Preparation and Swelling Behaviors of High-Strength Hemicellulose-g-Polydopamine Composite Hydrogels

Hemicellulose-based composite hydrogels were successfully prepared by adding polydopamine (PDA) microspheres as reinforcing agents. The effects of PDA microsphere size, dosage, and nitrogen content in hydrogel on the mechanical and rheological properties was studied. The compressive strength of hydrogel was increased from 0.11 to 0.30 MPa. The storage modulus G’ was increased from 7.9 to 22.0 KPa. The gaps in the hemicellulose network are filled with PDA microspheres. There is also chemical cross-linking between them. These gaps increased the density of the hydrogel network structure. It also has good water retention and pH sensitivity. The maximum cumulative release rate of methylene blue was 62.82%. The results showed that the release behavior of hydrogel was pH-responsive, which was beneficial to realizing targeted and controlling drug release.

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Synthesis of multifunctional high strength, highly swellable, stretchable and self-healable pH-responsive ionic double network hydrogels

Polymer International ◽

10.1002/pi.5741 ◽

2018 ◽

Vol 68 (3) ◽

pp. 503-515 ◽

Cited By ~ 7

Author(s):

Akansha Dixit ◽

Dibyendu S Bag ◽

Dhirendra K Sharma ◽

Namburi Eswara Prasad

Keyword(s):

High Strength ◽

Ph Responsive ◽

Double Network

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In situ polymerization approach to cellulose–polyacrylamide interpenetrating network hydrogel with high strength and pH-responsive properties

Cellulose ◽

10.1007/s10570-018-2171-y ◽

2018 ◽

Vol 26 (3) ◽

pp. 1825-1839 ◽

Cited By ~ 12

Author(s):

Fengcai Lin ◽

Xiangchao Lu ◽

Zi Wang ◽

Qilin Lu ◽

Guanfeng Lin ◽

...

Keyword(s):

In Situ Polymerization ◽

High Strength ◽

Ph Responsive ◽

Interpenetrating Network

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Facile preparation of low swelling, high strength, self-healing and pH-responsive hydrogels based on the triple-network structure

Frontiers of Materials Science ◽

10.1007/s11706-019-0450-7 ◽

2019 ◽

Vol 13 (1) ◽

pp. 54-63 ◽

Cited By ~ 4

Author(s):

Zhicun Wang ◽

Xiaoman Han ◽

Yixi Wang ◽

Kenan Men ◽

Lin Cui ◽

...

Keyword(s):

Network Structure ◽

High Strength ◽

Self Healing ◽

Ph Responsive ◽

Facile Preparation ◽

Responsive Hydrogels

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Nanohydroxyapatite Reinforced Chitosan Composite Hydrogel with Tunable Mechanical and Biological Properties for Cartilage Regeneration

Scientific Reports ◽

10.1038/s41598-019-52042-7 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 13

Author(s):

B. Y. Santosh Kumar ◽

Arun M. Isloor ◽

G. C. Mohan Kumar ◽

Inamuddin ◽

Abdullah M. Asiri

Keyword(s):

Cartilage Regeneration ◽

Biological Properties ◽

Composite Hydrogel ◽

Time Dependent ◽

Chitosan Hydrogel ◽

Composite Hydrogels ◽

Hydrogel Network ◽

Strength And Durability ◽

Chitosan Composite ◽

L929 Mouse

Abstract With the continuous quest of developing hydrogel for cartilage regeneration with superior mechanobiological properties are still becoming a challenge. Chitosan (CS) hydrogels are the promising implant materials due to an analogous character of the soft tissue; however, their low mechanical strength and durability together with its lack of integrity with surrounding tissues hinder the load-bearing application. This can be solved by developing a composite chitosan hydrogel reinforced with Hydroxyapatite Nanorods (HANr). The objective of this work is to develop and characterize (physically, chemically, mechanically and biologically) the composite hydrogels loaded with different concentration of hydroxyapatite nanorod. The concentration of hydroxyapatite in the composite hydrogel was optimized and it was found that, reinforcement modifies the hydrogel network by promoting the secondary crosslinking. The compression strength could reach 1.62 ± 0.02 MPa with a significant deformation of 32% and exhibits time-dependent, rapid self-recoverable and fatigue resistant behavior based on the cyclic loading-unloading compression test. The storage modulus value can reach nearly 10 kPa which is needed for the proposed application. Besides, composite hydrogels show an excellent antimicrobial activity against Escherichia coli, Staphylococcus aureus bacteria’s and Candida albicans fungi and their cytocompatibility towards L929 mouse fibroblasts provide a potential pathway to developing a composite hydrogel for cartilage regeneration.

