scholarly journals Algae-Derived Anti-Inflammatory Compounds against Particulate Matters-Induced Respiratory Diseases: A Systematic Review

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 317
Author(s):  
Pek Xyen Tan ◽  
Krishnapriya Thiyagarasaiyar ◽  
Cheng-Yau Tan ◽  
You-Jin Jeon ◽  
Mohd Shahrul Mohd Nadzir ◽  
...  

Air pollution has recently become a subject of increasing concern in many parts of the world. The World Health Organization (WHO) estimated that nearly 4.2 million early deaths are due to exposure to fine particles in polluted air, which causes multiple respiratory diseases. Algae, as a natural product, can be an alternative treatment due to potential biofunctional properties and advantages. This systematic review aims to summarize and evaluate the evidence of metabolites derived from algae as potential anti-inflammatory agents against respiratory disorders induced by atmospheric particulate matter (PM). Databases such as Scopus, Web of Science, and PubMed were systematically searched for relevant published full articles from 2016 to 2020. The main key search terms were limited to “algae”, “anti-inflammation”, and “air pollutant”. The search activity resulted in the retrieval of a total of 36 publications. Nine publications are eligible for inclusion in this systematic review. A total of four brown algae (Ecklonia cava, Ishige okamurae, Sargassum binderi and Sargassum horneri) with phytosterol, polysaccharides and polyphenols were reported in the nine studies. The review sheds light on the pathways of particulate matter travelling into respiratory systems and causing inflammation, and on the mechanisms of actions of algae in inhibiting inflammation. Limitations and future directions are also discussed. More research is needed to investigate the potential of algae as anti-inflammatory agents against PM in in vivo and in vitro experimental models, as well as clinically.

Author(s):  
Ghotekar D S ◽  
Vishal N Kushare ◽  
Sagar V Ghotekar

Coronaviruses are a family of viruses that cause illness such as respiratory diseases or gastrointestinal diseases. Respiratory diseases can range from the common cold to more severe diseases. A novel coronavirus outbreak was first documented in Wuhan, Hubei Province, China in December 2019. The World Health Organization (WHO) has declared the coronavirus disease 2019 (COVID-19) a pandemic. A global coordinated effort is needed to stop the further spread of the virus. A novel coronavirus (nCoV) is a new strain that has not been identified in humans previously. Once scientists determine exactly what coronavirus it is, they give it a name (as in the case of COVID-19, the virus causing it is SARS-CoV-2).


2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Francesca Gimigliano ◽  
◽  
Sara Liguori ◽  
Antimo Moretti ◽  
Giuseppe Toro ◽  
...  

Abstract Background The identification of existing rehabilitation interventions and related evidence represents a crucial step along the development of the World Health Organization’s (WHO) Package of Interventions for Rehabilitation (PIR). The methods for such identification have been developed by the WHO Rehabilitation Programme and Cochrane Rehabilitation under the guidance of the WHO’s Guideline Review Committee secretariat. The aim of this paper is to report on the results of the systematic search for clinical practice guidelines (CPGs) relevant to the rehabilitation of adults with fractures and to present the current state of evidence available from the identified CPGs. Methods This paper is part of the Best Evidence for Rehabilitation (be4rehab) series, developed according to the methodology presented in the World Health Organization’s (WHO) Package of Interventions for Rehabilitation (PIR) introductory paper. It is a systematic review of existing CPGs on fractures in adult population published from 2009 to 2019. Results We identified 23 relevant CPGs after title and abstract screening. According to inclusion/exclusion criteria, we selected 13 CPGs. After checking for quality, publication time, multiprofessionality, and comprehensiveness, we finally included five CPGs dealing with rehabilitative management of fractures in adult population, two CPGs addressing treatment of distal radius fracture and three the treatment of femoral/hip fracture. Conclusion The selected CPGs on management of distal radius and femoral/hip fracture include few recommendations regarding rehabilitation, with overall low to very low quality of evidence and weak/conditional strength of recommendation. Moreover, several gaps in specific rehabilitative topics occur. Further high-quality trials are required to upgrade the quality of the available evidence. Level of evidence Level 1.


