Improvement of Drug Release and Compatibility between Hydrophilic Drugs and Hydrophobic Nanofibrous Composites

Electrospinning is a flexible polymer processing method to produce nanofibres, which can be applied in the biomedical field. The current study aims to develop new electrospun hybrid nanocomposite systems to benefit the sustained release of hydrophilic drugs with hydrophobic polymers. In particular, electrospun hybrid materials consisting of polylactic acid (PLA):poly(ε-caprolactone) (PCL) blends, as well as PLA:PCL/halloysite nanotubes-3-aminopropyltriethoxysilane (HNT-ASP) nanocomposites were developed in order to achieve sustained release of hydrophilic drug tetracycline hydrochloride (TCH) using hydrophobic PLA:PCL nanocomposite membranes as a drug carrier. The impact of interaction between two commonly used drugs, namely TCH and indomethacin (IMC) and PLA:PCL blends on the drug release was examined. The drug release kinetics by fitting the experimental release data with five mathematical models for drug delivery were clearly demonstrated. The average nanofiber diameters were found to be significantly reduced when increasing the TCH concentration due to increasing solution electrical conductivity in contrast to the presence of IMC. The addition of both TCH and IMC drugs to PLA:PCL blends reduced the crystallinity level, glass transition temperature (Tg) and melting temperature (Tm) of PCL within the blends. The decrease in drug release and the impairment elimination for the interaction between polymer blends and drugs was accomplished by mobilising TCH into HNT-ASP for their embedding effect into PLA:PCL nanofibres. The typical characteristic was clearly identified with excellent agreement between our experimental data obtained and Ritger–Peppas model and Zeng model in drug release kinetics. The biodegradation behaviour of nanofibre membranes indicated the effective incorporation of TCH onto HNT-ASP.

Download Full-text

Tuneable spheroidal hydrogel particles for cell and drug encapsulation

Soft Matter ◽

10.1039/c8sm00921j ◽

2018 ◽

Vol 14 (27) ◽

pp. 5622-5627 ◽

Cited By ~ 9

Author(s):

Isabel M. Bjørge ◽

Ana M. S. Costa ◽

A. Sofia Silva ◽

João P. O. Vidal ◽

J. Miguel Nóbrega ◽

...

Keyword(s):

Drug Release ◽

Release Kinetics ◽

Cell Encapsulation ◽

Drug Encapsulation ◽

Drug Release Kinetics ◽

Hydrogel Particles ◽

The Impact

Straight-forward production of spheroidal particles allows the assessment of the impact of geometry on cell encapsulation viability and drug release kinetics.

Download Full-text

Investigating Halloysite Nanotubes as a Potential Platform for Oral Modified Delivery of Different BCS Class Drugs: Characterization, Optimization, and Evaluation of Drug Release Kinetics

International Journal of Nanomedicine ◽

10.2147/ijn.s299261 ◽

2021 ◽

Vol Volume 16 ◽

pp. 1725-1741

Author(s):

Tazeen Husain ◽

Muhammad Harris Shoaib ◽

Farrukh Rafiq Ahmed ◽

Rabia Ismail Yousuf ◽

Sadaf Farooqi ◽

...

Keyword(s):

Drug Release ◽

Release Kinetics ◽

Halloysite Nanotubes ◽

Drug Release Kinetics

Download Full-text

Drug release kinetics and biological properties of a novel local drug carrier system

Dental Research Journal ◽

10.4103/1735-3327.330875 ◽

2021 ◽

Vol 18 (1) ◽

pp. 94

Author(s):

Mehrsima Ghavami-Lahiji ◽

Farhad Shafiei ◽

TaherehSadat Jafarzadeh Kashi ◽

Farhood Najafi

Keyword(s):

Drug Release ◽

Release Kinetics ◽

Drug Carrier ◽

Biological Properties ◽

Carrier System ◽

Drug Release Kinetics ◽

Drug Carrier System

Download Full-text

FORMULATION AND IN VITRO EVALUATION OF BILAYER TABLET OF ATENOLOL FOR BIPHASIC DRUG RELEASE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i5.22975 ◽

2018 ◽

Vol 11 (5) ◽

pp. 114

Author(s):

Tarun Parashar ◽

Nardev Singh

Keyword(s):

