scholarly journals Mitigation of Particulate Matter-Induced Inflammation and Vasoactivity in Human Vascular Endothelial Cells by Omega-3 Polyunsaturated Fatty Acids

2018 ◽  
Vol 15 (10) ◽  
pp. 2293
Author(s):  
Jaya Sriram ◽  
Olorunfemi Adetona ◽  
Tonya Orchard ◽  
Chieh-Ming Wu ◽  
James Odei
Keyword(s):  
Fatty Acids ◽  
Endothelial Cells ◽  
Particulate Matter ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Umbilical Vein ◽  
Diesel Exhaust Particles ◽  
Omega 3 ◽  
Oil Formulation

Airborne particulate matter (PM) exposure remains the leading environmental risk factor for disease globally. Interventions to mitigate the adverse effects of PM are required, since there is no discernible threshold for its effects, and exposure reduction approaches are limited. The mitigation of PM (specifically diesel exhaust particles (DEP))-induced release of pro-inflammatory cytokines interleukin-6 (IL-6) and interleukin-8 (IL-8) and vasoconstrictor endothelin-1 (ET-1) after 24 and 48 h of exposure by pre-treatment with individual pure, combined pure, and an oil formulation of two fish oil omega-3 polyunsaturated fatty acids (ω-3 PUFAs), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) were all tested at an equivalent concentration of 100 µM in vitro in human umbilical vein endothelial cells. The PUFAs and fish oil formulation completely mitigated or diminished the DEP-induced release of IL-6, IL-8, and ET-1 by 14–78%. DHA was more effective in reducing the levels of the DEP-induced release of the cytokines, especially IL-6 after 48 h of DEP exposure in comparison to EPA (p < 0.05), whereas EPA seemed to be more potent in reducing ET-1 levels. The potential of fish ω-3 PUFAs to mitigate PM-induced inflammation and vasoactivity was demonstrated by this study.

scholarly journals Fish oil omega-3 polyunsaturated fatty acids attenuate oxidative stress-induced DNA damage in vascular endothelial cells

PLoS ONE ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. e0187934 ◽  
Author(s):  
Chiemi Sakai ◽  
Mari Ishida ◽  
Hideo Ohba ◽  
Hiromitsu Yamashita ◽  
Hitomi Uchida ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Dna Damage ◽  
Endothelial Cells ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Omega 3

scholarly journals The Effect of Omega-3 and Omega-6 Polyunsaturated Fatty Acids on the Production of Cyclooxygenase and Lipoxygenase Metabolites by Human Umbilical Vein Endothelial Cells

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 966 ◽  
Author(s):  
Pedro Araujo ◽  
Ikram Belghit ◽  
Niels Aarsæther ◽  
Marit Espe ◽  
Eva Lucena ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Endothelial Cells ◽  
Polyunsaturated Fatty Acids ◽  
Umbilical Vein ◽  
Principal Component ◽  
Omega 3 ◽  
Human Umbilical Vein ◽  
Omega 6 ◽  
Umbilical Vein Endothelial Cells ◽  
Main Effects

Although the correlation between polyunsaturated fatty acids (PUFA) and the production of pro- and anti-inflammatory metabolites is well documented, little is known about the simultaneous effect of different PUFA on the production of cyclooxygenase and lipoxygenase metabolites. The present research examines the association between different omega-3 (ω-3) and omega-6 (ω-6) PUFA and the release of four cyclooxygenase and six lipoxygenase metabolites in cell medium by human umbilical vein endothelial cells (HUVEC). The different combinations of ω-3 and ω-6 PUFA were prepared according to a full 24 factorial design that enables studying not only the main effects but also the different interactions between fatty acids. In addition, interactions diagrams and principal component analysis were useful tools for interpreting higher order interactions. To the best of our knowledge, this is the first report addressing the combined effect of ω-3 and ω-6 PUFA on the signaling of prostaglandins, prostacyclins, leukotrienes and resolvins by HUVEC.

Enrichment of spreadable fats with polyunsaturated fatty acids omega-3 using fish oil

2001 ◽  
Vol 52 (6) ◽  
pp. 469-476 ◽  
Author(s):  
Wojciech Kolanowski ◽  
Franciszek Swiderski ◽  
Ewa Lis ◽  
Stanislaw Berger
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Omega 3

scholarly journals Successful high‐level accumulation of fish oil omega‐3 long‐chain polyunsaturated fatty acids in a transgenic oilseed crop

2013 ◽  
Vol 77 (2) ◽  
pp. 198-208 ◽  
Author(s):  
Noemi Ruiz‐Lopez ◽  
Richard P. Haslam ◽  
Johnathan A. Napier ◽  
Olga Sayanova
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Oilseed Crop ◽  
Omega 3 ◽  
High Level ◽  
Long Chain

scholarly journals Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E2and Nitric Oxide during Experimental Murine Paracoccidioidomycosis

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
S. C. Sargi ◽  
M. M. O. Dalalio ◽  
A. G. Moraes ◽  
J. E. L. Visentainer ◽  
D. R. Morais ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Peritoneal Macrophages ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Potential Health ◽  
Macrophage Activity ◽  
Experimental Paracoccidioidomycosis

There has recently been increased interest in the potential health effects of omega-3 polyunsaturated fatty acids on the immune system. Paracoccidioidomycosis is the most important endemic mycosis in Latin America. Macrophages have a fundamental role and act as first line of organism defense. The purpose of this study was to analyze the effect of n-3 fatty acids on the production of PGE2and NO by mice infected with Pb18 and fed a diet enriched with LNA for 8 weeks. To study the effect of omega-3 fatty acids on macrophage activity during experimental paracoccidioidomycosis, mice were infected with Pb18 and fed a diet supplemented with LNA. PGE2in the serum of animals was analyzed and NO in the supernatants of macrophages cultured and challengedin vitrowith Pb18 was measured. Omega-3 fatty acids seemed to decrease the production of PGE2in vivoin the infected group fed an LNA-supplemented diet during the 4th and 8th weeks of the experiment. At the same time, we observed an increase in synthesis of NO by peritoneal macrophages in this group. Omega-3 fatty acids thus appear to have an immunomodulatory effect in paracoccidioidomycosis.

Biomarkers of Fish Oil Omega-3 Polyunsaturated Fatty Acids Intake in Humans

2013 ◽  
Vol 29 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Veronica Silva ◽  
Rocco Barazzoni ◽  
Pierre Singer
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Omega 3
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