scholarly journals SARS-CoV-2 Infection and Oral Health: Therapeutic Opportunities and Challenges

2021 ◽  
Vol 10 (1) ◽  
pp. 156
Author(s):  
Christopher J. Coke ◽  
Brandon Davison ◽  
Niariah Fields ◽  
Jared Fletcher ◽  
Joseph Rollings ◽  
...  
Keyword(s):  
Oral Health ◽  
Metabolic Diseases ◽  
The United States ◽  
Global Scale ◽  
The Novel ◽  
Periodontal Health ◽  
Dental Clinics ◽  
Dental Profession ◽  
Patients Experience ◽  
Taste And Smell

The novel corona virus, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), and the disease it causes, COVID-19 (Coronavirus Disease-2019) have had multi-faceted effects on a number of lives on a global scale both directly and indirectly. A growing body of evidence suggest that COVID-19 patients experience several oral health problems such as dry mouth, mucosal blistering, mouth rash, lip necrosis, and loss of taste and smell. Periodontal disease (PD), a severe inflammatory gum disease, may worsen the symptoms associated with COVID-19. Routine dental and periodontal treatment may help decrease the symptoms of COVID-19. PD is more prevalent among patients experiencing metabolic diseases such as obesity, diabetes mellitus and cardiovascular risk. Studies have shown that these patients are highly susceptible for SARS-CoV-2 infection. Pro-inflammatory cytokines and oxidative stress known to contribute to the development of PD and other metabolic diseases are highly elevated among COVID-19 patients. Periodontal health may help to determine the severity of COVID-19 infection. Accumulating evidence shows that African-Americans (AAs) and vulnerable populations are disproportionately susceptible to PD, metabolic diseases and COVID-19 compared to other ethnicities in the United States. Dentistry and dental healthcare professionals are particularly susceptible to this virus due to the transferability via the oral cavity and the use of aerosol creating instruments that are ubiquitous in this field. In this review, we attempt to provide a comprehensive and updated source of information about SARS-CoV-2/COVID-19 and the various effects it has had on the dental profession and patients visits to dental clinics. Finally, this review is a valuable resource for the management of oral hygiene and reduction of the severity of infection.

scholarly journals Evolutionary Frequency of the Available Human Coronavirus Genomes

2020 ◽  
Author(s):  
Ashfaq Ahmad ◽  
Sidra Majaz ◽  
Faisal Nouroz
Keyword(s):  
Evolutionary Process ◽  
The United States ◽  
Spatial Diversity ◽  
Global Scale ◽  
The Novel ◽  
Human Coronavirus ◽  
The Usa ◽  
Severity Of The Disease ◽  
Novel Coronavirus ◽  
Insight Into

Abstract Background. A novel, human-infecting coronavirus causing CoVID-19 was first identified in Wuhan, China in late December, 2019. Within a short span of time more the virus has recorded more than 1 million deaths world-wide. This study is designed to address the overall evolutionary process of the novel Coronavirus complete genomes. Addressing the complexity and huge population size, network-based approaches are used in mapping samples to their reported locations. Results. Total of 473 complete human-coronavirus genomes representing 20 different countries are studied including 17 states from the United States and samples collected from the Cruise-diamond princess. The phylodynamic network of global-scale is classified into five clusters contained two clusters U1 and U2 of the USA samples. Cluster B is a shared cluster of China and the USA while A and C are of diverse nature. We found that Chinese samples aggregated in cluster A and B which aided in retaining the homogeneous viral genomic pool. In contrast, samples from the USA and Spain were split into distinct clusters indicating multiple port entries and a possibility in implying a delay in quarantine measures. Among the samples from the USA, we found that sequences reported from Washington and Virginia are scattered indicating evolutionary diversity.Conclusion. This report provides insight into the transmission pattern of CoV2 which is complicated to evaluate exclusively through conventional surveillance means. Our data not only identify the transmission network but also suggest that the severity of the disease is linked to the spatial diversity of infection.

scholarly journals Timeline of COVID-19 and its therapeutics in the United States

2020 ◽  
Vol 3 (3) ◽  
pp. 01-04
Author(s):  
Pankaj Bansal
Keyword(s):  
United States ◽  
Severe Acute Respiratory Syndrome ◽  
Vaccine Development ◽  
The United States ◽  
Global Scale ◽  
The Novel ◽  
Therapeutic Trials ◽  
Rapid Spread ◽  
Novel Coronavirus ◽  
Poor Efficacy

The novel coronavirus was first discovered and reported in December 2019. Later termed the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COv-2) virus, rapid spread was detected in China. Overtime, SARS-COv-2 spread to various other countries requiring swift intervention on a global scale. As infection spread, several therapeutics have been investigated for Coronavirus Disease- 2019 (COVID-19), including remdesivir, lopinavir/ritonavir, hydroxychloroquine, dexamethasone, etc. Furthermore, rapid investigation and construction of several potential vaccines have begun, some of which are in late stage testing. We present a concise timeline representing the evolution of COVID-19, therapeutic trials, and vaccine development. Ultimately, evident by the overall poor efficacy of several medications investigated so far, vaccination success remains the most likely effective step to combat COVID-19.

