scholarly journals Beneficial Properties of Green Tea Catechins

2020 ◽  
Vol 21 (5) ◽  
pp. 1744 ◽  
Author(s):  
Claudia Musial ◽  
Alicja Kuban-Jankowska ◽  
Magdalena Gorska-Ponikowska
Keyword(s):  
Green Tea ◽  
Antioxidant Properties ◽  
Biologically Active ◽  
Hydroxyl Groups ◽  
Molecular Signaling ◽  
Epicatechin Gallate ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Antioxidant Agents ◽  
Anti Inflammatory

Green tea (Camellia sinesis) is widely known for its anticancer and anti-inflammatory properties. Among the biologically active compounds contained in Camellia sinesis, the main antioxidant agents are catechins. Recent scientific research indicates that the number of hydroxyl groups and the presence of characteristic structural groups have a major impact on the antioxidant activity of catechins. The best source of these compounds is unfermented green tea. Depending on the type and origin of green tea leaves, their antioxidant properties may be uneven. Catechins exhibit the strong property of neutralizing reactive oxygen and nitrogen species. The group of green tea catechin derivatives includes: epicatechin, epigallocatechin, epicatechin gallate and epigallocatechin gallate. The last of these presents the most potent anti-inflammatory and anticancer potential. Notably, green tea catechins are widely described to be efficient in the prevention of lung cancer, breast cancer, esophageal cancer, stomach cancer, liver cancer and prostate cancer. The current review aims to summarize the potential anticancer effects and molecular signaling pathways of major green tea catechins. It needs to be clearly emphasized that green tea as well as green tea catechols cannot replace the standard chemotherapy. Nonetheless, their beneficial effects may support the standard anticancer approach.

scholarly journals Computational Molecular Docking and X-ray Crystallographic Studies of Catechins in New Drug Design Strategies

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 2020 ◽  
Author(s):  
Shogo Nakano ◽  
Shin-ichi Megro ◽  
Tadashi Hase ◽  
Takuji Suzuki ◽  
Mamoru Isemura ◽  
...  
Keyword(s):  
Green Tea ◽  
Protein Interactions ◽  
Crystallographic Analysis ◽  
New Drugs ◽  
Hydroxyl Groups ◽  
Epicatechin Gallate ◽  
Tea Catechins ◽  
Computational Docking ◽  
X Ray ◽  
Green Tea Catechins

Epidemiological and laboratory studies have shown that green tea and green tea catechins exert beneficial effects on a variety of diseases, including cancer, metabolic syndrome, infectious diseases, and neurodegenerative diseases. In most cases, (−)-epigallocatechin gallate (EGCG) has been shown to play a central role in these effects by green tea. Catechins from other plant sources have also shown health benefits. Many studies have revealed that the binding of EGCG and other catechins to proteins is involved in its action mechanism. Computational docking analysis (CMDA) and X-ray crystallographic analysis (XCA) have provided detailed information on catechin-protein interactions. Several of these studies have revealed that the galloyl moiety anchors it to the cleft of proteins through interactions with its hydroxyl groups, explaining the higher activity of galloylated catechins such as EGCG and epicatechin gallate than non-galloylated catechins. In this paper, we review the results of CMDA and XCA of EGCG and other plant catechins to understand catechin-protein interactions with the expectation of developing new drugs with health-promoting properties.

Anti-inflammatory activity and molecular mechanism of Oolong tea theasinensin

2014 ◽  
Vol 5 (8) ◽  
pp. 1891-1897 ◽  
Author(s):  
Ayami Hisanaga ◽  
Hisako Ishida ◽  
Kozue Sakao ◽  
Takayuki Sogo ◽  
Takuma Kumamoto ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Green Tea ◽  
Bioactive Compounds ◽  
Black Tea ◽  
Tea Polyphenols ◽  
Inflammatory Activity ◽  
Tea Catechins ◽  
Oolong Tea ◽  
Green Tea Catechins ◽  
Anti Inflammatory

Oolong tea theasinensins are a group of tea polyphenols different from green tea catechins and black tea theaflavins, and they are considered as bioactive compounds in oolong tea.

Green Tea Catechins Improve Liver Dysfunction Following Massive Hepatectomy Through Anti-Oxidative and Anti-Inflammatory Activities in Rats

2011 ◽  
Vol 140 (5) ◽  
pp. S-928 ◽  
Author(s):  
Yu Saito ◽  
Mitsuo Shimada ◽  
Tohru Utsunomiya ◽  
Satoru Imura ◽  
Yuji Morine ◽  
...  
Keyword(s):  
Green Tea ◽  
Liver Dysfunction ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Massive Hepatectomy ◽  
Anti Inflammatory

scholarly journals Green Tea Catechins Improve Human Forearm Vascular Function and Have Potent Anti-Inflammatory and Anti-Apoptotic Effects in Smokers

2010 ◽  
Vol 49 (23) ◽  
pp. 2553-2559 ◽  
Author(s):  
Jun-ichi Oyama ◽  
Toyoki Maeda ◽  
Makoto Sasaki ◽  
Kazuya Kozuma ◽  
Ryuji Ochiai ◽  
...  
Keyword(s):  
Green Tea ◽  
Vascular Function ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Human Forearm ◽  
Anti Inflammatory ◽  
Apoptotic Effects

scholarly journals Green tea and obesity: Effects of catechins on the energetic metabolism

