Psoriasis and metabolic syndrome: comorbidity mechanisms

2019 ◽  
Vol 1 (7) ◽  
pp. 34-38
Author(s):  
E. V. Dontsova ◽  
O. Yu. Olisova ◽  
L. S. Kruglova
Keyword(s):  
Metabolic Syndrome ◽  
Negative Correlation ◽  
Inflammatory Cytokine ◽  
Antioxidant Ability ◽  
Weak Correlation ◽  
Strong Negative Correlation ◽  
The Metabolic Syndrome ◽  
Diagnostic Signs ◽  
Weak Negative Correlation ◽  
Correlation Link

Objectives: to study communications of separate components of the metabolic syndrome (MS) and immune and oxidative characteristics of patients with psoriasis in combination with MS. Methods. The research included 312 patients with psoriasis having diagnostic signs of a metabolic syndrome. Biochemical and immunological researches were conducted by means of immunofermental and immunokhemilyuminestsentny analyses. Results. At patients with psoriasis at a combination to MS abdominal obesity, a giperleptinemiya, insulin resistance, high oxidizing potential and hyperactivity of interleukins (ILS) -1β,-6,-8, a factor of a necrosis of tumors an alpha (FNO-α), interferon scale (INF-γ) are noted. the waist circle’ is characteristic direct weak correlation with the pro-inflammatory tsitokina oxidized by lipoproteins of blood (LDL-ok) and with the general oxidizing ability of blood (OOS), weak negative correlation of an indicator - with the general antioxidant ability of blood (OAS) and superoxide dismutase (SOD). The HOMA-IR index has direct correlation link of moderate force with levels of a leptin of blood, LDL-ok, OOS, pro-inflammatory tsitokin, negative correlation of moderate force - with OAS, SOD. At patients with psoriasis with MS direct strong correlation link of level of a leptin of blood with activity of the studied pro-inflammatory cytokine, LDL-ok, OOS moderated is established with the level of insulin in the blood., the HOMA-IR index, strong negative correlation with OAS, SOD. Conclusion. Presence at patients with psoriasis of signs of a metabolic syndrome is followed by increase in activity of immune and inflammatory mechanisms, development of oxidative stress.

scholarly journals Serum interleukin-23 protects, whereas methotrexate treatment stimulates selected components of the metabolic syndrome in patients with SAPHO syndrome

2021 ◽  
Vol 17 (1) ◽  
pp. 120-126
Author(s):  
Hanna Przepiera-Będzak ◽  
Katarzyna Fischer ◽  
Marek Brzosko
Keyword(s):  
Metabolic Syndrome ◽  
Growth Factor ◽  
Negative Correlation ◽  
Density Lipoprotein ◽  
Sapho Syndrome ◽  
Lipoprotein Cholesterol ◽  
Skin Changes ◽  
The Metabolic Syndrome ◽  
Methotrexate Treatment ◽  
The Impact

IntroductionThe aim of the study was to evaluate the impact of disease activity, selected serum cytokines, and therapy on metabolic syndrome (MetS) components in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome.Material and methodsWe studied 46 SAPHO patients (40 women, 6 men). We recorded age, sex, disease duration, arthritis localization, type of skin changes, bone scintigraphy results, comorbidities, BASDAI, VAS, and treatment. We measured erythrocyte sedimentation rate, C-reactive protein, lipid profile, serum IL-6, IL-18, IL-23, endothelin-1, vascular endothelial growth factor, and epidermal growth factor (EGF).Results97.8% of patients had sternoclavicular joint arthritis, 91.3% of patients palmoplantar pustulosis. In 65.2% of SAPHO patients skin changes and arthritis started simultaneously. Apart from non-steroidal anti-inflammatory drugs, patients were treated with methotrexate (41.3%), sulfasalazine (41.3%), and antibiotics (39.1%). 19.5% of patients met MetS criteria. Serum IL-23 correlated positively with total cholesterol (TC; p = 0.02) and high-density lipoprotein cholesterol (HDL-C) (p = 0.01) in the SAPHO group. There was a negative correlation between HDL-C and BASDAI (p = 0.02). Patients treated with methotrexate had higher triglyceride (p = 0.01) and low-density lipoprotein cholesterol (LDL-C) (p = 0.01) levels. There was a negative correlation between TC and EGF (p = 0.03). Increased prevalence of autoimmune diseases and depression was observed in SAPHO patients.ConclusionsSerum IL-23 protects, whereas methotrexate treatment stimulates selected components of the MetS in patients with SAPHO syndrome.

