scholarly journals Habitual Combined Exercise Protects against Age-Associated Decline in Vascular Function and Lipid Profiles in Elderly Postmenopausal Women

Author(s):  
Elizabeth J. Pekas ◽  
John Shin ◽  
Won-Mok Son ◽  
Ronald J. Headid ◽  
Song-Young Park

Postmenopausal status is associated with increased risks for cardiovascular diseases (CVD). This study investigated differences in vascular function, lipids, body composition, and physical fitness in elderly postmenopausal women active in combined resistance and aerobic exercise (CRAE) training for 1 year versus a sedentary cohort of similar-in-age counterparts. Elderly postmenopausal women performing habitual CRAE training for 1 year (age ~75 year; CRAE, n = 57) and elderly sedentary postmenopausal women (age ~78 year; SED, n = 44) were recruited. Arterial stiffness (brachial-to-ankle pulse-wave velocity, baPWV), blood pressure, blood lipids, anthropometrics, 2-min walking distance, and muscular strength were assessed for both groups. There were significant differences for baPWV, systolic blood pressure, low-density lipoprotein, and body fat percentage, which were significantly lower (p < 0.05) in CRAE vs. SED, and both 2 min walking distance and muscular strength were significantly greater (p < 0.05) in CRAE vs. SED. These results indicate that elderly postmenopausal women participating in habitual CRAE training may have better protection against risks for CVD and have better physical fitness compared to SED counterparts.

2018 ◽  
Vol 16 (2) ◽  
pp. 175-177
Author(s):  
Gita Khakurel ◽  
Rajat Kayastha ◽  
Sanat Chalise ◽  
Prabin K Karki

Background: Hyperlipidemia is one of the important risk factor for development of cardiovascular disease in post menopausal women.Our study compared the serum lipid profile and atherogenic index of plasma between premenopausal and post menopausal women.Methods: This was a cross sectional study conducted in Kathmandu Medical College. A total number of 194 women in the age group 30 to 60 years were studied. They include 108 postmenopausal women and 86 premenopausal controls. Total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and triglycerides were determined. Results: The mean value of total cholesterol, low-density lipoprotein cholesterol and triglyceride were significantly increased in postmenopausal women when compared to premenopausal women. There was increase in high-density lipoprotein cholesterol in postmenopausal women but the difference was not significant. The atherogenic index of plasma was increased in postmenopausal women (0.22 ± 0.25 mmol/l). This shows that postmenopausal women in our setting are at medium risk of developing cardiovascular disease. Atherogenic index of plasma was positively and significantly correlated with age (r= 0.29, p<0.05), body mass index (r=0.24, p<0.05), systolic blood pressure (r=0.20, p<0.05) and diastolic blood pressure (r=0.45, p<0.05).Conclusions: Postmenopausal women were at greater risk for developing cardiovascular disease when compared to premenopausal women due to increase in atherogenic lipid profile. There was a significant correlation of atherogenic index of plasma with age, body mass index, systolic blood pressure and diastolic blood pressure.Keywords: Keywords: Atherogenic index of plasma; lipid profile; menopause.


