scholarly journals Blue-Print Autophagy in 2020: A Critical Review

Marine Drugs ◽  
2020 ◽  
Vol 18 (9) ◽  
pp. 482
Author(s):  
Sergey A. Dyshlovoy
Keyword(s):  
Experimental Data ◽  
Critical Review ◽  
Biological Process ◽  
Data Interpretation ◽  
Published Data ◽  
Pathological Conditions ◽  
Complex Biological Process ◽  
Time Period ◽  
Blue Print ◽  
Marine Natural Compounds

Autophagy is an elegant and complex biological process that has recently attracted much attention from the scientific community. The compounds which are capable of control and modulation of this process have a promising potential as therapeutics for a number of pathological conditions, including cancer and neurodegenerative disorders. At the same time, due to the relatively young age of the field, there are still some pitfalls in the autophagy monitoring assays and interpretation of the experimental data. This critical review provides an overview of the marine natural compounds, which have been reported to affect autophagy. The time period from the beginning of 2016 to the middle of 2020 is covered. Additionally, the published data and conclusions based on the experimental results are re-analyzed with regard to the guidelines developed by Klionsky and colleagues (Autophagy. 2016; 12(1): 1–222), which are widely accepted by the autophagy research community. Remarkably and surprisingly, more than half of the compounds reported to be autophagy activators or inhibitors could not ultimately be assigned to either category. The experimental data reported for those substances could indicate both autophagy activation and inhibition, requiring further investigation. Thus, the reviewed molecules were divided into two groups: having validated and non-validated autophagy modulatory effects. This review gives an analysis of the recent updates in the field and raises an important problem of standardization in the experimental design and data interpretation.

Critical Review on Standard Operative Procedure of Yapana Basti Karma

2018 ◽  
Vol 3 (5) ◽  
Author(s):  
Dr. Rishu Sharma ◽  
Dr. Gyanendra Datta Shukla ◽  
Dr. Alok Kumar Srivastava
Keyword(s):  
Side Effects ◽  
Critical Review ◽  
Treatment Modality ◽  
Operative Procedure ◽  
The Body ◽  
Dosage Schedule ◽  
Dual Function ◽  
Time Period ◽  
Curative Action

Panchakarma therapy is one of the vital branch of Ayurveda, which deals mainly with purification of the provoked Doshas from the body. Basti Chikitsa is regarded as the prime treatment modality among the Panchakarma. It is having not only curative action but also preventive and promotive actions. It is considered as best treatment for Vata Dosha. Yapana Basti is a subtype of Asthapana Basti, which is having the property to support life and promote longevity and widely used in various disorders. Rajayapana Basti is superior amongst all the Yapana Bastis described by Acharya Charaka as it is the king of Yapana. This Rasayana Yapana Basti performs dual function of both Anuvasana and Niruha; hence this is Srotoshodhaka and Brimhana at the sametime. That’s why there is no need to administer separate Anuvasana while giving Yapana Basti. There is an urgent need of standardizing the classical Panchakarma procedures in consideration of the need of today. The dosage schedule, exact procedures, medicaments, effects, and side effects are to be standardized so that uniform procedure of practice should be followed all over nation. Standardization is the need of hour for physicians, to prevent Atiyoga (over activity), Ayoga (less or no activity) and to get adequate effects in a systematic and sophisticated manner within desired time period.

Lateral skull base surgery: a complicated pursuit?

2007 ◽  
Vol 122 (3) ◽  
pp. 221-229
Author(s):  
V C Cousins
Keyword(s):  
Skull Base ◽  
Skull Base Surgery ◽  
Treatment Modalities ◽  
Published Data ◽  
Know How ◽  
Team Assessment ◽  
Pathological Conditions ◽  
Lateral Skull Base ◽  
Wide Range ◽  
Multi Disciplinary Team

AbstractThe management of lesions of the lateral skull base is a highly sophisticated branch of surgery generally performed by otolaryngology–head and neck surgeons as part of a multi-disciplinary team. Assessment of patients with diseases affecting the lateral skull base can be complex, as can the application of the various treatment modalities and the management of the expected and unexpected side effects of that treatment.A wide range of pathological conditions occur in the lateral skull base. Many operations and procedures have been described for dealing with them. There is not necessarily one correct solution to the management of any particular problem in the skull base, with multiple factors to be considered in planning and intervention.As surgeons, we need to know how our own results and outcomes compare with pooled, published data concerning the implications and complications occurring as a result of intervention, in order to better advise our patients on their management.