2021 ◽  
pp. 104365962110469
Author(s):  
Giorgia Rudes ◽  
Claudia Fantuzzi

Introduction: The World Health Organization states that suicide is the second leading cause of death among youngs, and racism has been proven to have detrimental effects on both physical and mental health. These two plagues represent a public health priority, especially for susceptible minorities. Method: This systematic review analyzed 23 studies from multiple database searches, to understand the relationship between racism and suicidality in young minority groups. Results: The review demonstrated the correlation between racism and suicidality with the consequent development of mental disorders. There is strong evidence that the main suicide risk factor is acculturation, interpreted as the assimilation of the dominant culture with the loss of values from one’s cultural background. Discussion: Health care professionals should not underestimate the risk of suicidality associated with racism. Prevention is crucial and it should be implemented from a young age, in schools, through a joint intervention with children and their families, aiming toward integration without acculturation.


2021 ◽  
Vol 18 ◽  
Author(s):  
Roopal Mittal ◽  
Shailesh Sharma ◽  
Ajay Singh Kushwah

Background: Inflammation is the earliest body defence mechanism in which the immune system recognises and counters the antigens and aids in healing the disease. The World Health Organisation suggests that inflammation is one of the greatest causes of death in the world. Inflammation could be acute or chronic due to the release of inflammatory mediators i.e. prostaglandins, leukotrienes due to mitogens, antigens or cytokines found in the body. Methods: Bibliographic database using pub med cites for peer-reviewed research articles with titles containing dual COX-2 and 5-LOX enzyme inhibitors, heterocyclic moieties, with AND Boolean operator's terms since last ten years of literature work. The quality papers containing the natural or synthetic lead compounds were extracted; the detailed study and conceptual framework attracted its attention. Results: Out of 127 research and review articles evaluated, 54 articles were cited to provide high quality data regarding pharmacoactive molecules having anti-inflammatory activity via dual COX-2/5-LOX inhibition. In addition, highlighting their in silico and experimental wet laboratory studies in increasing order over the past decade with the best illustration of dual enzyme inhibitory activity. Conclusion: This review gathered details of isolated bioactive compounds such as pyrazole, coumaperine, indoles, phenanthrene derivatives that have been significantly reported for anti-inflammatory activities.


2021 ◽  
pp. 172-180
Author(s):  
Fitrio Deviantony ◽  
Grysha Viofananda ◽  
Nurul Hidayah ◽  
Nadhifa Eriyanti

permasalahan serius di dunia dan Indonesia. Data dari World Health Organization sekitar 21 juta orang mengalami skizofrenia. Prevalensi skizofrenia di Indonesia mengalami peningkatan proporsi per 1000 penduduk (1,7%) pada tahun 2013 menjadi (7%) pada tahun 2018. Faktanya terapi keperawatan untuk halusinasi belum optimal sedangkan teknologi terus berkembang seperti Virtual Reality (VR). VR mampu menurunkan gejala pada skizofrenia dengan kemampuan membuat perilaku interaktif dan tersimpan dalam otak agar tidak menimbulkan halusinasi. Teknologi ini digunakan untuk mengetahui manfaat E-Health Nursing VR sebagai terapi halusinasi pada pasien skizofrenia. Metode penelitian menggunakan systematic review dari 5 database yaitu Nature, Frontiers, BMC, Science Direct, NEJM sehingga didapat total 55 literatur. Mayoritas 63% mengulas terapi VR untuk mengurangi halusinasi pada skizofrenia. Perkembangan manfaat VR diverifikasi dalam beberapa pengobatan: skizofrenia, PTSD, kecemasan, akrofobia, ganguan citra tubuh, claustrophobia, dan lain-lain. Beberapa studi skizofrenia menyatakan terapi VR sangat efektif menangani delusi, halusinasi, gejala kepribadian skizoid. VR juga berguna dalam rehabilitas kognitif pada orang dewasa atau anak-anak autis dalam keterampilan dan kemandirian. Kesimpulan penelitian ini adalah VR terbukti efektif sebagai terapi kesehatan jiwa di masa mendatang. Disisi lain terdapat terapi psikologis pilihan seperti terapi perilaku kognitif, dan psikoterapi interpersonal. Oleh karenanya diperlukan kombinasi terapi VR dengan terapi komplementer tersebut dalam mengurangi halusinasi pada skizofrenia.   Mental health become a severe problem in the world and Indonesia. Data from the World Health Organization (WHO, 2016) estimated that 21 million people have schizophrenia. The prevalence of schizophrenia in Indonesia has increased proportion per 1000 population (1,7%) in 2013 to (7%) in 2018. In fact of nursing, therapy for hallucination is not optimal while constantly evolving technology such as Virtual Reality (VR). VR can reduce symptoms in schizophrenia with the ability to create interactive behavior and stored in the brain in order to cause hallucinations. The objective of this study was to review the benefit of VR as a hallucination therapy in schizophrenia patients. This research used a systematic literature review from five databases Nature, Frontiers, BMC, Science Direct, NEJM, and resulted in the retrieval of 55 papers. The majority of a result found a 63% review in Virtual Reality therapy can reduce hallucination in schizophrenia. VR is a technology browser and manipulator sensory environment in real-time 3D. The progressing benefit of VR verified in the treatment of schizophrenia, PSTD, anxiety, acrophobia, body image disorder, claustrophobia, and others. Some studies of schizophrenia declare that virtual reality therapy is effective in treating delusions, hallucinations, and a symptom of schizoid behavior. VR also has benefits in cognitive rehabilitation in adults or children with autism's inability and self-reliance. VR has a bright future as the treatment of mental health. The progressing of technology and research has an excellent opportunity for VR to reduce schizophrenia. Moreover, there is psychological therapy, such as cognitive-behavioral therapy and interpersonal psychotherapy. Therefore a combination needed of virtual therapy with the complementary therapy for reducing hallucination in schizophrenia.


