Subclinical Signs of Retinal Involvement in Hereditary Angioedema

To explore retinal abnormalities using spectral domain optical coherence tomography (SD-OCT) and OCT-angiography (OCT-A) in a highly selective cohort of patients with type I hereditary angioedema (HAE). This prospective case-control study included 40 type I HAE patients and 40 age-/sex-matched healthy subjects (HC). All participants underwent SD-OCT-scanning of retinal posterior pole (PP), peripapillary retinal nerve fiber layer (pRNFL), and optic nerve head (ONH). Superficial/deep capillary density was analyzed by OCT-A. A total of 80 eyes from 40 HAE and 40 eyes from HC were evaluated. The pRNFL was thicker in HAE than in HC in nasal superior (p < 0.0001) and temporal quadrants (p = 0.0005 left, p = 0.003 right). The ONH thickness in HAE patients was greater than in HC in the nasal (p = 0.008 left, p = 0.01 right), temporal (p = 0.0005 left, p = 0.003 right), temporal inferior (p = 0.007 left, p = 0.0008 right), and global (p = 0.005 left, p = 0.007 right) scans. Compared to HC, HAE showed a lower capillary density in both superficial (p = 0.001 left, p = 0.006 right) and deep (p = 0.008 left, p = 0.004 right) whole images, and superficial (p = 0.03 left) and deep parafoveal (p = 0.007 left, p = 0.005 right) areas. Our findings documented subclinical retinal abnormalities in type I HAE, supporting a potential role of the retinal assessment by SD-OCT/OCT-A as a useful tool in the comprehensive care of HAE patients.

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An evidence-based review of the potential role of icatibant in the treatment of acute attacks in hereditary angioedema type I and II

Core Evidence ◽

10.2147/ce.s24743 ◽

2012 ◽

pp. 105 ◽

Cited By ~ 6

Author(s):

Bernard Floccard ◽

Hautin ◽

Laurence Bouillet ◽

Coppere ◽

Allaouchiche

Keyword(s):

Hereditary Angioedema ◽

Potential Role ◽

Evidence Based ◽

Type I ◽

Acute Attacks

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The potential role of serum vitamin D level in migraine headache: a case–control study

Journal of Pain Research ◽

10.2147/jpr.s216314 ◽

2019 ◽

Vol Volume 12 ◽

pp. 2529-2536 ◽

Cited By ~ 1

Author(s):

Mona Hussein ◽

Wael Fathy ◽

Rehab Abd Elkareem

Keyword(s):

Vitamin D ◽

Migraine Headache ◽

Potential Role ◽

Case Control Study ◽

Serum Vitamin ◽

Case Control ◽

Serum Vitamin D ◽

Control Study

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Potential Role of Vegetarianism on Nutritional and Cardiovascular Status in Taiwanese Dialysis Patients: A Case-Control Study

PLoS ONE ◽

10.1371/journal.pone.0156297 ◽

2016 ◽

Vol 11 (6) ◽

pp. e0156297 ◽

Cited By ~ 7

Author(s):

Shih-Hsiang Ou ◽

Mei-Yin Chen ◽

Chien-Wei Huang ◽

Nai-Ching Chen ◽

Chien-Hsing Wu ◽

...

Keyword(s):

Potential Role ◽

Case Control Study ◽

Case Control ◽

Dialysis Patients ◽

Control Study

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Maternal obesity and stillbirth at term; placental pathology—A case control study

PLoS ONE ◽

10.1371/journal.pone.0250983 ◽

2021 ◽

Vol 16 (4) ◽

pp. e0250983

Author(s):

Hanna Åmark ◽

Magnus Westgren ◽

Meeli Sirotkina ◽

Ingela Hulthén Varli ◽

Martina Persson ◽

...

Keyword(s):

Logistic Regression ◽

Potential Role ◽

Maternal Obesity ◽

Case Control Study ◽

Case Control ◽

Normal Weight ◽

Obese Women ◽

Control Study ◽

Velamentous Cord Insertion

Objective The aim was to explore the potential role of the placenta for the risk of stillbirth at term in pregnancies of obese women. Methods This was a case-control study comparing placental findings from term stillbirths with placental findings from live born infants. Cases were singleton term stillbirths to normal weight or obese women, identified in the Stockholm stillbirth database, n = 264 and n = 87, respectively. Controls were term singletons born alive to normal weight or obese women, delivered between 2002–2005 and between 2018–2019. Placentas were compared between women with stillborn and live-born infants, using logistic regression analyses. Results A long and hyper coiled cord, cord thrombosis and velamentous cord insertion were stronger risk factors for stillbirth in obese women compared to normal weight women. When these variables were adjusted for in the logistic regression analysis, also adjusted for potential confounders, the odds ratio for stillbirth in obese women decreased from 1.89 (CI 1.24–2.89) to 1.63 (CI 1.04–2.56). Conclusion Approximately one fourth of the effect of obesity on the risk of stillbirth in term pregnancies is explained by umbilical cord associated pathology.

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Serum levels of leptin and adiponectin in patients with multiple sclerosis

The Egyptian Journal of Neurology Psychiatry and Neurosurgery ◽

10.1186/s41983-021-00369-2 ◽

2021 ◽

Vol 57 (1) ◽

Author(s):

Rasha M. Fahmi ◽

Amr E. Kamel ◽

Dorreya A. Elsayed ◽

Amal A. Zidan ◽

Noha T. Sarhan

Keyword(s):

Multiple Sclerosis ◽

Potential Role ◽

Case Control Study ◽

Serum Levels ◽

Serum Leptin ◽

Disability Status ◽

Egyptian Patients ◽

Disability Severity ◽

Control Study

Abstract Background The role of adipokines such as leptin and adiponectin in regulating the immunity has been documented, however data concerning their consequence on multiple sclerosis (MS) Egyptian patients are deficient. The aim of this study is to demonstrate the serum levels of leptin and adiponectin in MS patients and to assess their association with disease disability and severity. A case–control study including 60 subjects (30 MS patients and 30 age, sex and body mass index-matched healthy controls) was performed. Results Serum leptin level was significantly higher among MS patients than controls (P < 0.001) while adiponectin was not significantly elevated in MS patients (P = 0.24). There was a significant positive correlation between leptin levels with MS disability (Expanded Disability Status Scale) (r = 0.678; P < 0.001), severity (Multiple Sclerosis Severity Score) (r = 0.631; P < 0.001) and progression (progression index) (r = 0.461; P = 0.01). There was no statistically significant correlation between adiponectin with disease disability, severity or progression. Conclusions MS patients had significantly higher serum leptin levels and insignificant adiponectin levels compared to controls. Leptin has a potential role in multiple sclerosis disability and severity. However, adiponectin is not useful as a biomarker of MS disease, disability and severity.

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