scholarly journals Association between Asthma Control and Exposure to Greenness and Other Outdoor and Indoor Environmental Factors: A Longitudinal Study on a Cohort of Asthmatic Children

2022 ◽  
Vol 19 (1) ◽  
pp. 512
Author(s):  
Giovanna Cilluffo ◽  
Giuliana Ferrante ◽  
Salvatore Fasola ◽  
Velia Malizia ◽  
Laura Montalbano ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Environmental Factors ◽  
Asthma Control ◽  
Vegetation Index ◽  
Normalized Difference Vegetation Index ◽  
Asthma Management ◽  
Asthmatic Children ◽  
Increased Risk ◽  
Passive Smoke ◽  
Unit Increase

Achieving and maintaining asthma control (AC) is the main goal of asthma management. Indoor and outdoor environmental factors may play an important role on AC. The aim of this longitudinal study was to evaluate the association between AC and exposure to greenness and other outdoor or indoor environmental factors in a cohort of asthmatic children. This study involved 179 asthmatic children (5–16 years). Parents were interviewed through a modified version of the SIDRIA questionnaire. AC was assessed at each visit. Exposure to greenness was measured using the normalized difference vegetation index (NDVI). A logistic regression model was applied for assessing risk factors for uncontrolled asthma (UA). Low NDVI exposure was a risk factor for UA (OR: 2.662, 95% CI (1.043–6.799)); children exposed to passive smoke during pregnancy had a higher risk of UA than those non-exposed to passive smoke during pregnancy (OR: 3.816, 95% CI (1.114–13.064)); and a unit increase in the crowding index was associated with an increased risk of UA (OR: 3.376, 95% CI (1.294–8.808)). In conclusion, the current study provided a comprehensive assessment of urban-related environmental exposures on asthma control in children, using multiple indicators of greenness and other outdoor or indoor environmental factors.

The relative importance of environmental factors on the interannual variability of carbon fluxes in the boreal forest

2020 ◽  
Author(s):  
Mariam El-Amine ◽  
Alexandre Roy ◽  
Pierre Legendre ◽  
Oliver Sonnentag
Keyword(s):  
Environmental Factors ◽  
Boreal Forest ◽  
Vegetation Index ◽  
Normalized Difference Vegetation Index ◽  
Carbon Sink ◽  
Growing Season ◽  
Carbon Uptake ◽  
Net Ecosystem Productivity ◽  
Ecosystem Productivity ◽  
Environmental Controls

<p>As climate change will cause a more pronounced rise of air temperature in northern high latitudes than in other parts of the world, it is expected that the strength of the boreal forest carbon sink will be altered. To better understand and quantify these changes, we studied the influence of different environmental controls (e.g., air and soil temperatures, soil water content, photosynthetically active radiation, normalized difference vegetation index) on the timing of the start and end of the boreal forest growing season and the net carbon uptake period in Canada. The influence of these factors on the growing season carbon exchanges between the atmosphere and the boreal forest were also evaluated. There is a need to improve the understanding of the role of the length of the growing season and the net carbon uptake period on the strength of the boreal forest carbon sink, as an extension of these periods might not necessarily result in a stronger carbon sink if other environmental factors are not optimal for carbon sequestration or enhance respiration.</p><p>Here, we used 31 site-years of observation over three Canadian boreal forest stands: Eastern, Northern and Southern Old Black Spruce in Québec, Manitoba and Saskatchewan, respectively. Redundancy analyses were used to highlight the environmental controls that correlate the most with the annual net ecosystem productivity and the start and end of the growing season and the net carbon uptake period. Preliminary results show that the timing at which the air temperature becomes positive correlates the most strongly with the start of the net carbon uptake period (r = 0.70, p < 0.001) and the start of the growing season (r = 0.55, p < 0.01). Although the increase of the normalized difference vegetation index also correlates with the start of these periods, a thorough examination of this result shows that the latter happens well before the former. No dependency between any environmental control and the end of the net carbon uptake period was identified. Also, the annual net ecosystem productivity is highly correlated with the length of the net carbon uptake period (r = 0.54, p < 0.01). Other environmental controls such as annual precipitations, the mean annual soil temperature or the maximum yearly normalized difference vegetation index have a smaller impact on the annual net ecosystem productivity. By extending the dataset to include forest stands that represent a wider climate and permafrost variability, we will examine the generalizability of these results.</p>

scholarly journals Leptospirosis, Climate and Satellite-based Environmental Factors: A Temporal Modeling