scholarly journals Visfatin and Adiponectin Have an Opposite Correlation with Inflammation and Metabolic Syndrome in Non-Diabetic Obese Indonesian Men

2009 ◽  
Vol 1 (3) ◽  
pp. 81
Author(s):  
Anna Meiliana ◽  
Gatot Susilo Lawrence ◽  
Ilhamjaya Patellongi ◽  
Andi Wijaya ◽  
Suryani As'ad
Keyword(s):  
Metabolic Syndrome ◽  
Negative Correlation ◽  
Significant Negative Correlation ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Metabolic Complications ◽  
The Metabolic Syndrome ◽  
Parallel Increase ◽  
Tnf Α ◽  
Anti Inflammatory

BACKGROUND: Along with the increase in obesity is a parallel increase in the prevalence of metabolic complications of obesity, often referred to as the metabolic syndrome (MetS). The role of adipose tissue in MetS has continued to evolve with the description of numerous secretory peptides from adipocytes named adipocytokines or adipokines. Recent studies have found visfatin as the regulation of inflammatory and immunomodulating prosesses, meanwhile adiponectin was known to have a potent anti-inflammatory properties. Here we try to assess the correlation between those two adipokines to MetS, via an inflammatory pathway.METHODS: This was a cross-sectional study on 128 non diabetic obese male subject (waist circumferences ≥90 cm). Visfatin and adiponectin were assessed by ELISA. Statistical analysis was performed using SPSS for Windows v.16.00 with signifcantly p<0.05. The correlations among biomarkers were assessed using Spearman's Rho test.RESULTS: This study showed a significant positive correlation between levels of visfatin and inflammatory markers TNF-α (r=0.22, p<0.005), and hsCRP (r=0.12, p=0.19), significant negative correlation between levels of adiponectin and TNF-α (r=-0.22-8, p<0.005-1), adiponectin and hsCRP (r=-0.14, p=0.11) and visfatin (r=-0.029, p<0.01). Plasma visfatin levels were increased along with the number MetS components, white plasma adiponectin showed inversely relation.CONCLUSION: Our present study has shown that visfatin has a proinflammatory properties and adiponectin has an anti-inflammatory properties, and how they have an opposite effects on MetS. Visfatin was found to have a positive correlaton while adiponectin was found to have a negative correlation with the number of MetS components.KEYWORDS: Obesity, Inflammation, Metabolic Syndrome, Adipocytokines, Visfatin, Adiponectin, TNF-α, hsCRP

Resistin: An Inflammatory Cytokine. Role in Cardiovascular Diseases, Diabetes and the Metabolic Syndrome

2014 ◽  
Vol 20 (31) ◽  
pp. 4961-4969 ◽  
Author(s):  
Nicola Abate ◽  
Hanaa Sallam ◽  
Manfredi Rizzo ◽  
Dragana Nikolic ◽  
Milan Obradovic ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Diseases ◽  
Inflammatory Cytokine ◽  
The Metabolic Syndrome

Abstract 1124: CD40L Induces Inflammation in Adipose Tissue - a Potential Link Between the Metabolic Syndrome and Atherosclerosis

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Anna Missiou ◽  
Isabel Platzer ◽  
Sandra Ernst ◽  
Uwe Schonbeck ◽  
Peter Libby ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Endothelial Cells ◽  
Adipose Tissue ◽  
Cardiovascular Risk ◽  
Inflammatory Cytokine ◽  
Inflammatory Responses ◽  
Human Adipose Tissue ◽  
Cell Types ◽  
High Cardiovascular Risk ◽  
The Metabolic Syndrome

Background: CD40L figures prominently as marker and mediator of atherosclerosis and its clinical complications. Recent data also demonstrate an association between CD40L and the metabolic syndrome. In the light of these data we hypothesized a functional pro-inflammatory role of CD40L in adipose tissue that provokes systemic pro-inflammatory responses and potentially mediates some of the high cardiovascular risk associated with the metabolic syndrome. Methods and Results: Adipocytes and preadipocytes isolated from adipose tissue obtained from bariatic surgery did not express CD40L but its receptor CD40 as assessed by PCR and immunohistochemistry. Furthermore, sections of human adipose tissue from obese donors contained more macrophages and T cells colocalizing with CD40L than those from lean controls. Stimulation of both adipocytes and preadipocytes with recombinant CD40L resulted in a concentration- and time-dependent release of the pro-inflammatory cytokine IL-6, the chemokines MCP -1 and IL-8 as well as the inhibitor of fibrinolysis PAI-1 into the supernatant as quantified by ELISA. Membranes isolated from a Murine cell line overexpressing human CD40L reproduced these pro-inflammatory effects compared to respective controls. Interestingly, fenofibrate but neither rosiglitazone, metformin, nor atorvastatin attenuated the CD40L-inducible expression of these pro-atherogenic mediators. Finally, supernatants from adipocytes and preadipocytes stimulated with CD40L activated endothelial cells and macrophages, typical cell types resident in atherosclerotic lesions, as assessed by FACS for tissue factor, Mac-1, and ICAM-1, respectively. Conclusions: Our data suggest that CD40L induces inflammatory cytokine production in adipose tissue resulting in activation of endothelial cells and macrophages. This new mechanism may contribute to the high cardiovascular risk of patients suffering from the metabolic syndrome.

