scholarly journals Quality of Life and Sleep in Patients with Pituitary Adenoma in Relation to Tumor Type and Compression of the Optic Chiasm

2021 ◽  
Vol 10 (9) ◽  
pp. 1879
Author(s):  
Karol Piotr Sagan ◽  
Elżbieta Andrysiak-Mamos ◽  
Ernest Tyburski ◽  
Leszek Michał Sagan ◽  
Anhelli Syrenicz
Keyword(s):  
Quality Of Life ◽  
Pituitary Adenoma ◽  
Sleep Quality ◽  
Effect Size ◽  
Pituitary Adenomas ◽  
Transsphenoidal Surgery ◽  
Short Form ◽  
Optic Chiasm ◽  
Tumor Type

Objective: To determine the effect of transsphenoidal surgery on quality of life and sleep in patients with pituitary adenomas depending on tumor type and compression of the optic chiasm. Methods: In this prospective study, patients with pituitary adenomas who were scheduled for transsphenoidal surgery completed the Short Form 36 Questionnaire, Pittsburgh Sleep Quality Index, and Epworth Sleepiness Scale preoperatively and 7.5 (±1.5) months after surgery. Patients were analyzed based on tumor type and compression of the optic chiasm. Results: Significant improvements with large effect sizes were seen for patients with Cushing’s disease in general health (Z = −2.37; p = 0.018), vitality (Z = −2.05; p = 0.041), and mental health (Z = −2.06; p = 0.040). A significant deterioration with large effect size occurred in physical functioning (Z = −2.02; p = 0.043) in patients with acromegaly. A significant improvement with medium effect size was seen in subjective sleep quality, (Z = −2.24; p = 0.025), sleep duration (Z = −2.11; p = 0.035), and habitual sleep efficiency (Z = −2.26; p = 0.024) after decompression of the optic chiasm. Multiple significant correlations were observed between sleep parameters and Short Form 36 subscales before and after treatment. Conclusions: Changes in quality of life during the follow-up period depend on tumor type. Circadian rhythm disturbances may resolve promptly after decompression of the optic chiasm. Quality of life in pituitary adenoma patients is associated with quality of sleep in many dimensions, thus implying that developing strategies to improve sleep quality could increase overall well-being and everyday functioning in pituitary adenoma patients.

scholarly journals Prospective comparison of sinonasal outcomes after microscopic sublabial or endoscopic endonasal transsphenoidal surgery for nonfunctioning pituitary adenomas

2016 ◽  
Vol 125 (2) ◽  
pp. 323-333 ◽  
Author(s):  
Carrie L. Pledger ◽  
Mohamed A. Elzoghby ◽  
Edward H. Oldfield ◽  
Spencer C. Payne ◽  
John A. Jane
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Endoscopic Surgery ◽  
Pituitary Adenomas ◽  
Transsphenoidal Surgery ◽  
Short Form ◽  
Nasal Symptoms ◽  
Sf 36 ◽  
Total P

OBJECT Both endoscopic and microscopic transsphenoidal approaches are accepted techniques for the resection of pituitary adenomas. Although studies have explored patient outcomes for each technique individually, none have prospectively compared sinonasal and quality of life outcomes in a concurrent series of patients at the same institution, as has been done in the present study. METHODS Patients with nonfunctioning adenomas undergoing transsphenoidal surgery were assessed for sinonasal function, quality of life, and pain using the Sino-Nasal Outcome Test-20 (SNOT-20), the short form of the Nasal Obstruction Symptom Evaluation (NOSE) instrument, the SF-36, and a headache scale. Eighty-two patients undergoing either endoscopic (47 patients) or microscopic (35 patients) surgery were surveyed preoperatively and at 24–48 hours, 2 weeks, 4 weeks, 8 weeks, and 1 year after surgery. RESULTS Patients who underwent endoscopic and microscopic transsphenoidal surgery experienced a similar recovery pattern, showing an initial increase in symptoms during the first 2 weeks, followed by a return to baseline by 4 weeks and improvement beyond baseline functioning by 8 weeks. Patients who underwent endoscopic surgery experienced better sinonasal outcomes at 24–48 hours (SNOT total p = 0.015, SNOT rhinologic subscale [ssRhino] p < 0.001), 2 weeks (NOSE p = 0.013), and 8 weeks (SNOT total p = 0.032 and SNOT ssRhino p = 0.035). By 1 year after surgery, no significant differences in sinonasal outcomes were observed between the 2 groups. Headache scales at 1 year improved in all dimensions except duration for both groups (total result 73%, p = 0.004; severity 46%, p < 0.001; frequency 53%, p < 0.001), with 80% of either microscopic or endoscopic patients experiencing improvement or resolution of headache symptoms. Endoscopic and microscopic patients experienced reduced vitality preoperatively compared with US population norms and remained low postoperatively. By 8 weeks after surgery, both groups experienced significant improvements in mental health (13%, p = 0.005) and vitality (15%, p = 0.037). By 1 year after surgery, patients improved significantly in mental health (14%, p = 0.03), role physical (14%, p = 0.036), social functioning (16%, p = 0.009), vitality (22%, p = 0.002), and SF-36 total (10%, p = 0.024) as compared with preoperative measures. There were no significant differences at any time point between the 2 groups for the total SF-36 or for any of the 8 subscales. CONCLUSIONS Patients who underwent either an endoscopic or a microscopic approach experienced the greatest nasal symptoms at 2 weeks postoperatively and exhibited similar time courses of recovery in nasal, headache, and quality of life assessments. Although patients who underwent endoscopic surgery experienced significantly fewer nasal symptoms during the first 8 weeks, by 1 year after surgery, there were no significant differences between the 2 groups.

