scholarly journals Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders

2021 ◽  
Vol 22 (21) ◽  
pp. 11584
Author(s):  
Annia Galano ◽  
Eduardo G. Guzmán-López ◽  
Russel J. Reiter
Keyword(s):  
Neurodegenerative Disorders ◽  
Multiple Target ◽  
Multifactorial Diseases ◽  
Theoretical Perspectives ◽  
The Subject ◽  
New Compounds ◽  
Multiple Health ◽  
Related Compounds ◽  
Potential Use ◽  
Molecular Framework

Although melatonin is an astonishing molecule, it is possible that chemistry will help in the discovery of new compounds derived from it that may exceed our expectations regarding antioxidant protection and perhaps even neuroprotection. This review briefly summarizes the significant amount of data gathered to date regarding the multiple health benefits of melatonin and related compounds. This review also highlights some of the most recent directions in the discovery of multifunctional pharmaceuticals intended to act as one-molecule multiple-target drugs with potential use in multifactorial diseases, including neurodegenerative disorders. Herein, we discuss the beneficial activities of melatonin derivatives reported to date, in addition to computational strategies to rationally design new derivatives by functionalization of the melatonin molecular framework. It is hoped that this review will promote more investigations on the subject from both experimental and theoretical perspectives.

scholarly journals Imaging Familial and Sporadic Neurodegenerative Disorders Associated with Parkinsonism

2021 ◽  
Author(s):  
David J. Brooks
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurodegenerative Disorders ◽  
Lewy Body Dementia ◽  
Imaging Biomarkers ◽  
Imaging Findings ◽  
Subclinical Disease ◽  
Similarities And Differences ◽  
Potential Use

AbstractIn this paper, the structural and functional imaging changes associated with sporadic and genetic Parkinson’s disease and atypical Parkinsonian variants are reviewed. The role of imaging for supporting diagnosis and detecting subclinical disease is discussed, and the potential use and drawbacks of using imaging biomarkers for monitoring disease progression is debated. Imaging changes associated with nonmotor complications of PD are presented. The similarities and differences in imaging findings in Lewy body dementia, Parkinson’s disease dementia, and Alzheimer’s disease are discussed.

Corruption Measurements: Caught Between Conceptualizing the Phenomenon and Promoting New Governance Agenda?

2021 ◽  
pp. 097226292098394
Author(s):  
Kannan Perumal
Keyword(s):  
Data Aggregation ◽  
Policy Advocacy ◽  
New Governance ◽  
Methodological Issues ◽  
Topic Evolution ◽  
Theoretical Perspectives ◽  
Control Framework ◽  
The Subject ◽  
Theoretical Issues ◽  
Insight Into

The work ‘Corruption Measurements: Caught Between Conceptualizing the Phenomenon and Promoting New Governance Agenda?’ is a qualitative study based on reviewing the literature available on the subject. It starts with the introduction that explains the evolution of the idea of measuring corruption, its relevance to governance and associated theoretical issues. The topic, ‘Evolution of Corruption Measurements’ gives an overview about different corruption indices. While the topic ‘Challenges to Corruption Measurements’ briefly introduces the challenges faced by corruption measurements, the topics ‘Conceptualizing Corruption’ and ‘Methodological Issues’ give insight into the contentions faced by corruption measurements from different theoretical perspectives. Also, explained in these sections are how the corruption measurements have conceptualized corruption over the period of three decades; and how do they keep evolving their methods in order to become more relevant in policy advocacy. Issues associated with data aggregation also are explained in-depth in this work. This work demonstrates that though continuous methodological evolution and empirical research have helped corruption measurements to improve their acceptance level, the gap that exist between corruption control framework and practice will remain a challenge to address in future if corruption measurements do not genuinely account the contextual realities.

scholarly journals Synthesis and Bioinformatic Characterization of New Schiff Bases with Possible Applicability in Brain Disorders

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4160
Author(s):  
Speranta Avram ◽  
Ana Maria Udrea ◽  
Diana Camelia Nuta ◽  
Carmen Limban ◽  
Adrian Cosmin Balea ◽  
...  
Keyword(s):  
Schiff Bases ◽  
Neurodegenerative Disorders ◽  
Aromatic Aldehydes ◽  
Brain Disorders ◽  
Ir And Nmr Spectroscopy ◽  
Bioinformatics Tools ◽  
Ft Ir ◽  
New Treatments ◽  
New Compounds