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Pandji W. Dhewantara ◽  
Wenbiao Hu ◽  
Wenyi Zhang ◽  
Wenwu Yin ◽  
Fan Ding ◽  
...  
Keyword(s):  
Remote Sensing ◽  
Environmental Factors ◽  
Land Surface Temperature ◽  
Early Warning ◽  
Physical Environment ◽  
Land Surface ◽  
Vegetation Index ◽  
Normalized Difference Vegetation Index ◽  
Remotely Sensed ◽  
Environmental Data

ObjectiveTo quantify the effects of climate variability, selected remotely-sensed environmental factors on human leptospirosis in the high-risk counties in China.IntroductionLeptospirosis is a zoonotic disease caused by the pathogenic Leptospira bacteria and is ubiquitously distributed in tropical and subtropical regions. Leptospirosis transmission driven by complex factors include climatic, environmental and local social conditions 1. Each year, there are about 1 million cases of human leptospirosis reported globally and it causes approximately 60,000 people lost their lives due to infection 2. Yunnan Province and Sichuan Province are two of highly endemic areas in the southwest China that had contributed for 47% of the total national reported cases during 2005-2015 3. Factors underlying local leptospirosis transmission in these two areas is far from clear and thus hinder the efficacy of control strategies. Hence, it is essential to assess and identify local key drivers associated with persistent leptospirosis transmission in that areas to lay foundation for the development of early-warning systems. Currently, remote sensing technology provides broad range of physical environment data at various spatial and temporal scales 4, which can be used to understand the leptospirosis epidemiology. Utilizing satellite-based environmental data combined with locally-acquired weather data may potentially enhance existing surveillance programs in China so that the burden of leptospirosis could be reduced.MethodsThis study was carried out in two counties situated in different climatic zone in the southwestern China, Mengla and Yilong County (Fig 1). Total of 543 confirmed leptospirosis cases reported during 2006-2016 from both counties were used in this analysis. Time series decomposition was used to explore the long-term seasonality of leptospirosis incidence in two counties during the period studied. Monthly remotely-sensed environmental data such as normalized difference vegetation index (NDVI), modified normalized water difference index (MNDWI) and land surface temperature (LST) were collected from satellite databases. Climate data include monthly precipitation and relative humidity (RH) data were obtained from local weather stations. Lagged effects of rainfall, humidity, normalized difference vegetation index (NDVI), modified normalized difference water index (MNDWI) and land surface temperature (LST) on leptospirosis was examined. Generalized linear model with negative binomial link was used to assess the relationships of climatic and physical environment factors with leptospirosis. Best-fitted model was determined based on the lowest information criterion and deviance.ResultsLeptospirosis incidence in both counties showed strong and unique annual seasonality. Bi-modal temporal pattern was exhibited in Mengla County while single epidemic curve was persistently demonstrated in Yilong County (Fig 2). Total of 10 and 20 models were generated for Mengla and Yilong County, respectively. After adjusting for seasonality, final best-fitted models indicated that rainfall at lag of 6-month (incidence rate ratio (IRR)= 0.989; 95% confidence interval (CI) 0.985-0.993, p<0.001) and current LST (IRR=0.857, 95%CI:0.729-0.929, p<0.001) significantly associated with leptospirosis in Mengla County (Table 1). While in Yilong, rainfall at 1-month lag, MNDWI (5-months lag) and LST (3-months lag) were associated with an increased incidence of leptospirosis with a risk ratio of 1.013 (95%CI: 1.003-1.023), 7.960 (95%CI: 1.241-47.66) and 1.193 (95%CI:1.095-1.301), respectively.ConclusionsOur study identified lagged effect and relationships of weather and remotely-sensed environmental factors with leptospirosis in two endemic counties in China. Rainfall in combination with satellite derived physical environment factors such as flood/water indicator (MNDWI) and temperature (LST) could help explain the local epidemiology as well as good predictors for leptospirosis outbreak in both counties. This would also be an avenue for the development of leptospirosis early warning system in to support leptospirosis control in China.References1. Haake, D. A. , Levett, P. N. Leptospirosis in humans. Current Topics in Microbiology and Immunology 2015, 387, 65-97.2. Costa, F. et al. Global Morbidity and Mortality of Leptospirosis: A Systematic Review. PLOS Neglected Tropical Diseases 2015, 9, e0003898.3. Dhewantara, P. W. et al. Epidemiological shift and geographical heterogeneity in the burden of leptospirosis in China. Infectious Diseases of Poverty 2018, 7, 57.4. Herbreteau, V., Salem, G., Souris, M., Hugot, J. P. & Gonzalez, J. P. Thirty years of use and improvement of remote sensing, applied to epidemiology: from early promises to lasting frustration. Health & Place 2007, 13, 400-403. 