2019 ◽  
Vol 7 (11) ◽  
pp. 63
Author(s):  
Pelin Akyol P. ◽  
Osman İmamoğlu

In this study, we aimed to investigate the effects of three months of aerobic exercise on physical fitness, body composition and some blood parameters in sedentary Female. 45 sedentary Female with an average age of 36.11±1.04 years, high of 158.9 ±0.76 cm and weight of 70.83 ±1.67 kg have been selected. Sedentary Females were trained through an aerobic exercises programmed one hour a day for three days a week.  The aerobic exercise time was on 12 weeks. Setting-up exercises and training in each training session were arranged in such a way as to make each woman’s heart rate to between a levels of 130-140 beats per minute. Statistical analysis were done with Paired-t test, Variance analysis and Scheffe tests. At the end of the three months exercise programmed, a decrease of %9.06 in body weight, %9.96 in systolic blood pressure, %6.94 in diastolic blood pressure, %12.42 in total cholesterol, %22.44 in Triglyceride, %21.16 in low density lipoprotein and %21.4 in fat content ratio have been registered. However, there were increases of %26.22 in hand grip power, %63.83 in the maximum oxygen transfer, %6.2 in aerobic strength and %16.34 in high density lipoprotein. Even though the three months exercise has produced significant effect to on systolic blood pressure, jumping, high density lipoprotein cholesterol, Apo-B, Triglyceride, Hip circumference at .01 level. On number of heart beats, hand grip power, waist circumference, the maximum oxygen transfer, Low density lipoprotein cholesterol, Apo A I and fat contents, diastolic blood pressure and aerobic strength at .05 level. Conclusions: The result of three months low intensity aerobic exercises have shown the fact that such exercises could improve high density lipoprotein cholesterol values and physical fitness. Also by the changes of body fat, Triglyceride, total cholesterol and low density lipoprotein cholesterol values parameters it reduces body parameters. The risk for cardiovascular problems are reduced on sedentary females. Aerobic exercises programmers may be recommended to reduce hypertension, weight loss, diabetes, cardiovascular diseases or metabolic diseases on sedentary females between 130-140 heart rate.


2021 ◽  
Vol 12 (2) ◽  
pp. 113-117
Author(s):  
Md Shariful Islam ◽  
TH Johora Moon Moon ◽  
Masuma Amanullah ◽  
Nasima Akhter ◽  
M Moniruzzaman ◽  
...  

Cardiovascular disease (CVD) is one of the leading causes of death worldwide which is more prevalent in women after menopause. Hormonal changes associated with menopause are accountable for dyslipidemia pattern that causes CVD and associated complications. Therefore, the present study was commenced to compare the lipid profile in pre- and postmenopausal women. A total of 100 samples were collected from women, 50 from premenopausal and 50 from postmenopausal women, and analyzed for Total Cholesterol (TC), Triglyceride (TG), High-Density Lipoprotein (HDL) and Low-Density Lipoprotein (LDL-). TC, TG, HDL, and LDL were highly significantly increased in postmenopausal women when compared to premenopausal women. DL/HDL ratio was significantly elevated in postmenopausal women than in premenopausal women. MI was significantly positively correlated with TC and TG in both pre- and postmenopausal population and it was positively correlated with HDL in the premenopausal population while negatively correlated in the postmenopausal population. Since more of the atherogenic lipid parameters are increased in postmenopausal women, they appear to be more prone to have CVD and associated complications in the near future. Hence, it is mandatory to monitor and manage dyslipidemia patterns in every woman experiencing menopause. To investigate whether menopause may induce left ventricular structural and functional adaptations in normotensive and hypertensive women, we compared in a case-control setting 50 untreated hypertensive premenopausal women with 50 postmenopausal women and 50 normotensive premenopausal women with 50 postmenopausal women. Subjects were individually physically examined & matched by age (38.2±5.9years to 50±1.03years), clinic systolic blood pressure (128.6±1.05mm Hg & 134±1.2mm Hg), clinic diastolic blood pressure (74.6±1.3mm Hg & 74.6±1.2mm Hg), and body mass index (55.3±8.8kg to 55.6±5.9kg) respectively. We conclude that menopause is associated with blunted day-night blood pressure reduction, impaired left the ventricular systolic performance, and concentric left ventricular geometric pattern. These findings are independent of the presence or absence of high blood pressure.


Author(s):  
Abdulmecit Afşin ◽  
Eren Bozyılan ◽  
Ramazan Asoğlu ◽  
Fethi Yavuz ◽  
Aykut Dündar

Abstract Objectives To evaluate the effects of an eight week exercise program on the lipid profile in serum, serum levels of adropin, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in male volleyball players. Methods Sixteen healthy male volleyball players participated in this study. Subjects performed eight weeks of aerobic and resistance training, and body mass index (BMI), body fat ratio, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), adropin, SBP, and DBP values were measured at the start (untrained) and end (trained) of training. Non-HDL-C was calculated by subtracting HDL-C from TC. Results Body fat percentage and BMI values decreased significantly after eight weeks of exercise training. There was a statistically significant decrease in the post-test values of LDL-C, TG, non-HDL-C, and DBP compared to pre-test measurements. There was a significant increase in the trained levels of adropin and HDL-C compared to untrained levels. Pearson’s correlation analyses revealed a negative and significant relationship between changes in DBP and adropin levels before and after exercise. Conclusions Eight weeks of exercise training decreased LDL-C, TG, non-HDL-C, and DBP and an increased serum levels of adropin in male volleyball players.