Drug Release ◽

Sustained Release ◽

Guar Gum ◽

Regression Coefficient ◽

Release Kinetics ◽

Immediate Release ◽

Drug Release Kinetics ◽

Gum Acacia ◽

Bilayer Tablet

Objective: In the present research work, the aim was to prepare the bilayer tablet of atenolol for biphasic drug release to improve its bioavailability and absorption in the lower gastrointestinal tract. Methods: In the formulation of immediate release crospovidone, croscarmellose sodium, and sodium starch glycolate was used as super disintegrate and was directly compressed. For a sustained release portion different grade hydroxypropyl methylcellulose (HPMC) K4M, HPMC K15M, gum tragacanth, gum acacia, guar gum, and ethyl cellulose. Preformulation studies were performed before compression. The compressed bilayer tablets were evaluated for weight variation, dimension, hardness, friability, drug content, disintegration time, and in vitro drug release using USP dissolution apparatus type 2 (paddle). Results: The formulation IR3 showed 95% drug release in 30 min, and regression coefficient value (r2) value was found to be 0.994 suggesting first-order drug release kinetics. The F9 formulation using HPMC K15M and gum acacia (1:1) showed 91.20% drug release at the end of 12 h, and regression coefficient value (r2) was 0.992 suggesting zero-order drug release kinetics. Formulation IR3F9 showed faster drug release for bilayer tablet containing 5%w/w crospovidone in immediate release layer and HPMC and guar gum (1:1) in sustained release. Formulation IR3F9 showed swelling index 206%, floating lag time was found to be 2 min and total floating time up to 12 h. Conclusion: The formulation IR3F9 showed a faster drug release profile among the others in the preparation of the atenolol bilayer tablet. Hence, it was considered as an optimized formulation.

Download Full-text

Novel Sustained Release Drug Delivery System of Alfuzosin Hydrochloride with Improved Bioavailability: Investigation of Drug Release Kinetics

Journal of Pharmaceutical Research ◽

10.18579/jpcrkc/2013/12/4/79322 ◽

2013 ◽

Vol 12 (4) ◽

pp. 134

Author(s):

Kilor Vaishali ◽

Khan Imtiaz ◽

Sapkal Nidhi

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Sustained Release ◽

Drug Delivery System ◽

Delivery System ◽

Release Kinetics ◽

Drug Release Kinetics ◽

Release Drug ◽

Alfuzosin Hydrochloride

Download Full-text

Evaluation of the Influence of Stirring Speed on the Release Kinetics of Fexofenadine HCl Polymeric Microspheres

Biosciences Biotechnology Research Asia ◽

10.13005/bbra/2955 ◽

2021 ◽

Vol 18 (4) ◽

pp. 733-741 ◽

Cited By ~ 1

Author(s):

Paroma Arefin ◽

Md Shehan Habib ◽

Mohammad Mostafa ◽

Dipankar Chakraborty ◽

Sreebash Chandra Bhattacharjee ◽

...

Keyword(s):

Drug Release ◽

Sustained Release ◽

Release Kinetics ◽

Drug Loading ◽

Solvent Evaporation ◽

Solvent Evaporation Method ◽

Evaporation Method ◽

Stirring Rate ◽

The Impact ◽

Fexofenadine Hcl

Microspheres, a potential drug delivery approach, has opened a new era for attaining versatile release patterns needed. By optimizing the formulation variables, they can be prepared to obtain targeted release, immediate release, sustained release patterns. The release of the active drug material depends upon a number of formulation parameters such as polymers, stirring speed (rpm), methodology, surfactants, etc. Fexofenadine hydrochloride (HCl) is a second generation antihistamine. Our present research has explored the effects of using different rpm (600- 1000 rpm) in preparing fexofenadine hydrochloride (HCl) microspheres by emulsion solvent evaporation method. The formulation is aimed to provide sustained release for the required long period with a high margin of safety. We used a blended mixture of Hydroxy Propyl Methyl Cellulose (HPMC) K 100 MCR and Eudragit RL100 polymers to have sustained-release microspheres. The impact of different rpm on Yield, drug encapsulation efficiency, flow properties, and dissolution pattern were appraised. We observed the release of the drug for 10 hours in phosphate buffer (pH 6.8) and evaluated the drug release spectrophotometrically. Our study finds that the release of fexofenadine HCl from the microspheres was significantly increased with drug loading. We found the dosage forms to follow Higuchi release kinetics and Hixson-Crowell release kinetics the most, indicating successful achievement of sustained-release pattern in the dosage form. The change in drug release rate was statistically significant for variation in the stirring rate. We found that 600 rpm was the most optimized stirring rate for preparing microspheres in the emulsion solvent evaporation method.

Download Full-text

Effects of polymer intercalation in calcium silicate hydrates on drug loading capacities and drug release kinetics: an X-ray absorption near edge structure study

Canadian Journal of Chemistry ◽

10.1139/cjc-2016-0660 ◽

2017 ◽

Vol 95 (11) ◽

pp. 1122-1129 ◽

Cited By ~ 2

Author(s):

Xiaoxuan Guo ◽

Jin Wu ◽

Yun-Mui Yiu ◽

Yongfeng Hu ◽

Ying-Jie Zhu ◽

...

Keyword(s):

Drug Release ◽

Calcium Silicate ◽

Release Kinetics ◽

Drug Carrier ◽

Drug Loading ◽

Precipitation Reaction ◽

Edge Structure ◽

X Ray ◽

Drug Release Kinetics ◽

X Ray Absorption

Different calcium silicate hydrate (CSH)/polymer composites are synthesized by using a controlled precipitation reaction between calcium salt and silicate salt, followed by the addition of various polymer solutions at room temperature. X-ray absorption near edge structure (XANES) spectroscopy has been used to extensively investigate the structural changes after hybrid biomaterials formation and the drug–carrier interactions on the molecular level. We find that the polymers alter the structure of CSH to various degrees and that this behaviour further influences the drug loading capacities and drug release kinetics.

Download Full-text