of the compound in polar media. Because of this, since the development of the first Food and Drug Administration (FDA)-approved formulation (Taxol®), consistent efforts have been made to obtain suitable delivery systems able to preserve/increase PTX efficacy and to overcome the side effects correlated to the presence of some excipients. The exploitation of natural polymers as potential materials for drug delivery purposes has favored the modulation of the bioavailability and the pharmacokinetic profiles of the drug, and in this regard, several formulations have been developed that allow the controlled release of the active compound. In this mini-review, the recent advances concerning the design and applications of natural polymer-based hydrogels containing PTX-loaded biocompatible nanocarriers are discussed. The technological features of these formulations as well as the therapeutic outcome achieved following their administration will be described, demonstrating their potential role as innovative systems to be used in anti-tumor therapy.

Polyacrylamide Based Polymers: Smart Materials Used in Wastewater Treatment

2020 ◽  
Vol 12 (1) ◽  
pp. 105-107 ◽  
Author(s):  
Amar Nath ◽  
P. P. Pande
Keyword(s):  
Wastewater Treatment ◽  
Smart Materials ◽  
Chemical Properties ◽  
Industrial Effluents ◽  
Solid Residue ◽  
Natural Polymers ◽  
High Affinity ◽  
Physico Chemical ◽  
Materials Used ◽  
Very High

Now-a-days synthetic polyelectrolytes are frequently used by the industries in the treatment of industrial effluents. Such materials have a variety of properties such as easily changeable structure as per the specific requirement, higher purity, highstability and have more efficiency than the natural polymers. These polymers do not add any solid residue in the sludge, exhibit no change in the physico-chemical properties of the treated water and therefore this water may be recycled. Polyacrylamide is a synthetic polyelectrolyte which is hydrophilic in nature and insoluble in organic solvents. It has very high affinity towards the suspended particles present in water. Therefore, polyacrylamide based polymers are highly effective for the flocculation of suspended contaminated particle present in the effluents. Polyacrylamide is very important polymer for wastewater treatment which enhances the flocculation potential by modification of its nature into non-ionic, anionic and cationic forms.

scholarly journals Gelatin: sources, preparation and application in food and biomedicine

2020 ◽  
pp. 28-46
Author(s):  
Elvira Shatabayeva ◽  
Grigoriy Mun ◽  
Yerengaip Shaikhutdinov ◽  
Vitaliy Khutoryanskiy
Keyword(s):  
Pharmaceutical Industry ◽  
Food Packaging ◽  
Chemical Properties ◽  
Essential Amino Acids ◽  
Biologically Active ◽  
Wound Dressings ◽  
Human Gastrointestinal Tract ◽  
Physico Chemical ◽  
Anti Cancer ◽  
Cell Adhesion And Proliferation

Gelatin is a proteinaceous substance composed of all the essential amino acids (except tryptophan) and derived from collagen using a hydrolysis technique. Hydrogels and modified composites based on gelatin are widely used in the food industry, biomedicine, pharmaceutical industry and food packaging materials due to their biocompatibility, biodegradability, nonimmunogenicity and ability to stimulate cell adhesion and proliferation. Gelatin can absorb 5-10 times its weight of water and is the main ingredient of hard and soft capsules in pharmaceutical industry. It melts above 30°C and easily releases biologically active compounds, nutrients and drugs in human gastrointestinal tract. In addition, gelatin contains arginine-glycine-asparagine RGD-sequences in the polymer structure and contributes to various functions such as antioxidant, anti-hypertensive, anti-microbial, tissue regeneration, wound healing, enhances bone formation and anti-cancer therapy. This article reports a brief overview of gelatin sources, gelatin preparation processes and its physico-chemical properties, as well as advances in the preparation of gelatin-based composite materials and hydrogels for tissue engineering, drug delivery, wound dressings, active packaging using various cross-linking techniques.

