scholarly journals Gelatin: sources, preparation and application in food and biomedicine

2020 ◽  
pp. 28-46
Author(s):  
Elvira Shatabayeva ◽  
Grigoriy Mun ◽  
Yerengaip Shaikhutdinov ◽  
Vitaliy Khutoryanskiy
Keyword(s):  
Pharmaceutical Industry ◽  
Food Packaging ◽  
Chemical Properties ◽  
Essential Amino Acids ◽  
Biologically Active ◽  
Wound Dressings ◽  
Human Gastrointestinal Tract ◽  
Physico Chemical ◽  
Anti Cancer ◽  
Cell Adhesion And Proliferation

Gelatin is a proteinaceous substance composed of all the essential amino acids (except tryptophan) and derived from collagen using a hydrolysis technique. Hydrogels and modified composites based on gelatin are widely used in the food industry, biomedicine, pharmaceutical industry and food packaging materials due to their biocompatibility, biodegradability, nonimmunogenicity and ability to stimulate cell adhesion and proliferation. Gelatin can absorb 5-10 times its weight of water and is the main ingredient of hard and soft capsules in pharmaceutical industry. It melts above 30°C and easily releases biologically active compounds, nutrients and drugs in human gastrointestinal tract. In addition, gelatin contains arginine-glycine-asparagine RGD-sequences in the polymer structure and contributes to various functions such as antioxidant, anti-hypertensive, anti-microbial, tissue regeneration, wound healing, enhances bone formation and anti-cancer therapy. This article reports a brief overview of gelatin sources, gelatin preparation processes and its physico-chemical properties, as well as advances in the preparation of gelatin-based composite materials and hydrogels for tissue engineering, drug delivery, wound dressings, active packaging using various cross-linking techniques.

scholarly journals Cell Behavior of Primary Fibroblasts and Osteoblasts on Plasma-Treated Fluorinated Polymer Coated with Honeycomb Polystyrene

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 889
Author(s):  
Klára Fajstavrová ◽  
Silvie Rimpelová ◽  
Dominik Fajstavr ◽  
Václav Švorčík ◽  
Petr Slepička
Keyword(s):  
Chemical Properties ◽  
Plasma Exposure ◽  
Research Teams ◽  
Polymer Substrates ◽  
Substrate Activation ◽  
Physico Chemical ◽  
Polystyrene Solution ◽  
Primary Fibroblasts ◽  
Positive Effect ◽  
Cell Adhesion And Proliferation

The development of new biocompatible polymer substrates is still of interest to many research teams. We aimed to combine a plasma treatment of fluorinated ethylene propylene (FEP) substrate with a technique of improved phase separation. Plasma exposure served for substrate activation and modification of surface properties, such as roughness, chemistry, and wettability. The treated FEP substrate was applied for the growth of a honeycomb-like pattern from polystyrene solution. The properties of the pattern strongly depended on the primary plasma exposure of the FEP substrate. The physico-chemical properties such as changes of the surface chemistry, wettability, and morphology of the prepared pattern were determined. The cell response of primary fibroblasts and osteoblasts was studied on a honeycomb pattern. The prepared honeycomb-like pattern from polystyrene showed an increase in cell viability and a positive effect on cell adhesion and proliferation for both primary fibroblasts and osteoblasts.

Thermodynamics and acoustic effects of quercetin on micellization and interaction behaviour of CTAB in different hydroethanol solvent systems

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Vikrant Abbot ◽  
Poonam Sharma
Keyword(s):  
Pharmaceutical Industry ◽  
Hydrophobic Interactions ◽  
Chemical Properties ◽  
Formulation Development ◽  
Surfactant Interactions ◽  
Physico Chemical ◽  
Ultrasonic Sound ◽  
Apparent Molar Compressibility ◽  
Solvent Systems ◽  
Thermoacoustic Properties

