scholarly journals Design of Gelatin-Capped Plasmonic-Diatomite Nanoparticles with Enhanced Galunisertib Loading Capacity for Drug Delivery Applications

2021 ◽  
Vol 22 (19) ◽  
pp. 10755
Author(s):  
Chiara Tramontano ◽  
Bruno Miranda ◽  
Giovanna Chianese ◽  
Luca De Stefano ◽  
Carlo Forestiere ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Polymer Concentration ◽  
Localized Surface Plasmon ◽  
Loading Capacity ◽  
Predictive Tool ◽  
Optical Modeling ◽  
Hybrid Platform ◽  
Drug Delivery Applications ◽  
First Time

Inorganic diatomite nanoparticles (DNPs) have gained increasing interest as drug delivery systems due to their porous structure, long half-life, thermal and chemical stability. Gold nanoparticles (AuNPs) provide DNPs with intriguing optical features that can be engineered and optimized for sensing and drug delivery applications. In this work, we combine DNPs with gelatin stabilized AuNPs for the development of an optical platform for Galunisertib delivery. To improve the DNP loading capacity, the hybrid platform is capped with gelatin shells of increasing thicknesses. Here, for the first time, full optical modeling of the hybrid system is proposed to monitor both the gelatin generation, degradation, and consequent Galunisertib release by simple spectroscopic measurements. Indeed, the shell thickness is optically estimated as a function of the polymer concentration by exploiting the localized surface plasmon resonance shifts of AuNPs. We simultaneously prove the enhancement of the drug loading capacity of DNPs and that the theoretical modeling represents an efficient predictive tool to design polymer-coated nanocarriers.

scholarly journals Preparation and Evaluation of Eudragit® L100 Nanoparticles LoadedImpregnated with KT Tromethamine Loaded PVA -HEC Insertions forOphthalmic Drug Delivery

2019 ◽  
Vol 9 (4) ◽  
pp. 593-600
Author(s):  
Ghobad Mohammadi ◽  
Shahla Mirzaeei ◽  
Shiva Taghe ◽  
Pardis Mohammadi
Keyword(s):  
Drug Delivery ◽  
Moisture Absorption ◽  
Drug Loading ◽  
Polymer Concentration ◽  
Hydroxyethyl Cellulose ◽  
Moisture Loss ◽  
Physiochemical Parameters ◽  
Ft Ir ◽  
First Time ◽  
Preparation And Evaluation

Purpose: The purpose of the present study was to improve the ocular delivery for ketorolactromethamine (KT) used to treat inflammation of the eye.Methods: Eudragit nanoparticles loaded with KT were prepared and incorporated in polyvinylalcohol (PVA) and hydroxyethyl cellulose (HEC) films. Nanoparticles were characterized byFourier transform-infrared (FT-IR), scanning electron microscopy (SEM). Physicochemicalproperties and encapsulation effciency were investigated for nanoparticles. Also, the insertswere evaluated for their physiochemical parameters like percentage moisture absorption,percentage moisture loss, thickness and folding endurance.Results: Mean particle size and zeta potential were in range of 153.8-217 nm and (-10.8) -(-40.7) mV, respectively. The results show that the use of a surfactant has not led to any majorchange on drug loading. The loading increases with the amount of polymer. The insert had athickness varying from 0.072 ± 0.0098 to 0.0865 ± 0.0035 mm. The thicknesses of the insertsand the folding endurance increased with the total polymer concentration. The physicochemicalproperties showed that the Eudragit® L-100 nanoparticles loaded PVA-HEC films could be aneffective carrier for KT.Conclusion: For the first time, inserts of Eudragit nanoparticles were successfully prepared forophthalmic drug delivery system to prevent frequent drug administration and enhance patientcompliance.<br />

Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24142-24153
Author(s):  
Andreea S. Voda ◽  
Kevin Magniez ◽  
Nisa V. Salim ◽  
Cynthia Wong ◽  
Qipeng Guo
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene ◽  
First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

scholarly journals Synthesis and Characterization of Stearic Acid-Beclomethasone Dipropionate Conjugates with the Potential for Improving Loading Capacity in Lipid-based Nanoparticles

2021 ◽  
Author(s):  
Shishuai Dang ◽  
Zhengwei Huang ◽  
Ying Huang ◽  
Xin Pan ◽  
Chuanbin Wu
Keyword(s):  
Drug Delivery ◽  
Stearic Acid ◽  
Beclomethasone Dipropionate ◽  
Drug Loading ◽  
Pulmonary Delivery ◽  
Dynamics Simulation ◽  
Loading Capacity ◽  
Technology Platform ◽  
New Type ◽  
Model Drug

