scholarly journals In Vitro Analysis of Wearing of Hip Joint Prostheses Composed of Different Contact Materials

Materials ◽  
2021 ◽  
Vol 14 (14) ◽  
pp. 3805
Author(s):  
Jian Su ◽  
Jian-Jun Wang ◽  
Shi-Tong Yan ◽  
Min Zhang ◽  
Hui-Zhi Wang ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Vitamin E ◽  
Femoral Head ◽  
Wear Rate ◽  
Hip Joint ◽  
Cobalt Chromium ◽  
Significant Difference ◽  
Joint Prostheses ◽  
Hip Joint Simulator

Cobalt-chromium-molybdenum alloy (CoCrMo) and ceramic are the two most common materials for the femoral head in hip joint prostheses, and the acetabular liner is typically made from ultra-high molecular weight polyethylene (UHMWPE), highly cross-linked polyethylene (XLPE), or highly cross-linked polyethylene blended with Vitamin E (VEXLPE). The selection of suitable materials should consider both wear performance and cost-effectiveness. This study compared the wear rate between different friction pairs using a hip joint simulator and then recommended a suitable prosthesis based on the corresponding processing technology and cost. All wear simulations were performed in accordance with ISO 14242, using the same hip joint simulator and same test conditions. This study found that when using the same material for the femoral head, the XLPE and VEXLPE liners had a lower wear rate than the UHMWPE liners, and the wear rate of the XLPE liners increased after blending with Vitamin E (VEXLPE). There was no significant difference in the wear rate of XLPE when using a CoCrMo or ceramic head. Considering the wear rate and cost-effectiveness, a CoCrMo femoral head with an accompanying XLPE liner is recommended as the more suitable combination for hip prostheses.

Biotribological behaviour of Vitamin E-blended highly cross-linked UHMWPE in a hip joint simulator

2016 ◽  
Vol 68 (5) ◽  
pp. 548-553 ◽  
Author(s):  
Guomei Chen ◽  
Zifeng Ni ◽  
Shanhua Qian ◽  
Yongwu Zhao
Keyword(s):  
Wear Resistance ◽  
Vitamin E ◽  
Hip Joint ◽  
Oxidative Degradation ◽  
Test Environment ◽  
Content Type ◽  
Artificial Hip Joint ◽  
Hip Simulator ◽  
Directional Motion ◽  
Hip Joint Simulator

Purpose The purposes of this paper are to investigate the biotribological behaviour of Vitamin E-blended highly cross-linked ultra-high molecular weight polyethylene (HXL-UHMWPE) under multi-directional motion by using a CUMT II artificial joint hip simulator and compare it with HXL-UHMWPE and conventional UHMWPE. Design/methodology/approach The biotribological behaviour of conventional, highly cross-linked and Vitamin E-blended highly cross-linked UHMWPE acetabular cups counterfaced with CoCrMo alloy femoral head under multi-directional motion were investigated by using CUMT-II artificial hip joint simulator for one-million walking cycles. The test environment was at 36.5 ± 0.5°C and 25 per cent bovine serum was used as lubricant. A Paul cycle load with a peak of 784 N was applied; the motion and loading were synchronized at 1 Hz. Findings The wear resistance of Vitamin E-blended highly cross-linked UHMWPE was significantly higher than that of highly cross-linked and conventional UHMWPE. The wear marks observed from the worn surface of UHMWPE were multi-directional, with no dominant wear direction. Only abrasion occurred on the surface of Vitamin E-blended highly cross-linked UHMWPE, while yielding and accumulated plastic flow processes occurred on the surface of conventional UHMWPE and flaking-like facture and abrasion occurred on the surface of highly cross-linked UHMWPE. Originality/value Besides the prevention of oxidative degradation, blending with Vitamin E can also reduce the incidence of fatigue crack occurred in the surface layer of HXL-UHMWPE samples. Therefore, the wear resistance of HXL-UHMWPE under multi-directional motion can be further enhanced by blending with Vitamin E.