Side-Stream Cigarette Smoke Induces Dose–Response in Systemic Inflammatory Cytokine Production and Oxidative Stress

2002 ◽  
Vol 227 (9) ◽  
pp. 823-829 ◽  
Author(s):  
Jin Zhang ◽  
Yingying Liu ◽  
Jiaqi Shi ◽  
Douglas F. Larson ◽  
Ronald Ross Watson
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Stroke Volume ◽  
Negative Correlation ◽  
Inflammatory Cytokine ◽  
Antioxidant Vitamin ◽  
Contractile Dysfunction ◽  
Strong Negative Correlation ◽  
Side Stream ◽  
Tnf Α

Side-stream cigarette smoke (SSCS), a major component of secondhand smoke, induces reactive oxygen species, which promote oxidative damage in tissues and organs. Inflammatory cytokines play an important role in the pathogenesis of atherosclerosis and heart failure. The present 4-month study examined the effect of various chronic SSCS exposure levels on splenic inflammatory cytokine secretion, heart contractile function, and pathology at 60- and 120-min per day, 5 days per week, for a total of 16 weeks. Tissue vitamin E level and lipid peroxide production also were tested to estimate the oxidative stress. The study found that the pro-inflammatory cytokines, interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β, significantly increased in 120-min SSCS-exposed mice. Decreased stroke volume and increased peripheral arterial resistance were observed in mice exposed to 120-min SSCS per day. Heart pathology was only found in 120-min SSCS-exposed mice. Cardiac and hepatic antioxidant vitamin E levels were decreased as a result of oxidative stress. Hepatic lipid peroxides were Increased upon 60-min SSCS exposure. The data also demonstrated that the cardiac α-tocopherol level has a strong correlation with stroke volume; splenic IL-1β has a strong negative correlation with stroke volume; splenic TNF-α has a very strong negative correlation with stroke volume. In conclusion, SSCS exposure induced systemic inflammatory responses. SSCS exposure also accentuated systemic lipid peroxidation with depletion of cardiac and hepatic antioxidant vitamin E level. Finally, SSCS exposure at 120 min per day decreased stroke volume and increased vascular resistance. Systemic IL-1 β and TNF-α production are responsible for heart contractile dysfunction. Free radicals may be responsible for the progression to heart contractile dysfunction induced, in part, by SSCS. Oxidized lipoprotein could contribute to the vascular functional changes. Exploring the mechanism of vascular dysfunction in mice is warranted. A more precise quantification of the smoking exposure dose in mice needs to be determined as well.

Pro-inflammatory cytokine levels in postmenopausal women with the metabolic syndrome

2010 ◽  
Vol 27 (9) ◽  
pp. 685-691 ◽  
Author(s):  
Peter Chedraui ◽  
Winston Jaramillo ◽  
Faustino R. Pérez-López ◽  
Gustavo S. Escobar ◽  
Nancy Morocho ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Postmenopausal Women ◽  
Inflammatory Cytokine ◽  
The Metabolic Syndrome ◽  
Cytokine Levels

Nitric oxide and pro-inflammatory cytokine serum levels in postmenopausal women with the metabolic syndrome

2012 ◽  
Vol 28 (10) ◽  
pp. 787-791 ◽  
Author(s):  
Peter Chedraui ◽  
Gustavo S. Escobar ◽  
Cecibel Ramírez ◽  
Faustino R. Pérez-López ◽  
Luis Hidalgo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Metabolic Syndrome ◽  
Postmenopausal Women ◽  
Inflammatory Cytokine ◽  
Serum Levels ◽  
The Metabolic Syndrome

scholarly journals Diabetic Ketoacidosis on Hospitalization with COVID-19 in a Previously Nondiabetic Patient: A Review of Pathophysiology

