scholarly journals Potential Beneficial Effects of Vitamin K in SARS-CoV-2 Induced Vascular Disease?

Immuno ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 17-29
Author(s):  
Mateusz Kudelko ◽  
Tsz Fung Yip ◽  
Grace Chun Hei Law ◽  
Suki Man Yan Lee
Keyword(s):  
Vascular Disease ◽  
Vitamin K ◽  
Cardiovascular Complications ◽  
Coagulation System ◽  
Vitamin K Deficiency ◽  
Beneficial Effects ◽  
Disease Outcomes ◽  
Potential Benefits ◽  
K Deficiency

Prevalent coagulopathy and thromboembolism are observed in severe COVID-19 patients with 40% of COVID-19 mortality being associated with cardiovascular complications. Abnormal coagulation parameters are related to poor prognosis in COVID-19 patients. Victims also displayed presence of extensive thrombosis in infected lungs. Vitamin K is well-known to play an essential role in the coagulation system. Latest study revealed an existing correlation between vitamin K deficiency and COVID-19 severity, highlighting a role of vitamin K, probably via coagulation modulation. In agreement, other recent studies also indicated that anti-coagulant treatments can reduce mortality in severe cases. Altogether, potential mechanisms linking COVID-19 with coagulopathy in which vitamin K may exert its modulating role in coagulation related with disease pathogenesis are established. In this review, we discuss the recent evidence supporting COVID-19 as a vascular disease and explore the potential benefits of using vitamin K against COVID-19 to improve disease outcomes.

scholarly journals Vitamin K in COVID-19—Potential Anti-COVID-19 Properties of Fermented Milk Fortified with Bee Honey as a Natural Source of Vitamin K and Probiotics

Fermentation ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 202
Author(s):  
Amira Mohammed Ali ◽  
Hiroshi Kunugi ◽  
Hend A. Abdelmageed ◽  
Ahmed S. Mandour ◽  
Mostafa Elsayed Ahmed ◽  
...  
Keyword(s):  
Vitamin K ◽  
Vitamin K Antagonists ◽  
Oral Anticoagulants ◽  
Empirical Studies ◽  
Fermented Milk ◽  
Organ Damage ◽  
Natural Source ◽  
Vitamin K Deficiency ◽  
K Deficiency

Vitamin K deficiency is evident in severe and fatal COVID-19 patients. It is associated with the cytokine storm, thrombotic complications, multiple organ damage, and high mortality, suggesting a key role of vitamin K in the pathology of COVID-19. To support this view, we summarized findings reported from machine learning studies, molecular simulation, and human studies on the association between vitamin K and SARS-CoV-2. We also investigated the literature for the association between vitamin K antagonists (VKA) and the prognosis of COVID-19. In addition, we speculated that fermented milk fortified with bee honey as a natural source of vitamin K and probiotics may protect against COVID-19 and its severity. The results reported by several studies emphasize vitamin K deficiency in COVID-19 and related complications. However, the literature on the role of VKA and other oral anticoagulants in COVID-19 is controversial: some studies report reductions in (intensive care unit admission, mechanical ventilation, and mortality), others report no effect on mortality, while some studies report higher mortality among patients on chronic oral anticoagulants, including VKA. Supplementing fermented milk with honey increases milk peptides, bacterial vitamin K production, and compounds that act as potent antioxidants: phenols, sulforaphane, and metabolites of lactobacilli. Lactobacilli are probiotic bacteria that are suggested to interfere with various aspects of COVID-19 infection ranging from receptor binding to metabolic pathways involved in disease prognosis. Thus, fermented milk that contains natural honey may be a dietary manipulation capable of correcting nutritional and immune deficiencies that predispose to and aggravate COVID-19. Empirical studies are warranted to investigate the benefits of these compounds.

scholarly journals PREVENTION OF BLEEDING ASSOCIATED WITH LATE VITAMIN K DEFICIENCY IN INFANTS OF THE FIRST THREE MONTHS OF LIFE - TACTICS OF REDUCTION OF DEATHS AND DISABILITY

2020 ◽  
pp. 52-60
Author(s):  
M. M. Kiselovа
Keyword(s):  
Vitamin K ◽  
The United States ◽  
Hemorrhagic Disease ◽  
Vitamin K Deficiency ◽  
Chronic Cholestasis ◽  
K Deficiency ◽  
Prophylactic Use ◽  
Role Of Parents ◽  
Current Guidelines