Vision-Related Quality of Life after Transsphenoidal Surgery for Pituitary Adenoma

2010 ◽  
Vol 51 (7) ◽  
pp. 3405 ◽  
Author(s):  
Yoshifumi Okamoto ◽  
Fumiki Okamoto ◽  
Shozo Yamada ◽  
Maiko Honda ◽  
Takahiro Hiraoka ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pituitary Adenoma ◽  
Transsphenoidal Surgery ◽  
Related Quality

scholarly journals Prevalence, Correlations, and Impact of Sleep Disturbance in Chinese Meningioma Patients

2021 ◽  
Author(s):  
Dandan Zhang ◽  
Jing Wang ◽  
Xixi Gu ◽  
Zhifeng Gu ◽  
Liren Li ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Logistic Regression ◽  
Sleep Quality ◽  
Sleep Disturbance ◽  
Short Form ◽  
Binary Logistic Regression ◽  
Anxiety And Depression ◽  
Newly Diagnosed ◽  
Chi Square Analysis

Abstract Purpose Sleep disturbance is common in meningioma patients and may lead to disease aggravation and decreases health-related quality of life (HRQoL). However, the sleep quality of meningioma patients newly diagnosed and ready for surgery has not been well clarified in China. This study aims to evaluate the prevalence, correlates, and impact of sleep disturbance among Chinese meningioma patients. Methods In this cross-sectional study, meningioma patients were recruited from the Affiliated Hospital of Nantong University from January 2020 to November 2020. A series of questionnaires were applied: the 0–10 Numerical Rating Scale (NRS), the Hospital Anxiety and Depression Scale (HADS), the Multidimensional Fatigue Inventory (MFI-20), the Epworth Sleepiness Scale (ESS), the Short-Form 36 (SF-36), the Pittsburgh Sleep Quality Index (PSQI). Independent samples t test, Mann-Whitney U test, chi-square analysis, Pearson/Spearman correlation, and binary logistic regression were used to analyze the data. Results 100 meningioma patients completed the questionnaires. Sleep disturbance affected 43% of the meningioma patients and was linked to many concomitant symptoms, such as headache, fatigue, anxiety and depression. Binary logistic regression indicated that fatigue and headache were predictors of sleep disturbance in meningioma patients. Meanwhile, severe sleep disturbance led to lower quality of life. Conclusions These findings demonstrated that a considerable number of meningioma patients newly diagnosed and ready for surgery suffered from sleep disturbance, potentially contributing to impair HRQoL. Medical personnel should pay more attention to meningioma patients with sleep disturbance and take effective measures to improve sleep quality, with the ultimate goal to improve their HRQoL.

scholarly journals Relationship between Sleep Disorders and Health Related Quality of Life—Results from the Georgia SOMNUS Study

2018 ◽  
Vol 15 (8) ◽  
pp. 1588 ◽  
Author(s):  
Nato Darchia ◽  
Nikoloz Oniani ◽  
Irine Sakhelashvili ◽  
Mariam Supatashvili ◽  
Tamar Basishvili ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sleep Quality ◽  
Sleep Disorders ◽  
Developing World ◽  
Short Form ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Insomnia Severity

