scholarly journals Oral Bioavailability of Omega-3 Fatty Acids and Carotenoids from the Microalgae Phaeodactylum tricornutum in Healthy Young Adults

Marine Drugs ◽  
2021 ◽  
Vol 19 (12) ◽  
pp. 700
Author(s):  
Lena Stiefvatter ◽  
Katja Lehnert ◽  
Konstantin Frick ◽  
Alexander Montoya-Arroyo ◽  
Jan Frank ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Phaeodactylum Tricornutum ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Sustainable Food ◽  
Epa And Dha ◽  
Beta Glucans ◽  
Randomized Intervention ◽  
Safety Parameters ◽  
Sea Fish

The microalgae Phaeodactylum tricornutum (PT) contains valuable nutrients such as proteins, polyunsaturated omega-3 fatty acids (n-3 PUFA), particularly eicosapentaenoic acid (EPA) and some docosahexaenoic acid (DHA), carotenoids such as fucoxanthin (FX), and beta-glucans, which may confer health benefits. In a randomized intervention trial involving 22 healthy individuals, we administered for two weeks in a crossover manner the whole biomass of PT (5.3 g/day), or fish oil (FO) containing equal amounts of EPA and DHA (together 300 mg/day). In an additional experiment, sea fish at 185 g/week resulting in a similar EPA and DHA intake was administered in nine individuals. We determined the bioavailability of fatty acids and carotenoids and assessed safety parameters. The intake of PT resulted in a similar increase in the n-3 PUFA and EPA content and a decrease in the PUFA n-6:n-3 ratio in plasma. PT intake caused an uptake of FX that is metabolized to fucoxanthinol (FXOH) and amarouciaxanthin A (AxA). No relevant adverse effects occurred following PT consumption. The study shows that PT is a safe and effective source of EPA and FX—and likely other nutrients—and therefore should be considered as a future sustainable food item.

Comparative study of tissue deposition of omega-3 fatty acids from polar-lipid rich oil of the microalgae Nannochloropsis oculata with krill oil in rats

2015 ◽  
Vol 6 (1) ◽  
pp. 185-191 ◽  
Author(s):  
Michael L. Kagan ◽  
Aharon Levy ◽  
Alicia Leikin-Frenkel
Keyword(s):  
Fatty Acids ◽  
Comparative Study ◽  
Polar Lipid ◽  
Rat Plasma ◽  
Nannochloropsis Oculata ◽  
Polar Lipids ◽  
Omega 3 Fatty Acids ◽  
Krill Oil ◽  
Omega 3 ◽  
Epa And Dha

An oil from micro-algae rich in EPA with no DHA and consisting of 15% polar lipids (phospholipids and glycolipids) showed equivalent uptake of EPA into rat plasma and organs as omega-3 krill oil consisting of EPA and DHA and 40% phospholipids.

scholarly journals Potential Benefits of Icosapent Ethyl on the Lipid Profile: Case Studies

2014 ◽  
Vol 8 ◽  
pp. CMC.S13571 ◽  
Author(s):  
Daniel E. Hilleman ◽  
Mark A. Malesker
Keyword(s):  
Fatty Acids ◽  
Case Reports ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Heart Association ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Icosapent Ethyl ◽  
Epa And Dha ◽  
Potential Benefits

The cardiovascular benefits of marine-derived omega-3 fatty acids are supported by epidemiologic and clinical studies. Both healthy patients and those with confirmed coronary heart disease are advised by the American Heart Association to consume omega-3 fatty acids either through dietary fatty fish or fish oil products. We present two case reports of patients with dyslipidemia who were switched from an omega-3 dietary supplement or a prescription omega-3 drug containing eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) to a new prescription EPA-only drug, icosapent ethyl (IPE). Products containing a combination of EPA and DHA, including dietary supplements and prescription products, are more likely to increase low-density lipoprotein cholesterol (LDL-C) levels compared with pure EPA-only products. The lipid profiles of these two patients were improved with IPE treatment, illustrating the potentially favorable effects of IPE compared with other products containing both EPA and DHA.

scholarly journals KANDUNGAN LEMAK DAN KOMPOSISI ASAM-ASAM LEMAK PADA BAGIAN BADAN IKAN JULUNG-JULUNG (Hemiramphus brasiliensis)

2020 ◽  
Vol 12 (2) ◽  
Author(s):  
Louisa M. F. Josephus ◽  
Julius Pontoh ◽  
Lidya I. Momuat
Keyword(s):  
Fatty Acids ◽  
Gas Chromatography ◽  
Palmitic Acid ◽  
Eicosatrienoic Acid ◽  
Fat Content ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Water Heating ◽  
Epa And Dha

ABSTRAK Telah dilakukan penelitian mengenai kandungan lemak dan komposisi asam-asam lemak pada bagian badan ikan julung-julung. Penentuan kadar lemak pada penelitian ini menggunakan metode ekstraksi pemanasan dengan air (wet rendering). Kadar lemak pada bagian badan ikan julung-julung yaitu 0,02%. Ekstrak lemak ikan yang diperoleh di transesterifikasi basa menggunakan metode derivatisasi kemudian diinjeksikan pada alat kromatografi gas. Hasil penelitian ini menyimpulkan bahwa asam-asam lemak utama yang ada pada bagian badan ikan julung-julung adalah asam palmitat dan DHA. Sedangkan untuk asam-asam lemak omega-3 yang diperoleh yaitu asam eikosatrienoat, EPA dan DHA, dengan total kandungan omega-3 pada bagian badan yaitu 27,0%. ABSTRACT Research has been conducted for the fat content and composition of fatty acids in the part of body of the julung-julung fish. Determination of fat content in this study using the method of water heating extraction (wet rendering). Fat content in the part of body of the julung-julung fish is 0.02%. The extract of fish fat was transesterified bases using the derivatization method and then injected on a gas chromatography device. The results of this study prove that the main fatty acids present in the part of body of the julung-julung fish are palmitic acid and DHA. As for the omega-3 fatty acids obtained, namely eicosatrienoic acid, EPA and DHA, with the total omega-3 content in the part of body is 27.0%. 

