Assessment of Multiple Sclerosis Disability Progression Using a Wearable Biosensor: A Pilot Study

Background: The evaluation of walking activity of people with multiple sclerosis (pwMS) is desirable. We evaluate the power of the correlation of motor parameters detected by the accelerometer in the Samsung Gear S2 smartwatch with multiple sclerosis (MS) disability measures and patient reported outcomes (PROs). Methods: We enrolled 25 relapsing remitting MS patients. We assessed disability with the expanded disability status scale, two-minute walking test (2MWT), timed 25-foot walk test (T25FWT), and nine-hole peg test. We collected PROs measuring fatigue, ambulatory ability, depression, quality of life, and bladder/bowel function. Participants were asked to wear the accelerometer for a period of 30 days. Results: The Spearman’s rank correlation coefficient showed a moderate negative correlation between the patient-determined disease steps (PDDS) score with the mean steps/day, a strong negative correlation between the PDDS score with the maximum number of daily steps (MNDS) and a moderate negative correlation between the fatigue severity scale score and MNDS. A moderate negative correlation between MNDS and the 2MWT and a moderate negative correlation between MNDS and the T25FW was found. Conclusion: Our results suggest that motor parameters derived from the accelerometer could be a reliable measure of motor disability in pwMS.

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Functional Balance and Motor Impairment Correlations with Gait Parameters during Timed Up and Go Test across Three Attentional Loading Conditions in Stroke Survivors

Stroke Research and Treatment ◽

10.1155/2014/439304 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 3

Author(s):

Haidzir Manaf ◽

Maria Justine ◽

Mazlifah Omar

Keyword(s):

Negative Correlation ◽

Dual Task ◽

Motor Impairment ◽

Rank Correlation ◽

Stroke Survivors ◽

Loading Conditions ◽

Timed Up And Go ◽

Strong Negative Correlation ◽

Functional Balance ◽

Gait Parameters

The aim of this study was to determine whether stroke survivor’s gait performance during dual-task Timed Up and Go (TUG) test is correlated with the level of functional balance and motor impairment. Thirty stroke survivors (22 men, 8 women) were recruited for this study. The level of functional balance (Berg Balance Scale) and motor impairment (Fugl-Meyer assessment lower extremity) were assessed prior to the TUG test. TUG test was conducted under three attentional loading conditions (single, dual motor, and dual-cognitive). The time and number of steps were used to quantify gait parameters. The Spearmen’s rank correlation coefficient was used to evaluate the relationship between these variables. There was moderate to strong negative correlation between functional balance and gait parameters (range −0.53 to −0.73,P<0.05). There was a weak negative correlation observed between the time taken to complete the single task and motor impairment (rs=-0.43;P=0.02) dual motor task and motor impairment (rs=-0.41;P=0.02). However, there were no significant correlations between lower limb motor impairment and the number of steps in all conditions. These findings suggest that functional balance may be an influential domain of successful dual-task TUG in stroke.

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Faktor Predisposisi Pengetahuan, Sikap, Nilai dan Budaya Eks Wanita Pekerja Seksual dengan Kejadian HIV/AIDS di Wilayah Kediri

Care Jurnal Ilmiah Ilmu Kesehatan ◽

10.33366/jc.v7i1.1159 ◽

2019 ◽

Vol 7 (1) ◽

pp. 53

Author(s):

Indah Jayani ◽

Fatma Sayekti Ruffaida

Keyword(s):

Social Services ◽

Negative Correlation ◽

Health Workers ◽

Rank Correlation ◽

Sampling Technique ◽

Deficiency Syndrome ◽

Strong Negative Correlation ◽

Cross Sectional ◽

Immunodeficiency Virus ◽

Hiv Aids

Human Immunodeficiency Virus (HIV)/ Immuno Deficiency Syndrome (AIDS) is a global health problem as a cause of a high mortality rate. The phenomenon of an increase in HIV/AIDS infection in the Kediri region was mostly obtained from the former Sexual Workers Woman (WPS). The purpose of the study was to determine the correlation between knowledge, attitudes, values and culture with the prevalence of HIV/AIDS among former sexual worker women in Kediri, East Java Province. This study was a correlation analytic study with a cross sectional. The population in this study was 448 with a proportional stratifed sampling technique which obtained a sample of 58 people. The instrument used in data collection is questionnaire. The results of the analysis with the Spearman rank correlation test showed there was a strong negative correlation between knowledge with HIV/AIDS events (ρ=0,00; r=-0,571), a strong negative correlation between attitudes and HIV/AIDS events (ρ=0,00; r=-0,538), a strong negative correlation between value and HIV/AIDS events (ρ=0,00; r=-0,784) and a strong negative correlation between cultures and HIV/AIDS events was indicated by (ρ=0,00; r=-0,456) among former WPS in Kediri, East Java Province 2017. Based on the results, the suggestions for health workers and related social services should continue to improve services by providing continuous education to former WPS related to how HIV/AIDS prevention and transmission are carried out, providing assistance, monitoring bio, psycho, socio-spiritual to change attitudes maladaptive becomes adaptive, and to disseminate culture to reduce the risk of HIV/ AIDS.