A Critical Review of NOx Correlations for Gas Turbine Combustors

1975 ◽  
Author(s):  
D. A. Sullivan ◽  
P. A. Mas
Keyword(s):  
Experimental Data ◽  
Data Base ◽  
Gas Turbine ◽  
Critical Review ◽  
Inlet Temperature ◽  
Nox Emissions ◽  
Empirical Correlations ◽  
Gas Turbine Combustors ◽  
Semi Empirical ◽  
Adequate Data

The effect of inlet temperature, pressure, air flowrate and fuel-to-air ratio on NOx emissions from gas turbine combustors has received considerable attention in recent years. A number of semi-empirical and empirical correlations relating these variables to NOx emissions have appeared in the literature. They differ both in fundamental assumptions and in their predictions. In the present work, these simple NOx correlations are compared to each other and to experimental data. A review of existing experimental data shows that an adequate data base does not exist to evaluate properly the various NOx correlations. Recommendations are proposed to resolve this problem in the future.

A Critical Review on the Determination of Pressure Drop During Condensation in Smooth and Enhanced Tubes

2013 ◽  
Author(s):  
Ahmet Selim Dalkiliç ◽  
Ali Celen ◽  
Mohamed M. Awad ◽  
Somchai Wongwises
Keyword(s):  
Neural Network ◽  
Heat Transfer ◽  
Experimental Data ◽  
Heat Transfer Coefficient ◽  
Transfer Coefficient ◽  
Critical Review ◽  
Heat Exchangers ◽  
Numerical Analyses ◽  
Enhanced Tubes

Heat exchangers using in-tube condensation have great significance in the refrigeration, automotive and process industries. Effective heat exchangers have been rapidly developed due to the demand for more compact systems, higher energy efficiency, lower material costs and other economic incentives. Enhanced surfaces, displaced enhancement devices, swirl-flow devices and surface tension devices improve the heat transfer coefficients in these heat exchangers. This study is a critical review on the determination of the condensation heat transfer coefficient of pure refrigerants flowing in vertical and horizontal tubes. The authors’ previous publications on this issue, including the experimental, theoretical and numerical analyses are summarized here. The lengths of the vertical and horizontal test sections varied between 0.5 m and 4 m countercurrent flow double-tube heat exchangers with refrigerant flowing in the inner tube and cooling water flowing in the annulus. The measured data are compared to theoretical and numerical predictions based on the solution of the artificial intelligence methods and CFD analyses for the condensation process in the smooth and enhanced tubes. The theoretical solutions are related to the design of double tube heat exchangers in refrigeration, air conditioning and heat pump applications. Detailed information on the in-tube condensation studies of heat transfer coefficient in the literature is given. A genetic algorithm (GA), various artificial neural network models (ANN) such as multilayer perceptron (MLP), radial basis networks (RBFN), generalized regression neural network (GRNN), and adaptive neuro-fuzzy inference system (ANFIS), and various optimization techniques such as unconstrained nonlinear minimization algorithm-Nelder-Mead method (NM), non-linear least squares error method (NLS), and Ansys CFD program are used in the numerical solutions. It is shown that the convective heat transfer coefficient of laminar and turbulent condensing film flows can be predicted by means of theoretical and numerical analyses reasonably well if there is a sufficient amount of reliable experimental data. Regression analysis gave convincing correlations, and the most suitable coefficients of the proposed correlations are depicted as compatible with the large number of experimental data by means of the computational numerical methods.

Ignition delay in hydrogen–air and syngas–air mixtures: Experimental data interpretation via flame propagation

2010 ◽  
Vol 157 (7) ◽  
pp. 1436-1438 ◽  
Author(s):  
Sergey P. Medvedev ◽  
Gennady L. Agafonov ◽  
Sergey V. Khomik ◽  
Boris E. Gelfand
Keyword(s):  
Experimental Data ◽  
Flame Propagation ◽  
Ignition Delay ◽  
Data Interpretation

Application of Polyhedral Mesh for Vortex Formation Study for Simple Single Pump Sump

CFD letters ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 13-27
Author(s):  
Mohamad Lutfi Samsudin ◽  
Hasril Hasini
Keyword(s):  
Experimental Data ◽  
Complex Geometry ◽  
Vortex Formation ◽  
Tetrahedral Mesh ◽  
Published Data ◽  
Hexahedral Mesh ◽  
The Past ◽  
Polyhedral Mesh ◽  
Pump Sump ◽  
Comparison Of The Results

Meshing of domain in CFD is an important step to ensure accuracy of the solution. In the past, hexahedral or tetrahedral mesh systems were commonly used, and both have their merits and demerits. For large and complex geometry, polyhedral is another option but its accuracy is claimed to be lacking. In this paper, the use of polyhedral mesh system by past researchers are reviewed. Evaluation on the application of polyhedral mesh system for the study of the vortex formation with a simple single pump sump model is made. Validation was made through the comparison of the results from hexahedral, tetrahedral and polyhedral mesh sizes and the experimental data from published data. The polyhedral mesh system was found to perform satisfactorily and was able to match the results from the hexahedral mesh system as well as the experimental data.

