scholarly journals Roles of AMPK and Its Downstream Signals in Pain Regulation

Life ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 836
Author(s):  
Shenglan Wang ◽  
Yi Dai
Keyword(s):  
Quality Of Life ◽  
Animal Models ◽  
Mammalian Cells ◽  
Emotional State ◽  
Adenosine Monophosphate ◽  
Central Nervous Systems ◽  
Metabolic Sensor ◽  
And Function ◽  
Pain Regulation

Pain is an unpleasant sensory and emotional state that decreases quality of life. A metabolic sensor, adenosine monophosphate-activated protein kinase (AMPK), which is ubiquitously expressed in mammalian cells, has recently attracted interest as a new target of pain research. Abnormal AMPK expression and function in the peripheral and central nervous systems are associated with various types of pain. AMPK and its downstream kinases participate in the regulation of neuron excitability, neuroinflammation and axonal and myelin regeneration. Numerous AMPK activators have reduced pain behavior in animal models. The current understanding of pain has been deepened by AMPK research, but certain issues, such as the interactions of AMPK at each step of pain regulation, await further investigation. This review examines the roles of AMPK and its downstream kinases in neurons and non-neuronal cells, as well as their contribution to pain regulation.

scholarly journals Inclusive Design: Systems Interaction Society - Textile Means of Rehabilitation - Child

2020 ◽  
Vol 6 (1) ◽  
pp. 198-206
Author(s):  
A. Golubchikova ◽  
N. Korobtseva
Keyword(s):  
Quality Of Life ◽  
Children With Disabilities ◽  
Emotional State ◽  
Structure And Function ◽  
The Body ◽  
Basic Principles ◽  
External Appearance ◽  
Design Systems ◽  
And Function

One of the goals of rehabilitation of children with disabilities (HHS) is to improve their quality of life. For this purpose, various technical means, devices and adaptations which solve a number of problems in life of the child are developed. But there is another aspect that affects the quality of life of such children — is the attitude of people around them. The child is emotionally unstable individual, his psyche is very vulnerable to react to negative emotions. In this case the saying that ‘meet on clothes’ is very applicable. And if the child looks aesthetically pleasing, then others perceive him positively. But in some diseases (physical deviations from the norm) there is no ergonomic and aesthetic clothing. The paper considers the interaction of the systems Society — Textile means of rehabilitation — Child. It is revealed that textile means of rehabilitation, including inclusive clothing have an impact not only on the child’s condition, but also on the emotional state of the society in contact with him, especially his parents. Research on the systematization of information about violations of the structure and function of the body allowed to identify and group the possible causes of violations of the proportions of the child’s body. Some can be compensated by the use of fixing products, others through the use of illusions that contribute to the visual alignment of the proportions of the child. The article formulates the basic principles of designing textile means of rehabilitation and inclusive clothing for children with disabilities, aimed at harmonizing the perception of the external appearance of the child.

Results of osteopathic correction of patients with post-traumatic coccygodynia

2019 ◽  
pp. 19-27
Author(s):  
Yu. V. Antonova ◽  
A. M. Iskandarov ◽  
I. B. Mizonova
Keyword(s):  
Quality Of Life ◽  
Emotional State ◽  
Pain Syndrome ◽  
Control Group ◽  
Life Questionnaire ◽  
Treatment Area ◽  
Diffi Cult ◽  
Osteopathic Treatment ◽  
Post Traumatic

