scholarly journals The Function of SUMOylation and Its Critical Roles in Cardiovascular Diseases and Potential Clinical Implications

2021 ◽  
Vol 22 (19) ◽  
pp. 10618
Author(s):  
Congcong Du ◽  
Xu Chen ◽  
Qi Su ◽  
Wenbin Lu ◽  
Qiqi Wang ◽  
...  
Keyword(s):  
Therapeutic Strategy ◽  
Life Quality ◽  
Research Progress ◽  
Common Disease ◽  
High Morbidity ◽  
Cardiovascular Development ◽  
Lysine Residues ◽  
And Function ◽  
Substrate Proteins

Cardiovascular disease (CVD) is a common disease caused by many factors, including atherosclerosis, congenital heart disease, heart failure, and ischemic cardiomyopathy. CVD has been regarded as one of the most common diseases and has a severe impact on the life quality of patients. The main features of CVD include high morbidity and mortality, which seriously threaten human health. SUMO proteins covalently conjugate lysine residues with a large number of substrate proteins, and SUMOylation regulates the function of target proteins and participates in cellular activities. Under certain pathological conditions, SUMOylation of proteins related to cardiovascular development and function are greatly changed. Numerous studies have suggested that SUMOylation of substrates plays critical roles in normal cardiovascular development and function. We reviewed the research progress of SUMOylation in cardiovascular development and function, and the regulation of protein SUMOylation may be applied as a potential therapeutic strategy for CVD treatment.

scholarly journals Characteristics and Clinical Significance of Spondylolisthetic and Spino-pelvic Sagittal Parameters in Kyphotic Low-grade Degenerative Lumbar Spondylolisthesis

2020 ◽  
Author(s):  
Chongqing Xu ◽  
Mengchen Yin ◽  
Wen Mo
Keyword(s):  
Life Quality ◽  
Observer Agreement ◽  
Common Disease ◽  
Low Grade ◽  
Significant Difference ◽  
Degenerative Lumbar Spondylolisthesis ◽  
Sagittal Parameters ◽  
Lumbar Spondylolisthesis ◽  
The Impact

Abstract Background: Degenerative lumbar spondylolisthesis (DLS) has been a common disease that make increasing patients suffer from different degrees of low back pain and radicular symptoms. At present, the incidence of kyphosis in DLS and the differences in spinal sagittal morphology between kyphotic and non-kyphotic DLS still remain unclear. Our study aimed to determine the incidence of kyphosis in DLS, explore the characteristics of spondylolisthetic and spino-pelvic sagittal parameters, and evaluate the impact of kyphosis on the life quality of patients with DLS.Methods/Design: All 108 patients with L4/5 low-grade DLS were enrolled and divided into kyphotic and non-kyphotic group. 2 spine surgeons who have certain clinical experience were selected to measure the spondylolisthetic and spino-pelvic parameters, as well as visual analogue scale (VAS) and Oswestry disability index (ODI). Differences between the 2 groups and characteristics of measurements were analyzed.Results: The inter-observer agreement of all parameters between the 2 spine surgeons were excellent with each ICC > 0.75. Kyphotic group had higher SA, SD, SDM, SAM, PDH, PT and SVA, and lower ADH, SS and LL than those in non-kyphotic group (p < 0.01). There was no significant difference in PI and TK between the two groups (p > 0.05).Conclusion: The incidence of kyphotic spondylolisthesis in patients with L4/5 low-grade DLS is 16.7%. Compared with those in non-kyphotic group, patients with kyphosis show inferior results of spondylolisthetic parameters, more severe loss of LL, more obvious pelvic retroversion and trunk anteversion, which indicates worse spino-pelvic sagittal balance. In addition, their quality of life was significantly lower than that of patients in non-kyphotic group.

Study on the Treatment of Ischemic Stroke Based on Poly(lactic-co-glycolic acid) (PLGA) Nanotechnology

2021 ◽  
Vol 1027 ◽  
pp. 58-63
Author(s):  
Rong Liu ◽  
Ge Jian Zhu ◽  
Peng Qing
Keyword(s):  
Ischemic Stroke ◽  
Polymer Material ◽  
Synthetic Polymer ◽  
Polymer Materials ◽  
Research Progress ◽  
Common Disease ◽  
Social Burden ◽  
Neuroprotective Drugs ◽  
Normal Work

Ischemic stroke is a common disease in neurology, which seriously affects people's normal work and quality of life and brings a heavy social burden. The nanoparticle carrier generally consists of natural polymer material or synthetic polymer material. Among the synthetic polymer materials, PLGA is one of the most popular carrier materials in recent years. This paper introduces the application of PLGA nanomaterials in ischemic stroke, and reviews the application of PLGA nanomaterials in the diagnosis and tissue repair of ischemic stroke, and drug delivery of neuroprotective drugs. It provides a theoretical basis for the research progress of PLGA nanotechnology in the treatment of anti-stroke and the development of anti-stroke drugs.