Author(s):  
Rômulo José Mota Júnior ◽  
Renata Aparecida Rodrigues Oliveira ◽  
Mayse Faria Fialho Resende ◽  
Luciana Moreira Lima ◽  
Sylvia Do Carmo Castro Franceschini ◽  
...  

The aim of this study was to verify general and central obesity, as well as the association of anthropometric indicators with cardiovascular risk factors (CvRF) in teachers of the private network of Viçosa-MG. A cross-sectional observational study was conducted with 150 teachers. Body mass index (BMI), conicity index (CI), body adiposity index (BAI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), waist circumference (WC), abdominal circumference (AC) and body fat percentage (%BF); systolic blood pressure (SBP) and diastolic blood pressure (DBP); glycemia (GL), total cholesterol (TC), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) and triglycerides (TG) were evaluated. The prevalence of general and central obesity was calculated in addition to the simple linear regression to verify the association of anthropometric indicators between themselves and with CvRF. General and central obesity was identified in 19% and 17% of teachers respectively. The best associations between anthropometric indicators were between BMI and WHtR (R² = 0.81), WHtR and AC (R² = 0.78) and BMI and AC (R² = 0.76), all of which were positive. Between anthropometric indicators and CvRF, the best associations were found between WHtR and TG (R² = 0.25), AC and SBP (R² = 0.18) and WHR and HDL-c (R² = 0.19), the first two associations being positive and the last negative. It was concluded that approximately one in five teachers presented obesity. The general obesity indicator, BMI, was positively associated with anthropometric indicators and with most CvRF. However, central obesity indicators presented greater explanatory power on CvRF. 


2018 ◽  
Vol 16 (2) ◽  
pp. 175-177
Author(s):  
Gita Khakurel ◽  
Rajat Kayastha ◽  
Sanat Chalise ◽  
Prabin K Karki

Background: Hyperlipidemia is one of the important risk factor for development of cardiovascular disease  in post menopausal women.Our study compared the serum lipid profile and atherogenic index of plasma  between premenopausal and  post menopausal women.Methods: This was a cross sectional study conducted in Kathmandu Medical College.  A total number of 194 women in the age group 30 to 60 years were studied. They include 108 postmenopausal women and 86 premenopausal controls. Total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol  and triglycerides  were determined. Results: The mean value of total cholesterol, low-density lipoprotein cholesterol and triglyceride were significantly increased in postmenopausal women when compared to premenopausal women. There was increase in high-density lipoprotein cholesterol  in postmenopausal women but the difference was not significant. The atherogenic index of plasma was  increased in postmenopausal women (0.22 ± 0.25 mmol/l). This shows that postmenopausal women in our setting are at medium risk of developing cardiovascular disease. Atherogenic index of plasma was positively and significantly correlated with age (r= 0.29, p<0.05), body mass index (r=0.24, p<0.05), systolic blood pressure (r=0.20, p<0.05) and diastolic blood pressure (r=0.45, p<0.05).Conclusions: Postmenopausal women were at greater risk for developing cardiovascular disease when compared to premenopausal women due to increase in atherogenic lipid profile. There was a significant correlation of atherogenic index of plasma  with age, body mass index, systolic blood pressure  and diastolic blood pressure.


Author(s):  
В.В. Шерстнев ◽  
М.А. Грудень ◽  
В.П. Карлина ◽  
В.М. Рыжов ◽  
А.В. Кузнецова ◽  
...  