Introduction.Coccygodynia is a multidisciplinary disease which is diffi cult to treat. It seriously limits the ability to work and signifi cantly affects the quality of life of patients. The study of somatic dysfunctions in patients with coccygodynia and the analysis of the results of osteopathic treatment of such patients makes it possible to justify the necessity of osteopathic correction of coccygodynia.Goal of the study— to determine the structure of the leading somatic dysfunctions in patients with coccygodynia and to study the effectiveness of osteopathic treatment of this pathology.Materials and methods.The study involved 44 patients from 25 to 65 years old, randomly divided into two groups. The main group of 24 people (20 women and 4 men) received osteopathic treatment, in accordance with the identifi ed leading somatic dysfunctions. Patients of the control group (16 women and 4 men) were treated locally with soft manual techniques (the treatment area was limited by the pelvic region). In order to assess the results of the treatment, we examined the intensity of the pain syndrome and the psycho-emotional state of patients. The severity of the pain syndrome was assessed in accordance with the visual analogue scale (VAS). The psycho-emotional state (with physical and mental components) was assessed with the help of the SF-36 quality of life questionnaire.Results.Somatic dysfunctions typical for patients with coccygodynia have been identifi ed. Osteopathic treatment has proven to be more effective in comparison with local manual therapy of coccygodynia both in early periods and in 3 months after the end of the treatment course.Conclusion.Osteopathic treatment of post-traumatic coccygodynia is effective, and can be recommended for treatment of such patients.

Regeneration of market squares in historic town centres: ideas, discussions, controversies

2018 ◽  
Vol 60 (1) ◽  
pp. 67-79
Author(s):  
Natalia Bursiewicz
Keyword(s):  
Quality Of Life ◽  
Form And Function ◽  
Points Of View ◽  
And Function ◽  
Historic Cities ◽  
Lower Silesia

Abstract In Poland, the last 15 years have been marked by various, numerous regeneration projects of historic cities that were supposed to improve the citizens quality of life and their security, as well as to create an attractive tourist offer. Those programs were often focused on the renewal, reshape and modernization of public squares. Such changes never go unnoticed. On contrary, these are frequently associated with criticism, debate and disagreements. The research has been focused on the analysis of regeneration projects from selected Market Squares in historic cities and town centres in Lower Silesia. The main aim was to exhibit the medieval origin of those squares and recently introduced contemporary layout. Moreover it was to present diverse opinions regarding square’s form and function, that can be crucial in understanding the architects, planners and citizens’ points of view and their ‘feelings’ towards the space.

scholarly journals Associations of emotional state and quality of life with lipid concentration, duration of the disease, and the way of treating the disease in persons with type 2 diabetes mellitus

Medicina ◽  
2009 ◽  
Vol 45 (2) ◽  
pp. 85 ◽  
Author(s):  
Lina Lašaitė ◽  
Jūratė Lašienė ◽  
Gintautas Kazanavičius ◽  
Antanas Goštautas
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Emotional State ◽  
Lipid Concentration ◽  
Males And Females ◽  
Anxiety Depression

The aim of the study was to evaluate associations of emotional state and quality of life with lipid concentration, duration of the disease, and the way of treating the disease in males and females with type 2 diabetes mellitus. A total of 53 persons with type 2 diabetes mellitus (27 males and 26 females; mean age, 58.7±8.9 years) and 56 healthy persons (26 males and 30 females; mean age, 54.7±8.3 years) participated in the study. Emotional state was evaluated by means of Profile of Mood State and quality of life by means of WHO Brief Quality of Life Questionnaire. Emotional state and quality of life were significantly worse, tension-anxiety and fatigue-inertia were significantly higher, vigor-activity was significantly lower in male patients with type 2 diabetes mellitus than in healthy males. In females, no significant differences in emotional state and quality of life comparing type 2 diabetes mellitus group and controls were detected. In females with type 2 diabetes mellitus, emotional state and quality of life were significantly better, scores of tension-anxiety, depression dejection, anger-hostility, and fatigue-inertia were significantly lower, and score of vigor-activity was significantly higher than in males with type 2 diabetes mellitus. Some significant correlations were found. In males, vigor-activity correlated with total cholesterol level and negatively correlated with triglyceride level. In females, significant correlations were found between scores of emotional state (tension-anxiety, depression-dejection, confusion-bewilderment, and total score of emotional state) and lipid levels (total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels). There were no significant associations of emotional state and quality of life with duration of the disease in males and females with type 2 diabetes mellitus. No significant differences in emotional state and quality of life were found between males and females with type 2 diabetes mellitus, who were treated with oral antidiabetic preparations and insulin preparations.