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Synthesis of dual temperature – and pH-responsive yolk-shell nanoparticles by conventional etching and new deswelling approaches: DOX release behavior

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2018.02.010 ◽

2018 ◽

Vol 165 ◽

pp. 1-8 ◽

Cited By ~ 20

Author(s):

Goolia Nikravan ◽

Vahid Haddadi-Asl ◽

Mehdi Salami-Kalajahi

Keyword(s):

Release Behavior ◽

Ph Responsive ◽

Shell Nanoparticles

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One-pot construction of cellulose-gelatin supramolecular hydrogels with high strength and pH-responsive properties

Carbohydrate Polymers ◽

10.1016/j.carbpol.2018.05.020 ◽

2018 ◽

Vol 196 ◽

pp. 225-232 ◽

Cited By ~ 14

Author(s):

Qilin Lu ◽

Songhua Zhang ◽

Mingcheng Xiong ◽

Fengcai Lin ◽

Lirong Tang ◽

...

Keyword(s):

High Strength ◽

Ph Responsive ◽

One Pot

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ENZYMATICALLY SYNTHESIZED pH-RESPONSIVE IPN FOR IN-SITU RELEASE OF PANTOPRAZOLE SODIUM

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2019v11i4.31043 ◽

2019 ◽

pp. 98-103

Author(s):

Saruchi Sharma ◽

VANEET KUMAR

Keyword(s):

Drug Release ◽

Polymer Network ◽

Lateral Diffusion ◽

Ph Sensitive ◽

Interpenetrating Polymer Network ◽

Release Behavior ◽

Ph Responsive ◽

Gum Tragacanth ◽

Swelling Capacity

Objective: This study involves the synthesis of Gum tragacanth (gt) based interpenetrating polymer network (ipn) and its utilization for sustained release of anti-ulcerative drug i.e. pantoprazole sodium. Methods: IPN was synthesized from Gum tragacanth, polyacrylic acid (gt-cl-paa) hydrogel. gt-cl-paa was kept in distilled water. Further, acryamide (aam) and methylmethacrylate (mma) was added and then kept for overnight. Later on, lipase and glutaraldehyde were added. Homopolymers and the unreacted monomers were removed using acetone. Synthesized IPN was dried at 50 °C for further study. Synthesized ipn was swelled in water and the drug was added to it. The drug was entrapped in the pores of the synthesized ipn and then drug release behavior was studied using uv-vis spectrophotometer. Results: Gt, paa and mma based crosslinked IPN were synthesized using lipase-glutaraldehyde as initiator-crosslinker system. The synthesized IPN was pH sensitive and possessed the desired swelling capacity required for the controlled and systematic liberation of pantoprazole sodium at 37 °C. The kinetic of drug release was studied and found that lateral diffusion (DL) of drug was higher as compared to the initial diffusion (DI). The prepared IPN can be used as prospective carrier for prolonged drug delivery. Conclusion: A novel pH sensitive and colon targeted IPN was synthesized. It acts as an effective device for the controlled release of drug pantoprazole sodium.

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Zr(IV)-Crosslinked Polyacrylamide/Polyanionic Cellulose Composite Hydrogels with High Strength and Unique Acid Resistance

Journal of Polymer Science Part B Polymer Physics ◽

10.1002/polb.24853 ◽

2019 ◽

Vol 57 (15) ◽

pp. 981-991 ◽

Cited By ~ 4

Author(s):

Xiaofu Dai ◽

Jianquan Wang ◽

Fei Teng ◽

Ziqiang Shao ◽

Xiaonan Huang

Keyword(s):

Acid Resistance ◽

High Strength ◽

Composite Hydrogels ◽

Cellulose Composite

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High strength and low swelling composite hydrogels from gelatin and delignified wood

Scientific Reports ◽

10.1038/s41598-020-74860-w ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Shennan Wang ◽

Kai Li ◽

Qi Zhou

Keyword(s):

Mechanical Strength ◽

High Strength ◽

Honeycomb Structure ◽

Composite Hydrogel ◽

High Porosity ◽

High Mechanical Strength ◽

Composite Hydrogels ◽

Freeze Dried ◽

Strength And Stiffness ◽

Phosphate Buffered Saline

Abstract A delignified wood template with hydrophilic characteristics and high porosity was obtained by removal of lignin. Gelatin was infiltrated into the delignified wood and further crosslinked with a natural crosslinker genipin to form hydrogels. The composite hydrogels showed high mechanical strength under compression and low swelling in physiological condition. The effect of genipin concentrations (1, 50 and 100 mM) on structure and properties of the composite hydrogels were studied. A porous honeycomb structure with tunable pore size and porosity was observed in the freeze-dried composite hydrogels. High elastic modulus of 11.82 ± 1.51 MPa and high compressive yield stress of 689.3 ± 34.9 kPa were achieved for the composite hydrogel with a water content as high as 81%. The equilibrium water uptake of the freeze-dried hydrogel in phosphate buffered saline at 37 °C was as low as 407.5%. These enables the delignified wood structure an excellent template in composite hydrogel preparation by using infiltration and in-situ synthesis, particularly when high mechanical strength and stiffness are desired.

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