scholarly journals Omega-3 Fatty Acids versus Heavy Metals: A Quantitative Estimation of the Benefit-Risk Ratio for the Consumption of Commonly-Consumed Fish and Products in Metro Manila

KIMIKA ◽  
2016 ◽  
Vol 26 (2) ◽  
pp. 39-50 ◽  
Author(s):  
Dave P. Briones ◽  
Nancy Lazaro-Llanos
Keyword(s):  
Heavy Metals ◽  
Fatty Acids ◽  
Health Risks ◽  
Risk Ratio ◽  
Essential Fatty Acids ◽  
Skipjack Tuna ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Epa And Dha ◽  
Metro Manila

Fish and other marine products consumption is the main route of heavy metal exposure to human which poses health risks if taken in high dosage. On the other hand, the nutritional benefits of fish are mainly due to the content of high-quality protein and high content of the two kinds of omega-3 polyunsaturated fatty acids (PUFA): eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The study aims to assess and compare the benefit-risk ratio for the consumption of commonly-consumed fish and products in Metro Manila. Fish and product samples were analyzed for moisture, crude fat, heavy metals (As, Cd, Pb) and fatty acid profile (saturated, mono- and polyunsaturated) including omega-3 fatty acids EPA and DHA. These findings generally indicate that the consumption of fish and products studied posed no risk to human health. Essential fatty acids EPA and DHA were highest for dried anchovy, Stolephorus indicus (1.5 and 7.3mg/g sample); mussel, Mytilus smaragdinus (1.5 and 1.0mg/g sample); round scad, Decapterus macrosoma (0.9 and 3.4mg/g sample); and skipjack tuna, Auxis thazard (1.1 and 3.9mg/g sample). The hazard quotients of essential fatty acids versus heavy metals were also less than 1 except for Cd in squid (1.8), In the case of dried sardine (19.9), squid (1.8), shrimp (3.4), and skipjack tuna (1.7), these foods should be monitored regularly. In conclusion, the target hazard quotients for most of the fish and products showed values less than 1, which suggest that health risks were insignificant.

scholarly journals Dietary Intakes of EPA and DHA Omega-3 Fatty Acids among US Childbearing-Age and Pregnant Women: An Analysis of NHANES 2001–2014

Nutrients ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 416 ◽  
Author(s):  
Zhiying Zhang ◽  
Victor Fulgoni ◽  
Penny Kris-Etherton ◽  
Susan Mitmesser
Keyword(s):  
Fatty Acids ◽  
Pregnant Women ◽  
Dietary Intakes ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Childbearing Age ◽  
Epa And Dha

scholarly journals Exploration of the perceived and actual benefits of omega-3 fatty acids and the impact of FADS1 and FADS2 genetic information on dietary intake and blood levels of EPA and DHA

2017 ◽  
Vol 42 (3) ◽  
pp. 333-333 ◽  
Author(s):  
Kaitlin Roke
Keyword(s):  
Fatty Acids ◽  
Young Adults ◽  
Genetic Information ◽  
Online Survey ◽  
Blood Levels ◽  
Nucleotide Polymorphisms ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Epa And Dha ◽  
The Impact

From a global health perspective, increased intake of omega-3 fatty acids (FAs), in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are beneficial for human health. However, the consumption of EPA- and DHA-rich foods such as fatty fish is low in the Western diet. Therefore, finding new ways to motivate people to increase their consumption of omega-3 FAs is essential. To find effective ways to motivate individuals, understanding people’s awareness of omega-3 FAs and how they obtain their knowledge about nutrition and health is critical. Consequently, we developed an online survey to assess awareness and self-reported intake of omega-3 FAs and supplements in young adults. EPA and DHA are also produced endogenously to a limited extent through a pathway regulated by fatty acid desaturase 1 and 2 (FADS1 and FADS2) genes. Of relevance, single nucleotide polymorphisms (SNPs) in the FADS genes influence levels of omega-3 FAs, where minor allele carriers have lower levels compared with major allele carriers. Accordingly, we conducted a clinical trial to investigate FA levels in response to dietary EPA and DHA supplementation in young adults stratified by SNPs in FADS1 and FADS2. The level of reported awareness of omega-3 terminology varied depending on an individual’s field of study and thus providing all participants with the same set of nutrition information could be an effective tool to increase knowledge and motivate behaviour change. Additionally, the variation in FA levels in accordance to SNPs in FADS1 and FADS2 could be used to create tailored nutritional recommendations which may improve lifestyle habits. The results discovered in the first 2 studies regarding awareness of omega-3 FAs and genetic variation were subsequently used to design a nutrigenetics intervention in young adults. Individuals who received their FADS1 genetic information were more aware of different omega-3 FAs and reported fewer barriers to their consumption by the end of the study, compared with those who did not receive their personal genetic information. All participants increased their intake of EPA and DHA, which was reflected in the analyses of red blood cells. Overall, this thesis demonstrates the power of combining nutritional and genetic information as motivators to increase omega-3 consumption.

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