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Correlation between Adiponectin and Triglyceride Levels in Pregnancy with and without Gestational Diabetes Mellitus

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v27i3.1697 ◽

2021 ◽

Vol 27 (3) ◽

pp. 313

Author(s):

I Nyoman Gde Sudana ◽

Windarwati Windarwati ◽

Budi Mulyono

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Negative Correlation ◽

Glucose Transporter ◽

Strong Negative Correlation ◽

Cross Sectional ◽

Pregnant Females ◽

Moderate Negative Correlation ◽

In Pregnancy

Gestational Diabetes Mellitus (GDM) is glucose intolerance during pregnancy. Adiponectin causes a decrease in glucose transporter 4 translocation, which reduces glucose uptake due to downstream insulin signal delivery and decreases non-esterified fatty acids so that triglyceride synthesis decreases in pregnancy. This study was conducted to determine the relationship between adiponectin and triglyceride levels in pregnancy, especially in a pregnant female with and without gestational diabetes mellitus. This observational cross-sectional study was conducted by measuring the levels of adiponectin and triglycerides in pregnancy, with and without gestational diabetes mellitus. Researchers proved by analyzing 75 subjects, 24-28 weeks pregnant females who were examined at the primary health center and Dr. Sardjito Hospital, Yogyakarta. Adiponectin levels have a moderate negative correlation with triglycerides in pregnant females (r= -0.420 and p=0.002), a strong negative correlation with GDM (r = -0.680 and p=0.001), and moderate negative correlation (r= -0.455, and p=0.022) with those without GDM. Based on this research can be concluded that adiponectin has a moderate negative correlation with triglycerides in pregnancy, a strong negative correlation in pregnant females with gestational diabetes mellitus, and a moderate negative correlation in those without gestational diabetes.

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Variation in Reporting of Penicillin Allergy and its Consequences: an Evaluation of 13 Hospitals

Open Forum Infectious Diseases ◽

10.1093/ofid/ofx163.814 ◽

2017 ◽

Vol 4 (suppl_1) ◽

pp. S341-S342

Author(s):

Florian Daragjati ◽

David Silver ◽

Roy Guharoy ◽

Clariecia Groves ◽

Danielle Sebastian ◽

...

Keyword(s):

Negative Correlation ◽

Medical Records ◽

Generation Cephalosporin ◽

Penicillin Allergy ◽

Fourth Generation ◽

Strong Negative Correlation ◽

Antibiotic Allergy ◽

Defined Daily Doses ◽

Moderate Negative Correlation ◽

Systemic Antibiotics

Abstract Background Penicillin allergy is the most common antibiotic allergy noted within medical records, and its inaccurate reporting leads to increased use of alternative antibiotics that may be less effective, broader in spectrum, more toxic, and costly. Methods We retrospectively reviewed the reported allergies to penicillin in patients cared for at 13 hospitals within one health system over a 3 month period (June-August 2016). The data were abstracted from the electronic medical records on penicillin allergy status for both inpatient and outpatient visits. Hospitals were compared on their use of systemic antibiotics for inpatients. The proportions of total defined daily doses (DDD) for quinolones, aztreonam, carbapenems, cephalosporins, and penicillins were compared. Spearman’s rank and Pearson’s correlation were used to evaluate the strength of the relation between increased penicillin allergy reported and the use of the different antibiotic classes. Results 23,290 of 169,912 (13.7%; range 8%–20%) patients from 13 hospitals were reported penicillin allergic. There was a strong correlation between the proportion of patients with penicillin allergy and quinolone use (rho=0.77; P = 0.002; Figure 1), cephalosporins excluding fourth-generation (r=0.70; P = 0.007; Figure 2), and a weaker correlation with carbapenem use (rho=0.52; P = 0.168) and aztreonam (r=0.53; P = 0.06). On the other hand, penicillins had a moderate negative correlation (r=-0.58; P = 0.036; Figure 3), and extended spectrum penicillins had a strong negative correlation (r=-0.72; P < 0.005). Fourth-generation cephalosporin use did not correlate with the penicillin allergy rate (rho=-0.03; P = 0.92). Conclusion Reported penicillin allergy varies between hospitals and higher reported allergy is associated with more quinolone and cephalosporin use, and less use of penicillin-based regimens. Adequate documentation of penicillin allergy may promote the choice of more optimal regimens when treating patients. Disclosures All authors: No reported disclosures.