scholarly journals Asthma and COVID-19: Emphasis on Adequate Asthma Control

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
David D. Nassoro ◽  
Leodegard Mujwahuzi ◽  
Issakwisa Habakkuk Mwakyula ◽  
Mwajabu K. Possi ◽  
Sylvester L. Lyantagaye
Keyword(s):  
Asthma Control ◽  
Seasonal Influenza ◽  
Inhaled Corticosteroids ◽  
Asthma Management ◽  
Cell Mediated Immunity ◽  
Level Of Evidence ◽  
Increased Risk ◽  
Wide Availability ◽  
The Relationship ◽  
Increased Susceptibility

Asthmatics are at an increased risk of developing exacerbations after being infected by respiratory viruses such as influenza virus, parainfluenza virus, and human and severe acute respiratory syndrome coronaviruses (SARS-CoV). Asthma, especially when poorly controlled, is an independent risk factor for developing pneumonia. A subset of asthmatics can have significant defects in their innate, humoral, and cell-mediated immunity arms, which may explain the increased susceptibility to infections. Adequate asthma control is associated with a significant decrease in episodes of exacerbation. Because of their wide availability and potency to promote adequate asthma control, glucocorticoids, especially inhaled ones, are the cornerstone of asthma management. The current COVID-19 pandemic affects millions of people worldwide and possesses mortality several times that of seasonal influenza; therefore, it is necessary to revisit this subject. The pathogenesis of SARS-CoV-2, the virus that causes COVID-19, can potentiate the development of acute asthmatic exacerbation with the potential to worsen the state of chronic airway inflammation. The relationship is evident from several studies that show asthmatics experiencing a more adverse clinical course of SARS-CoV-2 infection than nonasthmatics. Recent studies show that dexamethasone, a potent glucocorticoid, and other inhaled corticosteroids significantly reduce morbidity and mortality among hospitalized COVID-19 patients. Hence, while we are waiting for more studies with higher level of evidence that further narrate the association between COVID-19 and asthma, we advise clinicians to try to achieve adequate disease control in asthmatics as it may reduce incidences and severity of exacerbations especially from SARS-CoV-2 infection.

scholarly journals Assessment of Asthma Control and Severity among Children According to Global Initiative for Asthma Guidelines in Sulaimani City-Iraq

2016 ◽  
Vol 12 (3) ◽  
pp. 160
Author(s):  
Adnan M. H. Hamawandi ◽  
Kosar M Ali ◽  
Ali Z. Naji
Keyword(s):  
Asthma Control ◽  
Objective Assessment ◽  
Asthma Management ◽  
Persistent Asthma ◽  
Cross Sectional ◽  
Asthmatic Children ◽  
Global Initiative For Asthma ◽  
Severe Persistent Asthma ◽  
Global Initiative ◽  
Gina Guidelines

Background: Asthma is a common and potentially serious chronic disease that imposes a substantial burden on patients, their families and the community. Objective: Assessment of the level of asthma control and severity in asthmatic children in Sulaimani city according to the global initiative for asthma (GINA) guidelines. Methods: A cross-sectional study of 82 patients who are known cases of asthma, aged 5 – 15 years , from 1st of March 2014 to 1st of August 2014. Results: Out of 82 patients in our study, 20.8%were classified as having intermittent asthma all of them have well controlled asthma, 42.7% of those classified as having mild persistent asthma 65.7% of them have well controlled asthma, 26.8% of those classified as having moderate persistent asthma 54.5% of them have partly controlled asthma, and 9.8%of those classified as having severe persistent asthma the majority of them 87.5% have uncontrolled asthma and none of them reached to the controlled asthma level according to GINA guidelines. Regarding the peak expiratory flow (PFT) we notice that 58.8% of asthmatic children who were classified as having intermittent severity, their PEF measurements ranged between 160- 250 l/min while those with severe persistent asthma 75% of them have readings between 50-150 l/min. Conclusion: Current levels of asthma control in the Sulaimani city fall far short of the goals specified in the GINA guidelines for asthma management. Also there is a strong correlation between PEF measurements and the level of asthma severity,