<p>Lipid-based nanoparticles (LBNs) are a new type of nanoparticulate drug delivery system, which have been gradually shown broad prospects in pulmonary drug delivery systems. However, the main disadvantage of these LBNs for inhalable drugs with limited lipophilicity is the low encapsulation capacity. Herein, this study anticipates establishing a technology platform to improve the loading capacity of low lipophilicity drugs in LBNs, for the therapy of lung diseases. A proof-of-concept was carried out using Beclomethasone dipropionate (BDP) as a model drug. BDP was conjugated with stearic acid (SA), a kind of the lipid matrix for LBN. The conjugate was characterized and the interactions between the conjugate and SA were investigated by molecular dynamics simulation. It is expected that the drug loading capacity of weak-lipophilic drugs in LBN can be increased by establishing the technology platform, and the application of LBNs in pulmonary delivery can be broadened.</p>

Metal–organic frameworks: a universal strategy towards super-elastic hydrogels

2019 ◽  
Vol 10 (18) ◽  
pp. 2263-2272 ◽  
Author(s):  
Huaizhi Liu ◽  
Hao Peng ◽  
Yumeng Xin ◽  
Jiuyang Zhang
Keyword(s):  
Drug Delivery ◽  
Mechanical Performance ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
High Loading ◽  
Loading Capacity ◽  
Metal Organic ◽  
First Time ◽  
Organic Framework

We reported for the first time using metal–organic framework (MOF) nanoparticles as effective nanofillers to significantly enhance the mechanical performance of hydrogels. The MOF hydrogels have been developed for drug delivery materials with high loading capacity and much extended drug releasing profiles.

scholarly journals Synthesis and characterization of magnetic chitosan microspheres for drug delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 7163-7169
Author(s):  
Xin Li ◽  
Danlin Zeng ◽  
Ping Ke ◽  
Guanghui Wang ◽  
Dengke Zhang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Synthesis And Characterization ◽  
Loading Capacity ◽  
Microemulsion Polymerization ◽  
Magnetic Microsphere ◽  
Magnetic Chitosan Microspheres ◽  
Protein Drug Delivery

A novel magnetic microsphere was prepared by the simple microemulsion polymerization for protein drug delivery systems. This magnetic microsphere exhibited good magnetism and superior drug loading capacity and evident sustained-release performance.

scholarly journals In Vitro Cytotoxicity and Antitumor Activity of Dual-Targeting Drug Delivery System Based on Modified Magnetic Carbon by Folate

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Jinglei Du ◽  
Qiang Li ◽  
Lin Chen ◽  
Shicai Wang ◽  
Li Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hela Cells ◽  
Folate Receptor ◽  
Drug Loading ◽  
Magnetic Characteristics ◽  
Loading Capacity ◽  
Dual Targeting

A dual-targeting drug delivery system (DTDDS) with magnetic targeting and active targeting was obtained to improve the targeting and drug-loading capacity of magnetic drug nanocarriers. An ultraviolet-visible spectrophotometer and flow cytometry were used to investigate the drug-loading and release capacity, cytotoxicity, and inhibition of tumor cell proliferation, separately. Results show that DTDDS has obvious magnetic characteristics, on which the modification amount of folic acid is 64.82 mg g-1. Doxorubicin was taken as a template drug to evaluate its drug-loading capacity, which was as high as 577.12 mg g-1. Good biocompatibility and low cytotoxicity of DTDDS were further confirmed. Moreover, DTDDS can target the folate receptor on the surface of HeLa cells and deliver doxorubicin into HeLa cells, thereby increasing the proliferation inhibition for cancer cells. Therefore, this new dual-targeting drug delivery system shows potential in significantly reducing the toxic side effects of chemotherapy and improving chemotherapy efficiency.

scholarly journals Cellulose Beads Derived from Waste Textiles for Drug Delivery

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1621
Author(s):  
Beini Zeng ◽  
Xungai Wang ◽  
Nolene Byrne
Keyword(s):  
Drug Delivery ◽  
Ionic Liquids ◽  
Surface Area ◽  
Pore Volume ◽  
Potential Application ◽  
Drug Loading ◽  
Loading Capacity ◽  
Fibrous Morphology ◽  
Morphological Differences ◽  
The Impact

Cellulose beads were successfully prepared from waste denim using a dissolution-regeneration approach with ionic liquids as the dissolving solvent. Cellulose beads with different morphologies were achieved by altering the dissolving and coagulating solvents. The morphological differences were quantified by N2 physisorption. The impact of morphology on the cellulose beads’ potential application was investigated in the context of drug loading and release. The results show that the fibrous morphology showed a better loading capacity than the globular analogue due to its higher surface area and pore volume.

scholarly journals Synthesis and compatibility evaluation of versatile mesoporous silica nanoparticles with red blood cells: an overview

RSC Advances ◽  
2019 ◽  
Vol 9 (61) ◽  
pp. 35566-35578 ◽  
Author(s):  
Subhankar Mukhopadhyay ◽  
Hanitrarimalala Veroniaina ◽  
Tadious Chimombe ◽  
Lidong Han ◽  
Wu Zhenghong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Blood Cells ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
High Drug Loading

Protean mesoporous silica nanoparticles are propitious candidates over decades for nanoscale drug delivery systems due to their unique characteristics, including changeable pore size, mesoporosity, high drug loading capacity and biodegradability.

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