scholarly journals MicroRNA-Mediated Gene Regulatory Mechanisms in Mammalian Female Reproductive Health

2021 ◽  
Vol 22 (2) ◽  
pp. 938
Author(s):  
Samuel Gebremedhn ◽  
Asghar Ali ◽  
Munir Hossain ◽  
Michael Hoelker ◽  
Dessie Salilew-Wondim ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Ovarian Function ◽  
Mammalian Species ◽  
Extracellular Fluid ◽  
Health Issues ◽  
Physiological Factors ◽  
Female Reproductive Health ◽  
Extracellular Mirnas ◽  
Mammalian Female ◽  
Post Transcriptional Regulation

Mammalian reproductive health affects the entire reproductive cycle starting with the ovarian function through implantation and fetal growth. Various environmental and physiological factors contribute to disturbed reproductive health status leading to infertility problems in mammalian species. In the last couple of decades a significant number of studies have been conducted to investigate the transcriptome of reproductive tissues and organs in relation to the various reproductive health issues including endometritis, polycystic ovarian syndrome (PCOS), intrauterine growth restriction (IUGR), preeclampsia, and various age-associated reproductive disorders. Among others, the post-transcriptional regulation of genes by small noncoding miRNAs contributes to the observed transcriptome dysregulation associated with reproductive pathophysiological conditions. MicroRNAs as a class of non-coding RNAs are also known to be involved in various pathophysiological conditions either in cellular cytoplasm or they can be released to the extracellular fluid via membrane-bounded extracellular vesicles and proteins. The present review summarizes the cellular and extracellular miRNAs and their association with the etiology of major reproductive pathologies including PCOS, endometritis, IUGR and age-associated disorders in various mammalian species.

scholarly journals Men’s reproductive health knowledge in Mankweng District, Limpopo Province

Curationis ◽  
2017 ◽  
Vol 40 (1) ◽  
Author(s):  
Richard M. Rasesemola ◽  
Tendani S. Ramukumba ◽  
Majapi Masala-Chokwe ◽  
Zerish Z. Nkosi
Keyword(s):  
Reproductive Health ◽  
Health Knowledge ◽  
Limpopo Province ◽  
Modern Contraceptive ◽  
Health Issues ◽  
Sexually Transmitted ◽  
Descriptive Research ◽  
Female Reproductive Health ◽  
Multistage Sampling ◽  
Reproductive Health Knowledge

Background: Gender roles influence men’s attitudes towards reproductive health, and society might assume that reproductive health issues, fertility and family planning are women’s responsibilities. Moreover, literature shows that men have insufficient knowledge about reproductive health matters and some misconceptions about modern contraceptive practices.Objectives: The aim of the study was to describe reproductive health knowledge of men in Mankweng District and was conducted in 2015.Methods: A descriptive research study was conducted by using quantitative approach. Data were collected by means of questionnaires. Cluster random multistage sampling was used to select villages in Mankweng District and convenient sampling was used to identify participants who met the inclusion criteria to participate on the study.Results: A total of 200 questionnaires were distributed and returned; 197 (98.5%) of the returned questionnaires were eligible for analysis. The findings indicated that the majority of participants, 74% (n = 145), considered their partners to be unclean during menstruation, and 84.77% (n = 167) of participants did not know how to perform self-testicular examination. More than half of the participants, 55.83% (n = 67), were not in favour of vasectomy and had strong opinions about it; some of those who reportedly knew what a vasectomy involves had some misconceptions.Conclusion: The findings showed that despite participants’ reported knowledge about some reproductive health matters their perceptions were unfavourable towards them. Despite men’s sufficient knowledge about sexually transmitted infections (STIs) and ways to protect themselves against STIs men had limited knowledge about other male and female reproductive health matters.

Potential role of microRNAs in mammalian female fertility

2017 ◽  
Vol 29 (1) ◽  
pp. 8 ◽  
Author(s):  
Dawit Tesfaye ◽  
Dessie Salilew-Wondim ◽  
Samuel Gebremedhn ◽  
Md Mahmodul Hasan Sohel ◽  
Hari Om Pandey ◽  
...  
Keyword(s):  
Embryo Development ◽  
Oocyte Maturation ◽  
Potential Role ◽  
Mammalian Species ◽  
Female Fertility ◽  
Conditional Knockout ◽  
Female Reproduction ◽  
Extracellular Mirnas ◽  
Mammalian Female

