ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations

The ENAM gene is important in the formation of tooth enamel; an alteration can affect the lengthening of the crystals, and the thickness in enamel. The objective was to determine the presence of the single nucleotide variant (SNV) rs12640848 of the ENAM gene in students exposed to different concentrations of fluoride. Methods: A cross-sectional study was conducted on students exposed to high concentrations of fluoride in the city of Durango which were divided according to the severity of fluorosis and dental caries. Genotype determination was performed by DNA sequencing. The relationship between the severity of dental fluorosis and the allele distribution was determined by the Fisher’s exact and Kruskal–Wallis tests. Results: Seventy-one students were included for the sequencing. In the different allelic variations, for the normal genotype AA/TT, the control group presented 75%, for the AG/TC variation, 70.8% in the TF ≤ 4 group, 65% in TF ≥ 5, and 16.7% in TF = 0; with respect to GG/CC variation, 12.5% in TF ≤ 4, 22% in TF ≥ 5, and 8.3% in TF = 0 group (p = 0.000). Conclusion: The ENAM gene showed an association in the population exposed to different concentrations of fluoride.

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The Interaction between Coffee: Caffeine Consumption, UCP2 Gene Variation, and Adiposity in Adults—A Cross-Sectional Study

Journal of Nutrition and Metabolism ◽

10.1155/2019/9606054 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Harry Freitag Luglio Muhammad ◽

Dian Caturini Sulistyoningrum ◽

Emy Huriyati ◽

Yi Yi Lee ◽

Wan Abdul Manan Wan Muda

Keyword(s):

Body Weight ◽

Body Fat ◽

Coffee Consumption ◽

Cross Sectional Study ◽

Caffeine Intake ◽

Coffee Intake ◽

Cross Sectional ◽

Gene Variation ◽

Ucp2 Gene ◽

The Relationship

Background. Coffee is suggested as an alternative option for weight loss but the relationship between coffee consumption and adiposity in population-based studies is still controversial. Therefore, this study was aimed at evaluating the relationship between coffee intake and adiposity in adults and to test whether uncoupling protein 2 (UCP2) gene variation was able to affect this relationship. Methods. This was a cross-sectional study conducted in male and female adults living in the urban area of Yogyakarta, Indonesia. Adiposity was determined based on body weight, body mass index (BMI), percent body fat, and waist and hip circumference. Data on coffee consumption and other dietary components were collected using a semiquantitative food frequency questionnaire along with other caffeine-containing beverages such as tea, chocolate, and other beverages. The −866 G/A UCP2 gene variation was analyzed using polymerase chain reaction-restriction fragment length polymorphism. The correlation between coffee intake and adiposity was tested using linear regression test with adjustment for sex, age, energy intake, table sugar intake, and total caffeine intake. Results. In all subjects, coffee intake was inversely correlated with body weight (β = −0.122, p=0.028), BMI (β = −0.157, p=0.005), and body fat (β = −0.135, p=0.009). In subjects with AA + GA genotypes, coffee intake was inversely correlated with body weight (β = −0.155, p=0.027), BMI (β = −0.179, p=0.010), and body fat (β = −0.148, p=0.021). By contrast, in subjects with GG genotype, coffee intake was not correlated with body weight (β = −0.017, p=0.822), BMI (β = −0.068, p=0.377), and body fat (β = −0.047, p=0.504). Conclusion. We showed that coffee intake was negatively correlated with adiposity, and this was independent of total caffeine intake. Additionally, we showed that the −866 G/A UCP2 gene variation influences the relationship between coffee intake and adiposity.

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Mathematical modeling of the health condition of medical workers

Kazan medical journal ◽

10.17816/kmj2164 ◽

2012 ◽

Vol 93 (1) ◽

pp. 129-134

Author(s):

T A Ermolina ◽

A V Shishova ◽

N A Martynova ◽

A G Kalinin ◽

S V Krasilnikov

Keyword(s):