AbstractFlavonoids amongst the class of secondary metabolites possess numerous health benefits, are known for its use in pharmaceutical industry. Quercetin, a flavonoid has more prominent medical advantages however its utilization is constrained because of various instability and insolubility issues and therefore, taken into consideration for studying its physico-chemical properties. In view of that, the thermodynamic and thermoacoustic properties of quercetin were examined in presence of cationic surfactant cetyltrimethylammonium bromide (CTAB) at different hydroethanolic concentrations and temperatures. The conductivity studies were used to calculate change in enthalpy (∆Hom), change in entropy (∆Som) and change in Gibbs free Energy (∆Gom) of micellization. The interactions between quercetin and CTAB were found to be endothermic, entropically controlled and spontaneous. Further, ultrasonic sound velocity and density studies were carried out and utilized for the calculation of thermoacoustic parameters i.e. apparent molar volume and apparent molar compressibility. Thermoacoustic properties revealed that at higher surfactant concentration, hydrophobic interactions are dominant. The results suggested that the flavonoid-surfactant interactions in hydroethanolic solutions is more favourable as compared with aqueous solution. Overall, the data is favourable for the framework to be used for detailing advancement, drug development, drug industry, pharmaceutical industry, medical administration and formulation development studies.

scholarly journals Modification of Physico-Chemical Properties of Acryl-Coated Polypropylene Foils for Food Packaging by Reactive Particles from Oxygen Plasma

Materials ◽  
2018 ◽  
Vol 11 (3) ◽  
pp. 372 ◽  
Author(s):  
Tomislava Vukušić ◽  
Alenka Vesel ◽  
Matej Holc ◽  
Mario Ščetar ◽  
Anet Jambrak ◽  
...  
Keyword(s):  
Food Packaging ◽  
Oxygen Plasma ◽  
Chemical Properties ◽  
Physico Chemical ◽  
Reactive Particles

Anti-Cancer and Antibacterial Effects of Terfezia boudieri-Derived Silver Nanoparticles

2020 ◽  
Vol 23 ◽  
Author(s):  
Hashem Yaghoubi ◽  
Amin Izadpanah ◽  
Shahla Nedaei ◽  
Hossein Akbari ◽  
Elmira Mikaeili Agah ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Chemical Properties ◽  
Chemotherapeutic Agents ◽  
Dependent Manner ◽  
Biomedical Sciences ◽  
Synthesis Time ◽  
Physico Chemical ◽  
Anti Cancer ◽  
Bactericidal Effects ◽  
Terfezia Boudieri

Background: The use of nanoparticles has markedly increased in biomedical sciences. The silver nanoparticles (AgNPs) have been investigated for their applicability to deliver chemotherapeutic agents in cancer treatment. However, the existing chemical and physical methods of synthesizing AgNPs are considered inefficient and expensive, and are fraught with toxicity. Objective: Natural products have emerged as viable candidates for nanoparticle production, including the use of Terfezia boudieri (T. boudieri), a member of the edible truffle family. Accordingly, our goal was to synthesize AgNPs using the aqueous extract of T. boudieri (green synthesized AgNPs). Since certain infectious agents are linked to cancer, we further investigated their potential as anti-cancer and antibacterial agents. Methods: The physico-chemical properties of green synthesized AgNPs were analyzed by UV-Vis, FT-IR, XRD, SEM and TEM. In addition, their potential to inhibit cancer cell (MCF-7 and AGS) proliferation as well as the growth of infectious bacteria were investigated. Synthesis of AgNPs was confirmed by the presence of an absorption peak at 450nm by spectroscopy. Results: The size of nanoparticles ranged between 20-30nm and exerted significant cytotoxicity and bactericidal effects in a concentration and time dependent manner compared to T. boudieri extract alone. Interestingly, synthesis of smaller AgNPs correlated with longer synthesis time and enhanced cytotoxic and bactericidal properties. Conclusion: This study shows that synthesis of smaller AgNPs correlated with longer synthesis time and enhanced cytotoxic and anti-bacterial effects.

scholarly journals Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process

RSC Advances ◽  
2018 ◽  
Vol 8 (45) ◽  
pp. 25436-25443 ◽  
Author(s):  
Robert Ccorahua ◽  
Silvia Moreno ◽  
Hannes Gumz ◽  
Karin Sahre ◽  
Brigitte Voit ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Freeze Drying ◽  
Chemical Properties ◽  
Biologically Active ◽  
Enzymatic Reactions ◽  
Drying Process ◽  
Physico Chemical ◽  
And Storage

Polymersomes can retain their physico-chemical properties and membrane permeability for enzymatic reactions after lyophilization or cryogenic freezing and storage.

scholarly journals HPMA-Based Polymer Conjugates for Repurposed Drug Mebendazole and Other Imidazole-Based Therapeutics

Polymers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 2530
Author(s):  
Martin Studenovský ◽  
Anna Rumlerová ◽  
Libor Kostka ◽  
Tomáš Etrych
Keyword(s):  
Chemical Properties ◽  
Drug Repurposing ◽  
Water Soluble ◽  
Biologically Active ◽  
Lysosomal Hydrolases ◽  
Polymer Carrier ◽  
Design Synthesis ◽  
Polymer Conjugates ◽  
Synthetic Strategy ◽  
Physico Chemical

