scholarly journals Tragacanth Gum/Chitosan Polyelectrolyte Complexes-Based Hydrogels Enriched with Xanthan Gum as Promising Materials for Buccal Application

Materials ◽  
2020 ◽  
Vol 14 (1) ◽  
pp. 86
Author(s):  
Joanna Potaś ◽  
Emilia Szymańska ◽  
Anna Basa ◽  
Anita Hafner ◽  
Katarzyna Winnicka
Keyword(s):  
Electrostatic Interactions ◽  
Xanthan Gum ◽  
Drug Dosage ◽  
Dosage Forms ◽  
Polyelectrolyte Complexes ◽  
Tragacanth Gum ◽  
Buccal Drug Delivery ◽  
Interpolymer Complexation ◽  
Zeta Potential Analysis ◽  
Complexation Process

Polyelectrolyte complexes based on the electrostatic interactions between the polymers mixed are of increasing importance, therefore, the aim of this study was to develop hydrogels composed of anionic tragacanth gum and cationic chitosan with or without the addition of anionic xanthan gum as carriers for buccal drug delivery. Besides the routine quality tests evaluating the hydrogel’s applicability on the buccal mucosa, different methods directed toward the assessment of the interpolymer complexation process (e.g., turbidity or zeta potential analysis, scanning electron microscopy and Fourier-transform infrared spectroscopy) were employed. The addition of xanthan gum resulted in stronger complexation of chitosan that affected the hydrogel’s characteristics. The formation of a more viscous PEC hydrogel with improved mucoadhesiveness and mechanical strength points out the potential of such polymer combination in the development of buccal drug dosage forms.

Formulation and Evaluation of Bilayer Sustained Release Tablets of Salbutamol and Theophylline

2009 ◽  
Vol 2 (3) ◽  
pp. 638-646
Author(s):  
R. Nagaraju ◽  
Rajesh Kaza
Keyword(s):  
Ethyl Cellulose ◽  
Xanthan Gum ◽  
Dosage Forms ◽  
In Vitro Dissolution ◽  
Dissolution Studies ◽  
Sustained Release Tablets ◽  
Dissolution Apparatus ◽  
Single Dosage

Salbutamol and theophylline are available in conventional dosage forms, administered four times a day, leading to saw tooth kinetics and resulting in ineffective therapy. The combination of these two drugs in a single dosage form will enhance the patient compliance and prolong bronchodilation. Various polymers, such as hydroxy propyl methylcellulose K4M (HPMC- K4M), hydroxy propyl methylcellulose K100M (HPMC- K100M), xanthan gum, ethyl cellulose and hydroxy propyl methylcellulose phthalate (HPMC-P) were studied. HPMC-P and HPMC- K4M were found to be best in controlling the release. In-vitro dissolution studies were carried out for all the bi-layered tablets developed using USP dissolution apparatus type 2 (paddle). It was found that the tablet FB15-FW3 showed 50% release of salbutamol in first hour and the remaining was released for eight hours. However, theophylline was found to be released as per the USP specifications. The IR spectrum was taken for FB15-FW3 formulation and it revealed that there is no disturbance in the principal peaks of pure drugs salbutamol and theophylline. This further confirms the integrity of pure drugs and no incompatibility of them with excipients. Also, formulation of FB15-FW3 has shown required release pattern and complies with all the evaluated parameters and comparable to the marketed formulation.

scholarly journals COPROCESSED EXCIPIENTS OF CROSSLINKED AMYLOSE AND XANTHAN GUM FOR USE IN CONTROLLED RELEASE DOSAGE FORMS

2018 ◽  
Vol 10 (1) ◽  
pp. 59
Author(s):  
Silvia Surini ◽  
Lusiana Ariani ◽  
Kurnia Ss Putri ◽  
Hayun Hayun ◽  
Effionora Anwar
Keyword(s):  
Controlled Release ◽  
Moisture Content ◽  
Xanthan Gum ◽  
Dosage Forms ◽  
Gel Strength ◽  
Pharmaceutical Dosage Forms ◽  
Sodium Trimetaphosphate ◽  
Substitution Degree ◽  
Phosphate Groups ◽  
Polymer Ratio