Prevalence and seasonal variation of Fasciola hepatica in slaughtered cattle: the role of climate and environmental factors in Mexico

2021 ◽  
Vol 95 ◽  
Author(s):  
K. Hernández-Guzmán ◽  
P. Molina-Mendoza ◽  
J. Olivares-Pérez ◽  
Y. Alcalá-Canto ◽  
A. Olmedo-Juárez ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Surface Temperature ◽  
Land Surface Temperature ◽  
Land Surface ◽  
Vegetation Index ◽  
Normalized Difference Vegetation Index ◽  
Fasciola Hepatica ◽  
Temperate Climate ◽  
Wet Season ◽  
Dry Land

Abstract The objective of this study is to determine the prevalence of Fasciola hepatica infection in cattle slaughterhouses, as well as its association with climatic/environmental factors (derived from satellite data), seasonality and climate regions in two states in Mexico. Condemned livers from slaughtered animals were obtained from three abattoirs in the states of Puebla and Veracruz. The overall prevalence of the parasite in cattle between January and December of 2017 was 20.6% (1407 out of 6834); the highest rate of condemnation was observed in Veracruz (26.3%; tropical climate), and the lowest rate was found in Puebla (15.5%; temperate climate). The seasonal prevalence of fluke infection was 18.6%, 14.8% and 28.4% during the wet season, and 17.1%, 12.4% and 22.8% during the dry season in the three abattoir sites, located in the districts of Zacatlán, Teziutlán and Ciudad Alemán, respectively. Liver condemnations due to bovine fasciolosis were prevalent in the Zacatlán, Teziutlán and Ciudad Alemán districts during summer, autumn and summer, respectively. Using generalized estimating equations analysis, we determined six variables – rainfall (wet/dry), land surface temperature day, land surface temperature night, normalized difference vegetation index, seasonality and climate regions (temperate/tropical) – to be significantly associated with the prevalence of condemned livers. Climate region was the variable most strongly associated with F. hepatica infection (odds ratio (OR) 266.59; 95% confidence interval (CI): 241.90–353.34), followed by wet and dry seasons (OR 25.56; 95% CI: 20.56–55.67).

scholarly journals Childhood obesity in relation to poor asthma control and exacerbation: a meta-analysis

2016 ◽  
Vol 48 (4) ◽  
pp. 1063-1073 ◽  
Author(s):  
Fariba Ahmadizar ◽  
Susanne J.H. Vijverberg ◽  
Hubertus G.M. Arets ◽  
Anthonius de Boer ◽  
Jason E. Lang ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Asthma Control ◽  
Meta Analysis ◽  
Odds Ratios ◽  
Cross Sectional ◽  
Random Effects Models ◽  
Asthmatic Children ◽  
Asthma Exacerbations ◽  
Increased Risk ◽  
A Minor

To estimate the association between obesity and poor asthma control or risk of exacerbations in asthmatic children and adolescents, and to assess whether these associations are different by sex.A meta-analysis was performed on unpublished data from three North-European paediatric asthma cohorts (BREATHE, PACMAN (Pharmacogenetics of Asthma medication in Children: Medication with Anti-inflammatory effects) and PAGES (Pediatric Asthma Gene Environment Study)) and 11 previously published studies (cross-sectional and longitudinal studies). Outcomes were poor asthma control (based on asthma symptoms) and exacerbations rates (asthma-related visits to the emergency department, asthma-related hospitalisations or use of oral corticosteroids). Overall pooled estimates of the odds ratios were obtained using fixed- or random-effects models.In a meta-analysis of 46 070 asthmatic children and adolescents, obese children (body mass index ≥95th percentile) compared with non-obese peers had a small but significant increased risk of asthma exacerbations (OR 1.17, 95% CI 1.03–1.34; I2: 54.7%). However, there was no statistically significant association between obesity and poor asthma control (n=4973, OR 1.23, 95% CI 0.99–1.53; I2: 0.0%). After stratification for sex, the differences in odds ratios for girls and boys were similar, yet no longer statistically significant.In asthmatic children, obesity is associated with a minor increased risk of asthma exacerbations but not with poor asthma control. Sex does not appear to modify this risk.