Sharp Decrease ◽

Cross Sectional Study ◽

Health Condition ◽

Control Group ◽

Immunological Parameters ◽

Cross Sectional ◽

Histocompatibility Complex ◽

Hla Dr ◽

The Social ◽

The Relationship

Aim. To create a mathematical model for identification of the relationship between the health of medical workers and the social and occupational factors, as well as a number of laboratory parameters. Methods. In an oncological hospital conducted was a cross-sectional study of the immune status of medical workers, principally the content of subpopulations of T and B lymphocytes. The model «level of health of medical workers» is based on an examination of 96 members of the medical staff who work on radiation emitting equipment, which were divided into five groups according to the nosological forms of identified diseases. The control group consisted of 98 individuals of the same medical facility, who are office workers. Results. In the individuals, who are exposed to radiation, revealed was a reduction in the functional activity of T lymphocytes, as well as an increase in the activity of natural killer cells. In the first and fifth groups (risk of tumors and diseases of the nervous system) noted was a sharp decrease in the expression of the antigens of the major histocompatibility complex system, and a reduction of the number of HLA-DR cells. In the first and second groups (risk of tumors and respiratory diseases) a decrease in the number of cells with receptors for transferrin CD71 occurred. Conclusion. The presented method of mathematical interpretation of the immunological parameters of blood will make it possible to determine the appurtenance of new study objects to a particular risk group, that is, to identify a predisposition to various diseases.

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Is salivary fluoride a better noninvasive indicator of progressive periodontal disease than invasive serum fluoride – A Cross Sectional study

International Journal Of Medical Science And Clinical Invention ◽

10.18535/ijmsci/v5i4.09 ◽

2018 ◽

Vol 5 (4) ◽

pp. 3756-3759

Author(s):

Dr. Suryakanth Malgikar ◽

Dr. Madanika P

Keyword(s):

Periodontal Disease ◽

Disease Severity ◽

Chronic Periodontitis ◽

Dental Fluorosis ◽

Test Group ◽

Cross Sectional Study ◽

Control Group ◽

Cross Sectional ◽

Group I ◽

Electrode Method

Periodontitis is seen as resulting from a complex interplay of bacterial infection and host response, modified by behavioral and systemic risk factors.There is high prevalence of endemic fluorosis among the patients in certain regions in India and scarcity of information on the effects of levels of fluoride in serum and saliva to the periodontal disease severity. Aim of the present study was to estimate the levels of fluoride in serum and saliva and in ground water of chronic periodontitis subjects in the endemic fluorosed area and to correlate the levels of fluoride in serum and saliva to the periodontal disease severity.140 subjects were divided into two groups. Group I (Test group) consisted of 100 dental subjects diagnosed with dental fluorosis and chronic periodontitis. Group II (Control group) consisted of 40 non-fluorosed subjects. Ion selective electrode method was used for assessingthe fluoride in serumand saliva. There was no significant correlation between salivary and serum fluoride levels and the periodontal disease severity. However the mean salivary fluoride levels were found to significantly influence the dental fluorosis severity (p<0.005*).

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Relationship between migraine and sleep disorders in adolescents

Paediatrica Indonesiana ◽

10.14238/pi53.4.2013.214-7 ◽

2013 ◽

Vol 53 (4) ◽

pp. 214

Author(s):

Lina Waty ◽

Supriatmo Supriatmo ◽

Bistok Saing

Keyword(s):