2021 ◽  
Vol 75 ◽  
pp. 265-271
Author(s):  
Patrycja Gogga ◽  
Monika Szałajda ◽  
Agata Janczy
Keyword(s):  
Green Tea ◽  
Body Mass ◽  
Significant Risk ◽  
Biologically Active ◽  
Acid Oxidation ◽  
Dependent Manner ◽  
Energetic Metabolism ◽  
Tea Catechins ◽  
Green Tea Catechins

Obesity is a metabolic disease which has now reached epidemic proportions, becoming a major health, social, and economic problem worldwide. Untreated obesity is associated with decreased quality of life and is a significant risk factor for the development of other serious health problems, such as diabetes and cardiovascular diseases. For this reason, new approaches to prevent excess body mass and to support its reduction if necessary are being examined. Catechins extracted from green tea – especially epigallocatechin gallate (EGCG) – are one of the most widely investigated biologically active substances. In addition to the antioxidant, anti-inflammatory, and anticarcinogenic properties of the catechins, they also exhibit a role in maintaining normal fat mass and body mass. There are numerous research studies showing that regular green tea consumption is associated with lower body mass, BMI, and waist circumference. In vitro and animal experiments confirm beneficial effects of catechins on the energetic metabolism. These compounds lower lipid and carbohydrates absorption in the intestine. Additionally, they affect the energetic metabolism, lowering the rate of lipogenesis and adipogenesis, while stimulating lipolysis and fatty acid oxidation, and increasing energy expenditure. Moreover, it has been established that green tea catechins have an effect on the glucose uptake in the insulin-dependent manner – by GLUT4. The aim of the following paper was to review and summarize the literature data concerning the role of green tea catechins in the prevention and treatment of obesity.

scholarly journals Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup® Dietary Supplement: Role of Green Tea Catechins

2020 ◽  
Vol 21 (4) ◽  
pp. 1404 ◽  
Author(s):  
Yuchen Gu ◽  
Gautier Moroy ◽  
Jean-Louis Paul ◽  
Anne-Sophie Rebillat ◽  
Mara Dierssen ◽  
...  
Keyword(s):  
Green Tea ◽  
Epigallocatechin Gallate ◽  
Nutritional Supplement ◽  
Green Tea Extract ◽  
Epicatechin Gallate ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Tea Extract ◽  
Vitro Effect

Epigallocatechin gallate (EGCG) is an inhibitor of DYRK1A, a serine/threonine kinase considered to be a major contributor of cognitive dysfunctions in Down syndrome (DS). Two clinical trials in adult patients with DS have shown the safety and efficacy to improve cognitive phenotypes using commercial green tea extract containing EGCG (45% content). In the present study, we performed a preclinical study using FontUp®, a new nutritional supplement with a chocolate taste specifically formulated for the nutritional needs of patients with DS and enriched with a standardized amount of EGCG in young mice overexpressing Dyrk1A (TgBACDyrk1A). This preparation is differential with previous one used, because its green tea extract has been purified to up 94% EGCG of total catechins. We analyzed the in vitro effect of green tea catechins not only for EGCG, but for others residually contained in FontUp®, on DYRK1A kinase activity. Like EGCG, epicatechin gallate was a noncompetitive inhibitor against ATP, molecular docking computations confirming these results. Oral FontUp® normalized brain and plasma biomarkers deregulated in TgBACDyrk1A, without negative effect on liver and cardiac functions. We compared the bioavailability of EGCG in plasma and brain of mice and have demonstrated that EGCG had well crossed the blood-brain barrier.

scholarly journals Green tea catechin enhances cholesterol 7α-hydroxylase gene expression in HepG2 cells

2008 ◽  
Vol 99 (6) ◽  
pp. 1182-1185 ◽  
Author(s):  
Mak-Soon Lee ◽  
Ju-Yeon Park ◽  
Hedley Freake ◽  
In-Sook Kwun ◽  
Yangha Kim
Keyword(s):  
Green Tea ◽  
Promoter Activity ◽  
Human Subjects ◽  
Mrna Level ◽  
Transcriptional Level ◽  
Dependent Manner ◽  
Human Hepatoma Cells ◽  
Epicatechin Gallate ◽  
Tea Catechins ◽  
Green Tea Catechins

Green tea catechins are known to have hypocholesterolaemic effects in animals and human subjects. In the present study, we investigated the effects of green tea catechins on the mRNA level and promoter activity of hepatic cholesterol 7α-hydroxylase (CYP7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acids, in human hepatoma cells. Real-time PCR assays showed that different catechins, ( − )-epicatechin gallate (ECG), ( − )-epigallocatechin-3-gallate (EGCG), ( − )-epigallocatechin (EGC) and ( − )-epicatechin (EC), up regulated the CYP7A1 mRNA level by 5·5-, 4·2-, 2·9- and 1·9-fold, respectively, compared with the control. The − 1312/+358 bp of the CYP7A1 promoter was subcloned into the pGL3 basic vector that includes luciferase as a reporter gene. ECG or EGCG significantly increased CYP7A1 promoter activity by 6·0- or 4·0-fold, respectively, compared with the control. Also, EGCG stimulated CYP7A1 at both mRNA level and promoter activity in a dose-dependent manner. These results suggest that the expression of the CYP7A1 gene may be directly regulated by green tea catechins at the transcriptional level.

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