Scale-Location Dependence of the Relationship between NDVI and Environmental Factors in Wuyi Mountain

2014 ◽  
Vol 955-959 ◽  
pp. 3828-3834
Author(s):  
Wei Cheng Zou ◽  
G. R. Xiao
Keyword(s):  
Environmental Factors ◽  
Large Scale ◽  
Vegetation Index ◽  
Normalized Difference Vegetation Index ◽  
Windward Side ◽  
Slope Aspect ◽  
Leeward Side ◽  
Small Scale ◽  
Medium Scale ◽  
Wavelet Coherency

The correlation between Normalized Difference Vegetation Index (NDVI) and environmental factors is examined at different scales and locations in world heritage of Wuyi Mountain by wavelet coherency. These factors are elevation, slope, aspect, distance to nearest resident, distance to nearest road , and distance to nearest river along two transects based on data of DEM, residents, roads, rivers and ALOS remote sensing image in 2009.The results show that:(1) The relationships between NDVI and environmental factors change along with scale. The relationships between NDVI and environmental factors in the first transect are all weak at small scale (<480m). At medium scale (480-7680m), NDVI is significantly correlated with elevation, slope, resident , and road. At large scale (>7680m), NDVI is significantly correlated with elevation, resident and river. For the second transect, NDVI is significantly correlated with aspect at small scale; and significantly correlated with elevation, aspect, slope and river at medium scale; and significantly correlated with elevation, aspect, and slope at large scale. Thus elevation is the dominant controlling factors on the vegetation cover.(2)The relationships between NDVI and environmental factors also change when location changes. There is positive correlation between NDVI and elevation below the altitude of 600 m and the windward side of the southeast monsoon above 600m, while it is negative in the leeward side above 600m. Besides, NDVI is directly related with road, resident, slope, and river in the areas where the elevation is below 1200m, but inversely above 1200m.

scholarly journals Determination of Plant Developmental Stability in Plant Lighting with Hyperspectral Imaging

2021 ◽  
Vol 15 (1) ◽  
pp. 4-8
Author(s):  
S. A. Rakutko ◽  
E. N. Rakutko ◽  
A. P. Mishanov,
Keyword(s):  
Environmental Factors ◽  
Hyperspectral Imaging ◽  
Fluctuating Asymmetry ◽  
Vegetation Index ◽  
Normalized Difference Vegetation Index ◽  
Light Quality ◽  
Leaf Surface ◽  
Vegetation Indices ◽  
Developmental Stability ◽  
Hyperspectral Camera

The authors showed that a convenient, accurate and fast way of assessing the degree of influence of environmental factors on plants was needed to optimize photoculture. They emphasized the importance of non-destructive monitoring of crops physiological state of, for which they used phenomics technologies, for example, remote sensing using hyperspectral cameras.(Research purpose) To reveal the possibility of using hyperspectral imaging to determine the plant developmental stability.(Materials and methods) As a measure of the favorable impact of environmental factors on the growth and development of plants, their developmental stability was taken, numerically characterized by the fluctuating asymmetry value. The authors proposed to use vegetation indices determined from the leaf reflection spectra as a bilateral feature. The object of experimental research was juvenile cucumber plants. The studies were carried out in laboratory conditions. The spectral characteristics of cucumber leaves grown under different light quality of radiation were determined using a Specim IQ hyperspectral camera. Information on the spectral reflectances was extracted from the resulting data hypercube. As an example calculations were performed for Normalized Difference Vegetation Index.(Results and discussion) The authors revealed differences in the productivity indicators of plants grown under different light quality. They revealed a significant frequency of occurrence of Normalized Difference Vegetation Index asymmetry in two halves of the cucumber leaf surface. The fluctuating nature of this asymmetry was confirmed. They found that with a light quality providing a higher productivity of plants, lower values of fluctuating asymmetry were observed, which indicate greater stability of plant development.(Conclusions) The authors proposed a method for determining the plant developmental stability using a hyperspectral camera. The method was based on the assessment of the fluctuating asymmetry of vegetation indices calculated for points on the leaf surface, characterized by the same location conditions relative to the border of its left and right halves. A preliminary assessment of the possibility of determining the developmental stability by the results of phenotyping using the example of cucumber plants showed the feasibility of the method and its practical applicability. 

scholarly journals Vegetation index cartography as a methodology complement to the terroir zoning for its use in precision viticulture

