scholarly journals Retrotransposons in Plant Genomes: Structure, Identification, and Classification through Bioinformatics and Machine Learning

2019 ◽  
Vol 20 (15) ◽  
pp. 3837 ◽  
Author(s):  
Simon Orozco-Arias ◽  
Gustavo Isaza ◽  
Romain Guyot
Keyword(s):  
Gene Expression ◽  
Machine Learning ◽  
Deep Learning ◽  
Transposable Elements ◽  
Structural Diversity ◽  
Structure Identification ◽  
Gene Expression And Regulation ◽  
Plant Genomes ◽  
Bioinformatics Software

Transposable elements (TEs) are genomic units able to move within the genome of virtually all organisms. Due to their natural repetitive numbers and their high structural diversity, the identification and classification of TEs remain a challenge in sequenced genomes. Although TEs were initially regarded as “junk DNA”, it has been demonstrated that they play key roles in chromosome structures, gene expression, and regulation, as well as adaptation and evolution. A highly reliable annotation of these elements is, therefore, crucial to better understand genome functions and their evolution. To date, much bioinformatics software has been developed to address TE detection and classification processes, but many problematic aspects remain, such as the reliability, precision, and speed of the analyses. Machine learning and deep learning are algorithms that can make automatic predictions and decisions in a wide variety of scientific applications. They have been tested in bioinformatics and, more specifically for TEs, classification with encouraging results. In this review, we will discuss important aspects of TEs, such as their structure, importance in the evolution and architecture of the host, and their current classifications and nomenclatures. We will also address current methods and their limitations in identifying and classifying TEs.

scholarly journals ProtTox: Toxin identification from Protein Sequences

2020 ◽  
Author(s):  
Sathappan Muthiah ◽  
Debanjan Datta ◽  
Mohammad Raihanul Islam ◽  
Patrick Butler ◽  
Andrew Warren ◽  
...  
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Synthetic Biology ◽  
Real World ◽  
Protein Sequences ◽  
Structural Diversity ◽  
Manual Annotation ◽  
Real World Applications ◽  
Automated Machine Learning

AbstractToxin classification of protein sequences is a challenging task with real world applications in healthcare and synthetic biology. Due to an ever expanding database of proteins and the inordinate cost of manual annotation, automated machine learning based approaches are crucial. Approaches need to overcome challenges of homology, multi-functionality, and structural diversity among proteins in this task. We propose a novel deep learning based method ProtTox, that aims to address some of the shortcomings of previous approaches in classifying proteins as toxins or not. Our method achieves a performance of 0.812 F1-score which is about 5% higher than the closest performing baseline.

scholarly journals Breast Cancer Type Classification Using Machine Learning

2021 ◽  
Vol 11 (2) ◽  
pp. 61
Author(s):  
Jiande Wu ◽  
Chindo Hicks
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Machine Learning ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Genomic Research ◽  
Support Vector ◽  
Cancer Type ◽  
Classification Models

Background: Breast cancer is a heterogeneous disease defined by molecular types and subtypes. Advances in genomic research have enabled use of precision medicine in clinical management of breast cancer. A critical unmet medical need is distinguishing triple negative breast cancer, the most aggressive and lethal form of breast cancer, from non-triple negative breast cancer. Here we propose use of a machine learning (ML) approach for classification of triple negative breast cancer and non-triple negative breast cancer patients using gene expression data. Methods: We performed analysis of RNA-Sequence data from 110 triple negative and 992 non-triple negative breast cancer tumor samples from The Cancer Genome Atlas to select the features (genes) used in the development and validation of the classification models. We evaluated four different classification models including Support Vector Machines, K-nearest neighbor, Naïve Bayes and Decision tree using features selected at different threshold levels to train the models for classifying the two types of breast cancer. For performance evaluation and validation, the proposed methods were applied to independent gene expression datasets. Results: Among the four ML algorithms evaluated, the Support Vector Machine algorithm was able to classify breast cancer more accurately into triple negative and non-triple negative breast cancer and had less misclassification errors than the other three algorithms evaluated. Conclusions: The prediction results show that ML algorithms are efficient and can be used for classification of breast cancer into triple negative and non-triple negative breast cancer types.

scholarly journals Machine Learning and Deep Learning Techniques, Features and Obstacles in the Cataract Diagnosis

2020 ◽  
Vol 9 (3) ◽  
pp. 87-93
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Literature Review ◽  
Congenital Cataract ◽  
Low Cost ◽  
Current Situation ◽  
Learning Techniques ◽  
Research Questions ◽  
New Research

Cataract is a degenerative condition that, according to estimations, will rise globally. Even though there are various proposals about its diagnosis, there are remaining problems to be solved. This paper aims to identify the current situation of the recent investigations on cataract diagnosis using a framework to conduct the literature review with the intention of answering the following research questions: RQ1) Which are the existing methods for cataract diagnosis? RQ2) Which are the features considered for the diagnosis of cataracts? RQ3) Which is the existing classification when diagnosing cataracts? RQ4) And Which obstacles arise when diagnosing cataracts? Additionally, a cross-analysis of the results was made. The results showed that new research is required in: (1) the classification of “congenital cataract” and, (2) portable solutions, which are necessary to make cataract diagnoses easily and at a low cost.

scholarly journals Review of the State of the Art of Deep Learning for Plant Diseases: A Broad Analysis and Discussion

Plants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 1302 ◽  
Author(s):  
Reem Ibrahim Hasan ◽  
Suhaila Mohd Yusuf ◽  
Laith Alzubaidi
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Early Detection ◽  
Feature Fusion ◽  
State Of The Art ◽  
Vital Role ◽  
Considerable Improvement ◽  
Plant Diseases ◽  
Recent Emergence

Deep learning (DL) represents the golden era in the machine learning (ML) domain, and it has gradually become the leading approach in many fields. It is currently playing a vital role in the early detection and classification of plant diseases. The use of ML techniques in this field is viewed as having brought considerable improvement in cultivation productivity sectors, particularly with the recent emergence of DL, which seems to have increased accuracy levels. Recently, many DL architectures have been implemented accompanying visualisation techniques that are essential for determining symptoms and classifying plant diseases. This review investigates and analyses the most recent methods, developed over three years leading up to 2020, for training, augmentation, feature fusion and extraction, recognising and counting crops, and detecting plant diseases, including how these methods can be harnessed to feed deep classifiers and their effects on classifier accuracy.

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