The clinical relevance of hip joint simulator testing: In vitro and in vivo comparisons

Wear ◽  
2005 ◽  
Vol 259 (7-12) ◽  
pp. 882-886 ◽  
Author(s):  
Aaron Essner ◽  
Gregg Schmidig ◽  
Aiguo Wang
Keyword(s):  
Hip Joint ◽  
Clinical Relevance ◽  
Hip Joint Simulator

Workspace analysis of 3SPS+1PS bionic parallel test platform for hip joint simulator

2011 ◽  
Vol 225 (9) ◽  
pp. 2216-2231 ◽  
Author(s):  
G Cheng ◽  
J-L Yu ◽  
S-R Ge ◽  
S Zhang
Keyword(s):  
Hip Joint ◽  
Parallel Manipulator ◽  
Jacobi Matrix ◽  
Parallel Test ◽  
Flexion Extension ◽  
Test Platform ◽  
Moving Platform ◽  
Joint Prostheses ◽  
Hip Joint Simulator ◽  
Orientation Workspace

In order to evaluate the movement performance of a human hip joint, a novel parallel manipulator called 3SPS+1PS bionic parallel test platform is proposed in this article. SPS denotes the spherical-prismatic-spherical leg, and PS the prismatic-spherical leg where only the prismatic joint is actuated and hence underlined. For the 3SPS+1PS bionic parallel test platform with four degrees of freedom including three rotations and one translation, the formulae for solving the inverse kinematics equations are derived based on the quaternion method. Unit quaternion is used to represent the position and orientation of a moving platform, and singularities caused by Euler angles are avoided. Combining the topological structure characteristics of the parallel manipulator, the orientation workspace of the moving platform at a given translation position is constructed. Moreover, the procedures to solve and evaluate the orientation workspace of the parallel manipulator are obtained. In order to ensure dexterity and obtain more workspace, the condition index is studied by the condition number and singular values analysis of the dimensionally homogeneous Jacobi matrix. The parallel manipulator has three rotations about the Z-axis, the Y-axis, and the X-axis applied to represent three rotation motions (flexion/extension (FE), abduction/adduction (AA), and internal/external (IE) rotation motion) of a human hip joint, respectively. The numerical results illustrate that the 3SPS + 1PS bionic parallel test platform generates ±25° to ±108° in FE, −20° to 20° in AA, and −21° to 21° in IE rotation where the maximum permissible condition numbers of Jacobi matrix are set within the range 15–20 and the parallel manipulator can provide full-scale friction motion for hip joint simulator. In the dexterous orientation workspace, the slide track on the friction counterface of hip joint prostheses can be varied consistently. By verifying the lengths of the SPS-type active legs, the parallel manipulator can provide cross-path multidirectional slide motion for hip joint prostheses. The three-dimensional model and kinematics simulation of the manipulator are established and analysed. The simulation results prove that the 3SPS + 1PS bionic parallel test platform can accurately represent human hip joint motion and provide more reliable experimental data for hip joint prostheses in clinical application. The research builds the theoretical basis for its bionic motion simulation in practical application.

scholarly journals Retention Strength of Cobalt-Chromium vs Nickel-Chromium Titanium vs CP Titanium in a Cast Framework Association of Removable Partial Overdenture

2011 ◽  
Vol 12 (3) ◽  
pp. 179-186
Author(s):  
Adriana Cristina Zavanelli ◽  
Recardo Alexandre Zavanelli ◽  
José Everaldo de Aquino Souza ◽  
Nelson Renato França Alves da Silva ◽  
Paulo Guilherme Coelho ◽  
...  
Keyword(s):  
Potential Risk ◽  
Artificial Saliva ◽  
Pure Titanium ◽  
Commercially Pure Titanium ◽  
Cobalt Chromium ◽  
Nickel Chromium ◽  
Commercially Pure ◽  
Significant Difference ◽  
Retention Strength