OENO One ◽  
2017 ◽  
Vol 51 (3) ◽  
pp. 289 ◽  
Author(s):  
Alvaro Martínez ◽  
Vicente D Gomez-Miguel
Keyword(s):  
Environmental Factors ◽  
Vegetation Index ◽  
Normalized Difference Vegetation Index ◽  
Alluvial Soil ◽  
Soil Features ◽  
Vegetation Indexes ◽  
Soil Elevation ◽  
Precision Viticulture ◽  
Simple Ratio ◽  
Terrain Features

<p><strong>Aim</strong>: Precision Viticulture (PV) is a form of vineyard management based on tools that offer winegrowers georeferenced information of each vineyard, mainly sector mapping (sub-areas) differentiated by characteristics capable of influencing vineyard usage. This provides knowledge of the variations in these sectors and PV treats each one of them in an independent and optimised manner. This allows, amongst many other possibilities, to monitor fruit ripening with the objective of performing site-specific harvest based on the characteristics of each given sector. Local variations in soil features and natural environmental factors, such as climate, lithology, geomorphology and soil, determine the units that drive or limit PV.</p><p><strong>Methods and results</strong>: In this paper, multispectral images are used. These have been obtained between veraison and harvest in three different years in order to calculate four vegetation indexes (VI) that have been used since the end of the last century to delimit homogenous sectors in vineyards: the Normalized Difference Vegetation Index (NDVI), the Improved Soil Adjusted Vegetation Index (MSAVI), the Simple Ratio Index (SR) and the Modified Simple Ratio Index (MSR). Mapping of these VI has allowed to relate their distribution with natural environmental factors with the objective of valuing their use in the discrimination of homogenous sectors as a complement and/or alternative to traditional methodologies to <em>terroir</em> zoning. Results show that, in the area studied, the vineyards planted in alluvial soil and conglomerated zones, over dominant fine-loamy, mixed, mesic, Calcixerollic Xerochrept soil series, at elevations between 519 and 604 m, oriented east and on slopes less than 5º present higher values for all four indexes throughout the three years of study.</p><p><strong>Conclusions</strong>: It is precisely these environmental elements (lithology, soil, elevation, orientation and slope) and many soil features that must be relatively uniform in order to make an efficient use of the studied VI.</p><p><strong>Significance and impact of the study</strong>: The study addresses the use of VI as a companion tool to viticultural zoning, which has not been much explored at such scale level. In addition, the results obtained may lead to changes in the use of VI, which are usually used without taking into account soil and/or terrain features.</p>

Leisure sedentary time and physical activity are higher in neighbourhoods with denser greenness and better built environments: An analysis of the Canadian Longitudinal Study on Aging

2021 ◽  
Author(s):  
Irmina Klicnik ◽  
John David Cullen ◽  
Dany Doiron ◽  
Caroline Barakat ◽  
Chris Ardern ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Longitudinal Study ◽  
Vegetation Index ◽  
Normalized Difference Vegetation Index ◽  
Sedentary Time ◽  
Middle Aged ◽  
Using Data ◽  
Research Consortium ◽  
Middle Aged Adults

Associations of environmental variables with physical activity and sedentary time using data from the Canadian Longitudinal Study on Aging, and the Canadian Urban Environment Research Consortium (Canadian Active Living Environments (Can-ALE) dataset, and Normalized Difference Vegetation Index (NDVI, greenness) dataset) were assessed. The main outcome variables were physical activity and sedentary time as measured by a modified version of the Physical Activity for Elderly Scale. The sample consisted of adults aged 45 and older (n = 36,580, mean age 62.6±10.2, 51% female). Adjusted ordinal regression models consistently demonstrated that those residing in neighbourhoods in the highest Can-ALE category (most well-connected built environment) reported more physical activity and sedentary time. For example, males aged 75+ in the highest Can-ALE category had 1.9 times higher odds of reporting more physical activity (OR = 1.9, 95%CI = 1.1-3.4) and 1.8 higher odds of reporting more sedentary time (OR = 1.8, 95%CI = 1.0-3.4). Neighbourhoods with higher greenness scores were also associated with higher odds of reporting more physical activity and sedentary time. It appears that an environment characterized by higher Can-ALE and higher greenness may facilitate physical activity, but it also facilitates more leisure sedentary time in older adults; research using device measured total sedentary time, and consideration of the types of sedentary activities being performed is needed. Novelty: ●Middle-aged and older adults living in neighbourhoods with higher Can-ALE scores and more greenness report more physical activity and leisure sedentary time ●Greenness is important for physical activity and sedentary time in middle-aged adults

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