Objective: This study was aimed to obtain a new excipient that can be used as a polymer matrix for the formulation of controlled release dosage forms.Methods: This study used coprocessing and crosslinking methods on amylose and xanthan gum (XG) to obtain a new excipient that can be usedfor controlled release matrix of pharmaceutical dosage forms. The coprocessing step was conducted by drum drying, and the crosslinking step wasprepared using 6 and 12% sodium trimetaphosphate (STMP). The produced novel excipients were characterized in terms of infrared (IR) spectrum,substitution degree, moisture content, swelling index, and gel strength.Results: Our results showed that amylose–XG excipients crosslinked using 6% STMP have greater gel strength and better swelling indexes thanexcipients crosslinked using 12% STMP. All coprocessed excipients exhibited no differences in their IR spectra, whereas the crosslinked excipientsdid, indicating a structural change due to the addition of phosphate groups. Crosslinking amylose–xanthan-coprocessed excipients using 6% STMPproduced degrees of substitution (DSs) of 7–8 phosphates per 100 monomeric subunits. The excipients had a moisture content of 8.21–12.85%, andthe pH of a 1% solution of excipients was 6.21–6.43. In addition, the swelling index and gel strength of the excipient where both amylose and XG werecrosslinked together Were more than 1 where only amylose was crosslinked.Conclusion: The crosslinking amylose–xanthan-coprocessed excipient using 6% STMP is more suitable for use in controlled release dosage forms,particularly when the polymer ratio is 1:1.

scholarly journals Continuous end-to-end production of solid drug dosage forms: Coupling flow synthesis and formulation by electrospinning

2018 ◽  
Vol 350 ◽  
pp. 290-299 ◽  
Author(s):  
Attila Balogh ◽  
András Domokos ◽  
Balázs Farkas ◽  
Attila Farkas ◽  
Zsolt Rapi ◽  
...  
Keyword(s):  
Drug Dosage ◽  
Dosage Forms ◽  
Flow Synthesis ◽  
End To End

Bacillus licheniformis levan as a functional biopolymer in topical drug dosage forms: From basic colloidal considerations to actual pharmaceutical application

2020 ◽  
Vol 142 ◽  
pp. 105109 ◽  
Author(s):  
Ivana Pantelić ◽  
Milica Lukić ◽  
Gordana Gojgić-Cvijović ◽  
Dragica Jakovljević ◽  
Ines Nikolić ◽  
...  
Keyword(s):  
Bacillus Licheniformis ◽  
Drug Dosage ◽  
Dosage Forms ◽  
Pharmaceutical Application

scholarly journals P08 Is there a difference in the frequency of manipulated orally and rectally administered medicines to paediatric in-patients in Sweden in the year 2009 and 2018 respectively? A register study

2019 ◽  
Vol 104 (6) ◽  
pp. e20.2-e20
Author(s):  
A Andersson ◽  
S Eksborg ◽  
S Lindemalm ◽  
U Förberg
Keyword(s):  
Drug Dosage ◽  
Drug Dose ◽  
Dosage Forms ◽  
Age Group ◽  
Vulnerable Patients ◽  
Change In Practice ◽  
Drug Dosage Form ◽  
Child Friendly ◽  
One Year ◽  
Dosing Accuracy

BackgroundSince there is a lack of drugs in suitable strengths and child-friendly dosage forms, manipulation is sometimes necessary in paediatrics. A manipulation is the physical alteration of a drug dosage form with the purpose to extract and administer the prescribed proportion of a drug dose.The purpose of this study was to calculate the frequency of manipulated medicines administered to paediatric in-patients at a large Children´s Hospital for two separate years and compare whether there has been a change in practice.Material and MethodsData were collected for all administered doses during 2 separate years (2009 and 2018) at the paediatric wards at our Children´s Hospital, from a hospital-based electronic register. All administered doses where the number of tablets or suppositories were decimal were added and calculated as a percentage of the total number of oral and rectal administrations. Data are anonymous but information regarding gender, age, hospital ward and number of drugs per patient were available and were analysed.ResultsIn one year, approximately 450 000 doses of medicine are administered to paediatric patients in our Children´s hospital.The results will be analysed with regards to differences between patient age, gender, prescribing year and drug substance. A pilot study showed that 10% of all solid oral administrations to patients 6 - 12 years old, were part of a tablet. For patients 0 - 2 years over 20% of all solid rectal administrations were part of a suppository.The extent of manipulation is affected by a lot of factors, where the most prominent is whether there are strengths suitable for that age-group available on the market or not.ConclusionMost often there is a lack of knowledge how manipulation of medicines influences the dosing accuracy and often we do this to our most vulnerable patients.Disclosure(s)Nothing to disclose

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