Sleep Disorders ◽

Cross Sectional Study ◽

Control Group ◽

Cross Sectional ◽

Significant Difference ◽

Headache Type ◽

Migraine Group ◽

And Control ◽

The Relationship ◽

Sleeping Disorder

Background Headaches and sleep disorders may influenceacademic performances, personality, memory, and interpersonalrelationships. Migraine is the most common headache type seen inadolescents. Although headaches and sleep disorders are believedto be related, there has been little study in this area.Objectives To assess the relationship between migraine andsleep disorders in adolescents and compare different types ofsleep disorders found in adolescents with migraine vs. healthyadolescents.Methods We conducted a cross sectional study in December 2009on students of three junior high schools in the Secanggang District,Langkat Regency, North Sumatera. We included adolescents aged12 to 17 years who suffered from migraines, as defined by theInternational Cftissificaticm of Headache Disorders, 2nd edition criteria(ICHD-II), and h ealthy adolescents who did not experien cemigraines as the control group. Parents filled questionnaires ontheir child's sleep patterns for one week.Results A total of 100 adolescents were enrolled in the study,consisted of 50 adolescents in the migraine group and the others50 in the control group. There was a significant difference in theincidence of sleep disorders between the two groups (76% and30%, in the case and control groups, respectively; P= 0.0001).Moreover, significant differences were also found in the prevalenceof different sleeping disorder types between the case and controlgroups, i.e. insomnia (62% and 30%, respectively; P= 0.003), sleepapnea (56% and 16%, respectively; P= 0.0001), restlessness (56%and 18%, respectively; P= 0.0001) , parasomnia (76% and 10%,respectively; P= 0.0001), narcolepsy (42% and 16%, respectively;P= 0.008), and excessive daytime sleepiness (50% and 26%,respectively; P= 0.023).Conclusions Migraine in adolescents is significantly associatedwith sleep disorders. Parasomnia is the most common type ofsleeping disorder observed in adolescents with migraines in ourstudy.

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Asbestos-Related Malignant Mesothelioma in The South of Iran: A Cross-Sectional Study

10.21203/rs.3.rs-122294/v2 ◽

2021 ◽

Author(s):

Alireza Rezvani ◽

Sahar Jahanshahi ◽

Damoun Fouladi ◽

Bizhan Ziaian ◽

Mohammad Javad Fallahi ◽

...

Keyword(s):

Malignant Mesothelioma ◽

Asbestos Exposure ◽

Cross Sectional Study ◽

Control Group ◽

Sectional Study ◽

Cross Sectional ◽

Rare Malignancy ◽

The Relationship ◽

Oil Company

Abstract Objective: Malignant Mesothelioma (MM) is a rare malignancy of the serosa membranes with a high mortality rate and long latent period. The relationship between a group of mineral fibers known as asbestos and mesothelioma is now well accepted in which people can be exposed to these fibers by various means during their lifetime.Method: In this study, we analyzed the demographic features and occupations of confirmed cases of MM in Shiraz, southern Iran along with the follow-up of the patients' disease from 2008 to 2018.Results: Among the 35 confirmed cases of MM with an average of 61 years, 9 (25.7%) were female and 26 (74.3%) were male. At the time 12 patients have already died with a mean of 11.26 months after diagnosis. Our results showed a higher prevalence of MM among housekeepers and oil company employees. Compared to the control group, we concluded that employees of the oil company are at a high risk of MM in Iran. Also, individuals living near refinery locations had higher MM rates.Conclusion: Exposure with asbestos, either through occupation or proximate living location to a source, had a significant correlation with MM occurrence. MM can be prevented if asbestos exposure is reduced.

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The Relationship between Serum Sclerostin Levels and Bone Mineral Disorders and Vascular Calcification in Hemodialysis Patients

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2021.7578 ◽

2021 ◽

Vol 9 (B) ◽

pp. 1664-1671

Author(s):

Emad Abdallah ◽

Nevine Sherif ◽

Osama Mosbah ◽

Amna Metwally ◽

Ibrahim Abd ElAzim ◽

...

Keyword(s):