2020 ◽  
Vol 13 ◽  
pp. 117955142098412
Author(s):  
Rawan M Eskandarani ◽  
Shaima Sawan
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Metabolic Acidosis ◽  
Diabetic Ketoacidosis ◽  
Inflammatory Cytokine ◽  
Nondiabetic Patient ◽  
Cytokine Storm ◽  
Mortality Risks ◽  
The Metabolic Syndrome ◽  
Inflammatory State

Hyperglycaemia during inpatient admission is indicative of higher morbidity and mortality risks in critically ill patients. The severe acute respiratory distress coronavirus 2 (SARS-CoV-2) has been reported to induce ketoacidosis and diabetic ketoacidosis (DKA) even in nondiabetic patients. The pathophysiology of the SARS-CoV-2 infection that can contribute to hyperglycaemia, and the exacerbated inflammatory cytokine storm can overlap with the metabolic chronic inflammatory state attributable to the metabolic syndrome, which underlies diabetes mellitus. In this report, we explore the possible pathophysiology and metabolic mechanisms that lead to metabolic acidosis in nondiabetic patients.

scholarly journals Hemostatic system state and cytokine profile in patients with metabolic syndrome

2015 ◽  
Vol 96 (5) ◽  
pp. 728-734
Author(s):  
V A Sumerkina ◽  
Vl S Chulkov ◽  
V S Chulkov ◽  
E V Ozhigina
Keyword(s):  
Metabolic Syndrome ◽  
Interleukin 6 ◽  
Peripheral Blood ◽  
Inflammatory Cytokine ◽  
Interleukin 10 ◽  
Cytokine Profile ◽  
Control Group ◽  
The Metabolic Syndrome ◽  
Blood Cytokines ◽  
D Dimer

Aim. Examine the hemostasis state and cytokine profile in patients with metabolic syndrome. Methods. The study included 71 patients aged 20 to 44 years. Patients were allocated to four groups matched on age: the first group - females with the metabolic syndrome (n=15), the second - healthy females (control group, n=20), the third - males with the metabolic syndrome (n=19), the fourth group - healthy males (control group, n=17). Laboratory parameters of lipid, carbohydrate metabolism, hemostatic parameters, the levels of cytokines were measured in peripheral blood. Results. Changes in plasma, fibrinolytic and anticoagulant links were revealed in metabolic syndrome (increased concentration of fibrinogen, soluble fibrin monomer complex, D-dimer - in patients of both gender, increased level of tissue factor pathway inhibitor and plasminogen activator inhibitor type 1 - in females). Metabolic syndrome was associated with an increased concentration of interleukin-6 (males and females), interleukin-10 (females) and decreased level of interleukin-8 (males) in peripheral blood. In females, the interrelation between fibrinolytic system activity and pro-inflammatory cytokines serum levels was revealed. In males with metabolic syndrome, a correlation of interleukin-6 pro-inflammatory cytokine level and D-dimer, interferon γ, insulin and insulin resistance index (HOMA) levels was discovered. The level of anti-inflammatory cytokine interleukin-10 correlated with serum triglycerides level. Conclusion. Metabolic syndrome in patients of younger age is accompanied by changes in plasma fibrinolytic links of hemostasis, regardless of gender. In patients with metabolic syndrome, there are no gender differences in levels of peripheral blood cytokines inherent in healthy people.

scholarly journals Impact of Prompting Agents on Task Completion in the Virtual World

2017 ◽  
Vol 13 (06) ◽  
pp. 35 ◽  
Author(s):  
Tao Xie ◽  
Laiming Luo
Keyword(s):  
Negative Correlation ◽  
Virtual Laboratory ◽  
Task Completion ◽  
Control Group ◽  
Virtual Agents ◽  
Strong Positive Correlation ◽  
Strong Negative Correlation ◽  
Perceived Satisfaction ◽  
Correlation Degree ◽  
Weak Negative Correlation

Based on a realized 3D virtual laboratory and virtual agents, this study was to investigate whether the virtual agents influence task completion. A total of 90 students participated in the experiment. They were evenly divided into three groups, one for the control group with no intervention and the other two for experiment groups with different interventional levels. The results show students who used the virtual agents worked much faster and more efficient than those who did not. The satisfaction of the experiment groups was superior to that of the control group. The correlation analysis showed a weak negative correlation between time in total and satisfaction (<em>r</em> = -.365), a strong positive correlation between speed and satisfaction (<em>r</em> = .626), and a strong negative correlation between time per task and satisfaction (<em>r</em> = -.685). However, correlation degree wasn't in concord with the interventional levels. This study suggests that virtual agents have promising effects on task completion and perceived satisfaction.

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