scholarly journals Importance of Diagnostic Waxing in Oral Rehabilitation: Case Report

2020 ◽  
Vol 22 (2) ◽  
pp. 146-150
Author(s):  
Mariana Lima da Costa Valente ◽  
Marcela Silva Costa ◽  
Paulo Marcos Bérgamo ◽  
Denise Tornavoi de Castro
Keyword(s):  
Quality Of Life ◽  
Treatment Plan ◽  
Dental Restoration ◽  
Oral Rehabilitation ◽  
Correct Treatment ◽  
Life Planning ◽  
End Of Treatment ◽  
Patient Reported ◽  
And Function

Currently, aesthetics, and especially the smile, adds considerable social value. In this way, patients suffering from dental loss wish that their rehabilitation be performed quickly and safely. The aim of oral rehabilitation is to restore masticatory, phonetic, aesthetic and quality of life to the patient. The diagnostic step is one of the most important and relevant steps in establishing a correct treatment plan and, in this way, it is possible to obtain excellent results. The present study aimed to demonstrate the importance of diagnostic waxing in oral rehabilitation. Patient sought treatment at the Dental Prosthesis Specialization Course at Odonto School, due to complaints associated with aesthetics and function. To improve their quality of life, planning of case was carried out through diagnostic waxing and a prosthetic solution was proposed. At the end of treatment and during the follow-up of the case, the patient reported satisfaction and significant improvement in quality of life. It can be concluded that the diagnostic waxing presents customized solutions offering, through a previous study, an effective clinical resolution to the patient. Keywords: Mouth Rehabilitation. Dental Restoration, Temporary. Dental Restoration, Temporary. Resumo Atualmente, a estética, e em especial o sorriso, agregam um valor social considerável. Dessa forma, ao sofrerem a perda dental, os pacientes desejam que sua reabilitação seja realizada de forma rápida e segura. A reabilitação oral tem como objetivo devolver ao paciente a eficiência mastigatória, fonética, estética e a qualidade de vida. A etapa diagnóstica constitui um dos passos mais importantes e relevantes no estabelecimento de um correto planejamento do tratamento e, desta forma, torna-se possível obter resultados de excelência. O presente estudo teve como objetivo demonstrar a importância do enceramento diagnóstico na reabilitação oral. Paciente procurou tratamento no Curso de Especialização em Prótese Dentária da Odonto School, devido a queixas associadas a estética e função. Para melhorar sua qualidade de vida, foi realizado o planejamento do caso por meio do enceramento diagnóstico e uma solução protética foi proposta. Ao final do tratamento e durante o acompanhamento do caso, a paciente relatou satisfação e melhora significativa na qualidade de vida. Pode-se concluir que o enceramento diagnóstico apresenta soluções personalizadas oferecendo, por meio de estudo prévio, uma resolução clínica efetiva ao paciente. Palavras-chave: Reabilitação Bucal. Restauração Dentária Temporária. Prótese Dentária Temporária.

scholarly journals INTERRELATION BETWEEN THE CHANGES IN QUALITY OF LIFE AND ARTERIAL STIFFNESS IN PATIENTS WITH DIABETES MELLITUS TYPE 2 AND CONCOMITANT OBESITY

2018 ◽  
Vol 18 (4) ◽  
pp. 71-75
Author(s):  
I.M. Fushtey ◽  
Ye.A. Solovyuk ◽  
A.O. Solovyuk
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Diabetes Mellitus ◽  
Emotional State ◽  
Eating Behaviour ◽  
Overweight And Obesity ◽  
Healthy Individuals ◽  
Patients With Diabetes