Vascular Calcification ◽

Bone Mineral ◽

Cross Sectional Study ◽

Hemodialysis Patients ◽

Control Group ◽

Cross Sectional ◽

Valvular Calcification ◽

Bone Mineral Densitometry ◽

The Mean ◽

The Relationship

Background and aim of the study: Sclerostin is produced by osteocytes and has been shown to down-regulate the synthesis of many markers of bone formation by osteogenic cells. The aim of this study to investigate the relationship between serum sclerostin levels and bone mineral disorders and vascular calcification in hemodialysis patients (HD). Methods:This is a cross-sectional study of 70 patients with ESRD on regular HD for at least six months, Theodor Bilharz Research Institute, Giza, Egypt.Twenty-five subjects who matched the ages, genders, and demographics of the study patients were included as a control group.All patients and control groups included in the study underwent a full through history and clinical examination. Serum calcium, phosphorus, alkaline phosphatase and intact PTH (iPTH) levels were measured. Serum sclerostin was measured by an ELISA. Bone Mineral Densitometry Measurements BMD (g/cm2) was determined by dual-energy X-ray absorptiometry (DXA). CT scan was done to detect the presence or absence of vascular calcification and transthoracic echocardiogram to detect the presence or absence of valvular calcification. Results:The mean seumscleostin levels was a statistically significant high in the HD patients when compared with the control group (156.8 ±121.4 Vs.29.38±0.84, p =0.0001 ) and statistically significant high mean ALP in the HD patients when compared with the control group (147.2 ± 94.3 Vs. 38.8 ±23.4, p = 0.0001). The mean BMD was statistically significant low in the HD patients when compared with the controls (0.839±0.086 g/ m2 Vs.1.306 ±0.153 g/ m2, p = 0.0001).The mean seumscleostin levels was statistically significant high in the HD patients with vascular and valvular calcification when compared with HD patients without calcification.Using spearman correlation coefficient analysis, there was statistically significant negative correlations between serum sclerostin levels and iPTH(r=-0.362, p =0.0021), ALP (r=-0.301, p =0.0114), and BMD (r=-0.469, p =0.0278 ), and there was a statistically significant positive correlation between serum sclerostin levels and phosphate(r=0.5829, p =0.0001 ).Independent predictors of BMD in HD patients were determined using multi-variate regression analysis. Sclerostin levels, iPTH, ALP, and age were found to be independent predictors of BMD. Conclusion: High sclerostin levels in patients with ESRD on HD were associated with high risk of vascular and valvularcalcification and were independent predictors of low BMD in such population.

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Asbestos-Related Malignant Mesothelioma in The South of Iran: A Cross-Sectional Study

10.21203/rs.3.rs-122294/v1 ◽

2020 ◽

Author(s):

Alireza Rezvani ◽

Sahar Jahanshahi ◽

Damoun Fouladi ◽

Bizhan Ziaian ◽

Mohammad Javad Fallahi ◽

...

Keyword(s):

Malignant Mesothelioma ◽

Asbestos Exposure ◽

Cross Sectional Study ◽

Control Group ◽

Sectional Study ◽

Cross Sectional ◽

Rare Malignancy ◽

The Relationship ◽

Oil Company

Abstract Background: Malignant Mesothelioma (MM) is a rare malignancy of the serosa membranes with a high mortality rate and long latent period. The relationship between a group of mineral fibers known as asbestos and mesothelioma is now well accepted in which people can be exposed to these fibers by various means during their lifetime. In addition to occupations directly in contact with asbestos such as asbestos mines and factories, certain occupations are much more at risk of MM due to extensive use of asbestos in industry. Several studies have been conducted to identify these occupations.Method: In this study, we analyzed the demographic features and occupations of confirmed cases of MM in Shiraz, southern Iran along with the follow-up of the patients' disease from 2008 to 2018.Results: Among the 35 confirmed cases of MM with an average of 61 years, 9 (25.7%) were female and 26 (74.3%) were male. At the time 12 patients have already died with a mean of 11.26 months after diagnosis. Our results showed a higher prevalence of MM among housekeepers and oil company employees. Compared to the control group, we concluded that employees of the oil company are at a high risk of MM in Iran. Also, individuals living near refinery locations had higher MM rates. Conclusion: Our study demonstrated that exposure with asbestos, either through occupation or proximate living location to a source, had a significant correlation with MM occurrence. MM can be prevented if asbestos exposure is reduced.

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Coping Style as a Mediator of the Relationship Between Depressive Symptoms and Deliberate Self-Harm

Crisis ◽

10.1027/0227-5910/a000083 ◽

2011 ◽

Vol 32 (5) ◽

pp. 272-279 ◽

Cited By ~ 9

Author(s):

Allison S. Christian ◽

Kristen M. McCabe

Keyword(s):

Depressive Symptoms ◽

Undergraduate Students ◽

Cross Sectional Study ◽

Self Report ◽

Hierarchical Regression ◽

Cross Sectional ◽

Deliberate Self Harm ◽

Self Blame ◽

Self Harm ◽

The Relationship

Background: Deliberate self-harm (DSH) occurs with high frequency among clinical and nonclinical youth populations. Although depression has been consistently linked with the behavior, not all depressed individuals engage in DSH. Aims: The current study examined maladaptive coping strategies (i.e., self-blame, distancing, and self-isolation) as mediators between depression and DSH among undergraduate students. Methods: 202 students from undergraduate psychology courses at a private university in Southern California (77.7% women) completed anonymous self-report measures. Results: A hierarchical regression model found no differences in DSH history across demographic variables. Among coping variables, self-isolation alone was significantly related to DSH. A full meditational model was supported: Depressive symptoms were significantly related to DSH, but adding self-isolation to the model rendered the relationship nonsignificant. Limitations: The cross-sectional study design prevents determination of whether a casual relation exists between self-isolation and DSH, and obscures the direction of that relationship. Conclusions: Results suggest targeting self-isolation as a means of DSH prevention and intervention among nonclinical, youth populations.

