Association and Genetic Expression between Genes Involved in HPA Axis and Suicide Behavior: A Systematic Review

Background: Suicide behavior (SB) has been highly associated with the response to stress and the hypothalamic–pituitary–adrenal (HPA) axis. The aim of this study was to summarize the results obtained in genetic studies that analyzed the HPA axis—stress pathway and SB through a systematic review. Methods: We performed an online search in PubMed, EBSCO, Web of Science, Scopus, and PsycoInfo databases up to May 2021. We followed the PRISMA guidelines for systematic reviews. We included case-control and expression studies that provided data on mRNA expression and single-nucleotide polymorphisms of genes associated with SB. Results: A total of 21,926 individuals participated across 41 studies (not repeats); 34 studies provided data on single-nucleotide polymorphisms in 21,284 participants and 11 studies reported data on mRNA expression in 1034 participants. Ten genes were identified: FKBP5, CRH, CRHBP, CRHR1, CRHR2, NR3C1, NR3C2, SKA2, MC2R, and POMC. Conclusions: Our findings suggest that key stress pathway genes are significantly associated with SB and show potential as biomarkers for SB.

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The Influence of Single Nucleotide Polymorphisms of NOD2 or CD14 on Susceptibility to Tuberculosis: A Systematic Review

10.21203/rs.3.rs-91021/v1 ◽

2020 ◽

Author(s):

Juan M Cubillos-Angulo ◽

Catarina D Fernandes ◽

Davi N Araújo ◽

Cristinna A Carmo ◽

María B Arriaga ◽

...

Keyword(s):

Systematic Review ◽

Single Nucleotide Polymorphisms ◽

Causes Of Death ◽

Nucleotide Polymorphisms ◽

Chinese Han ◽

Single Nucleotide ◽

Genetic Studies ◽

Quality Scale ◽

Reported Data ◽

The Relationship

Abstract Background: Tuberculosis (TB) is still one of the leading causes of death worldwide. Genetic studies have pointed to the relevance of the NOD2 and CD14 polymorphic alleles in association with susceptibility or resistance to TB. Methods: A systematic review was performed on search platforms to examine the association between single nucleotide polymorphisms (SNP) and TB risk. Study quality was evaluated using the Newcastle-Ottawa Quality Scale (NOQS) Results: Thirteen studies matched the selection criteria. Of those, 9 investigated CD14 SNPs, and 6 reported a significant association between the T allele and TT genotypes of the rs2569190 SNP and increased TB risk. In contrast, the genotype CC was found to be protective against the disease. Furthermore, in two studies, rs2569191 SNP of the CD14, G allele was described to be significantly associated with increased TB risk. Four studies reported data uncovering the relationship between NOD2 SNPs and TB risk, with two of them reporting significant associations of rs1861759 and rs7194886 and higher TB risk in a Chinese Han population. Paradoxically, minor allele carriers (CG or GG) of rs2066842 and rs2066844 NOD2 SNPs were associated with lower TB risk in African Americans. Conclusions: The CD14 rs2569190 and rs2569191 polymorphisms influence TB risk depending on the allele. Furthermore, there is significant association between NOD2 SNPs rs1861759 and rs7194886 and augmented risk of TB, especially in persons with Chinese ethnicity. The referred polymorphisms of CD14 and NOD2 genes likely play an important role in TB susceptibility and physiopathology; such effect may be affected by ethnicity.Systematic review registration: CRD42020186523

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The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review

Systematic Reviews ◽

10.1186/s13643-021-01729-y ◽

2021 ◽

Vol 10 (1) ◽

Author(s):

Juan M. Cubillos-Angulo ◽

Catarina D. Fernandes ◽

Davi N. Araújo ◽

Cristinna A. Carmo ◽

María B. Arriaga ◽

...

Keyword(s):

Systematic Review ◽

Mycobacterium Tuberculosis ◽

Single Nucleotide Polymorphisms ◽

Nucleotide Polymorphisms ◽

Chinese Han ◽

Single Nucleotide ◽

Quality Scale ◽

Increased Risk ◽

Reported Data ◽

The Relationship

Abstract Background Tuberculosis (TB) is still one of the leading causes of death worldwide. Genetic studies have pointed to the relevance of the NOD2 and CD14 polymorphic alleles in association with the risk of diseases caused by Mycobacterium tuberculosis (Mtb) infection. Methods A systematic review was performed on PubMed, EMBASE, Scientific Electronic Library Online (SciELO), and Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs) to examine the association between single nucleotide polymorphisms (SNP) and risk of Mtb diseases. Study quality was evaluated using the Newcastle-Ottawa Quality Scale (NOQS), and the linkage disequilibrium was calculated for all SNPs using a webtool (Package LDpop). Results Thirteen studies matched the selection criteria. Of those, 9 investigated CD14 SNPs, and 6 reported a significant association between the T allele and TT genotypes of the rs2569190 SNP and increased risk of Mtb diseases. The genotype CC was found to be protective against TB disease. Furthermore, in two studies, the CD14 rs2569191 SNP with the G allele was significantly associated with increased risk of Mtb diseases. Four studies reported data uncovering the relationship between NOD2 SNPs and risk of Mtb diseases, with two reporting significant associations of rs1861759 and rs7194886 and higher risk of Mtb diseases in a Chinese Han population. Paradoxically, minor allele carriers (CG or GG) of rs2066842 and rs2066844 NOD2 SNPs were associated with lower risk of Mtb diseases in African Americans. Conclusions The CD14 rs2569190 and rs2569191 polymorphisms may influence risk of Mtb diseases depending on the allele. Furthermore, there is significant association between NOD2 SNPs rs1861759 and rs7194886 and augmented risk of Mtb diseases, especially in persons of Chinese ethnicity. The referred polymorphisms of CD14 and NOD2 genes likely play an important role in risk of Mtb diseases and pathology and may be affected by ethnicity. Systematic review registration CRD42020186523