Recent Advances of Artificial Intelligence in Cardiovascular Disease

2020 ◽  
Vol 16 (7) ◽  
pp. 1065-1081
Author(s):  
Zhu Chen ◽  
Changhu Xiao ◽  
Haihua Qiu ◽  
Xinxing Tan ◽  
Lian Jin ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Cardiovascular Disease ◽  
Therapeutic Strategy ◽  
High Morbidity ◽  
New Techniques ◽  
Science Field ◽  
Disease Prognosis ◽  
Pathogenic Genes ◽  
Discharged Patients

Cardiovascular disease (CVD) is one of the most serious health disorders with increasing prevalence and high morbidity and mortality. Although diagnosis and treatment of CVD have achieved huge breakthrough in recent years, it still needs additional enhancements, which result in the demand for new techniques. Artificial intelligence (AI) is an emerging science field that has been widely used to guide diseases diagnosis, evaluation and treatment. AI techniques are promising in CVD to explore novel pathogenic genes phenotype, guide optimal individualized therapeutic strategy, improve the management and quality of discharged patients, predict disease prognosis, and as adjuvant therapy tool. Thus, we summarize the latest application of AI techniques in clinical diagnosis, evaluation and treatment of CVD, aiming to provide novel beneficial evidence of AI and promote its application in CVD.

scholarly journals Putative Genes and Pathways Involved in the Acne Treatment of Isotretinoin via Microarray Data Analyses

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Biao Chen ◽  
Peishan Li ◽  
Jun Li ◽  
Jinping Chen
Keyword(s):  
Life Quality ◽  
Research Direction ◽  
Common Disease ◽  
Severe Acne ◽  
Protein Protein Interaction ◽  
Therapeutic Mechanism ◽  
Sebum Production ◽  
Acne Treatment ◽  
Microarray Datasets

Acne is the eighth most common disease worldwide. Disease burden of acne such as anxiety, reduced self-esteem, and facial scarring lowers the life quality of acne patients. Isotretinoin is the most potent treatment for moderate-severe acne. However, the adverse events of isotretinoin especially teratogenicity limit its use. This study aims at investigating the therapeutical mechanisms of isotretinoin using bioinformatics analysis. Differentially expressed genes (DEGs) were filtered from microarray datasets GSE10432, GSE10433, and GSE11792. Functional and pathway enrichment analyses of DEGs were performed. Protein–protein interaction (PPI) network and module analyses were also conducted based on DEGs. Using isotretinoin for 1 week, LCN2, PTGES, and GDF15 were upregulated and might mediate sebocytes apoptosis and thus decreased sebum production; CCL2 originated from activated TNF signaling pathway and S100A7 could be related with “acne-flare”. While treating with isotretinoin for 8 weeks, key genes were downregulated, including HMGCS1, HMGCR, FDFT1, MVD, IDI1, and FDPS, which may be associated with decreased sebum synthesis; HMGCS1, HMGCR, and FDFT1 also probably associated with apoptosis of sebocytes. There were only two common genes including ACSBG1 and BCAT2 which worked in both 1 week and 8 weeks and could associate with decreased sebum synthesis and apoptosis of sebocytes, respectively. These results indicate potential therapeutics and side effect mechanisms of isotretinoin in the acne treatment and provide a research direction to further investigate the therapeutic mechanism of isotretinoin and thus develop retinoid-like compounds with similar curative effect and without teratogenicity.

scholarly journals Hand Eczema: Quality of Life and Disease Severity in an Outpatient Portuguese Population

2018 ◽  
Vol 76 (2) ◽  
pp. 137-142
Author(s):  
Rui Pedro Santos ◽  
Laura Igreja ◽  
Cristina Resende ◽  
Teresa Pereira ◽  
Celeste Brito
Keyword(s):  
Quality Of Life ◽  
Disease Severity ◽  
Life Quality ◽  
Severity Index ◽  
Hand Eczema ◽  
Common Disease ◽  
Female Predominance ◽  
Duration Of Disease ◽  
A Prospective Study

Introduction: Hand eczema is a very common disease with a significant social and occupational impact.Objectives: To characterize a Portuguese outpatient population with hand eczema; to evaluate the impairment of the disease in quality of life (QoL); to relate the disease severity with QoL.Methods: The authors designed a prospective study. Information about atopy, psoriasis, occupational exposure and duration of disease, was recorded. The QoL was assessed by the DLQI questionnaire (Dermatology Life Quality Index) and the severity was assessed using the hand eczema severity index (HECSI). All participants were patch tested.Results: Eighty-five patients were included with a female predominance (78.8%). The median DLQI was 9.0. We found statistically significant differences in the variable HECSI between genders with greater impact in males. A significant positive correlation was found between HECSI and DLQI. DLQI and HECSI were independent of atopy, psoriasis or etiology. Increasing age significantly affects DLQI but not HECSI.Conclusions: Hand eczema has a significant impact in QoL. Although the disease is more prevalent among women it was found to be of greater severity among men. The QoL seems to be influenced by disease severity and increasing age but it was independent of the other studied variables.