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DYSLIPIDEMIA IN THYROID DISORDERS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v4i7.1308 ◽

2020 ◽

Vol 4 (7) ◽

Author(s):

Kashish Narula ◽

Narendra Kumar Dara ◽

Shyam Lal Meena

Keyword(s):

Lipid Metabolism ◽

Thyroid Dysfunction ◽

Cross Sectional Study ◽

Control Group ◽

Thyroid Disorders ◽

Cross Sectional ◽

Carbohydrate And Lipid Metabolism ◽

History Of ◽

Thyroid Profile ◽

Basal Energy Expenditure

Background: Thyroid hormones influence nearly all major metabolic pathways. Their most obvious and well-known action is the increase in basal energy expenditure obtained by acting on protein, carbohydrate and lipid metabolism. The lipid metabolism is more influenced by the thyroid hormone. Methods: A cross-sectional study was conducted on 100 patients with suspicion of thyroid disorders were taken as cases. One hundred patients with normal thyroid profile and no history of other chronic diseases were taken as control group. Results: The serum TC, TG and LDL levels in hypothyroid individuals (both overt and subclinical) were significantly higher than euthyroid subjects but the levels were comparable between hyperthyroid and euthyroid group. Conclusion: Dyslipidemias are associated with thyroid disorders, so biochemical screening for thyroid dysfunction in all dyslipidemic patients. Therefore, patients presenting with dyslipidemia are recommended for investigation to explore thyroid dysfunction. Keywords: Thyroid profile, Total cholesterol, Triglycerides and LDL

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Pengaruh bising lalu lintas terhadap penurunan fungsi pendengaran pada juru parkir di kota Denpasar

Oto Rhino Laryngologica Indonesiana ◽

10.32637/orli.v40i2.3 ◽

2013 ◽

Vol 40 (2) ◽

Cited By ~ 1

Author(s):

Ni Ketut Susilawati ◽

Wayan Sudana ◽

Eka Putra Setiawan

Keyword(s):

Hearing Impairment ◽

Noise Exposure ◽

Traffic Noise ◽

Hearing Threshold ◽

Noise Pollution ◽

Simple Random Sampling ◽

Cross Sectional Study ◽

Control Group ◽

Cross Sectional ◽

Hearing Function

Background: Noise pollution or noise is an unwanted sound which is disturbing to human beings.However small or soft the sound, if it is undesirable it is considered as noise. Noise induced hearingloss is a sensorineural hearing loss that is commonly encountered second to presbycusis. Purpose: Toknow the effect of traffic noise exposure on hearing impairment to the employees of the Parking DistrictCompany of the Denpasar city and to improve diagnostic detection on hearing impairment caused bynoise. Method: A cross sectional study was conducted at the Parking District Company office. Thepopulations of this study were the employees of the Parking District Company. Samples of this study were the employees who were exposed to traffic noise and control samples were an employee who was unexposed. Samples were selected by simple random sampling. Results: From 40 parking attendants,27 persons (67.5%) aged above 35 years old. The parking attendants who had been working for ten to fifteen years were 36 persons (90%) and no history using ear protection when working. Seven persons(17.5%) had referred DPOAE upon examination with increase hearing threshold on audiogram result.In this study the parking attendants who had hearing deficit induced by noise were 7 persons (17.5%)and only one person (2.5%) in control group. There was a statistically significant effect of traffic noiseto hearing function deficit (p<0.05). Conclusion: Traffic noise has effect in hearing function deficit onthe parking attendants.ORLI Vol. 40 No. 2 Tahun 2010Key words: NIHL, parking attendant, audiometry, DPOAE.

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