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Self-esteem, Motivation, and Anxiety of Korean University Students

Journal of Language Teaching and Research ◽

10.17507/jltr.0706.02 ◽

2016 ◽

Vol 7 (6) ◽

pp. 1069

Author(s):

Lelanie M. Basco ◽

Sang-Ho Han

Keyword(s):

Negative Correlation ◽

English Learners ◽

English Proficiency ◽

Self Esteem ◽

Strong Negative Correlation ◽

English Classes ◽

Proficiency Level ◽

Significant Difference ◽

Moderate Negative Correlation ◽

Low Levels

The purpose of this study was to examine the level of self-esteem, motivation, and anxiety of university English learners and their differences according to gender, year, English proficiency level, and KSAT level. This study further aimed to determine the correlation between self-esteem, motivation, and anxiety of the learners. The respondents of this study were 255 randomly selected college students enrolled in English classes from a local university. A survey questionnaire consisting of 43 items was administered to the students. The Mean was used to determine the level of students’ self-esteem, motivation, and anxiety, followed by t-test, ANOVA, and Pearson’s r analysis. The results showed that the students at the current school had a moderate level of self-esteem, motivation, and anxiety. Significant differences were found in the students’ level of self-esteem, motivation, and anxiety when they were grouped according to gender and English proficiency level. The males had higher level of self-esteem and motivation and lower level of anxiety when compared with the females. No significant difference existed when the students were grouped according to year. There was a positive correlation between self-esteem and motivation, with high levels of self-esteem associated with high levels of motivation. On the other hand, there was a strong, negative correlation between self-esteem and anxiety with high levels of self-esteem associated with low levels of anxiety. Furthermore, there was a moderate, negative correlation between motivation and anxiety, with high levels of motivation associated with low levels of anxiety.

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Psoriasis and metabolic syndrome: comorbidity mechanisms

Medical alphabet ◽

10.33667/2078-5631-2019-1-7(382)-34-38 ◽

2019 ◽

Vol 1 (7) ◽

pp. 34-38

Author(s):

E. V. Dontsova ◽

O. Yu. Olisova ◽

L. S. Kruglova

Keyword(s):

Metabolic Syndrome ◽

Negative Correlation ◽

Inflammatory Cytokine ◽

Antioxidant Ability ◽

Weak Correlation ◽

Strong Negative Correlation ◽

The Metabolic Syndrome ◽

Diagnostic Signs ◽

Weak Negative Correlation ◽

Correlation Link

Objectives: to study communications of separate components of the metabolic syndrome (MS) and immune and oxidative characteristics of patients with psoriasis in combination with MS. Methods. The research included 312 patients with psoriasis having diagnostic signs of a metabolic syndrome. Biochemical and immunological researches were conducted by means of immunofermental and immunokhemilyuminestsentny analyses. Results. At patients with psoriasis at a combination to MS abdominal obesity, a giperleptinemiya, insulin resistance, high oxidizing potential and hyperactivity of interleukins (ILS) -1β,-6,-8, a factor of a necrosis of tumors an alpha (FNO-α), interferon scale (INF-γ) are noted. the waist circle’ is characteristic direct weak correlation with the pro-inflammatory tsitokina oxidized by lipoproteins of blood (LDL-ok) and with the general oxidizing ability of blood (OOS), weak negative correlation of an indicator - with the general antioxidant ability of blood (OAS) and superoxide dismutase (SOD). The HOMA-IR index has direct correlation link of moderate force with levels of a leptin of blood, LDL-ok, OOS, pro-inflammatory tsitokin, negative correlation of moderate force - with OAS, SOD. At patients with psoriasis with MS direct strong correlation link of level of a leptin of blood with activity of the studied pro-inflammatory cytokine, LDL-ok, OOS moderated is established with the level of insulin in the blood., the HOMA-IR index, strong negative correlation with OAS, SOD. Conclusion. Presence at patients with psoriasis of signs of a metabolic syndrome is followed by increase in activity of immune and inflammatory mechanisms, development of oxidative stress.

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