Recently, the antitumor potential of benzimidazole anthelmintics, such as mebendazole and its analogues, have been reported to have minimal side effects, in addition to their well-known anti-parasitic abilities. However, their administration is strongly limited owing to their extremely poor solubility, which highly depletes their overall bioavailability. This study describes the design, synthesis, and physico-chemical properties of polymer-mebendazole nanomedicines for drug repurposing in cancer therapy. The conjugation of mebendazole to water-soluble and biocompatible polymer carrier was carried out via biodegradable bond, relying on the hydrolytic action of lysosomal hydrolases for mebendazole release inside the tumor cells. Five low-molecular-weight mebendazole derivatives, differing in their inner structure, and two polymer conjugates differing in their linker structure, were synthesized. The overall synthetic strategy was designed to enable the modification and polymer conjugation of most benzimidazole-based anthelmintics, such as albendazole, fenbendazole or albendazole, besides the mebendazole. Furthermore, the described methodology may be suitable for conjugation of other biologically active compounds with a heterocyclic N-H group in their molecules.

Eugenol as a potential drug candidate: A review

2021 ◽  
Vol 21 ◽  
Author(s):  
Mohamad Taleuzzaman ◽  
Pooja Jain ◽  
Rishabh Verma ◽  
Zeenat Iqbal ◽  
Mohd. Aamir Mirza
Keyword(s):  
Chemical Properties ◽  
Bioactive Compound ◽  
Alcoholic Beverages ◽  
Personal Hygiene ◽  
Drug Candidate ◽  
Drug Products ◽  
Physico Chemical ◽  
Chewing Gums ◽  
Anti Cancer ◽  
Baked Foods

: Eugenol is a bioactive compound widely available in many herbs like clove, cinnamon, tulsi, pepper etc. The compound is known for its antioxidant, antimicrobial, anaesthetic, anti-inflammatory, neuroprotective, anti-diabetic, and anti-cancer activities. In pharmaceutical analysis, eugenol is used as a marker for single drugs and drug products. Dental care, household, and personal hygiene products are other areas where it has established its potential. In the food industry, eugenol is used as a flavouring agent in non-alcoholic beverages, baked foods, and chewing gums. Considering the huge potential of eugenol, this review is an attempt to collate the regulatory information, physico-chemical properties, toxicity profile, marketed conventional and novel formulations, analytical methods, extraction procedures, recent patents and clinical trials of the moiety. Based on the literature survey, a schematic diagram of the mechanism of action has also been made.

Partially Defatted Pumpkin (Cucurbita maxima) Seeds - a Rich Source of Nutrients for Use in Food Products

2018 ◽  
Vol 69 (6) ◽  
pp. 1398-1402 ◽  
Author(s):  
Livia Apostol ◽  
Lavinia Berca ◽  
Claudia Mosoiu ◽  
Mihaela Badea ◽  
Simona Bungau ◽  
...  
Keyword(s):  
Amino Acids ◽  
Mineral Content ◽  
Chemical Properties ◽  
Essential Amino Acids ◽  
Rich Source ◽  
Cucurbita Maxima ◽  
Isoleucine Leucine ◽  
Physico Chemical ◽  
Total Carbohydrates ◽  
Pumpkin Seeds

Pumpkin (Cucurbita maxima) seeds are a rich source of ingredients such as aminoacids, fatty acids, minerals, and phytochemicals exhibiting nutraceutical effects on human health. In this work, partially defatted pumpkin seeds flour, a by-product obtained during the manufacture of pumpkin seeds oil, was studied as an additive for common wheat flour. We explored the physico-chemical properties as well the content in amino acids of the partially defatted pumpkin seeds. The obtained results revealed that partially defatted pumpkin seeds are a good source of protein (42.75% d.m.), lipids (12.28% d.m.), total carbohydrates (37.4% d.m.), from which crude fiber (26.64% d.m.). This by-product presents a high mineral content (mg/100g): potassium (1290), magnesium (693), iron (87.8), zinc (11.5) and copper (2.49).The partially defatted pumpkin seeds proteins contain significant amounts of essential amino acids such as valine, histidine, isoleucine, leucine, threonine and methionine.

Sign in / Sign up

Export Citation Format

Share Document