High-enthalpy, water-cooled and thin-walled ICP sources characterization and MHD optimization

2008 ◽  
Vol 74 (3) ◽  
pp. 391-429 ◽  
Author(s):  
G. HERDRICH ◽  
D. PETKOW
Keyword(s):  
Experimental Data ◽  
Magnetic Pressure ◽  
Maximum Pressure ◽  
Published Data ◽  
Space Vehicles ◽  
Maximum Plasma ◽  
Plasma Power ◽  
New Model ◽  
High Enthalpy ◽  
Lorentz Forces

AbstractThe development of the inductively driven plasma wind tunnel PWK3, which enables the electrodeless generation of high-enthalpy plasmas for the development of heat shield materials required for space vehicles performing entry manoeuvres in the atmospheres of Venus, Earth and Mars, is described. The facility with its modular inductive plasma generators allows operation with gases such as carbon dioxide, air, oxygen and nitrogen and was qualified for thermal plasma powers up to 60 kW. Previously developed models for determining plasma properties and plasma source related characteristics enable a maximum plasma power in combination with long operational periods using different operational gases and gas mixtures. This is achieved by an optimization using the optimum operational frequency, a minimization of field losses using very thin plasma tube wall thicknesses and the successful application of MHD effects. Based on the solved cylinder problem for ICPs, a one-dimensional model for radial Lorentz forces and magnetic pressure has been developed. Here, a synthesis of previously published data and works is made where the new algebraic model for the calculation of Lorentz forces and magnetic pressures in an ICP was used and applied to experimental data. In addition, results from the model using the experimental data are shown to be consistent and, in addition, a comparison with a simpler model based on the well-known exponential approach for ICPs showed that the simpler model is covered without fail by the new model. The new model also states that there is a maximum of the Lorentz forces over the damping parameter d/δ (plasma diameter divided by skin depth) which almost corresponds with the position of the maximum plasma power of the cylindric model for ICPs. For the magnetic pressure the position of the maximum pressure is identical to the value for d/δ for the maximum plasma power.

scholarly journals Optimization of Interfacial Energy for Langer-Schwartz Based Precipitation Simulations

2021 ◽  
Author(s):  
Conner Sarich ◽  
Adam Hope ◽  
Jim Rule
Keyword(s):  
Experimental Data ◽  
Interfacial Energy ◽  
Volume Fraction ◽  
Published Data ◽  
Low Alloy Steels ◽  
Interfacial Energies ◽  
Nucleation Sites ◽  
Alloy Steels ◽  
Thermal Histories ◽  
Al 2024

Abstract Precipitation kinetics were investigated in select Fe, Ni, and Al alloys using a CALPHAD based precipitation model based on Langer-Schwartz theory. Thermodynamic and kinetic data are taken from commercially available CALPHAD software, but reliable interfacial energy data for precipitates needed for the calculations is often lacking. While models exist to approximate these interfacial energies, this study has focused on deriving more reliable estimates by comparison with experimental data. By performing simulations with thermal histories, nucleation sites, and precipitate morphologies that closely replicate experimental data found in literature, the interfacial energies were optimized until volume fraction and mean radius values closely matched the published data. Using this technique, interfacial energy values have been determined for carbides in Grade 22 low alloy steels, delta phase in Ni 625 and 718, SPhase in Al 2024, and Q’ and β’’ in Al 6111, and can be used for future predictive precipitation simulations.

TheHydrobia ulvae–Maritrema subdolumassociation: cercarial emergence controlled by host activity

2002 ◽  
Vol 76 (4) ◽  
pp. 349-353 ◽  
Author(s):  
K.N. Mouritsen
Keyword(s):  
Experimental Data ◽  
Adaptive Significance ◽  
Published Data ◽  
Hydrobia Ulvae ◽  
Mud Snail ◽  
Emergence Rate ◽  
Presence And Absence ◽  
Marine Mud ◽  
Cercarial Emergence

AbstractThe release ofMaritrema subdolumcercariae (Digenea: Microphallidae) from the marine mud snailHydrobia ulvaeis significantly affected by temperature, salinity, light and exudates from the second intermediate amphipod host. Based on (i) previously published data on temperature–salinity dependentH. ulvaeactivity, (ii) new experimental data onH. ulvaeactivity in light and darkness as well as in the presence and absence of host exudates, and (iii) the cercarial emergence rate from free moving snails and snails prevented from crawling, the present analysis indicates that emergence ofM. subdolumlarvae is regulated mainly by host activity as the ultimate factor for release. The adaptive significance of such an emergence strategy is emphasized.

Sign in / Sign up

Export Citation Format

Share Document