(1) Background: The research aims to find new treatments for neurodegenerative diseases, in particular, Alzheimer’s disease. (2) Methods: This article presents a bioinformatics and pathology study of new Schiff bases, (EZ)-N′-benzylidene-(2RS)-2-(6-chloro-9H-carbazol-2-yl)propanehydrazide derivatives, and aims to evaluate the drug-like, pharmacokinetic, pharmacodynamic and pharmacogenomic properties, as well as to predict the binding to therapeutic targets by applying bioinformatics, cheminformatics and computational pharmacological methods. (3) Results: We obtained these Schiff bases by condensing (2RS)-2-(6-chloro-9H-carbazol-2-yl)propanehydrazide with aromatic aldehydes, using the advantages of microwave irradiation. The newly synthesized compounds were characterized spectrally, using FT-IR and NMR spectroscopy, which confirmed their structure. Using bioinformatics tools, we noticed that all new compounds are drug-likeness features and may be proposed as potentially neuropsychiatric drugs (4) Conclusions: Using bioinformatics tools, we determined that the new compound 1e had a high potential to be used as a good candidate in neurodegenerative disorders treatment.

scholarly journals Metabolomic Study of Heterotrophically Grown Chlorella sp. Isolated from Wastewater in Northern Sweden

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2410
Author(s):  
Jean Claude Nzayisenga ◽  
Anita Sellstedt
Keyword(s):  
Sustainable Development ◽  
Butyric Acid ◽  
Lipid Production ◽  
Growth Conditions ◽  
Northern Sweden ◽  
Metabolic Intermediate ◽  
Chlorella Sp ◽  
Lipid Contents ◽  
New Compounds ◽  
Potential Use

There are numerous strains of Chlorella with a corresponding variety of metabolic pathways. A strain we previously isolated from wastewater in northern Sweden can grow heterotrophically as well as autotrophically in light and has higher lipid contents under heterotrophic growth conditions. The aims of the present study were to characterize metabolic changes associated with the higher lipid contents in order to enhance our understanding of lipid production in microalgae and potentially identify new compounds with utility in sustainable development. Inter alia, the amino acids glutamine and lysine were 7-fold more abundant under heterotrophic conditions, the key metabolic intermediate alpha-ketoglutarate was more abundant under heterotrophic conditions with glucose, and maltose was more abundant under heterotrophic conditions with glycerol than under autotrophic conditions. The metabolite 3-hydroxy-butyric acid, the direct precursor of the biodegradable plastic PHB (poly-3-hydroxy-butyric acid), was also more abundant under heterotrophic conditions. Our metabolomic analysis has provided new insights into the alga’s lipid production pathways and identified metabolites with potential use in sustainable development, such as the production of renewable, biodegradable plastics, cosmetics, and nutraceuticals, with reduced pollution and improvements in both ecological and human health.

scholarly journals V. Researches on the action of sulphuric acid upon the amides and nitriles, with remarks on the conjugate sulpho-acids

1857 ◽  
Vol 8 ◽  
pp. 158-165 ◽  
Keyword(s):  
Sulphuric Acid ◽  
Royal Society ◽  
Short Summary ◽  
The Subject ◽  
New Compounds

Since we had the honour of addressing the Royal Society upon the subject of the behaviour of acetamide and acetonitrile towards sulphuric acid, we have completed our experiments upon the amides and nitriles, and extended our researches to other groups of bodies. The results of these additional inquiries we now beg to present in the form of a second short summary, the analytical details and the more extended description of the new compounds being given in the complete memoir, which, at the same time, we have the honour of submitting to the Society.

Core-modified porphyrins: novel building blocks in chemistry

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Aleksey E. Kuznetsov
Keyword(s):  
Periodic Table ◽  
Building Blocks ◽  
Effective Strategy ◽  
Research Groups ◽  
Structures And Properties ◽  
Porphyrin Core ◽  
Living Organisms ◽  
New Compounds ◽  
Related Compounds ◽  
Nitrogen Phosphorus

Abstract Various (metallo)porphyrins and related compounds have been intensively investigated by different research groups due to their extremely important role in living organisms along with their versatile applications in technology. The design of novel porphyrinoids by core-modification, or substitution of pyrrole nitrogens, with the elements of other groups of the Periodic Table has been considered as a highly promising methodology for tuning structures and properties of porphyrinoids and thus opening new possible applications for them. Much effort has been given to the modifications of the porphyrin core with elements of the main groups, namely O, S, Se (chalcogens), and the heavier congener of nitrogen, phosphorus. In general, the porphyrin core modification by replacing nitrogens with heteroatoms is a promising and effective strategy for obtaining new compounds with unusual structures and properties (optical, electrochemical, coordinating, etc.) as well as reactivity. These novel molecules can also be employed as promising building or construction blocks in various applications in the nanotechnology area.

scholarly journals Feminist Scholarship and Its Relevance for Political Engagement: The Test Case of Abortion in the US

