A Promising Biocompatible Platform: Lipid-Based and Bio-Inspired Smart Drug Delivery Systems for Cancer Therapy

Designing new drug delivery systems (DDSs) for safer cancer therapy during pre-clinical and clinical applications still constitutes a considerable challenge, despite advances made in related fields. Lipid-based drug delivery systems (LBDDSs) have emerged as biocompatible candidates that overcome many biological obstacles. In particular, a combination of the merits of lipid carriers and functional polymers has maximized drug delivery efficiency. Functionalization of LBDDSs enables the accumulation of anti-cancer drugs at target destinations, which means they are more effective at controlled drug release in tumor microenvironments (TMEs). This review highlights the various types of ligands used to achieve tumor-specific delivery and discusses the strategies used to achieve the effective release of drugs in TMEs and not into healthy tissues. Moreover, innovative recent designs of LBDDSs are also described. These smart systems offer great potential for more advanced cancer therapies that address the challenges posed in this research area.

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Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy

Current Drug Targets ◽

10.2174/1389450121666200514222900 ◽

2020 ◽

Vol 21 (11) ◽

pp. 1084-1098

Author(s):

Fengqian Chen ◽

Yunzhen Shi ◽

Jinming Zhang ◽

Qi Liu

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Cancer Therapy ◽

Drug Delivery Systems ◽

Therapeutic Index ◽

Delivery Systems ◽

Epigenetic Therapy ◽

Cancer Therapies ◽

Therapeutic Benefits ◽

High Therapeutic Index

This review summarizes the epigenetic mechanisms of deoxyribonucleic acid (DNA) methylation, histone modifications in cancer and the epigenetic modifications in cancer therapy. Due to their undesired side effects, the use of epigenetic drugs as chemo-drugs in cancer therapies is limited. The drug delivery system opens a door for minimizing these side effects and achieving greater therapeutic benefits. The limitations of current epigenetic therapies in clinical cancer treatment and the advantages of using drug delivery systems for epigenetic agents are also discussed. Combining drug delivery systems with epigenetic therapy is a promising approach to reaching a high therapeutic index and minimizing the side effects.

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Nanocarrier-based Drug Delivery System for Cancer Therapeutics: A Review of the Last Decade

Current Medicinal Chemistry ◽

10.2174/0929867327666201005111722 ◽

2020 ◽

Vol 27 ◽

Author(s):

Muhammad Sohail ◽

Wenna Guo ◽

Zhiyong Li ◽

Hui Xu ◽

Feng Zhao ◽

...

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Cancer Therapy ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Research Progress ◽

Cancer Drug ◽

Conventional Chemotherapy ◽

Anti Cancer ◽

Cancer Drug Delivery

: In recent years, due to the shortcomings of conventional chemotherapy, such as poor bioavailability, low treatment index and unclear side effects, the focus of cancer research has shifted to new nanocarriers of chemotherapeutic drugs. By using biodegradable materials, nanocarriers generally have the advantages of good biocompatibility, low side effects, targeting, controlled release profile, and improved efficacy. And more to the point, nanocarrier based anti-cancer drug delivery systems clearly show the potential to overcome the problems associated with conventional chemotherapy. In order to promote the deepening of research and development in this field, we herein summarized and analyzed various nanocarrier based drug delivery systems for cancer therapy, including the concepts, types, characteristics and preparation methods. The active and passive targeting mechanisms of cancer therapy were also included, along with a brief introduction of the research progress of nanocarriers used for anti-cancer drug delivery in the past decade.

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The effective role of hydroxyapatite-based composites in anti-cancer drug delivery systems

Critical Reviews in Therapeutic Drug Carrier Systems ◽

10.1615/critrevtherdrugcarriersyst.v33.i1.10 ◽

2016 ◽

Vol 33 (1) ◽

Author(s):

Samaneh Saber-Samandari

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Cancer Drug ◽

Anti Cancer ◽

Effective Role ◽

Cancer Drug Delivery

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Environment-responsive Polymeric Nanoparticles as Drug Delivery Systems for Cancer Therapy

ACTA AGRONOMICA SINICA ◽

10.3724/sp.j.1206.2013.00431 ◽

2013 ◽

Vol 40 (10) ◽

pp. 1039

Author(s):

Yang YANG ◽

Wen-Chuan SHE ◽

Kui LUO ◽

Zhong-Wei GU

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Delivery Systems ◽

Polymeric Nanoparticles ◽

Delivery Systems

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Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

Current Nanoscience ◽

10.2174/1573413714666180222134742 ◽

2018 ◽

Vol 14 (5) ◽

pp. 432-439 ◽

Cited By ~ 1

Author(s):

Juliana M. Juarez ◽

Jorgelina Cussa ◽

Marcos B. Gomez Costa ◽

Oscar A. Anunziata

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Therapeutic Efficacy ◽

Drug Delivery Systems ◽

Controlled Drug Release ◽

Delivery Systems ◽

The Body ◽

Fickian Diffusion ◽

Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

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Recent advances in polymer shell-oily core nanocapsules for drug delivery applications

Nanomedicine ◽

10.2217/nnm-2021-0037 ◽

2021 ◽

Author(s):

Ahmed S AbdElhamid ◽

Dina G Zayed ◽

Lamia Heikal ◽

Sherine N Khattab ◽

Omar Y Mady ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Early Stage ◽

Controlled Drug Release ◽

Delivery Systems ◽

Polymeric Membranes ◽

Polymer Shell ◽

Recent Advances ◽

Target Sites ◽

Different Types

Polymeric nanocapsules are vesicular drug delivery systems composed of an inner oily reservoir surrounded by polymeric membranes. Nanocapsules have various advantages over other nanovesicular systems such as providing controlled drug release properties. We discuss the recent advances in polymeric shell-oily core nanocapsules, illustrating the different types of polymers used and their implementation. Nanocapsules can be utilized for many purposes, especially encapsulation of highly lipophilic drugs. They have been shown to have variable applications, especially in cancer therapy, due to the ability of the polymeric shell to direct the loaded drugs to their target sites, as well as their high internalization efficacy. Those productive applications guaranteed their high potential as drug delivery systems. However, their clinical development is still in an early stage.

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