Since the first evidence for the involvement of microRNAs (miRNAs) in various reproductive processes through conditional knockout of DICER, several studies have been conducted to investigate the expression pattern and role of miRNAs in ovarian follicular development, oocyte maturation, embryo development, embryo–maternal communication, pregnancy establishment and various reproductive diseases. Although advances in sequencing technology have fuelled miRNA studies in mammalian species, the presence of extracellular miRNAs in various biological fluids, including follicular fluid, blood plasma, urine and milk among others, has opened a new door in miRNA research for their use as diagnostic markers. This review presents data related to the identification and expression analysis of cellular miRNA in mammalian female fertility associated with ovarian folliculogenesis, oocyte maturation, preimplantation embryo development and embryo implantation. In addition, the relevance of miRNAs to female reproductive disorders, including polycystic ovary syndrome (PCOS), endometritis and abnormal pregnancies, is discussed for various mammalian species. Most importantly, the mechanism of release and the role of extracellular miRNAs in cell–cell communication and their potential role as non-invasive markers in female fertility are discussed in detail. Understanding this layer of regulation in female reproduction processes will pave the way to understanding the genetic regulation of female fertility in mammalian species.

Reproductive Health Issues for Incarcerated Women: Challenges and Solutions

2010 ◽  
Author(s):  
Jennifer Clarke ◽  
Michaela Seadale ◽  
Rachel Salloway
Keyword(s):  
Reproductive Health ◽  
Incarcerated Women ◽  
Health Issues

Reproductive health issues in patients with psoriasis (literature review)

2019 ◽  
Vol 1 (7) ◽  
pp. 5-8
Author(s):  
L. S. Kruglova ◽  
A. A. Osina ◽  
A. A. Khotko
Keyword(s):  
Drug Therapy ◽  
Reproductive Health ◽  
Literature Review ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcome ◽  
Certolizumab Pegol ◽  
Genetically Engineered ◽  
Health Issues ◽  
Degree Of Confidence ◽  
Adverse Pregnancy

Among patients with psoriasis, approximately 50% are women and almost 75 % of them are under the age of 40 years. Thus, most women with psoriasis have childbearing potential. When pregnancy occurs in 22 % of patients, the activity of psoriasis persists, characteristic of the course before pregnancy, in 23 % of women, the course of the disease worsens. The article provides up-to-date data on the management of pregnant patients with psoriasis. To improve pregnancy outcomes in patients with psoriasis, it is important to prevent exacerbation of the disease. The choice of drug therapy in this case is based on an assessment of the ratio of the risk of undesirable effects of the drugs on the developing fetus and the risk of the development of exacerbation of psoriasis, which can cause an adverse pregnancy outcome. Despite the fact that the available clinical experience of using genetically engineered drugs is still limited, with a certain degree of confidence we can say that there is no increase in the risk of adverse pregnancy outcomes associated with therapy with certolizumab pegol.

Reproductive health issues in female patients with beta-thalassaemia major: a narrative literature review

2020 ◽  
Vol 40 (7) ◽  
pp. 902-911 ◽  
Author(s):  
Malihe Nourollahpour Shiadeh ◽  
Elena Cassinerio ◽  
Maryam Modarres ◽  
Armin Zareiyan ◽  
Zeinab Hamzehgardeshi ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Literature Review ◽  
Thalassaemia Major ◽  
Health Issues ◽  
Female Patients ◽  
Beta Thalassaemia ◽  
Narrative Literature ◽  
Narrative Literature Review

Gestational exposure to Δ9-THC impacts ovarian follicular dynamics and angiogenesis in adulthood in Wistar rats

2021 ◽  
pp. 1-5
Author(s):  
Annia A. Martínez-Peña ◽  
Kendrick Lee ◽  
James J. Petrik ◽  
Daniel B. Hardy ◽  
Alison C. Holloway
Keyword(s):  
Reproductive Health ◽  
Cannabis Sativa ◽  
Follicular Development ◽  
Angiogenic Factor ◽  
Postnatal Life ◽  
Adult Rat ◽  
Female Reproductive Health ◽  
Gestational Exposure ◽  
Follicular Dynamics

Abstract With the legalization of marijuana (Cannabis sativa) and increasing use during pregnancy, it is important to understand its impact on exposed offspring. Specifically, the effects of Δ-9-tetrahydrocannabinol (Δ9-THC), the major psychoactive component of cannabis, on fetal ovarian development and long-term reproductive health are not fully understood. The aim of this study was to assess the effect of prenatal exposure to Δ9-THC on ovarian health in adult rat offspring. At 6 months of age, Δ9-THC-exposed offspring had accelerated folliculogenesis with apparent follicular development arrest, but no persistent effects on circulating steroid levels. Ovaries from Δ9-THC-exposed offspring had reduced blood vessel density in association with decreased expression of the pro-angiogenic factor VEGF and its receptor VEGFR-2, as well as an increase in the anti-angiogenic factor thrombospondin 1 (TSP-1). Collectively, these data suggest that exposure to Δ9-THC during pregnancy alters follicular dynamics during postnatal life, which may have long-lasting detrimental effects on female reproductive health.

scholarly journals Thirty Years of Human Rights Study in the Web of Science Database (1990–2020)