scholarly journals Karakteristik penyakit kulit pada anak di poliklinik kulit dan kelamin RSUP. Dr. M. Djamil Padang periode 2016-2018

2020 ◽  
Vol 20 (3) ◽  
Author(s):  
Rina Gustia ◽  
Satya Wydya Yenny ◽  
Sigya Octari
Keyword(s):  
Fungal Infection ◽  
Skin Disease ◽  
Medical Records ◽  
Skin Diseases ◽  
Fungal Infections ◽  
Common Disease ◽  
High Morbidity ◽  
Common Skin ◽  
The Impact

Abstrak. Latar belakang : Penyakit kulit menyebabkan morbiditas yang tinggi, termasuk pada anak. Prevalensi dermatosis pada anak berkisar 34-87,7% dengan pola yang sangat bervariasi dan dipengaruhi oleh banyak faktor. Dampak penyakit kulit ini dapat mempengaruhi kualitas hidup anak.Metode : Penelitian retrospektif deskriptif  dengan  mengambil data dari rekam medis pasien anak dengan umur 1-18 tahun yang berobat ke Poliklinik Kulit dan Kelamin RSUP.Dr. M. Djamil Padang pada periode Januari 2016– Desember 2018. Hasil : Selama 3 tahun didapatkan 277 pasien baru, perempuan 123 (44,4%) dan laki - laki 154 (55,6%). Berdasarkan kelompok  penyakit yang terbanyak adalah dermatitis  (29, 9%), diikuti oleh infeksi jamur (16,9%), infestasi parasit (13, 4%),  infeksi virus (13, 3%), dan infeksi bakteri (6,9%).Kesimpulan:  Penyakit kulit terbanyak terjadi pada anak laki – laki. Infeksi jamur merupakan penyakit kulit paling sering, diikuti oleh infestasi parasit. Infeksi jamur yang sering terjadi adalah pitiriasis versikolor, sedangkan infestasi parasit yang paling sering adalah skabies.              Kata kunci: karakteristik penyakit kulit, anak, penelitian retrospektif Abstrack. Background: Skin disease causes high morbidity, including in children. The prevalence of dermatosis in children ranges from 34 to 87.7% with a pattern that is varied and influenced by many factors. The impact of this skin disease can affect the quality of life of childrenMethod : A descriptive retrospective, which is taking data from the medical records of patients aged 1 - 18 years who seek treatment at Dermatology and Venereology outpatient clinic at RSUP. M. Djamil Padang in the period January 2016 - December 2018.Result : During 3 years,there were 277 new patient which consist of 123 boy  (44.4%) and 154 girl (55.6%). Based on the group of diseases, dermatitis were the most common  disease (29,9%), followed by fungal infection (16.9%), parasit infestations (13,4%), viral infection (13,3%) and bacterial infection (6,9%). Conclusion : Most skin diseases occur in boys. Fungal infections were the most common skin diseases, followed by parasit infestations. The most common fungal infection is pityriasis versicolor, while the most frequent parasit infestation is scabies.Keywords:characterization of skin diseases, children, retrospective study

scholarly journals Characteristics and clinical significance of spondylolisthetic and spino-pelvic sagittal parameters in kyphotic low-grade degenerative lumbar spondylolisthesis

2020 ◽  
Author(s):  
Chongqing Xu ◽  
Mengchen Yin ◽  
Wen Mo
Keyword(s):  
Life Quality ◽  
Observer Agreement ◽  
Common Disease ◽  
Low Grade ◽  
Significant Difference ◽  
Degenerative Lumbar Spondylolisthesis ◽  
Sagittal Parameters ◽  
Lumbar Spondylolisthesis ◽  
The Impact