The extent to which sleep disorders are associated with impairment of health-related quality of life (HRQoL) is poorly described in the developing world. We investigated the prevalence and severity of various sleep disorders and their associations with HRQoL in an urban Georgian population. 395 volunteers (20–60 years) completed Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, STOP-Bang questionnaire, Insomnia Severity Index, Beck Depression Inventory-Short Form, and Short Form Health Survey (SF-12). Socio-demographic data and body mass index (BMI) were obtained. The prevalence of sleep disorders and their association with HRQoL was considerable. All SF-12 components and physical and mental component summaries (PCS, MCS) were significantly lower in poor sleepers, subjects with daytime sleepiness, apnea risk, or insomnia. Insomnia and apnea severity were also associated with lower scores on most SF-12 dimensions. The effect of insomnia severity was more pronounced on MCS, while apnea severity—on PCS. Hierarchical analyses showed that after controlling for potential confounding factors (demographics, depression, BMI), sleep quality significantly increased model’s predictive power with an R2 change (ΔR2) by 3.5% for PCS (adjusted R2 = 0.27) and by 2.9% for MCS (adjusted R2 = 0.48); for the other SF-12 components ΔR2 ranged between 1.4% and 4.6%. ESS, STOP-Bang, ISI scores, all exerted clear effects on PCS and MCS in an individual regression models. Our results confirm and extend the findings of studies from Western societies and strongly support the importance of sleep for HRQoL. Elaboration of intervention programs designed to strengthen sleep-related health care and thereof HRQoL is especially important in the developing world.

scholarly journals QOLP-27. USE OF THE NEURO-QOL COGNITIVE FUNCTION SHORT-FORM AS A TOOL FOR ASSESSING PATIENT-PERCEIVED NEUROCOGNITION FOLLOWING RADIOTHERAPY

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii180-ii181
Author(s):  
Sung Choi ◽  
Emily Kowalski ◽  
Rahul Khairnar ◽  
Mark Mishra
Keyword(s):  
Quality Of Life ◽  
Cognitive Function ◽  
Neurological Disorders ◽  
Short Form ◽  
Minimum Clinically Important Difference ◽  
Primary Objective ◽  
Study Cohort ◽  
Tumor Type

Abstract The Quality-of-Life in Neurological Disorders (Neuro-QOL) instruments are a practical set of validated tools utilized to measure a core set of health-related quality-of-life parameters that are relevant to patients with neurological disorders. The tools can be completed in approximately 1-minute. The primary objective of this study was to evaluate the feasibility of utilizing the eight-question Neuro-QoL Cognitive Function- Short Form (NCF-SF) tool (v2.0) to assess cognitive outcomes in patients with primary and secondary brain tumors undergoing radiotherapy. Patients completed the NCF-SF at baseline and during follow-up visits. Raw scores were converted to a standardized T-score that has been normalized to have mean score of 50 and standard deviation (SD) of 10. Descriptive statistical analyses were performed to assess the prevalence of baseline cognitive impairment (defined as &gt; 1 SD below the normative mean), and to assess longitudinal changes in Neuro-QOL scores. A minimum clinically important difference (MCID) was defined as a change from baseline of &gt;7.5, based on previously published literature. Ninety-one patients completed NCF-SF at baseline and at least one follow-up visit. The mean baseline score for the study cohort was 49.9 (SD 9.2). Nineteen percent of patients (n=17/91) had impaired function at baseline. Baseline scores did not differ based on tumor type (p=0.79): Glioma/ependymoma 49.6 (n=35); brain metastases 49.1 (n=24); Meningioma/benign 50.7 (n=32). Following radiation, 15% and 22% of patients experienced a MCID decline at 1- (n=60) and 3- months (n=65), respectively. However, 17% and 20% of patients demonstrated a MCID improvement at 1- and 3-months, respectively. In conclusion, this represents the first study to utilize the NCF-SF to measure cognitive function in patients undergoing brain radiotherapy. Use of NCG-SF was feasible, and identified patients with meaningful changes in cognitive function over time. Future clinical trials may consider use of Neuro-QOL to assess patient-perceived cognitive function.

scholarly journals Effects of Wuqinxi in the Patients with Chronic Low Back Pain: A Randomized Controlled Trial

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Chongjie Yao ◽  
Zhenrui Li ◽  
Shuaipan Zhang ◽  
Zhiwei Wu ◽  
Qingguang Zhu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Low Back Pain ◽  
Back Pain ◽  
Sleep Quality ◽  
Pain Intensity ◽  
Short Form ◽  
Low Back ◽  
Sf 36 ◽  
General Exercise