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The impact of vascular endothelial growth factor single nucleotide polymorphisms in the development and severity of endometriosis: A systematic review of the literature

Journal of Gynecology Obstetrics and Human Reproduction ◽

10.1016/j.jogoh.2020.101732 ◽

2020 ◽

Vol 49 (10) ◽

pp. 101732

Author(s):

Vasilios Pergialiotis ◽

Maria Fanaki ◽

Ioannis Bellos ◽

Konstantinos Stefanidis ◽

Dimitrios Loutradis ◽

...

Keyword(s):

Systematic Review ◽

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Single Nucleotide Polymorphisms ◽

Vascular Endothelial ◽

Nucleotide Polymorphisms ◽

Review Of The Literature ◽

Single Nucleotide ◽

Endothelial Growth Factor ◽

The Impact

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Associations between Single Nucleotide Polymorphisms and Total Energy, Carbohydrate, and Fat Intakes: A Systematic Review

Advances in Nutrition ◽

10.1093/advances/nmy024 ◽

2018 ◽

Vol 9 (4) ◽

pp. 425-453 ◽

Cited By ~ 10

Author(s):

Theresa Drabsch ◽

Jennifer Gatzemeier ◽

Lisa Pfadenhauer ◽

Hans Hauner ◽

Christina Holzapfel

Keyword(s):

Systematic Review ◽

Single Nucleotide Polymorphisms ◽

Total Energy ◽

Nucleotide Polymorphisms ◽

Single Nucleotide

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Association between melatonin receptor gene polymorphisms and polycystic ovarian syndrome: a systematic review and meta-analysis

Bioscience Reports ◽

10.1042/bsr20200824 ◽

2020 ◽

Vol 40 (6) ◽

Author(s):

Shiqi Yi ◽

Jiawei Xu ◽

Hao Shi ◽

Wenbo Li ◽

Qian Li ◽

...

Keyword(s):

Systematic Review ◽

Single Nucleotide Polymorphisms ◽

Polycystic Ovarian Syndrome ◽

Meta Analysis ◽

Genetic Models ◽

Cochrane Library ◽

Nucleotide Polymorphisms ◽

Melatonin Receptor ◽

Single Nucleotide ◽

Ovarian Syndrome

Abstract Background: Polycystic ovarian syndrome (PCOS) is a kind of common gynecological endocrine disorder. And the mutations of melatonin receptor (MTNR) genes are related to the occurrence of PCOS. But previous researches have shown opposite results. So, the object of our systematic review and meta-analysis is to investigate the relationship between MTNR 1A/B polymorphisms and PCOS. Methods: PubMed, Embase, Ovid, the Cochrane Library, Web of Science and three Chinese databases (VIP, CNKI and Wanfang) were used to retrieve eligible articles published between January 1980 and February 2020. And we used the odds ratio (OR) and its 95% confidence interval (CI) to investigate the strength of the association by six genetic models, allelic, codominant (homozygous and heterozygous), dominant, recessive and superdominant models. Review Manager 5.3, IBM SPSS statistics 25 and Stata MP 16.0 software were used to do this meta-analysis. Results: Our meta-analysis involved 2553 PCOS patients and 3152 controls, for two single nucleotide polymorphisms (rs10830963 C> G in MTNR1B and rs2119882 T> C in MTNR1A) and significant associations were found in some genetic models of these single nucleotide polymorphisms (SNPs). For rs10830963, strongly significant was found in the heterozygote model (GC vs. CC, P=0.02). Additionally, a slight trend was detected in the allelic (G vs. C), homozygote (GG vs. CC) and dominant (GG+GC vs. CC) model of rs10830963 (P=0.05). And after further sensitivity analysis, a study with high heterogeneity was removed. In the allelic (P=0.000), homozygote (P=0.001), dominant (P=0.000) and recessive (GG vs. GC+CC, P=0.001) model, strong associations between rs10830963 and PCOS were found. Moreover, for rs2119882, five genetic models, allelic (C vs. T, P=0.000), codominant (the homozygote (CC vs. TT, P=0.000) and heterozygote model (CT vs. TT, P=0.02), dominant (CC + CT vs. TT, P=0.03) and recessive model (CC vs. CT + TT, P=0.000) showed significant statistical associations with PCOS. Conclusion: MTNR1B rs10830963 and MTNR1B rs2119882 polymorphisms are associated with PCOS risk. However, the above conclusions still require being confirmed by much larger multi-ethnic studies.

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