The article, intended for neonatologists, general practitioners, family medicine, pediatricians, presents the main causes of disorders in the hemostasis system, which lead to the development of hemorrhagic syndrome in newborns and infants. Emphasis is placed on various forms of neonatal hemorrhagic disease (NHD), which is based on a deficiency of fat-soluble vitamin K. The main risk group for bleeding associated with late vitamin K deficiency is formed by children who are exclusively breastfed. The article presents modern approaches to the prevention of late bleeding associated with vitamin K deficiency, which is based on chronic problems of the digestive system – chronic cholestasis, cystic fibrosis and others. Describes and interprets current guidelines for the prophylactic use of vitamin K in infants in the first three months of life in European countries of high economic development, the United States, which reflects various effective schemes for the prevention of bleeding associated with vitamin K deficiency in infants, differing in single dose application of a preventive course and a way of administration of vitamin K (phytomenadione). The role of parents in the prevention of vitamin K deficiency in infants who are breastfed is emphasized.

Emerging Issues in Vitamin K Research

2011 ◽  
Vol 16 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Jennifer T. Truong ◽  
Sarah L. Booth
Keyword(s):  
At Risk ◽  
Reproductive Health ◽  
Vitamin K ◽  
Blood Clotting ◽  
Current Evidence ◽  
Vitamin K Deficiency ◽  
Emerging Issues ◽  
K Deficiency

Vitamin K is traditionally recognized for its role in blood clotting. More recently, new roles for vitamin K have emerged. The current evidence for the role of vitamin K in bone, cardiovascular, and reproductive health will be discussed. There will be a particular focus on populations who could be at risk for vitamin K deficiency.

Role of Vitamin A in Induction of Vitamin K Deficiency in the Rat

1962 ◽  
Vol 109 (1) ◽  
pp. 139-142 ◽  
Author(s):  
J. T. Matschiner ◽  
E. A. Doisy
Keyword(s):  
Vitamin A ◽  
Vitamin K ◽  
Vitamin K Deficiency ◽  
K Deficiency

scholarly journals Vitamin K Nutrition and Bone Health

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1909 ◽  
Author(s):  
Naoko Tsugawa ◽  
Masataka Shiraki
Keyword(s):  
Energy Metabolism ◽  
Fracture Risk ◽  
Vitamin K ◽  
Bone Health ◽  
Bone Fractures ◽  
Vitamin K Deficiency ◽  
Protein Levels ◽  
K Deficiency ◽  
Dependent Protein

Vitamin K is essential for blood coagulation and plays an important role in extrahepatic metabolism, such as in bone and blood vessels, and in energy metabolism. This review discusses the assessment of vitamin K sufficiency and the role of vitamin K in bone health. To elucidate the exact role of vitamin K in other organs, accurate tools for assessing vitamin K deficiency or insufficiency are crucial. Undercarboxylated vitamin K-dependent protein levels can be measured to evaluate tissue-specific vitamin K deficiency/insufficiency. Vitamin K has genomic action through steroid and xenobiotic receptor (SXR); however, the importance of this action requires further study. Recent studies have revealed that the bone-specific, vitamin K-dependent protein osteocalcin has a close relationship with energy metabolism through insulin sensitivity. Among the organs that produce vitamin K-dependent proteins, bone has attracted the most attention, as vitamin K deficiency has been consistently associated with bone fractures. Although vitamin K treatment addresses vitamin K deficiency and is believed to promote bone health, the corresponding findings on fracture risk reduction are conflicting. We also discuss the similarity of other vitamin supplementations on fracture risk. Future clinical studies are needed to further elucidate the effect of vitamin K on fracture risk.

Vitamin K Deficiency

PEDIATRICS ◽  
1985 ◽  
Vol 75 (2) ◽  
pp. 373-374
Author(s):  
NATHANIEL R. PAYNE ◽  
DUANE K. HASEGAWA
Keyword(s):  
Liver Disease ◽  
High Risk ◽  
Vitamin K ◽  
Late Onset ◽  
Cholestatic Liver Disease ◽  
Hemorrhagic Disease ◽  
Vitamin K Deficiency ◽  
Antitrypsin Deficiency ◽  
K Deficiency

In Reply.— We agree with Aballi that a combination of factors placed our patient1 at high risk for vitamin K deficiency during her first month of life. These factors include decreased intestinal absorption of vitamin K due to the cholestatic liver disease of α-1-antitrypsin deficiency and a diet consisting solely of breast milk which is known to have little vitamin K. Aballi correctly points out the lack of data on the role of vitamin K in preventing late-onset hemorrhagic disease.

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