Low back pain (LBP) is one of the major concerns of the current health care. The guidelines for chronic LBP recommend traditional Chinese exercise as an effective treatment. As one of the representatives of traditional Chinese exercise, Wuqinxi has been famous in China for its effects on improving health and treating chronic diseases for thousands of years. The objectives of the study were to assess the effects of Wuqinxi in the patients with chronic LBP on pain intensity, trunk muscle strength, and quality of life. The primary outcome measure was assessed by the Short-Form McGill Pain Questionnaire (SF-MPQ), including the Visual Analog Scale (VAS) and Present Pain Intensity (PPI) as the subtables. The effects of Wuqinxi on the quality of life were also assessed by the Short-Form Health Survey (SF-36) and the Pittsburgh Sleep Quality Index (PSQI) from physical component summary (PCS), mental component summary (MCS), and sleep quality. Besides, the electrical activities of the rectus abdominis (RA), obliquus externus abdominis (OEA), lumbar erector spinae (ES), and multifidus (MF) were assessed by integrated electromyogram (iEMG) after the end of the intervention. Both the groups showed statistically significant improvement in SF-MPQ, SF-36, PSQI, and iEMG at 12 weeks and 24 weeks when compared with baseline (P<0.05). However, Wuqinxi demonstrated better effects in SF-MPQ and MCS after 24 weeks of intervention compared with the general exercise (P<0.05). The patients in the Wuqinxi group (WQXG) also showed a significantly higher iEMG on OEA than the general exercise group (GEG) in 30°/s and 90°/s (P<0.05). Our results showed that Wuqinxi had better effects on chronic LBP for a long time compared with general exercise, including pain intensity and quality of life. Thus, Wuqinxi should be recognized as a possible standalone therapy and self-management skill in chronic LBP, which is suitable for long-term practice.

scholarly journals Reduced sleep quality and depression associate with decreased quality of life in patients with pituitary adenomas

2015 ◽  
Vol 172 (6) ◽  
pp. 733-743 ◽  
Author(s):  
Sarah M Leistner ◽  
Jens Klotsche ◽  
Christina Dimopoulou ◽  
Anastasia P Athanasoulia ◽  
Josefine Roemmler-Zehrer ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sleep Quality ◽  
Mixed Models ◽  
Pituitary Adenomas ◽  
Sleep Disturbances ◽  
Clinical Depression ◽  
Max Planck ◽  
Cross Sectional ◽  
Control Subjects

ObjectivesSeveral studies reported decreased quality of life (QoL) and sleep as well as increased rates of depression for patients with pituitary adenomas. Our aim was to explore to what extent differences in depression and sleep quality contribute to differences in QoL between patients with pituitary adenomas and controls.DesignA cross-sectional case–control study.SettingEndocrine Outpatient Unit of the Max Planck Institute of Psychiatry, Munich, Department of Internal Medicine, Ludwig-Maximilians-University, Munich, and the Institute of Clinical Psychology and Psychotherapy, Technical University, Dresden.ParticipantsPatients with pituitary adenomas (n=247) and controls (from the DETECT cohort, a large epidemiological study in primary care patients) matched individually by age and gender (n=757).MeasurementsSleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI) and QoL was measured by the generic EQ-5D and calculated by the time trade-off- and VAS-method. Depression was categorized as ‘no depression’, ‘subclinical depression’, and ‘clinical depression’ according to the Beck Depressions Inventory for patients and the Depression Screening Questionnaire for control subjects.Statistical analysesGeneral linear and generalized, logistic mixed models as well as proportional odds mixed models were calculated for analyzing differences in baseline characteristics and in different subgroups.ResultsPatients with pituitary adenomas showed decreased QoL (VAS index: 0.73±0.19) and sleep (PSQI score: 6.75±4.17) as well as increased rates of depression (subclinical or clinical depression: 41.4%) compared with their matched control subjects (VAS index: 0.79±0.18, PSQI score: 5.66±4.31, subclinical or clinical depression: 25.9%). We have shown that a substantial proportion of the reduced QoL (48% respectively 65%) was due to the incidence of depression and reduced sleep quality.ConclusionsThese findings emphasize the importance of diagnosing depressive symptoms and sleep disturbances in patients with pituitary disease, with the ultimate goal to improve QoL in patients with pituitary adenomas.