Author(s):  
Afsaneh Noormandi ◽  
Mohammad Fathalipour ◽  
Reza Daryabeygi-Khotbehsara ◽  
Soheil Hassanipour

Background and objective: COVID-19 has since been declared a global pandemic by the World Health Organization (WHO), infecting millions worldwide. The use of Interferon (INF) subtypes previously examined in the treatment of SARS and MERS is also being initiated in some clinical trials. Although different clinical trials were evaluated IFNs in the treatment of COVID-19, their efficacy and safety remain unknown. Therefore, this study aims to systematically assess IFNs efficacy and safety in treating patients with COVID-19. Methods: The protocol has been registered in the PROSPERO International Prospective Register (CRD42020200643) on 24 July 2020. This protocol has been arranged according to the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) 2015 checklist. Discussion: Due to lack of approved medication for the covid-19 treatment and also various mutations of this virus, evaluated the efficacy and safety of medications by various studies could help for finding treatments with high effectiveness. IFNs are one of the medications that have been administered in covid-19 infection.  Moreover, the best time of administration and dose of this medication was unknown. Although meta-analysis is a potent source for assessing the accuracy of subjects, heterogeneity of articles is a potent limitation of our work.


2017 ◽  
Vol 17 (14) ◽  
pp. 9223-9236 ◽  
Author(s):  
Wolfgang Knorr ◽  
Frank Dentener ◽  
Jean-François Lamarque ◽  
Leiwen Jiang ◽  
Almut Arneth

Abstract. Wildfires pose a significant risk to human livelihoods and are a substantial health hazard due to emissions of toxic smoke. Previous studies have shown that climate change, increasing atmospheric CO2, and human demographic dynamics can lead to substantially altered wildfire risk in the future, with fire activity increasing in some regions and decreasing in others. The present study re-examines these results from the perspective of air pollution risk, focussing on emissions of airborne particulate matter (PM2. 5), combining an existing ensemble of simulations using a coupled fire–dynamic vegetation model with current observation-based estimates of wildfire emissions and simulations with a chemical transport model. Currently, wildfire PM2. 5 emissions exceed those from anthropogenic sources in large parts of the world. We further analyse two extreme sets of future wildfire emissions in a socio-economic, demographic climate change context and compare them to anthropogenic emission scenarios reflecting current and ambitious air pollution legislation. In most regions of the world, ambitious reductions of anthropogenic air pollutant emissions have the potential to limit mean annual pollutant PM2. 5 levels to comply with World Health Organization (WHO) air quality guidelines for PM2. 5. Worst-case future wildfire emissions are not likely to interfere with these annual goals, largely due to fire seasonality, as well as a tendency of wildfire sources to be situated in areas of intermediate population density, as opposed to anthropogenic sources that tend to be highest at the highest population densities. However, during the high-fire season, we find many regions where future PM2. 5 pollution levels can reach dangerous levels even for a scenario of aggressive reduction of anthropogenic emissions.


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