Abstract Background: Degenerative lumbar spondylolisthesis (DLS) has been a common disease that make increasing patients suffer from different degrees of low back pain and radicular symptoms. At present, the incidence of kyphosis in DLS and the differences in spinal sagittal morphology between kyphotic and non-kyphotic DLS still remain unclear. Our study aimed to determine the incidence of kyphosis in DLS, explore the characteristics of spondylolisthetic and spino-pelvic sagittal parameters, and evaluate the impact of kyphosis on the life quality of patients with DLS.Methods/Design: All 108 patients with L4/5 low-grade DLS were enrolled and divided into kyphotic and non-kyphotic group. 2 spine surgeons who have certain clinical experience were selected to measure the spondylolisthetic and spino-pelvic parameters, as well as visual analogue scale (VAS) and Oswestry disability index (ODI). Differences between the 2 groups and characteristics of measurements were analyzed.Results: The inter-observer agreement of all parameters between the 2 spine surgeons were excellent with each ICC > 0.75. Kyphotic group had higher SA, SD, SDM, SAM, PDH, PT and SVA, and lower ADH, SS and LL than those in non-kyphotic group (p < 0.01). There was no significant difference in PI and TK between the two groups (p > 0.05).Conclusion: The incidence of kyphotic spondylolisthesis in patients with L4/5 low-grade DLS is 16.7%. Compared with those in non-kyphotic group, patients with kyphosis show inferior results of spondylolisthetic parameters, more severe loss of LL, more obvious pelvic retroversion and trunk anteversion, which indicates worse spino-pelvic sagittal balance. In addition, their quality of life was significantly lower than that of patients in non-kyphotic group.

Distraction Osteogenesis in the Treatment of Craniofacial Anomalies: Applications and Outcomes

2020 ◽  
Vol 5 (6) ◽  
pp. 1469-1481 ◽  
Author(s):  
Joseph A. Napoli ◽  
Carrie E. Zimmerman ◽  
Linda D. Vallino
Keyword(s):  
Distraction Osteogenesis ◽  
Bone Growth ◽  
Upper Airway ◽  
Craniofacial Anomalies ◽  
Craniofacial Skeleton ◽  
Facial Skeleton ◽  
Psychosocial Impairment ◽  
And Function ◽  
Correct Structure

Purpose Craniofacial anomalies (CFA) often result in growth abnormalities of the facial skeleton adversely affecting function and appearance. The functional problems caused by the structural anomalies include upper airway obstruction, speech abnormalities, feeding difficulty, hearing deficits, dental/occlusal defects, and cognitive and psychosocial impairment. Managing disorders of the craniofacial skeleton has been improved by the technique known as distraction osteogenesis (DO). In DO, new bone growth is stimulated allowing bones to be lengthened without need for bone graft. The purpose of this clinical focus article is to describe the technique and clinical applications and outcomes of DO in CFA. Conclusion Distraction can be applied to various regions of the craniofacial skeleton to correct structure and function. The benefits of this procedure include improved airway, feeding, occlusion, speech, and appearance, resulting in a better quality of life for patients with CFA.

Surgery for Lung Cancer and the Consequences for the Swallow

2016 ◽  
Vol 1 (13) ◽  
pp. 162-168
Author(s):  
Pippa Hales ◽  
Corinne Mossey-Gaston
Keyword(s):  
Lung Cancer ◽  
Treatment Options ◽  
Vocal Cord Palsy ◽  
Subsequent Treatment ◽  
Physiological Reserve ◽  
Palliative Phase ◽  
And Function ◽  
The Impact ◽  
Swallow Function

Lung cancer is one of the most commonly diagnosed cancers across Northern America and Europe. Treatment options offered are dependent on the type of cancer, the location of the tumor, the staging, and the overall health of the person. When surgery for lung cancer is offered, difficulty swallowing is a potential complication that can have several influencing factors. Surgical interaction with the recurrent laryngeal nerve (RLN) can lead to unilateral vocal cord palsy, altering swallow function and safety. Understanding whether the RLN has been preserved, damaged, or sacrificed is integral to understanding the effect on the swallow and the subsequent treatment options available. There is also the risk of post-surgical reduction of physiological reserve, which can reduce the strength and function of the swallow in addition to any surgery specific complications. As lung cancer has a limited prognosis, the clinician must also factor in the palliative phase, as this can further increase the burden of an already compromised swallow. By understanding the surgery and the implications this may have for the swallow, there is the potential to reduce the impact of post-surgical complications and so improve quality of life (QOL) for people with lung cancer.

Income and Life Quality of Farmer Households Suffering Social Exclusion

2012 ◽  
pp. 63-87
Author(s):  
Anh Mai Ngoc ◽  
Ha Do Thi Hai ◽  
Huyen Nguyen Thi Ngoc
Keyword(s):  
Labor Market ◽  
Statistical Method ◽  
Social Exclusion ◽  
Central Government ◽  
Life Quality ◽  
Economic Aspect ◽  
Local Authorities ◽  
The Impact

This study uses descriptive statistical method to analyze the income and life qual- ity of 397 farmer households who are suffering social exclusion in an economic aspect out of a total of 725 households surveyed in five Northern provinces of Vietnam in 2010. The farmers’ opinions of the impact of the policies currently prac- ticed by the central government and local authorities to give them access to the labor market are also analyzed in this study to help management officers see how the poli- cies affect the beneficiaries so that they can later make appropriate adjustments.

Sign in / Sign up

Export Citation Format

Share Document