scholarly journals A study protocol for a randomized controlled trial of an anti-inflammatory nutritional intervention in patients with fibromyalgia

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Ana Rita Silva ◽  
Alexandra Bernardo ◽  
Maria Fernanda de Mesquita ◽  
José Vaz Patto ◽  
Pedro Moreira ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sleep Quality ◽  
Inflammatory Markers ◽  
Short Form ◽  
Fibromyalgia Impact Questionnaire ◽  
Nutritional Intervention ◽  
Disease Assessment ◽  
Control Group ◽  
Anti Inflammatory

Abstract Background This study aims to analyze the effects of a potentially anti-inflammatory nutritional intervention in disease assessment parameters, inflammatory markers, and quality of life of fibromyalgia (FM) patients. Methods A sample of 100 female patients diagnosed with FM, followed up at Portuguese Institute of Rheumatology (IPR) in Lisbon, is being randomly allocated in two groups. Patients in the intervention group are adopting an anti-inflammatory diet, characterized by the exemption of the intake of foods containing gluten, dairy, sugar, and ultra-processed foods, during 3 months. During the first month, a low fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs) diet is implemented, along with the anti-inflammatory diet, followed by the reintroduction of all fruits and vegetables over a consecutive period of 2 months. Patients in the control group are adopting a diet based on general recommendations for healthy eating. The outcomes are pain, fatigue, quality of sleep, quality of life, gastrointestinal symptoms, and inflammation. Before and after the 3 months intervention, and also 1 month after beginning the intervention, the following questionnaires are applied: Revised Fibromyalgia Impact Questionnaire, visual analog pain scale, Brief Pain Inventory,visual analog scale from a list of common gastrointestinal and extraintestinal symptoms in FM, Short Form 36, Fatigue Severity Survey, and Pittsburg Sleep Quality Index. Ultra-sensitive serum C-reactive protein, eritrocyte sedimentation rate, and interleukin-8 are determined. Age, physical activity, anthropometric parameters, and body composition are being collected. Student’s t test will assess the association between the disease evaluation parameters, the inflammatory markers, and the dietary interventions. Discussion The results of this study are expected to determine whether a change in patient nutrition helps to alleviate symptoms, which would optimize medical intervention. Trial registration www.ClinicalTrials.gov NCT04007705. Registered on July 5, 2019.

scholarly journals Home-based exercise during confinement in COVID-19 pandemic and mental health in adults: a cross-sectional comparative study

2020 ◽  
Vol 25 ◽  
pp. 1-7
Author(s):  
Luiz José Frota Solon Júnior ◽  
Leonardo de Sousa Fortes ◽  
Bruno Teixeira Barbosa ◽  
José Valdir Alves Feitosa Júnior ◽  
Carlos Henrique Tomaz Ribeiro ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sleep Quality ◽  
Short Form ◽  
Eating Attitudes ◽  
Life Questionnaire ◽  
Cross Sectional ◽  
Eating Disorder Symptoms ◽  
Home Based ◽  
Physically Inactive

This study compared the quality of life, sleep quality, eating attitudes, and psychological aspects among adults (22.93 ± 2.58 years), whether physically inactive or not, before and during the COVID-19 pandemic. Participants were enrolled into: home-based exercise during the confinement (HBE group, n = 34), physically inactive during (PIDC group, n = 28), and before the confinement (PIBC group, n = 27). The depression, anxiety, and stress scale - Short Form, the Pittsburgh sleep quality index, the Eating Attitudes Test, and the quality of life questionnaire were used to assess variables. The covariance analysis (covariable - gender) was used to compare variables among the groups. The effect size was calculated by Cohen "d" (ESd). The HBE group presented a better quality of life compared to both PIDC (p = 0.002, ESd = 1.26) and PIBC (p = 0.008, ESd = 1.00) groups. Anxiety (p = 0.004, ESd = 0.96), depression (p = 0.02, ESd = 0.65) and stress (p = 0.02, ESd = 0.72) were significantly higher in the PIDC group when compared to HBE group. Self-reported sleep quality was better in the HBE group than in both other groups (p < 0.05). No group presented eating disorder symptoms; however, the HBE group has shown higher scores compared to both PIBC group (p = 0.01). In conclusion, adults who had exercised at home during the COVID-19 pandemic presented better quality of life, self-reported sleep quality, and reduced anxiety, depression, and stress levels than those physically inactive ones before and during the pandemic.

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