Oral health knowledge and practices of women attending dental clinics of Baghdad University

2019 ◽  
Vol 31 (1) ◽  
pp. 42-47
Author(s):  
Raya R. Al-Dafaai ◽  
Nibal M. Hoobi
Keyword(s):  
Oral Health ◽  
Educational Level ◽  
Health Knowledge ◽  
Arabic Language ◽  
Health Practices ◽  
Oral Diseases ◽  
Dental Floss ◽  
Number Of Children ◽  
Dental Clinics ◽  
Diet Control

Background: Knowledge is considered to be essential for developing healthy practices and preventing the main oral diseases. In some developing countries, women were at higher risk to develop these diseases. This study was conducted to evaluate women’s dental knowledge and practices through a specific questionnaire and the relationship with patient’s educational level and the number of their children. Subjects and method: Women, aged from 25-35 years old, were selected to participate in the current study. They were attending dental clinics in the teaching hospital of Baghdad University. Each participant was instructed to answer questionnaire sheet which is previously prepared in Arabic language by the authors. The total number of women was divided into three groups according to women’s educational level and the number of their children. Results: The number of women that participated in the study was 150. Higher percent of them (58.7%) have received instruction on the use of dental floss but 60.0% had no information about fluoride. Dental floss was used by only 24.7% of women. Higher percent of women eat candies, chocolate bars and cookies in between meals. Significant association was reported between educational level and oral health information. Educational level didn’t influence patients’ health practices. Frequency of follow-up appointments and toothbrushes changes were higher among women with less number of children. Conclusion: The study revealed important gaps in oral health practices especially in diet control and the use of dental floss. There is a need for frequent dental educational programmes among women to promote the proper practices and to achieve good oral hygiene.

Reducing Gingivitis Remotely using the iGAM mHealth app (part 2): Prospective Observational Study (Preprint)

2020 ◽  
Author(s):  
Guy Tobias ◽  
Assaf B Spanier
Keyword(s):  
Oral Health ◽  
Tooth Loss ◽  
Prospective Observational Study ◽  
Dental Clinics ◽  
Significant Difference ◽  
Observational Cohort ◽  
Group 2 ◽  
And Behavior ◽  
Oral Hygiene Habits ◽  
Group 1

BACKGROUND Gingivitis is a non-painful, inflammatory condition that can be treated with home remedies. Left untreated gingivitis can lead to tooth loss. Periodic dental examinations are important for early diagnosis and treatment of gum diseases. In order to contain the spread of the corona virus, governments, including in Israel, have restricted movements of their citizens which has caused routine dental checkups to be postponed. OBJECTIVE This study aimed to examine the ability of an mHealth app- iGAM to reduce gingivitis. METHODS A prospective observational cohort study was performed, 160 unpaid participants were divided into 2 equal groups and downloaded the iGAM app. Group 1 photographed their gums weekly for eight weeks. Group 2 photographed their gums at the time of recruitment and 8 weeks later. After photo submission, the participants received the message "It is recommended to read the information contained within the app regarding maintaining oral hygiene habits". A single blinded researcher examined the images and scored them according to the Modified Gingival Index (MGI). RESULTS The average age of group 1 was 26.77 (S.D. ± 7.43), and 28.53 (S.D. ± 10.44) for group 2. The majority were male (74.7% in group 1 vs. 66.7% in group 2), most participants described themselves as "secular", most were "single", non-smokers (74.7% vs. 78.4%) and did not take medications (85.3% vs. 78.4%). 126 subjects completed the study. A statistically significant difference (P <.001) was found in the dependent variable (MGI) in a linearly negative manner. As time passed, the gum condition improved, there were significantly lower gingivitis scores in group 1 (M = 1.16, S.D. ± 1.18) compared to group 2 (M = 2.16, S.D. ± 1.49), after eight weeks. Those with more recent dental visits had a lower MGI (p = .037). No association was found between knowledge and behavior, most participants were familiar with the recommendations for maintaining oral health, yet they only performed some. CONCLUSIONS A dental selfie taken once a week using an mHealth app (iGAM) reduced the signs of gingivitis and promoted oral health. During the current pandemic where social distancing recommendations may be causing people to avoid dental clinics, this app can remotely promote gum health. CLINICALTRIAL The protocol was approved by Hadassah research ethics committee (IRB, 0212-18-HMO)

Breaking Free

2017 ◽  
Author(s):  
Deirdre David
Keyword(s):  
United States ◽  
The United States ◽  
The Novel ◽  
Male Homosexuality ◽  
Domestic Life ◽  
The Family

In the mid- to late 1950s, Pamela emerged as a critically acclaimed novelist, particularly after the family returned to London. In perhaps her best-known novel, The Unspeakable Skipton, she explores the life of a paranoid writer who sponges on English visitors to Bruges. The novel was hailed for its wit and sensitive depiction of the life of a writer. She also published a fine study of a London vicar martyred in marriage to a vain and selfish wife: The Humbler Creation is remarkable for its incisive and empathetic depiction of male despair. The Last Resort sealed her distinction as a brilliant novelist of domestic life in its frank depiction of male homosexuality. While continuing to publish fiction, Pamela maintained her reputation as a deft reviewer. In 1954, she and Charles travelled to the United States—the first of many trips that were to follow.

The Oxford History of the Novel in English

2018 ◽  
Keyword(s):  
World War Ii ◽  
English Language ◽  
Book History ◽  
World Order ◽  
The United States ◽  
The Novel ◽  
History Of The Novel ◽  
Post Colonial ◽  
The World ◽  
History Of

Volume Nine of this series traces the development of the ‘world novel’, that is, English-language novels written throughout the world, beyond Britain, Ireland, and the United States. Focusing on the period up to 1950, the volume contains survey chapters and chapters on major writers, as well as chapters on book history, publishing, and the critical contexts of the work discussed. The text covers periods from renaissance literary imaginings of exotic parts of the world like Oceania, through fiction embodying the ideology and conventions of empire, to the emergence of settler nationalist and Indigenous movements and, finally, the assimilations of modernism at the beginnings of the post-imperial world order. The book, then, contains chapters on the development of the non-metropolitan novel throughout the British world from the eighteenth to the mid twentieth centuries. This is the period of empire and resistance to empire, of settler confidence giving way to doubt, and of the rise of indigenous and post-colonial nationalisms that would shape the world after World War II.

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