Anti-Cancer and Antibacterial Effects of Terfezia boudieri-Derived Silver Nanoparticles

2020 ◽  
Vol 23 ◽  
Author(s):  
Hashem Yaghoubi ◽  
Amin Izadpanah ◽  
Shahla Nedaei ◽  
Hossein Akbari ◽  
Elmira Mikaeili Agah ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Chemical Properties ◽  
Chemotherapeutic Agents ◽  
Dependent Manner ◽  
Biomedical Sciences ◽  
Synthesis Time ◽  
Physico Chemical ◽  
Anti Cancer ◽  
Bactericidal Effects ◽  
Terfezia Boudieri

Background: The use of nanoparticles has markedly increased in biomedical sciences. The silver nanoparticles (AgNPs) have been investigated for their applicability to deliver chemotherapeutic agents in cancer treatment. However, the existing chemical and physical methods of synthesizing AgNPs are considered inefficient and expensive, and are fraught with toxicity. Objective: Natural products have emerged as viable candidates for nanoparticle production, including the use of Terfezia boudieri (T. boudieri), a member of the edible truffle family. Accordingly, our goal was to synthesize AgNPs using the aqueous extract of T. boudieri (green synthesized AgNPs). Since certain infectious agents are linked to cancer, we further investigated their potential as anti-cancer and antibacterial agents. Methods: The physico-chemical properties of green synthesized AgNPs were analyzed by UV-Vis, FT-IR, XRD, SEM and TEM. In addition, their potential to inhibit cancer cell (MCF-7 and AGS) proliferation as well as the growth of infectious bacteria were investigated. Synthesis of AgNPs was confirmed by the presence of an absorption peak at 450nm by spectroscopy. Results: The size of nanoparticles ranged between 20-30nm and exerted significant cytotoxicity and bactericidal effects in a concentration and time dependent manner compared to T. boudieri extract alone. Interestingly, synthesis of smaller AgNPs correlated with longer synthesis time and enhanced cytotoxic and bactericidal properties. Conclusion: This study shows that synthesis of smaller AgNPs correlated with longer synthesis time and enhanced cytotoxic and anti-bacterial effects.

Eugenol as a potential drug candidate: A review

2021 ◽  
Vol 21 ◽  
Author(s):  
Mohamad Taleuzzaman ◽  
Pooja Jain ◽  
Rishabh Verma ◽  
Zeenat Iqbal ◽  
Mohd. Aamir Mirza
Keyword(s):  
Chemical Properties ◽  
Bioactive Compound ◽  
Alcoholic Beverages ◽  
Personal Hygiene ◽  
Drug Candidate ◽  
Drug Products ◽  
Physico Chemical ◽  
Chewing Gums ◽  
Anti Cancer ◽  
Baked Foods

: Eugenol is a bioactive compound widely available in many herbs like clove, cinnamon, tulsi, pepper etc. The compound is known for its antioxidant, antimicrobial, anaesthetic, anti-inflammatory, neuroprotective, anti-diabetic, and anti-cancer activities. In pharmaceutical analysis, eugenol is used as a marker for single drugs and drug products. Dental care, household, and personal hygiene products are other areas where it has established its potential. In the food industry, eugenol is used as a flavouring agent in non-alcoholic beverages, baked foods, and chewing gums. Considering the huge potential of eugenol, this review is an attempt to collate the regulatory information, physico-chemical properties, toxicity profile, marketed conventional and novel formulations, analytical methods, extraction procedures, recent patents and clinical trials of the moiety. Based on the literature survey, a schematic diagram of the mechanism of action has also been made.

Recent Advances in Gelatin-Based Nanomedicine for Targeted Delivery of Anti-Cancer Drugs

2021 ◽  
Vol 27 ◽  
Author(s):  
Faisal Raza ◽  
Liu Siyu ◽  
Hajra Zafar ◽  
Zul Kamal ◽  
Bo Zheng ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Cancer Therapeutics ◽  
Natural Polymers ◽  
Gelatin Nanoparticles ◽  
Good Surface ◽  
Recent Advances ◽  
Wide Range ◽  
Anti Cancer ◽  
Cancer Nanomedicine

: Nanoparticles based on natural polymers are utilized for the development of a wide range of drug delivery systems (DDS) in the current era. Gelatin-based nanoparticles, for example, are a remarkable cancer therapy with high efficacy and specificity. This paper reviews the recent advancements in gelatin-based nanomedicine for use in cancer therapeutics. Due to the characteristics features of gelatin, such as biocompatibility, biodegradability, stability, and good surface properties, these nanoparticles provide high therapeutic potency in cancer nanomedicine. The surface of gelatin can be modified in a number of ways using various ligands to explore the platform for the development of a more novel DDS. Various methods are available for the preparation of gelatin nanomedicine discussed in this review. In addition, various cross-linkers to stabilized nanocarriers and stimuli base gelatin nanoparticles are reviewed. Furthermore, recent advances and research in gelatin-based nanomedicine are discussed. Also, some drawbacks and challenges are evaluated. In general, this paper paves the pathway to identify the details about the gelatin-based DDS for cancer therapy.

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