ABSTRACT Aim There is little information considering the framework association between cast clasps and attachments. The aim of this study was to evaluate the retention strength of frameworks match circumferential clasps and extra resilient attachment cast in three different alloys (cobalt-chromium, nickel-chromium titanium and commercially pure titanium), using two undercut (0.25 and 0.75 mm) and considering different period of time (0, 1/2, 1, 2, 3, 4 and 5 years). Methods Using two metallic matrices, representing a partially edentulous mandibular right hemiarch with the first molar crown, canine root and without premolars, 60 frameworks were fabricated. Three groups (n = 20) of each metal were cast and each group was divided into two subgroups (n = 10), corresponding the molar undercut of 0.25 mm and 0.75 mm. The nylon male was positioned at the matrix and attached to the acrylic resin of the prosthetic base. The samples were subjected to an insertion and removal test under artificial saliva environment. Results The data were analyzed and compared with ANOVAs and Tukey's test at 95% of probability. The groups cast in cobaltchromium and nickel-chromium-titanium had the highest mean retention strength (5.58 N and 6.36 N respectively) without significant difference between them, but statistically different from the group cast in commercially pure titanium, which had the lowest mean retention strength in all the periods (3.46 N). The association frameworks using nickel-chromium- titanium and cobalt-chromium could be used with 0.25 mm and 0.75 mm of undercut, but the titanium samples seems to decrease the retention strength, mainly in the 0.75 mm undercut. The circumferential clasps cast in commercially pure titanium used in 0.75 mm undercuts have a potential risk of fractures, especially after the 2nd year of use. Conclusion This in vitro study showed that the framework association between cast clasp and an extra resilient attachment are suitable to the three metals evaluated, but strongly suggest extra care with commercially pure titanium in undercut of 0.75 mm. Clinical significance Frameworks fabricated in Cp Ti tend to decrease in retentive strength over time and have a potential risk of fracture in less than 0.75 mm of undercut. How to cite this article Souza JEdA, da Silva NRFA, Coelho PG, Zavanelli AC, Ferracioli RCSR, Zavanelli RA. Retention Strength of Cobalt-Chromium vs Nickel-Chromium Titanium vs CP Titanium in a Cast Framework Association of Removable Partial Overdenture. J Contemp Dent Pract 2011;12(3):179-186.

Vitamin E Succinate Induces Remission and Prolongs Survival in a Syngenic Transplant Model of Acute Promyelocytic Leukemia.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 4953-4953
Author(s):  
Rodrigo S. Abreu e Lima ◽  
Priscila S. Scheucher ◽  
Bárbara A.A. Santana ◽  
Ana Carolina T. Pintão ◽  
Ana Sílvia G. Lima ◽  
...  
Keyword(s):  
Vitamin E ◽  
Acute Promyelocytic Leukemia ◽  
Annexin V ◽  
Promyelocytic Leukemia ◽  
Rank Test ◽  
Histopathological Analysis ◽  
Vitamin E Succinate ◽  
Significant Difference ◽  
Transplant Model