2021 ◽  
Vol 18 (4) ◽  
pp. 2131
Author(s):  
Priscilla Paola Severo ◽  
Leonardo B. Furstenau ◽  
Michele Kremer Sott ◽  
Danielli Cossul ◽  
Mariluza Sott Bender ◽  
...  
Keyword(s):  
Mental Health ◽  
Decision Making ◽  
Human Rights ◽  
Network Analysis ◽  
Reproductive Health ◽  
Web Of Science ◽  
Health Issues ◽  
Human Beings ◽  
Field Of Study ◽  
The Web

The study of human rights (HR) is vital in order to enhance the development of human beings, but this field of study still needs to be better depicted and understood because violations of its core principles still frequently occur worldwide. In this study, our goal was to perform a bibliometric performance and network analysis (BPNA) to investigate the strategic themes, thematic evolution structure, and trends of HR found in the Web of Science (WoS) database from 1990 to June 2020. To do this, we included 25,542 articles in the SciMAT software for bibliometric analysis. The strategic diagram produced shows 23 themes, 12 of which are motor themes, the most important of which are discussed in this article. The thematic evolution structure presented the 21 most relevant themes of the 2011–2020 period. Our findings show that HR research is directly related to health issues, such as mental health, HIV, and reproductive health. We believe that the presented results and HR panorama presented have the potential to be used as a basis on which researchers in future works may enhance their decision making related to this field of study.

scholarly journals SARS-CoV-2 and the reproductive system: known and the unknown..!!

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Indu Sharma ◽  
Priti Kumari ◽  
Anuradha Sharma ◽  
Subhas Chandra Saha
Keyword(s):  
Reproductive Health ◽  
Vertical Transmission ◽  
Reproductive System ◽  
Ovarian Function ◽  
Sperm Count ◽  
Sperm Concentration ◽  
Reproductive Potential ◽  
Oocyte Quality ◽  
Main Body ◽  
Close Monitoring

Abstract Background COVID-19 is the most recent zoonotic outbreak of coronaviruses. Mostly, it invades the cells of the respiratory system by binding to the receptor angiotensin-converting enzyme 2 (ACE2) which is also present in other organs like the kidney, testis, ovaries, breast, heart, and intestine, rendering them prone to be infected. The reproductive potential is a must for the sustenance of any species and it is our prime duty to safeguard the reproductive system of the present generation from such a deadly virus. The previously reported coronaviruses like severe acute respiratory syndrome coronavirus (SARS-CoV) had a detrimental impact on reproductive organs. There is a dearth of sufficient research to provide substantial evidence for the harmful effects of this novel virus on the reproductive system. Hence, our review compiles the knowledge available until now to boost research in this regard and to take the necessary steps in time. Main body of abstract Here we tried to compile all the data available on the effect of SARS-CoV-2 on the reproductive system as well as vertical transmission of the virus. All related articles published from February to August 2020 were reviewed and thoroughly analyzed. SARS-CoV-2 has been found to affect the sperm concentration and motility, thus degrading the fertility of males. In females, it is suspected that this virus affects the oocyte quality and ovarian function, resulting in infertility or miscarriage. Traces of SARS-CoV-2 virus have also been found in the breast milk of the infected mothers and the semen of infected males. Vertical transmission of SARS-CoV-2 has also been reported in some cases. Conclusion Based on the literature review, SARS-CoV-2 seems to have the potential of affecting both male and female reproductive tracts. This review brings together the findings and observations made in the area of reproductive health during the current pandemic. The reproductive system of the young population is preordained for subsequent disorders, infertility, reduced sperm count, and motility. Therefore, the research and medical practices should focus on possible vulnerability being posed by SARS-CoV-2 to the gametes and future generations. We, hereby, recommend close monitoring of young and pregnant COVID-19 patients concerning reproductive health with utmost priority.

scholarly journals Lifestyle Medicine for Women: The Time Is Now!

2021 ◽  
pp. 155982762110042
Author(s):  
Cynthia Geyer ◽  
John McHugh ◽  
Michelle Tollefson
Keyword(s):  
Reproductive Health ◽  
Clinical Research ◽  
Women’S Health ◽  
Women's Health ◽  
Interest Group ◽  
Medical Conditions ◽  
Health Issues ◽  
Lifestyle Medicine ◽  
Research Education ◽  
Representation Of Women

As the founders of the American College of Lifestyle Medicine’s Women’s Health Member Interest Group, we welcome this issue focused on the important issues facing women, their providers, and researchers in this field. Women’s health extends beyond sex-specific reproductive health issues, by also encompassing the medical conditions that are more prevalent in women as well as conditions that are expressed differently in women. Inadequate representation of women in clinical research has contributed to poorer outcomes. As lifestyle medicine forms the foundation of true health, the time is now to recognize and address these issues with research, education, and advocacy.

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