Цель - исследование взаимосвязи факторов риска сердечно-сосудистых заболеваний и развития предгипертонии. Методика. Проведен сравнительный и корреляционный анализы показателей модифицируемых и немодифицируемых факторов риска сердечно-сосудистых заболеваний у обследованных лиц в возрасте 30-60 лет с «оптимальным» артериальным давлением, (n = 63, АД <120/80 мм рт.ст.) и лиц с предгипертонией (n = 52, АД = 120-139/80-89 мм рт.ст.). Результаты. Показано, что лица с предгипертонией по сравнению с группой лиц, имеющих «оптимальное» артериальное давление характеризуются статистически значимо повышенным содержанием холестерина и холестерина липопротеидов низкой плотности, интеллектуальным характером трудовой деятельности, а также значимыми сочетаниями факторов риска: повышенный уровень холестерина липопротеидов низкой плотности с интеллектуальным характером трудовой деятельности; повышенное содержание креатинина с уровнем триглициридов; наследственная отягощенность по заболеваниям почек и интеллектуальным характером трудовой деятельности; наследственная отягощенность по сахарному диабету и гипертрофия левого желудочка сердца. У лиц с предгипертонией документированы перестройки структуры взаимосвязи (количество, направленность и сила корреляций) между показателями факторов риска в сравнении с лицами, имеющими «оптимальное» артериальное давление. Заключение. Выявленные особенности взаимосвязей факторов риска сердечно-сосудистых заболеваний при предгипертонии рассматриваются как проявление начальной стадии дизрегуляционной патологии и нарушения регуляции физиологических систем поддержания оптимального уровня артериального давления. The aim of the study was to investigate the relationship between risk factors for cardiovascular disease and development of prehypertension. Methods. Comparative and correlation analyses of modifiable and non-modifiable risk factors for cardiovascular disease were performed in subjects aged 30-60 with «optimal» blood pressure (n = 63, BP <120/80 mm Hg) and prehypertension (n = 52, BP = 120-139 / 80-89 mm Hg). Results. The group with prehypertension compared with the «optimal» blood pressure group had significantly increased serum levels of low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol, sedentary/intellectual type of occupation, and significant combinations of risk factors. The risk factor combinations included an increased level of LDL cholesterol and a sedentary/intellectual occupation; increased serum levels of creatinine and triglycerides; hereditary burden of kidney disease and a sedentary/intellectual occupation; hereditary burden of diabetes mellitus and cardiac left ventricular hypotrophy. In subjects with prehypertension compared to subjects with «optimal» blood pressure, changes in correlations (correlation number, direction, and strength) between parameters of risk factors were documented. Conclusion. The features of interrelationships between risk factors for cardiovascular disease observed in prehypertension are considered a manifestation of early dysregulation pathology and disordered regulation of physiological systems, which maintain optimal blood pressure.


2021 ◽  
pp. 155982762110063
Author(s):  
Susan M. Friedman ◽  
Carol Hee Barnett ◽  
Robert Franki ◽  
Bruce Pollock ◽  
Beth Garver ◽  
...  

The 15-day Jumpstart was developed as an evidence-based, affordable, standardized, replicable, and scalable program, designed to demonstrate quickly to patients that changing what they eat can improve their health. The program was designed using the principles of the self-determination theory of motivation and personality. Patients were instructed to eat an Esselstyn-compliant, whole-food plant-based diet consisting of vegetables, fruits, whole grains, and legumes. Of the 389 participants in the program from September 2018 to February 2020, average weight loss was 5.8 pounds (7.3 for those whose body mass index was >30), average systolic blood pressure drop was 6.8 points (16.8 points for those with systolic blood pressure >140), average drop in cholesterol was 26 points (44 points for those with a cholesterol >200), average drop in low-density lipoprotein was 19 points (33 points for those with a low-density lipoprotein >100), and average drop in fasting blood sugar was 5.1 points (28.4 points for those starting in the diabetic range); P value was <.005 for fasting blood sugar and <.001 for all other comparisons. A 15-day program that helps patients adopt an Esselstyn-style whole-food plant-based diet, through education, individualized medical feedback, social support, and facilitated small group work, rapidly improves health.


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