2011 ◽  
Vol 1 (1) ◽  
pp. 18-43
Author(s):  
Margaret D. Kamitsuka
Keyword(s):  
Identity Politics ◽  
Political Engagement ◽  
Religious Studies ◽  
Test Case ◽  
Theoretical Perspectives ◽  
Starting Point ◽  
The Us ◽  
The Subject ◽  
Ethical Thinking ◽  
Societal Dynamics

This essay explores how gender studies in academe, including in religious studies, might remain relevant to ongoing feminist political engagement. I explore some specific dynamics of this challenge, using as my test case the issue of abortion in the US. After discussing how three formative feminist principles (women’s experience as feminism’s starting point, the personal is political, and identity politics) have shaped approaches to the abortion issue for feminist scholars in religion, I argue that ongoing critique, new theoretical perspectives, and attentiveness to subaltern voices are necessary for these foundational feminist principles to keep pace with fast-changing and complex societal dynamics relevant to women’s struggles for reproductive health and justice. The essay concludes by proposing natality as a helpful concept for future feminist theological and ethical thinking on the subject.

scholarly journals New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators

Molecules ◽  
2022 ◽  
Vol 27 (2) ◽  
pp. 545
Author(s):  
Niccolò Chiaramonte ◽  
Alessio Gabellini ◽  
Andrea Angeli ◽  
Gianluca Bartolucci ◽  
Laura Braconi ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Imidazole Ring ◽  
Aliphatic Chain ◽  
Amino Group ◽  
Carbonic Anhydrase I ◽  
Terminal Amino ◽  
Human Carbonic Anhydrase ◽  
New Compounds ◽  
Related Compounds ◽  
Micromolar Range

A series of histamine (HST)-related compounds were synthesized and tested for their activating properties on five physiologically relevant human Carbonic Anhydrase (hCA) isoforms (I, II, Va, VII and XIII). The imidazole ring of HST was replaced with different 5-membered heterocycles and the length of the aliphatic chain was varied. For the most interesting compounds some modifications on the terminal amino group were also performed. The most sensitive isoform to activation was hCA I (KA values in the low micromolar range), but surprisingly none of the new compounds displayed activity on hCA II. Some derivatives (1, 3a and 22) displayed an interesting selectivity for activating hCA I over hCA II, Va, VII and XIII.

Ethnologie

2017 ◽  
Keyword(s):  
Cultural Diversity ◽  
Social Anthropology ◽  
Anthropology Of Media ◽  
Theoretical Approaches ◽  
Theoretical Perspectives ◽  
History Of ◽  
The Subject ◽  
Insight Into ◽  
Development Anthropology

Researching cultural diversity is a central subject of social anthropology. 25 authors from institutes in Germany, Austria and Switzerland offer an insight into the subject, its contents and theoretical perspectives. The articles cover a variety of topics: the history of the discipline as well as basic theories and methods, subareas such as business or kinship anthropology, crosscutting issues such as anthropology of media, but also up-to-date specialised fields such as urban or development anthropology. The book is therefore invaluable for students and anyone interested in social anthropology who wants to open up fields of work, theoretical approaches and results of the subject.

scholarly journals Pharmacoepigenomic Interventions as Novel Potential Treatments for Alzheimer’s and Parkinson’s Diseases

2018 ◽  
Vol 19 (10) ◽  
pp. 3199 ◽  
Author(s):  
Oscar Teijido ◽  
Ramón Cacabelos
Keyword(s):  
Neurodegenerative Disorders ◽  
Molecular Mechanisms ◽  
Pathological Process ◽  
Epigenetic Mechanisms ◽  
Dietary Interventions ◽  
Parkinson’S Diseases ◽  
The World ◽  
Multifactorial Disorders ◽  
Late Stages ◽  
Potential Use

Cerebrovascular and neurodegenerative disorders affect one billion people around the world and result from a combination of genomic, epigenomic, metabolic, and environmental factors. Diagnosis at late stages of disease progression, limited knowledge of gene biomarkers and molecular mechanisms of the pathology, and conventional compounds based on symptomatic rather than mechanistic features, determine the lack of success of current treatments, including current FDA-approved conventional drugs. The epigenetic approach opens new avenues for the detection of early presymptomatic pathological events that would allow the implementation of novel strategies in order to stop or delay the pathological process. The reversibility and potential restoring of epigenetic aberrations along with their potential use as targets for pharmacological and dietary interventions sited the use of epidrugs as potential novel candidates for successful treatments of multifactorial disorders involving neurodegeneration. This manuscript includes a description of the most relevant epigenetic mechanisms involved in the most prevalent neurodegenerative disorders worldwide, as well as the main potential epigenetic-based compounds under investigation for treatment of those disorders and their limitations.

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