Abstract Vitamin E Succinate (VES) is a semisinthetic analogue of vitamin E with pro-apoptotic activity against several tumor cell lines and it has reported that the association of VES and other antioxidants with first-line chemotherapy may prolong survival of patients with ovarian carcinoma without significant adverse effects. Recently, we have demonstrated in vitro that VES induces apoptosis in primary cells from patients with Acute Promyelocytic Leukemia (APL) as well as in NB4 cells. In order to test in vivo the efficacy of VES treatment, we used a syngenic transplant model of APL. Leukemic blasts from PML/RARα transgenic mice (TM) were IV injected in non transgenic littermates. Recipients were irradiated with 700 cGy 24h prior to transplant. Massive infiltration of bone marrow (BM), spleen and liver was invariable detected by 21st Day. Forty-eight mice were randomly assigned to receive daily intraperitoneal (ip) injections of : VES (50UI/g/d) (n=8), Retinoic Acid (RA) (1.5μg/g/d) (n=7), As2O3 (2.5μg/g/d) (n=8) or the association VES + RA (n=7) and VES + As2O3 (n= 8) at the same doses. Control mice (n=10) were treated with vehicle (DMSO). Treatment was started four days after transplantation and maintained for 21 consecutive days. Survival analysis was based on Kaplan-Meyer estimation and groups were compared by the long-rank test. In any of the five therapeutic arms hematology remission was achieve and survival was significantly longer than in DMSO treated group (P<0.05) (Mean survival time of control: 29.8 days, 95% C.I. = 23.3 – 36.3 days; VES: 66 days, 95%CI = 51.9 – 80.1 days; RA: 60.7 days, 95% CI = 48.1 – 73.2 days; As2O3: 69.7 days, 95% CI = 55.4 –84 days; VES+RA: 49.8 days, 95% CI = 29 – 70.5 days; VES+ As2O3: 70.3 days, 95% CI = 57 – 83.5 days. Treatment toxicity was evaluated by histopathological analysis of heart, lung, brain, liver and kidney paraffin embedded specimens, and no significant organ damage was detected. In order to determine if the antileukemic effect of VES was due to induction of apoptosis, leukemic cells obtained from spleen were treated in vitro with 10, 20, 40μg/mL of VES or DMSO. After 24h cells were harvested and stained with anti-CD117 and anti-annexin V antibody conjugated with phycoerythrin (PE) or fluorescein isothyocyanate (FITC), and the number of CD117 / Annexin V double positive cells (apoptotic) was determined by flow cytometry (FC). The mean percentage of apoptotic cells in samples treated with 40μg/mL of VES (but not with 10 or 20μg/mL) was significantly higher than in controls (83 ± 8% versus 56 ± 4 %, p< 0.05). Differentiation was evaluated morphologically on Leishman stained cytospin preparations after 72h of in vitro treatment of VES at the same doses above. No significant difference in the number of mature granulocytic cells between treated and control samples was observed. In conclusion, our results demonstrate that treatment with VES alone or in combination with RA or As2O3 was well tolerated and extremely effective, and therefore may represent an alternative therapy to relapsed and/or refractory APL cases.

The influence of shape and sliding distance of femoral head movement loci on the wear of acetabular cups in total hip arthroplasty

2002 ◽  
Vol 216 (6) ◽  
pp. 393-402 ◽  
Author(s):  
D Bennett ◽  
J F Orr ◽  
D E Beverland ◽  
R Baker
Keyword(s):  
Femoral Head ◽  
Aspect Ratio ◽  
Hip Joint ◽  
Wear Rates ◽  
Total Hip ◽  
Aspect Ratios ◽  
Average Aspect Ratio ◽  
Sliding Distance

Wear of the polyethylene acetabular component is the most serious threat to the long-term success of total hip replacements (THRs). Greatly reduced wear rates have been reported for unidirectional, compared to multidirectional, articulation in vitro. This study considers the multidirectional motions experienced at the hip joint as described by movement loci of points on the femoral head for individual THR patients. A three-dimensional computer program determined the movement loci of selected points on the femoral head for THR patients and normal subjects using kinematic data obtained from gait analysis. The sizes and shapes of these loci were quantified by their sliding distances and aspect ratios with substantial differences exhibited between individual THR patients. The average sliding distances ranged from 10.0 to 18.1 mm and the average aspect ratios of the loci ranged from 2.5 to 9.2 for the THR patients. Positive correlations were found between wear rate and average sliding distance, the inverse of the average aspect ratio of the loci and the product of the average sliding distance and the inverse of the average aspect ratio of the loci. Patients with a normal hip joint range of motion produce multidirectional motion loci and tend to experience more wear than patients with more unidirectional motion loci. Differing patterns of multidirectional motion at the hip joint for individual THR patients may explain widely differing wear rates in vivo.

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