The purpose of this work was to study the general characteristics of quality of life (QoL), the effect of overweight on QoL, the nature of eating behaviour in patients with diabetes mellitus (DM) type 2 and   concomitant overweight (OW) and obesity, as well as to establish the correlation with indicators of functional state of the arterial vessels. 64 people (34 women and 30 men) with DM and concomitant  overweight and obesity (average age 56.3 ± 10.23 years) formed the 1 group, 34 people (19 women and 15 men), whose average age was 55.6 ± 11.92 years constituted the 2 group, and  28 healthy individuals formed the control group. SF-36v2 questionnaires were used to evaluate QoL. The effect of overweight on QoL was analyzed according to the IWQOL-Lite questionnaire data, the patterns of eating behaviour were determined by the COEQ4 for 7 days using FPRS questionnaire. The functional state of the arterial vessels was assessed by estimating the pulse wave velocity using the automated rheographic complex ReoCom (KhAI Medika (Ukraine)). The patients with DM and concomitant overweight and obesity were found to experience some changes in QoL according to the SF-36v2 questionnaire. The changes were primarily characterized by a decrease in physical activity, as well as in social and emotional status. These changes differed not only from the QoL assessment by healthy individuals, but also from those of patients with DM and normal body weight. The nature of eating behaviour in overweight or obese patients with DM was characterized by an increased hunger in parallel with a worsened emotional state and an increased desire to eat certain types of foods that can contribute to weight gain. Structural changes in arterial vessels that typically are indicative of arterial stiffness correlate with indicators of emotional state and physical activity in patients with DM and comorbid overweight and obesity.

Impediments in Healthcare Digital Transformation

2021 ◽  
pp. 1704-1719
Author(s):  
Robert Furda ◽  
Michal Gregus
Keyword(s):  
Quality Of Life ◽  
Information Technologies ◽  
Enterprise Architecture ◽  
Digital Transformation ◽  
Healthcare Sector ◽  
Successful Implementation ◽  
Managerial Decisions ◽  
And Function ◽  
Structural Aspects

This article is addressing the specific impediments that appear in the process of healthcare digital transformation. Enterprise architecture provides the framework for investigating the behavioral and active structural aspects that apply to business and application layers. This includes an analysis of, including inherent relationship between, selected scopes such as strategy, business, and education to standard elements such as process, service, and function of an application. The presented classification and assignment of individual impediments indicate to healthcare managers where they may potentially struggle during different stages of digital transformation. Among others, they facilitate strategic planning and managerial decisions during implementation of the emerging information technologies and techniques. In addition, the idea is to contribute to the successful implementation of healthcare digital transformation, thereby delivering business value within healthcare sector, and consequently to a better quality of life.

Personal, health and function, and career maintenance factors as determinants of quality of life among employed people with multiple sclerosis

Work ◽  
2020 ◽  
Vol 67 (1) ◽  
pp. 81-94 ◽  
Author(s):  
Phillip Rumrill ◽  
Jian Li ◽  
David Strauser ◽  
Richard T. Roessler ◽  
Malachy Bishop ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Multiple Regression Model ◽  
Future Research ◽  
Personal Health ◽  
Washington Dc ◽  
Perceived Quality Of Life ◽  
National Multiple Sclerosis Society ◽  
And Function

BACKGROUND: Multiple sclerosis (MS) is an intrusive disease that significantly affects labor force participation. OBJECTIVE: This study examined the extent to which factors at the personal, health and function, and environmental/career maintenance levels contribute to the predictability power for quality of life among employed people with MS. METHOD: Participants consisted of 523 members of nine National Multiple Sclerosis Society chapters representing 21 states and Washington, DC. These individuals were employed at the time of the survey, and they were primarily middle age (average age of 48 years) and Caucasian (74%). RESULTS: The final hierarchical multiple regression model explained 54 percent of the variability in participants’ quality of life scores, although none of the hypothesized personal/demographic predictors were significant. Participants who perceived better overall health and lower levels of stress, who experienced less severe cognitive and mobility-related MS symptoms, and who expressed stronger job-person matches and higher levels of job satisfaction reported higher quality of life scores than did other participants. CONCLUSIONS: The findings underscore the complexity involved in predicting perceived quality of life among employed people with MS. Implications of these findings for future research and clinical practice are discussed.

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